|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 踝关节创伤后关节炎的相关危险因素:一项随访18年的回顾性研究显示文摘踝关节创伤后关节炎十分常见,其发生率比髋膝关节高得多,而目前对其危险因素评估的长期随访研究报道很少。作者对1988年1月-1997年12月的373例进行切开复位内固定的踝关节骨折进行了回顾性研究,并进行统计学分析。Pilon骨折、距骨骨折及年龄〈18岁者未纳入研究。 | Lübbeke A Salvo D Stern R Hoffmeyer P Holzer N Assal M. 于涛 俞光荣 | 2012 | 中国矫形外科杂志2012，20，18： | 14 |
| 3 | 金刚石中硫同位素组成揭示大陆形成过程的差异性显示文摘厚的岩石圈地幔的出现使得地球古老大陆变得稳定,然而关于这些古老大陆岩石圈地幔的形成却存在不同的成因解释。一些学者认为古老的大陆岩石圈地幔可通过俯冲洋壳平流增厚或堆叠等水平构造过程形成,而其他学者则认为地幔柱增生、海洋高原基底的熔融或地幔柱熔融残留物的底辟作用等垂向构造过程,在古老大陆岩石群地幔的形成过程中扮演了重要角色。目前,关于最早岩石圈的形成是通过水平还是垂向增生方式完成依然存在很大的争议,而不同的增生模式对于理解地球早期演化和板块作用的起始时限具有完全不同的意义。 | Smit K V Shirey S B Hauri E H Stern R A 袁超 | 2019 | 矿物岩石地球化学通报2019，38，5： | 5 |
| 4 | Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis显示文摘AIM To investigate of pediatric ulcerative colitis activity index(PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity(Mayo endoscopic score).METHODS We reviewed charts from ulcerative colitis patients who had undergone both colonoscopy over 3 years. Clinical assessment of disease severity within 35 d(either before or after) the colonoscopy were included. Patients were excluded if they had significant therapeutic interventions(such as the start of corticosteroids or immunosuppressive agents) between the colonoscopy and the clinical assessment. Mayoendoscopic score of the rectum and sigmoid were done by two gastroenterologists. Inter-observer variability in Mayo score was assessed.RESULTS We identified 99 patients(53% female, 74% pancolitis) that met inclusion criteria. The indications for colonoscopy included ongoing disease activity(62%), consideration of medication change(10%), assessment of medication efficacy(14%), and cancer screening(14%). Based on PUCAI scores, 33% of patients were in remission, 39% had mild disease, 23% had moderate disease, and 4% had severe disease. There was 'moderate-substantial' agreement between the two reviewers in assessing rectal Mayo scores(kappa = 0.54, 95%CI: 0.41-0.68). CONCLUSION Endoscopic disease severity(Mayo score) assessed by reviewing photographs of pediatric colonoscopy has moderate inter-rater reliability, and agreement was less robust in assessing patients with mild disease activity. Endoscopic disease severity generally correlates with clinical disease severity as measured by PUCAI score. However, children with inflamed colons can have significant variation in their reported clinical symptoms. Thus, assessment of both clinical symptoms and endoscopic disease severity may be required in future clinical studies. | Basavaraj Kerur Heather J Litman Julia Bender Stern Sarah Weber Jenifer R Lightdale Paul A Rufo Athos Bousvaros | 2017 | World Journal of Gastroenterology2017，23，18： | 5 |
| 5 | WONCA研究论文摘要汇编——提高基层医疗中尿路感染幼儿的诊断和治疗:来自DUTY前瞻性诊断队列研究结果显示文摘目的基层医疗中有多达50%的尿路感染(UTIs)患儿被忽视。尿液培养是诊断的关键,但收集尿液通常很难。本文旨在通过以下方式对两步骤的临床规则进行内部验证:(1)按症状和体征来选择儿童进行尿液收集;(2)进行症状、体征和试纸测试以指导抗生素治疗。方法从英格兰和威尔士的基层医疗机构中选取5岁以下急性发病儿童233例。指数测试包括父母反映的症状、临床医生报告的体征、尿试纸结果以及关于尿路感染可能性的临床医生选择。以清洁尿样中的微生物培养结果作为确认尿路感染的参考标准。计算灵敏度、特异度、和基于系数(分级严重性)和分数(二分)的症状/体征的Logistic回归模型的受试者工作特征曲线下面积(AUROC),然后采用引导指令内部验证AUROC。结果 3 036例儿童提供了尿样,获得2 740份(90%)培养结果,其中60份(2.2%)呈阳性。临床诊断灵敏度为46.6%,AUROC为0.77。基于系数和分数的经验证模型的AUROC分别为0.87和0.86,在加入亚硝酸盐试纸、白细胞和血液后其分别增加至0.90和0.90。结论根据症状和体征的临床规则优于临床诊断,在识别儿童进行无创尿液取样方面表现良好。试纸结果为经验性抗生素治疗提供了进一步的诊断价值。 | HAY A D STERNE J A HOOD K 本刊编辑部 | 2016 | 中国全科医学2016，19，28： | 3 |
| 6 | Life events and depression in a community sample of siblings显示文摘 | Sham PC Sterne A | 2001 | Psychol Med2001，31，3： | 1 |
| 7 | Electrochemical Society显示文摘 | Geary A L | 1957 | Electrochemical Polarization I A Theoretical Analysis of the Shape of Polarization Curves1957，104，： | 1 |
| 8 | Electronic properties of two-dimensional systems 显示文摘 | Ando T Fowler A B Stern F | 1982 | Rev Mod Phys1982，54，2： | 1 |
| 9 | SFBs of Japanese plum(Prunussalicina):Cloning seven alleles and determining their linkage to the S-RNase gene显示文摘 | SAPIR G STERN R A GOLDWAY M | 2007 | Hortscience2007，42，7： | 1 |
| 10 | Frequency of abnormal karyotypes among abortuses from women with and without a history of recurrent spontaneous abortion 显示文摘 | Stern J J Dorfmann A D Gutierrez-Najar A J | 1996 | Fertil Steril1996，65，： | 1 |
| 11 | Treatment of B-lymphoproliferative disorder with a monoclonal anti-interlenkin-6 antibody in 12 patients: a multicenter phase 1-2 clinical trial显示文摘 | Haddad E Paezesny S Leblond V Seigneurin JM Stern M Achkar A | 2001 | Blood2001，97，6： | 1 |
| 12 | Mechanical properties and microstructure of gas tungsten arc welded magnesium AZ91Dplates显示文摘 | MUNITZ A COTLER C STERN A | 2001 | Materials Science and Engineering:A2001，302，1： | 1 |
| 13 | Estimation of the incidence of stroke using a capture-recapture model including covariates 显示文摘 | Tilling K Sterne J A Wolfe C D | 2002 | International Journal of Epidemiology2002，30，6： | 1 |
| 14 | The assessment of global minimum essential requirements in medical education 显示文摘 | STERN DT WOJTCZAK A SCHWARZ MR | 2003 | Med Teach2003，25，6： | 1 |
| 15 | Optical-cell evidencefor superheated ice under gas-hydrate-forming Conditions显示文摘 | STERN L A DAVID L H DURHAM W B | 1998 | Journal of Physical Chemistry1998，102，： | 1 |
| 16 | Pulmonary function in patients with diabetes mellitus显示文摘 | Carlos A Benbassa T Stern E | 2001 | Am J Med Sci2001，322，3： | 1 |
| 17 | Power measurement in the distribution显示文摘 | El-Ansary A I Stern L W | 1972 | Journal of Marketing Research1972，9，1： | 1 |
| 18 | Power measurement in the distribution channel显示文摘 | STERN L W | 1972 | Journal of Marketing Research1972，11，2： | 1 |
| 19 | Mushrooms,Tumors, and Irnmunily 显示文摘 | Borchers A T Stern J S Hanckman R M | 1999 | Proceedings of the Society for Experimental Biology and Medicine1999，221，： | 1 |
| 20 | Akinetic freezing and trick move- ments in Parkinson's disease 显示文摘 | Stern G Lander C Lees A | 1980 | J Neural Transm Suppl1980，，16： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员