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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | New Life for Aluminium显示文摘 | Gibbins M N Gibbins and Stern P H | 1989 | Aerospace America1989，，3： | 1 |
| 3 | Corticotropin-releasing factor and urocortin 1 activate CREB through functionally selective G/ signalling in hippocampal pyramidal neurons显示文摘 | Stern C M Meitzen J Mermelstein P G | 2011 | Eur J Neurosci2011，34，5： | 1 |
| 4 | High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors显示文摘 | RINCON I D WILLIAMS K STERN M P | 2001 | Arthritis Rheum2001，44，12： | 1 |
| 5 | Trace metal profiles in the varved sediment of an Arctic lake显示文摘 | Outridge P M Stern G A Hamilton P B | 2005 | Geochim Cosmochim Acta2005，69，20： | 1 |
| 6 | An un- steady single-phase level set method for viscous free sur- face flows 显示文摘 | CARRICA P M WILSON R V STERN F | 2007 | International Journal for Numerical Methods in Fluids2007，53，2： | 1 |
| 7 | Computations of self-propulsion free to sink and trim and of motions in head waves of the KRISO Container Ship(KCS) model显示文摘 | CARRICA P M FU Huiping STERN F | 2011 | Applied Ocean Research2011，，33： | 1 |
| 8 | Update in Sjogren syndrome显示文摘 | Fox RI Stern M Michelson P | 2000 | Curr Opin Rheumatol2000，12，5： | 1 |
| 9 | Full scale self- propulsion computations using diseretized propeller for the KRISO container ship KCS显示文摘 | Castro A M Carrica P M Stern F | 2011 | Computers & Fluids2011，51，1： | 1 |
| 10 | Update in Sjogren syndrome显示文摘 | Fox RI Stern M Michelson P | 2000 | Curr Opin Rheumatol2000，12，5： | 1 |
| 11 | MDS clinical diagnostic criteria for Parkinson's disease 显示文摘 | Postuma RB Berg D Stern M Poewe W Olanow CW Oertel W Obeso J Marek K Litvan I Lang AE Halliday G Goetz CG Gasser T Dubois B Chan P Bloem BR Adler CH Deuschl G | 2015 | Mov Disord2015，30，12： | 1 |
| 12 | URANS simulations of static and dynamic maneuvering for surface combatant显示文摘 | Sakamoto N Carrica P M Stern F | 2012 | Journal of Marine Science and Technology2012，17，4： | 1 |
| 13 | Grating compensation ofthird-order fiber dispersion显示文摘 | STERN M HERITAGE J P CHASE E W | 1992 | IEEE J Q E1992，28，12： | 1 |
| 14 | Full scale self-propulsion computations using diseretized propeller for the KRISO container ship KCS 显示文摘 | Castro A M Carrica P M Stern F | 2011 | Computers & Fluides2011，51，1： | 1 |
| 15 | The homeostasis model in the san antonio heart study显示文摘 | Haffner S M Miettinen H Stern M P | 1997 | Diabetes Care1997，20，： | 1 |
| 16 | Indomethacin inhibits thrombin-,but not thyroxin-stimulated resorption of fetal rat limb bones显示文摘 | Hoffmann O Klaushofer K Koller K Peterlik M Mavreas T Stern P | | 0，，： | 1 |
| 17 | Update in Sjogren syndrome 显示文摘 | Fox RI Stern M Michelson P | 2000 | Curr Opin Rheumatol2000，12，5： | 1 |
| 18 | The homeostasis model in the San Autonio heart study 显示文摘 | Haffner S M Miettinen H Stern M P | 1997 | Dibetes Care1997，20，7： | 1 |
| 19 | Vision-based hand- gesture applications 显示文摘 | J P Wachs M K/51sch H Stern Y Edan | 2011 | Communications of the ACM2011，54，2： | 1 |
| 20 | The inhibition of the effects of morphine by synthetic substance P(author’s transl)显示文摘 | Stern P Hukovic S Radivojevic M | 1976 | Experientia1976，32，10： | 1 |
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