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| 1 | Trefoil factors:Tumor progression markers and mitogens via EGFR/MAPK activation in cholangiocarcinoma显示文摘AIM:To investigate trefoil factor(TFF) gene copy number,mRNA and protein expression as potential biomarkers in cholangiocarcinoma(CCA).METHODS:TFF mRNA levels,gene copy number and protein expression were determined respectively by quantitative reverse transcription polymerase chain reaction(PCR),quantitative PCR and immunohistochemistry in bile duct epithelium biopsies collected from individuals with CCA,precancerous bile duct dysplasia and from disease-free controls.The functional impact of recombinant human(rh) TFF2 peptide treatment on proliferation and epidermal growth factor receptor(EGFR) /mitogenactivated protein kinase(MAPK) signaling was assessed in the CCA cell line,KMBC,by viable cell counting and immunoblotting,respectively.RESULTS:TFF1,TFF2 and TFF3 mRNA expression was significantly increased in CCA tissue compared to disease-free controls,and was unrelated to gene copy number.TFF1 immunoreactivity was strongly increased in both dysplasia and CCA,whereas TFF2 immunoreactivity was increased only in CCA compared to diseasefree controls.By contrast,TFF3 immunoreactivity was moderately decreased in dysplasia and further decreased in CCA.Kaplan-Meier analysis found no association of TFF mRNA,protein and copy number with age,gender,histological subtype,and patient survival time.Treatment of KMBC cells with rhTFF2 stimulated proliferation,triggered phosphorylation of EGFR and downstream extracellular signal related kinase(ERK),whereas co-incubation with the EGFR tyrosine kinase inhibitor,PD153035,blocked rhTFF2-dependent proliferation and EGFR/ERK responses.CONCLUSION:TFF mRNA/protein expression is indicative of CCA tumor progression,but not predictive for histological sub-type or survival time.TFF2 is mitogenic in CCA via EGFR/MAPK activation. | Kanuengnuch Kosriwong Trevelyan R Menheniott Andrew S Giraud Patcharee Jearanaikoon Banchob Sripa Temduang Limpaiboon | 2011 | World Journal of Gastroenterology2011，17，12： | 16 |
| 2 | Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines显示文摘AIM: To study the effect of a number of chemotherapeutic drugs on five human intrahepatic cholangiocarcinoma (CCA) cell lines. The expressions of genes that have been proposed to influence the resistance of chemotherapeutic drugs including thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), glutathione-S-transferase P1 (GSTP1), multidrug resistance protein (MDR1) and multidrug resistance-associated proteins (MRPs) were also determined.METHODS: Five human CCA cell lines (KKU-100, KKU M055, KKU-M156, KKU-M214 and KKU-OCA17) weretreated with various chemotherapeutic drugs and growth inhibition was determined by 3-(4,5-dimethylthiazol-2-yl)5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay. Semi-quantitative levels of gene expression were determined by a reverse transcriptase polymerase chain reaction (RT-PCR). Results of IC50 values and the ratios of gene expression were analyzed by linear regression to predict their relationship. RESULTS: Among five CCA cell lines, KKU-M055 was the most sensitive cell line towards all chemotherapeutic drugs investigated, particularly taxane derivatives with IC50 values of 0.02-3 nmol/L, whereas KKU-100 was apparently the least sensitive cell line. When compared to other chemotherapeutic agents, doxorubicin and pirarubicin showed the lowest IC50 values (<5 μmol/L) in all five CCA cell lines. Results from RT-PCR showed that TS, MRP1, MRP3 and GSTP1 were highly expressed in these five CCA cell lines while DPD and MRP2 were only moderately expressed. It should be noted that MDR1 expression was detected only in KKU-OCA17 cell lines. A strong correlation was only found between the level of MRP3 expression and the IC50 values of etoposide, doxorubicin and pirarubicin (r = 0.86-0.98, ,P<0.05). CONCLUSION: Sensitivity to chemotherapeutic agents is not associated with the histological type of CCA. Choosing of the appropriate chemotherapeutic regimen for the treatment of CCA requires knowledge of drug sensitivity. MRP3 was correlated with resistance of CCA cell lines to etoposide, doxorubicin and pirarubicin, whereas other chemotherapeutic drugs showed no association. The roleof this multidrug resistance-associated protein, MRP3, in chemotherapeutic resistance in CCA patients needs to be further investigated. | Nisana Tepsiri Liengchai Chaturat Banchob Sripa Wises Namwat Sopit Wongkham Vajarabhongsa Bhudhisawasdi Wichittra Tassaneeyakul | 2005 | World Journal of Gastroenterology2005，11，18： | 10 |
| 3 | Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion显示文摘AIM: Nitrative and oxidative DNA damage such as 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine(8-oxodG) formation has been implicated in initiation and/or promotion of inflammation-mediated carcinogenesis.The aim of this study is to clarify whether these DNA lesions participate in the progression of intrahepatic cholangiocarcinoma.METHODS: We investigated the relation of the formation of 8-nitroguanine and 8-oxodG and the expression of hypoxia-inducible factor-1α (HIF-1α) with tumor invasion in 37 patients with intra-hepatic cholangiocarcinoma.RESULTS: Immunohistochemical analyses revealed that 8-nitroguanine and 8-oxodG formation occurred to a much greater extent in cancerous tissues than in non-cancerous tissues. HIF-1α could be detected in cancerous tissues in all patients, suggesting low oxygen tension in the tumors.HIF-1α expression was correlated with inducible nitric oxide synthase (iNOS) expression (r= 0.369 and P = 0.025)and 8-oxodG formation (r = 0.398 and P = 0.015).Double immunofluorescence study revealed that iNOS and HIF-1α co-localized in cancerous tissues. Notably, the formation of 8-oxodG was correlated significantly with lymphatic invasion (r = 0.386 and P= 0.018). Moreover, 8-nitroguanine and 8-oxodG in non-cancerous tissues were associated significantly with neural invasion (P = 0.042and P = 0.026, respectively). These results suggest that reciprocal activation between HIF-1α and iNOS mediates persistent DNA damage, which induces tumor invasiveness via mutations, resulting in poor prognosis.CONCLUSION: The formation of 8-nitroguanine and 8-oxodG plays an important role in multiple steps of genetic changes leading to tumor progression, including invasiveness. | Somchai Pinlaor Banchob Sripa Ning Ma Yusuke Hiraku Puangrat Yongvanit Sopit Wongkham Chawalit Pairojkul Vajarabhongsa Bhudhisawasdi Shinji Oikawa Mariko Murata Reiji Semba Shosuke Kawanishi | 2005 | World Journal of Gastroenterology2005，11，30： | 9 |
| 4 | MUC1 and MUC5AC mucin expression in liver fluke-associated intrahepatic cholangiocarcinoma显示文摘AIM: To investigate the expressions of MUC1 and MUC5AC in intrahepatic cholangiocarcinoma (ICC). Association of expressions of mucins MUC1 and MUC5AC with clinical findings, metastasis, and survival of the liver fluke-associated ICC patients was determined.METHODS: The expressions of MUC1 and MUC5AC mucins were examined by immunohistochemical staining in 87cases of histologically-proven ICC. The expressions of mucins in relationship between clinicopathological significance and prognosis of the patients were evaluated.RESULTS: Fifty-two patients (60%) exhibited both MUC1 and MUC5AC expressions, whereas 31% expressed either MUC1or MUC5AC, and 9% expressed neither. High MUC1immunoreactivity displayed a significant correlation with tumor progression as reflected by vascular invasion (P<0.001),whereas high expression of MUC5AC significantly correlated with neural invasion (P = 0.022) and advanced ICC stage (P = 0.008). Patients with high expression of MUC1 had a significantly shorter survival (P = 0.0002). According to multivariate analyses, MUC1 reactivity (P = 0.026),histological grading and stage of tumor represented the least probability of survival.CONCLUSION: MUC1 is overexpressed in liver flukeassociated cholangiocarcinoma and relates to vascular invasion and poor prognosis, whereas MUC5AC mucin is neoexpressed and relates to neural invasion and advanced ICC stage. High MUC1 expression in tumor may be useful for predicting the poor outcome of ICC patients. | Chanchai Boonla Banchob Sripa Peti Thuwajit Ubon Cha-On Anucha Puapairoj Masanao Miwa Sopit Wongkham | 2005 | World Journal of Gastroenterology2005，11，32： | 6 |
| 5 | Opisthorchis viverrini:The carcinogenic human liver fluke显示文摘Opisthorchiasis caused by Opisthorchis viverrini remains a major public health problem in many parts of Southeast Asia, including Thailand, Lao PDR, Vietnam and Cambodia. The infection is associated with a number of hepatobiliary diseases, including cholangitis, obstructive jaundice, hepatomegaly, cholecystitis and cholelithiasis. Multi-factorial etiology of cholangiocarcinoma, mechanical damage, parasite secretions, and immunopathology may enhance cholangiocarcinogenesis. Moreover, both experimental and epidemiological evidences strongly implicate liver fluke infection as the major risk factor in cholangiocarcinoma, cancer of the bile ducts. The liver fluke infection is induced by eating raw or uncooked fish products that is the tradition and popular in the northeastern and northern region, particularly in rural areas, of Thailand. The health education programs to prevent and control opisthorchiasis are still required in the high-risk areas. | Natthawut Kaewpitoon Soraya J Kaewpitoon Prasit Pengsaa Banchob Sripa | 2008 | World Journal of Gastroenterology2008，14，5： | 6 |
| 6 | Apoptotic activity of caged xanthones from Garcinia hanburyi in cholangiocarcinoma cell lines显示文摘AIM:To investigate the growth inhibitory mechanism of four caged xanthones from Garcinia hanburyi in cholangiocarcinoma(CCA) KKU-100 and KKU-M156 cells.METHODS:Four caged xanthones,selected on the basis of their anticancer potency and chemical structure diversities(i.e.isomorellin,isomorellinol,forbesione and gambogic acid) were used in this study.Growth inhibition of these caged xanthones was determined using the sulforhodamine B assay.Induction of apoptosis was assessed by observing cell morphology,ethidium bromide and acridine orange staining and DNA fragmentation assay.Levels of apoptotic-related gene and protein expressions were determined by a real-time reverse transcriptase polymerase chain reaction and Western blotting analysis,respectively.RESULTS:The compounds were found to inhibit growth of both cell lines in a dose-dependent manner and also showed selective cytotoxicity against the cancer cells when compared with normal peripheral blood mononuclear cells.Growth suppression by these compounds was due to apoptosis,as evidenced by the cell morphological changes,chromatin condensation,nuclear fragmentation,and DNA ladder formation.At the molecular level,these compounds induced down-regulation of Bcl-2 and survivin proteins with up-regulation of Bax and apoptosisinducing factor proteins,leading to the activation of caspase-9 and-3 and DNA fragmentation.The functional group variations did not appear to affect the anticancer activity with regard to the two CCA cell lines;however,at a mechanistic level,isomorellinol exhibited the highest potency in increasing the Bax/Bcl-2 protein expression ratio(120 and 41.4 for KKU-100 and KKU-M156,respectively) and in decreasing survivin protein expression(0.01 fold as compared to control cells in both cell lines).Other activities at the molecular level indicate that functional groups on the prenyl side chain may be important.CONCLUSION:Our findings for the first time demonstrate that four caged xanthones induce apoptosis in CCA cells which is mediated through a mitochondriadependent signaling pathway. | Chariya Hahnvajanawong Wongwarut Boonyanugomol Tapanawan Nasomyon Watcharin Loilome Nisana Namwat Natthinee Anantachoke Wichittra Tassaneeyakul Banchob Sripa Wises Namwat Vichai Reutrakul | 2010 | World Journal of Gastroenterology2010，16，18： | 5 |
| 7 | Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100)显示文摘AIM To establish and dharacterize a nev cholangiocarcinoma cell line from a patient living in the Opisthorchis viverrini (O. viverrini) endemic area of Northeast Thailand.METHODS: Fresh liver biopsy and bile specimens were obtained from a 65-year-old Thai woman with cholangiocarcinoma of the porta hepatis. After digestion, the cells were cultured in Ham's F12 media. The established cell line was then characterized for growth kinetics, cell morphology, imm unocytochemistry and cytogenetics. Tumorigenicity of the cell line was determined by heterotransplanting in nude mice. RESULTS: The primary tumor was a poorly differentiated tubular adenocarcinoma. Examination of the bile revealed malignant cells with O. viverrini eggs. The cholangiocarcinoma cell line KKU-100 was established 4 mo after the primary culture-population doubling time was 72 h. KKU-100 possesses compact and polygonal-shapedepithelial cells. Immunocytochemically, this cell line exhibited cytokeratin, EMA, CEA, and CA125, but not α-fetoprotein (AFP), CA19-9, desmin, c-met, or p53. Such protein expressions parallel those of the primary tumor. Cytogenetic analysis identified aneuploidy karyotypes with a modal chromosome number of 78 and marked chromosomal structural changes. Inoculation of KKU-100 cells into nude mice produced a transplantable, poorly differentiated aden-ocarcinoma, similar to the original tumor.CONCLUSION: KKJ-100 is the first egg-proven, Opisthorchis- associated cholangiocarcinoma cell line, which should prove useful for further investigations of the tumor biology of this cancer. | Banchob Sripa Saman Leungwattanawanit Takayuki Nitta Chaisiri Wongkham Vajarabhongsa Bhudhisawasdi Anucha Puapairoj Chongrak Sripa Masanao Miwa | 2005 | World Journal of Gastroenterology2005，11，22： | 4 |
| 8 | High level of urokinase plasminogen activator contributes to cholangiocarcinoma invasion and metastasis显示文摘AIM: To investigate the role of urokinase plasminogen activator (uPA) in cholangiocarcinoma (CCA) invasion and its correlation with clinicopathological parameters. METHODS: uPA expression in CCA tissue was determined by immunohistochemistry. The level of uPA from two CCA cell lines (HuCCA-1 and KKU-M213) and a noncancer immortalized cholangiocyte cell line (H69) was monitored by plasminogen-gelatin zymography and western blotting, whereas that of plasminogen activator inhibitor type 1 (PAI-1) protein and uPA receptor (uPAR)mRNA was monitored by western blotting and quantitative real-time reverse transcriptase polymerase chain reaction, respectively. Two independent methods were employed to suppress uPA function: a synthetic uPA inhibitor (B428) and silencing of uPA gene expression using siRNA. In vitro invasion of the uPA-disrupted cells was assessed by Matrigel-coated Transwell assay. RESULTS: The immunohistochemical study showed that 75.3% (131/174) of CCA tissues expressed uPA. High uPA expression was correlated with lymphatic invasion and metastasis of CCA patients. Plasminogen-gelatin zymography of the conditioned media and cell-surface eluates showed that both CCA cell lines, but not H69, expressed both secreted and membrane-bound forms of uPA. Although the two CCA cell lines, HuCCA-1 and KKU-M213, expressed a relatively high level of uPA and uPAR, the latter exhibited a much lower degree of in vitro invasiveness, correlating with a high expression of PAI-1 in the latter, but not in the former. Suppressing uPA function with a specific uPA inhibitor, B428, or with siRNA against uPA reduced in vitro invasiveness of KKU-M213 cells, demonstrating the requirement for uPA in the invasiveness of CCA cells. Therefore, our in vivo and in vitro studies suggest that uPA is an important requirement for the invasion process of CCA. CONCLUSION: uPA expression correlates with lymphatic invasion and metastasis in vivo and is required for CCA cell invasion in vitro , suggesting its potential as a therapeutic target. | Parichut Thummarati Sitsom Wijitburaphat Aruna Prasopthum Apaporn Menakongka Banchob Sripa Rutaiwan Tohtong Tuangporn Suthiphongchai | 2012 | World Journal of Gastroenterology2012，18，3： | 4 |
| 9 | Amplification of chromosome 21q22.3 harboring trefoil factor family genes in liver fluke related cholangiocarcinoma is associated with poor prognosis显示文摘瞄准:在 cholangiocarcinoma (CCA ) 包括翘摇因素家庭基因(TFF ) 在染色体区域 21q22-qter 上决定突变而产生之遗传的不平衡病人和分析在突变而产生之遗传的不平衡和 clinicopathological 参数之间的关联。方法:量的 PCR 扩大用一条标准曲线和格林·西布尔在四个微卫星标记和翘摇因素家庭基因(TFF1, TFF2,和 TFF3 ) 上被执行我染料方法。相对拷贝数字被测试地点的 DNA 拷贝数字决定引用地点。当由有正常参考的比较的删除或扩大变化,相对拷贝数字被解释。在突变而产生之遗传的不平衡和 CCA 病人的 clinicopathological 参数之间的协会被 chi (2 ) 评估测试。Kaplan-Meier 方法被用来分析幸存。结果:在 D21S1890, D21S1893,和 TFF3 的扩大的频率分别地是 32.5% , 30.0% ,和 28.7% 。在盖住 D21S1893, D21S1890,和 TFF 的区域有扩大的病人显示出差的预后,而有删除的病人显示出有利预后(平均数:51.7 wk 对 124.82 wk, P = 0.012 ) 。穆尔蒂瓦里伊特·考克斯回归分析表明 D21S1893, D21S1890 和 TFF,血管侵略,和阶段的那扩大与差的预后被联系。结论:D21S1893-D21S1890 区域可以特别怀有候选人基因 TFF 和丝氨酸朊酶家庭,它可能涉及肿瘤侵略和转移贡献穷人幸存。在这个区域的扩大可以在 CCA 病人的治疗被用作一个预示的标记。 | Kanuengnuch Muenphon Temduang Limpaiboon Patcharee Jearanaikoon Chawalit Pairojkul Banchob Sripa Vajarabhongsa Bhudhisawasdi | 2006 | World Journal of Gastroenterology2006，12，26： | 3 |
| 10 | Prognostic significance of microsatellite alterations at 1p36 in cholangiocarcinoma显示文摘瞄准:在 cholangiocarcinoma (CCA ) 在染色体区域 1p36 磅上调查杂合现象(LOH ) 和微卫星不稳定性(MSI ) 的损失病人并且决定在微卫星改变和 clinicopathological 参数之间的协会。方法:十个多态的微卫星标记用 GS-3000 胶化扫描碎片自动分析器为 LOH 和 MSI 被决定。结果:68 在至少一部位从 90 个案例(75.6%) 显示出 LOH。LOH 最经常被发现在 D1S199 (40.0%) , D1S507 (34.6%) , D1S2845 (30.5%) ,和 D1S2734 (30.1%) 。MSI 在至少一部位在 90 个案例(37.8%) 中的 34 个中被发现。在 1p36 的好印射显示出普通损失的二个特殊区域,它是在 D1S507 和 D1S2734 之间的 D1S2845 和 25.5 厘米的区域,显示通常认为的肿瘤的存在压制或对可能的基因在 CCA 的发展起重要作用。有在 D1S234 的 LOH 的病人显示出不太淋巴的侵略(P = 0.017 ) ,而没有,有在 D1S2676 的 LOH 的病人比那些展出了更淋巴的侵略(P = 0.031 ) 。在 D1S2845 的 LOH 与神经侵略显示出重要关联(P = 0.029 ) 。而且,在 D1S228 表明了 MSI 的病人显示出差的预后(P = 0.0026 ) 。结论:突变而产生之遗传的损失在染色体 1p36 在微卫星改变起一个主要作用,它可以贡献肝吸虫的致癌作用和致病相关 CCA 和这些改变能为 CCA 病人被用作分子的预示的指示物。 | Temduang Limpaiboon Sumonta Tapdara Patcharee Jearanaikoon Banchob Sripa Vajarabhongsa Bhudhisawasdi | 2006 | World Journal of Gastroenterology2006，12，27： | 3 |
| 11 | Effects of thymidine phosphorylase on tumor aggressiveness and 5-fluorouracil sensitivity in cholangiocarcinoma显示文摘AIM: To evaluate the role of thymidine phosphorylase (TP) in cholangiocarcinoma using small interfering RNA (siRNA). METHODS: A human cholangiocarcinoma-derived cell line KKU-M139, which has a naturally high level of endogenous TP, had TP expression transiently knocked down using siRNA. Cell growth, migration, in vitro angiogenesis, apoptosis, and cytotoxicity were assayed in TP knockdown and wild-type cell lines. RESULTS: TP mRNA and protein expression were decreased by 87.1% ± 0.49% and 72.5% ± 3.2%, respectively, compared with control cells. Inhibition of TP significantly decreased migration of KKU-M139, and suppressed migration and tube formation of human umbilical vein endothelial cells. siRNA also reduced the ability of TP to resist hypoxia-induced apoptosis, while suppression of TP reduced the sensitivity of KKU-M139 to 5-fluorouracil. CONCLUSION: Inhibition of TP may be beneficial in decreasing angiogenesis-dependent growth and migration of cholangiocarcinoma but may diminish the response to 5-fluorouracil chemotherapy. | Jongkonnee Thanasai Temduang Limpaiboon Patcharee Jearanaikoon Banchob Sripa Chawalit Pairojkul Srisurang Tantimavanich Masanao Miwa | 2010 | World Journal of Gastroenterology2010，16，13： | 2 |
| 12 | Expression of sialyl Lewis^a relates to poor prognosis in cholangiocarcinoma显示文摘AIM: High levels of serum sialyl Lewisa (sLea) are frequently found in cholangiocarinnoma (CCA) patients and have been suggested to be a serum marker for CCA. However, the significance of this antigen in CCA is unknown. In this study,the clinical significance of sLea expression in CCA tissues and the possible role of sLea in vascular invasion in vitro were elucidated.METHODS: Expression of sLea in tumor tissues of 77patients with mass-forming CCA and 33 with periductal infiltrating CCA was determined using immunohistochemistry.The in vitro assays on adhesion and transmigration of CCA cells to human umbilical vein endothelial cells were compared between CCA cell lines with and without sLea expression.RESULTS: sLea was aberrantly expressed in 60% of CCA tumor tissues. A significant relationship was found between the frequency of sLea expression and the mass-forming type CCA (P = 0.041), well differentiated histological grading (P = 0.029), and vascular invasion (P = 0.030). Patients with positive sLea expression had a significantly poorer prognosis (21.28 wk, 95% CI = 16.75-25.81 wk) than those negative for sLea (37.30 wk, 95% CI = 27.03-47.57 wk)(P<0.001). Multivariate analysis with adjustment for all covariates showed that patients positive for sLea possessed a 2.3-fold higher risk of death than patients negative for sLea (P<0.001). The role of sLea in vascular invasion was demonstrated using in vitro adhesion and transmigration assays. KKU-M213, a human CCA cell-line with a high expression of sLea, adhered and transmigrated to IL-1β-activated endothelial cells of the human umbilical vein more than KKU-100, the line without sLea expression (P<0.001).These processes were significantly diminished when the antibodies specific to either sLea or E-selectin were added to the assays (P<0.001).CONCLUSION: This study demonstrates the clinical significance of sLea expression in vascular invasion, and an unfavorable outcome in CCA. The role of sLea in vascular invasion which may lead to poor prognosis is supported by the in vitro adhesion and transmigration studies. | Apa Juntavee Banchob Sripa Ake Pugkhem Narong Khuntikeo Sopit Wongkham | 2005 | World Journal of Gastroenterology2005，11，2： | 2 |
| 13 | Effects of Helicobacter pylori γ-Glutamyltranspeptidase on Apoptosis and Inflammation in Human Biliary Cells显示文摘 | Wongwarut Boonyanugomol Chariya Chomvarin Jea-Young Song Kyung-Mi Kim Jung-Min Kim Myung-Je Cho Woo-Kon Lee Hyung-Lyun Kang Kwang-Ho Rhee Banchob Sripa Chariya Hahnvajanawong Seung-Chul Baik | 2012 | Digestive Diseases and Sciences2012，，10： | 2 |
| 14 | Opisthorchiasis and Opisthorchis -associated cholangiocarcinoma in Thailand and Laos显示文摘 | Banchob Sripa Jeffrey M. Bethony Paiboon Sithithaworn Sasithorn Kaewkes Eimorn Mairiang Alex Loukas Jason Mulvenna Thewarach Laha Peter J. Hotez Paul J. Brindley | 2010 | Acta Tropica2010，，： | 2 |
| 15 | The tumorigenic liver fluke Opisthorchis viverrini – multiple pathways to cancer显示文摘 | Banchob Sripa Paul J. Brindley Jason Mulvenna Thewarach Laha Michael J. Smout Eimorn Mairiang Jeffrey M. Bethony Alex Loukas | 2012 | Trends in Parasitology2012，，10： | 1 |
| 16 | Secreted cysteine protcases of the carcinogenic liver fluke, Opisthorchis viverrini: regulation of cathepsin F activation by autocatalysis and trans-processing by cathepsin B显示文摘 | Sripa J Laha T To J et a/ | 2010 | Cell Microbiol2010，12，6： | 1 |
| 17 | Evaluation of liver fluke recombinant cathepsin B-1 protease as a serodiagnostic antigen for human opisthorehiasis显示文摘 | Sripa J Brindley PJ Sripa B | 2012 | Parasitol Int2012，61，1： | 1 |
| 18 | Ultrasonography assessment of hepatobiliary abnormalities in 3359 subjects with Opisthorchis viverrini infection in endemic areas of Thailand显示文摘 | Eimorn Mairiang Thewarach Laha Jeffrey M. Bethony Bandit Thinkhamrop Sasithorn Kaewkes Paiboon Sithithaworn Smarn Tesana Alex Loukas Paul J. Brindley Banchob Sripa | 2011 | Parasitology International2011，，1： | 1 |
| 19 | Fecal bacterial contamination in natural water reservoirs as an indicator of seasonal infection by Opisthorchis viverrini in snail intermediate hosts显示文摘 | Wanlop Kaewkes Sasithorn Kaewkes Smarn Tesana Thewarach Laha Banchob Sripa | 2011 | Parasitology International2011，，1： | 1 |
| 20 | Effect of light intensity on Opisthorchis viverrini cercarial shedding levels from Bithynia snails — A preliminary study显示文摘 | Sasithorn Kaewkes Wanlop Kaewkes Thidarut Boonmars Banchob Sripa | 2011 | Parasitology International2011，，1： | 1 |
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