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| 1 | Co-expression of CDX2 and MUC2 in gastric carcinomas: Correlations with clinico-pathological parameters and prognosis显示文摘AIM: To evaluate the role of CDX2 homeobox protein as a predictor for cancer progression and prognosis as well as its correlation with MUC2 expression. CDX2 represents a transcription factor for various intestinal genes (including MUC2) and thus an important regulator of intestinal differentiation, which could previously be identified in gastric carcinomas and intestinal metaplasia.METHODS: Formalin-fixed and paraffin-embedded tissues from 190 gastric carcinoma patients were stained with monodonal antibodies recognizing CDX2 and MUC2, respectively. Immunoreactivity was evaluated semiquantitatively and statistical analyses including χ2 tests, uni- and multi-variate survival analyses were performed.RESULTS: CDX2 was mostly expressed in a nuclear or supranuclear pattern, whereas MUC2 showed an almost exclusive supranuclear reactivity. Both antigens were present in >80% of areas exhibiting intestinal metaplasia. An immunoreactivity in >5% of the tumor area was observed in 57% (CDX2) or in 21% (MUC2) of the carcinomas. The presence of both molecules did not correlate with WHO,significantly stronger vlUC2 expression in mucinous tumors). CDX2 correlated with a lower pT and pN stage in the subgroups of intestinal and stage I cancers and was associated with MUC2 positivity. A prognostic impact of CDX2 or MUC2 was not observed. CONCLUSION: CDX2 and MUC2 play an important role in the differentiation of normal, inflamed, and neoplastic gastric tissues. According to our results, loss of CDX2 may represent a marker of tumor progression in early gastric cancer and carcinomas with an intestinal phenotype. | Kristina Roessler Stefan P.M(o|¨)nig Paul M.Schneider Franz-Georg Hanisch Stephanie Landsberg Juergen Thiele Arnulf H.H(o|¨)lscher Hans P.Dienes Stephan E.Baldus | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 2 | The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation显示文摘MRE11/RAD50/NBS1 建筑群是很快招募到 DNA 双海滨裂缝(DSB ) 的主要传感器。MRE11 被知道是由在它的 glycine-arginine-rich (长嘴硬鳞鱼) 以内的 PRMT1 的精氨酸 methylated 主题。在这研究,我们报导在 GAR 主题与离氨酸代替精氨酸并且产生 MRE11 缺乏 methylated 精氨酸的 RK 蛋白质。Mre11 RK/RK 老鼠对 γ 过分敏感;照耀(红外) 和从这些老鼠的房间显示了房间周期检查点缺点和染色体不稳定性。而且, Mre11 RK/RK MEF 展出了在 RPA 和 RAD51 的招募表明缺点和缺陷到损坏地点的 ATR/CHK1。M RK 形成的 RN 建筑群并且对 DNA 损坏并且通常的地点局部性响应红外激活 ATM 小径。M RK RN 建筑群在为响应红外在 vivo 观察的损害 DNA 结束切除术和 ATR 激活负责的 vitro 展出了 exonuclease 和 DNA 有约束力的缺点。我们的调查结果在 DSB 修理为 MRE11 长嘴硬鳞鱼主题的关键角色提供基因证据,并且在 MRE11 长嘴硬鳞鱼表明在 translational 以后修正之间的一个机械学的连接主题并且 DSB 处理,以及发信号的 ATR/CHK1 检查点。 | Zhenbao Yu Gillian Vogel Yan Coulombe Danielle Dubeau Elizabeth Spehalski Josee Hebert David O Ferguson Jean Yves Masson Stephane Richard | 2012 | Cell Research2012，22，2： | 5 |
| 3 | Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis显示文摘AIM:To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy.METHODS: An open label multicenter study was carried out in 39 patients with active ulcerative colitis (CAI6-8) despite continuous use of steroids (a minimum total dose of 400 mg prednisone within the last 4 wk).Patients received a total of five aphereses using a granulocyte adsorptive technique (Adacolumn(R), Otsuka Pharmaceutical Europe, UK). Assessments at wk 6 and during follow-up until 4 mo comprised clinical (CAI) and endoscopic (EI) activity index, histology, quality of life(IBDQ), and laboratory tests.RESULTS: Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 (37.1%) patients achieved clinical remission and 10/35 (28.6%) patients had endoscopic remission (CAI<4, EI<4). Quality of life (IBDQ) increased significantly (24 points, P<0.01)at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia.CONCLUSION: In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent. | Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert L(o|¨)fberg | 2005 | World Journal of Gastroenterology2005，11，44： | 4 |
| 4 | Aligned carbon nanotube arrays formed by cutting a polymer resin-nanotube composite显示文摘 | Ajayan P M Stephan O Colliex C | 1994 | Science1994，265，16： | 2 |
| 5 | Aligned carbon nanotube arrays formed by cutting a polymer resin-nanotube composite显示文摘 | AJAYAN P M STEPHAN O COLLIEX C | 1994 | Science1994，265，： | 1 |
| 6 | Aligned carbon nanotube arrays formed by cutting a polymer resin-nanotube composite显示文摘 | STEPHAN O COLLIEX C | 1994 | Science1994，265，： | 1 |
| 7 | Porcine endogenous retroviruses (PERVs):generation of specific antibodies,development of an immunoperoxidase assay(IPA) and inhibition by AZT 显示文摘 | Stephan O Schwendemann J Speeke V | 2001 | Xenotransplantation2001，8，4： | 1 |
| 8 | Aligned carbon nanotube arrays for med by cutting a polymer resin - nanotube composite 显示文摘 | Ajayan P M Stephan O Col lexC | 1994 | Science1994，265，5176： | 1 |
| 9 | The CT-STAT (Coronary Computed Tomographic Angiography for Systematic Triage of Acute Chest Pain Patients to Treatment) Trial显示文摘 | James A. Goldstein Kavitha M. Chinnaiyan Aiden Abidov Stephan Achenbach Daniel S. Berman Sean W. Hayes Udo Hoffmann John R. Lesser Issam A. Mikati Brian J. O’Neil Leslee J. Shaw Michael Y.H. Shen Uma S. Valeti Gilbert L. Raff | 2011 | Journal of the American College of Cardiology2011，，14： | 1 |
| 10 | Thrombocytopenia in a surgical ICU显示文摘 | Stephan F Hollande J Richard O | 1999 | Chest1999，115，5： | 1 |
| 11 | Aligned carbon canotube arrays formed by cutting a polymer resin-nanotube composite显示文摘 | AJAYAN P M STEPHAN O COLLIEX C | 1994 | Science1994，265，5176： | 1 |
| 12 | Thrombocytopenia in a surgical ICU显示文摘 | Stephan F Hollande J Richard O | 1999 | Chest1999，115，： | 1 |
| 13 | Effect of the synthesis method on distribution of C,B,and N elements in multiwall nanotubes:A spatially resolved electron energy loss spectroscopy study显示文摘 | Enouz-Vedrenne S Stephan O Glerup M | 2008 | J Phys Chem C2008，112，16： | 1 |
| 14 | Development of a real-time PCR and a sandwich ELISA for detection of potentially allergenic trace amounts of peanut(Arachis hypogaea) in processed foods显示文摘 | Stephan O Vieths S | | 0，，12： | 1 |
| 15 | The functions of ethnic identity: A New Mexico Hispanic example 显示文摘 | Doan G O Stephan V W | 2006 | International Journal of In- tercultural Relations2006，30，： | 1 |
| 16 | In vitro alterations of intestinal bacterial microbiota in fecal samples during storage显示文摘 | Stephan J O Meike M Kenneth N T | 2004 | Diagnostic Microbiology and Infectious Disease2004，50，： | 1 |
| 17 | Filling carbon nanotubes with metals by the arc - discharge method: the key role of sulfur显示文摘 | Demoncy N Stephan O Brun N | 1998 | The European Physical Journal B - Condensed Matter and Complex Systems1998，4，2： | 1 |
| 18 | Thrombocytopenia in a surgical ICU显示文摘 | Stephan F Hollande J Richard O | 1999 | Chest1999，115，5： | 1 |
| 19 | Thrombocytopenia in a surgical ICU显示文摘 | HOLLANDE J RICHARD O | 1999 | Chest1999，115，5： | 1 |
| 20 | Aligned carbon nanotube array formed by cutting a polymer resin-nanotube composite显示文摘 | Ajayan P Stephan O Colliex C | 1994 | Science1994，265，： | 1 |
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