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| 1 | Endocrine disruptors and falling sperm counts: lessons learned or not!显示文摘 | Stephen Safe | 2013 | Asian Journal of Andrology2013，15，2： | 2 |
| 2 | Aryl hydrocarbon receptor agonists directly activate estrogen receptor α in MCF-7 breast cancer cells显示文摘 | Shengxi Liu Maen Abdelrahim Shaheen Khan Eric Ariazi V. Craig Jordan Stephen Safe | 2006 | Biological Chemistry2006，，9： | 1 |
| 3 | Sterols of three lichen species: lobaria pulmoTtaria, lobaria serobieulata and usnea lon-gissima显示文摘 | Stephen S Safe L M Maass W S G | 1975 | Phytoehemistry1975，14，8： | 1 |
| 4 | Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a显示文摘 | Armando Del Follo-Martinez Nivedita Banerjee Xiangrong Li Stephen Safe Susanne Mertens-Talcott | 2013 | Nutrition and Cancer2013，，： | 1 |
| 5 | Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells显示文摘 | Ichen Chen Stephen Safe Leonard Bjeldanes | 1996 | Biochemical Pharmacology1996，，8： | 1 |
| 6 | Differential gene expression in response to methoxychlor and estradiol through ERα,ERβ and AR in reproductive tissues of female mice显示文摘 | Waters Katrina M Safe Stephen Gaido Kevin W | 2001 | Toxicological Sciences2001，63，1： | 1 |
| 7 | Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer显示文摘Specificity protein(Sp)transcription factors(TFs)Sp1,Sp3 and Sp4,and the orphan nuclear receptor 4A1(NR4A1)are highly expressed in pancreatic tumors and Sp1 is a negative prognostic factor for pancreatic cancer patient survival.Results of knockdown and overexpression of Sp1,Sp3 and Sp4 in pancreatic and other cancer lines show that these TFs are individually pro-oncogenic factors and loss of one Sp TF is not compensated by other members.NR4A1 is also a prooncogenic factor and both NR4A1 and Sp TFs exhibit similar functions in pancreatic cancer cells and regulate cell growth,survival,migration and invasion.There is also evidence that Sp TFs and NR4A1 regulate some of the same genes including survivin,epidermal growth factor receptor,PAX3-FOXO1,α5-andα6-integrins,β1-,β3-andβ4-integrins;this is due to NR4A1 acting as a cofactor and mediating NR4A1/Sp1/4-regulated gene expression through GC-rich gene promoter sites.Several studies show that drugs targeting Sp downregulation or NR4A1 antagonists are highly effective inhibitors of Sp/NR4A1-regulated pathways and genes in pancreatic and other cancer cells,and the triterpenoid celastrol is a novel dual-acting agent that targets both Sp TFs and NR4A1. | Stephen Safe Rupesh Shrestha Kumaravel Mohankumar Marcell Howard Erik Hedrick Maen Abdelrahim | 2021 | World Journal of Gastroenterology2021，27，38： | 1 |
| 8 | Methyl‐substituted diindolylmethanes as inhibitors of estrogen‐induced growth of T47D cells and mammary tumors in rats显示文摘 | Andrew McDougal Mona Sethi Gupta Derek Morrow Kavita Ramamoorthy Jeong‐Eun Lee Stephen H. Safe | 2001 | Breast Cancer Research and Treatment2001，，2： | 1 |
| 9 | Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment显示文摘 | Stephen H. Safe | 1994 | CRC Critical Reviews in Toxicology1994，，2： | 1 |
| 10 | Endocrine disruptors and human health: is there a problem显示文摘 | Stephen Safe a b | 2004 | Toxicology2004，，1： | 1 |
| 11 | Environmental levels and toxicological potencies of a novel mixed halogenated carbazole显示文摘The present work involves an extensive analytical and toxicological description of a recently identified mixed halogenated carbazole found in sediment samples,1,8-dibromo-3,6-dichloro-9H-carbazole(BCCZ).Concentrations and the relative effect potency(REP)were calculated for the target BCCZ in a set of stream sediments collected in 2008 in Ontario,Canada.The levels calculated for BCCZ as compared to those previously assessed for legacy persistent organic pollutants(POPs)in the same samples revealed a significant contribution of BCCZ to the total organic chemical contamination(<1%e95%;average 37%).The corresponding dioxin toxic equivalencies(TEQs)of BCCZ in the sediment extracts were estimated from experimental REP data.The experimental data presented supports the classification of this emerging halogenated chemical as a contaminant of emerging environmental concern.Although potential emission sources could not be identified,this study highlights the importance of on-going research for complete characterization of halogenated carbazoles and related compounds. | Miren Pena-Abaurrea Matthew Robson Sri Chaudhuri Nicole Riddell Robert McCrindle Brock Chittim Robert Parette Un-Ho Jin Stephen Safe David Poirier Ralph Ruffolo Richard Dyer Rachael Fletcher Paul A..Helm Eric J.Reiner | 2016 | Emerging Contaminants2016，2，3： | 0 |
| 12 | Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells显示文摘Non-small cell lung cancer(NSCLC)is often characterized by an underlying mutation in the epidermal growth factor receptor(EGFR),contributing to aggressive metastatic disease.Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate(CDODA-Me),a glycyrrhetinic acid derivative,reportedly improves the therapeutic response to erlotinib(ERL),an EGFR tyrosine kinase inhibitor.In the present study,we performed a series of studies to demonstrate the efficacy of CDODA-Me(2μM)in sensitizing HCC827 R(ERL-resistant)cells to ERL.Herein,we first established the selectivity of ERL-induced drug resistance in the HCC827 R cells,which was sensitized when ERL was combined with CDODA-Me(2μM),shifting the IC50 from 23.48μM to 5.46μM.Subsequently,whole transcriptomic microarray expression data demonstrated that the combination of ERL+CDODA-Me elicited 210 downregulated genes(0.44%of the whole transcriptome(WT))and 174 upregulated genes(0.36%of the WT),of which approximately 80%were unique to the ERL+CDODA-Me group.Synergistic effects centered on losses to cell cycle progression transcripts,a reduction of minichromosome maintenance complex components(MCM2-7),all key components of the Cdc45·MCM2-7 GINS(CMG)complex,and replicative helicases;these effects were tantamount to the upregulation of processes associated with the nuclear factor erythroid 2 like 2 translational response to oxidative stress,including sulfiredoxin 1,heme oxygenase 1,and stress-induced growth inhibitor 1.Collectively,these findings indicate that the synergistic therapeutic effects of ERL+CDODA-Me on resistant NSCLC cells are mediated via the inhibition of mitosis and induction of oxidative stress. | Ebony Nottingham Elizabeth Mazzio Sunil Kumar Surapaneni Shallu Kutlehria Arindam Mondal Ramesh Badisa Stephen Safe Arun K.Rishi Mandip Singh | 2021 | Journal of Pharmaceutical Analysis2021，11，6： | 0 |
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