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| 1 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet2010，，9726： | 4 |
| 2 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | 2010 (9726)2010，，9726： | 3 |
| 3 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet . 2010 (9726)2010，，： | 2 |
| 4 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 5 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 6 | Gradient projection for sparse reconstruction: application to compressed sensing and other inverse problems 显示文摘 | Figueiredo M T Nowak R D Stephen J W | 2007 | IEEE Journal of Selected Topics in Signal Processing2007，1，4： | 1 |
| 7 | DAVID gene ID conversion tool 显示文摘 | Huang D W Sherman B T Stephens R | 2008 | Bioinformation2008，2，10： | 1 |
| 8 | Sparse reconstruction by sepa- rable approximation 显示文摘 | STEPHEN J W ROBERT D | 2009 | IEEE Trance on Math2009，，1： | 1 |
| 9 | Analysis ofammonia-oxidizing bacteria of the beta subdivision of theclass Proteobacteria in coastal sand dunes by denaturinggradient gel electrophoresis and sequencing of PCR-ampli-fied 16S ribosomal DNA fragments显示文摘 | Kowalchuk G A Stephen J R Boer W D | 1997 | Appl Environ Mi-crobiol1997，63，： | 1 |
| 10 | Oxidant regulation of the Saccharomyces cerevisiae GSH1 gene 显示文摘 | Dormer U H Westwater J Stephen D W | 2002 | Biochim Biophys Aeta2002，1576，12： | 1 |
| 11 | Endogenous norepinephrine regulates tumor necrosis factor-alpha production from maerophages in vitro显示文摘 | Robert N Spengler Stephen W Chensue Giacherio D A | 1994 | J lmmunol1994，152，6： | 1 |
| 12 | The development and application of genetic markers for the Kuruma prawn Penaeus japonicus 显示文摘 | Stephen S M Vicki W Gerard P D | 1999 | Aquaculture1999，173，： | 1 |
| 13 | Specific genomic fingerprints of phytopathogenic Xanttzomonas and Pseudomonas pathovars and strains generated with repeti tive sequences and PCR显示文摘 | Louws F J Fulbright D W Stephens C T | 1994 | Applied and Environmental Microbiology1994，60，7： | 1 |
| 14 | Multiplex real-time PCR method to identify shiga toxin genes stx1 and stx2 and escherichia coli O157: H7/Hserotype显示文摘 | KAREN C J KEN J Y STEPHEN D W | 2003 | Applied and Environmental Microbiology2003，69，10： | 1 |
| 15 | Variance and the value of information显示文摘 | Stephens D W | 1989 | American Naturalist1989，134，： | 1 |
| 16 | Merastatic neuroblastoma confined to distant lymph nodes(stage 4N)predicts outcome in patients with stage 4 disease:a study from the International Neuroblastoma Risk Group database显示文摘 | Morgenstern D A London W B Stephens D | 2014 | J Clin Oncol2014，32，12： | 1 |
| 17 | A plant DNA minipreparation: version II 显示文摘 | Stephen L D Jonathan W James B H | 1983 | Plant Molecular Biology Reporter1983，1，4： | 1 |
| 18 | Investigation into the mechanisms of flame retardation on wool显示文摘 | GORDON P G MCMAHON D T W STEPHENS L J | 1977 | Text Res J1977，47，11： | 1 |
| 19 | Comparability of perioperative morbidity between abdominal myomectomy and hysterectomy for women with uterine leiomyomas显示文摘 | Stephen W Sawin M D et a1 | 2000 | Am J 0bstet Gynecol2000，183，6： | 1 |
| 20 | Host cytokine genotype is related to adverse prognosis and systemic inflammation in gastro-esophageal cancer显示文摘 | Chris D Matthew R Z Stephen W | 2006 | Ann Surg Oncol2006，10，14： | 1 |
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