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| 1 | Type 2 diabetes is associated with a worse functional outcome of ischemic stroke显示文摘AIM: To assess whether ischemic stroke severity and outcome is more adverse in patients with type 2 diabetes mellitus(T2DM). METHODS: Consecutive patients hospitalized for acute ischemic stroke between September 2010 and June 2013 were studied prospectively(n = 482; 40.2% males, age 78.8 ± 6.7 years). T2 DM was defined as self-reported T2 DM or antidiabetic treatment. Stroke severity was evaluated with the National Institutes of Health Stroke Scale(NIHSS) score at admission. The outcome was assessed with the modified Rankin scale(m RS) score at discharge and with in-hospital mortality. Adverse outcome was defined as m RS score at discharge ≥ 2 or in-hospital death. The length of hospitalization was also recorded.RESULTS: T2 DM was present in 32.2% of the study population. Patients with T2 DM had a larger waist circumference, higher serum triglyceride and glucose levels and lower serum high-density lipoprotein cholesterol levels as well as higher prevalence of hypertension, coronary heart disease and congestive heart failure than patients without T2 DM. On the other hand, diabetic patients had lower low-density lipoprotein cholesterol levels and reported smaller consumption of alcohol than non-diabetic patients. At admission, the NIHSS score did not differ between patients with and without T2DM(8.7 ± 8.8 and 8.6 ± 9.2, respectively; P = NS). At discharge, the m RS score also did not differ between the two groups(2.7 ± 2.1 and 2.7 ± 2.2 in patients with and without T2 DM, respectively; P = NS). Rates of adverse outcome were also similar in patients with and without T2DM(62.3% and 58.5%, respectively; P = NS). However, when we adjusted for the differences between patients with T2 DM and those without T2 DM in cardiovascular risk factors, T2 DM was independently associated with adverse outcome [relative risk(RR) = 2.39; 95%CI: 1.21-4.72, P = 0.012]. Inhospital mortality rates did not differ between patients with T2 DM and those without T2DM(9.0% and 9.8%, respectively; P = NS). In multivariate analysis adjusting for the difference in cardiovascular risk factors between the two groups, T2 DM was again not associated with in-hospital death. CONCLUSION: T2 DM does not appear to affect ischemic stroke severity but is independently associated with a worse functional outcome at discharge. | Konstantinos Tziomalos Marianna Spanou Stella D Bouziana Maria Papadopoulou Vasilios Giampatzis Stavroula Kostaki Vasiliki Dourliou Maria Tsopozidi Christos Savopoulos Apostolos I Hatzitolios | 2014 | World Journal of Diabetes2014，5，6： | 15 |
| 2 | Bariatric surgery as a treatment option in patients with type 2 diabetes mellitus显示文摘Type 2 diabetes mellitus (T2DM) is a leading cause of blindness, non-traumatic amputation and end-stage renal disease as well as a major cardiovascular risk factor. Tight glycemic control reduces the incidence of microvascular complications of T2DM whereas its effects on macrovascular complication are more controversial. However, glycemic targets are achieved by a minority of diabetic patients despite the availability of several antidiabetic agents. In the present commentary, we discuss the findings of two recent randomized studies that compared bariatric surgery with medical treatment in patients with uncontrolled T2DM. Both studies showed that bariatric surgery results in remission of T2DM in the majority of patients. However, both studies were limited to relatively young patients without comorbidities, had relatively short follow-up and did not assess the effects of surgery on T2DM complications. Moreover, the perioperative complications of bariatric surgery and its limited availability in some areas are additional barriers to the wider implementation of this therapeutic approach. On the other hand, the elucidation of the mechanisms underpinning the resolution of T2DM following bariatric surgery might resultin the development of novel, more effective pharmacotherapies for this common disease. | Marianna Spanou Konstantinos Tziomalos | 2013 | World Journal of Diabetes2013，4，2： | 6 |
| 3 | Nickel and nickel-phosphorous matrix composite electrocoatings显示文摘Nickel and nickel-phosphorous matrix composite coatings reinforced by TiO2,SiC and WC particles were produced under direct and pulse current conditions from an additive-free Watts' type bath.The influence of the variable electrolysis parameters(type of current,frequency of current pulses and current density) and the reinforcing particles properties(type,size and concentration in the bath) on the surface morphology and the structure of the deposits was examined.It is demonstrated that the embedding of ceramic particles modifies in various ways the nickel electrocrystallisation process.On the other hand,Ni-P amorphous matrix is not affected by the occlusion of the particles.Overall,the imposition of pulse current conditions leads to composite coatings with increased embedded percentage and more homogenous distribution of particles in the matrix than coatings produced under direct current regime. | Nicolas SPYRELLIS Evangelia A.PAVLATOU Styliani SPANOU Alexandros ZOIKIS-KARATHANASIS | 2009 | 中国有色金属学会会刊:英文版2009，19，4： | 5 |
| 4 | Fractures of the mandibular condyle: A review of 466 cases. Literature review, reflections on treatment and proposals显示文摘 | Nicholas Zachariades Michael Mezitis Constintine Mourouzis Demetrius Papadakis Athena Spanou | 2006 | Journal of Cranio-Maxillofacial Surgery2006，，7： | 2 |
| 5 | Cytokine gene polymorphisms and graft-versus-host disease in children after matched sibling hematopoietic stem cell transplantation:a single-center experience显示文摘Various polymorphisms in cytokine genes have recently been investigated as candidate risk factors in allogeneic hematopoetic stem cell transplantation(allo-HSCT).We retrospectively analyzed specific polymorphisms in genes for interleukin(IL)-10,IL-6,tumor-necrosis factor alpha(TNF-α)and interferon gamma(IFN-c)in a pediatric cohort of 57 histocompatibility leucocyte antigen(HLA)-identical sibling myeloablative transplants.Both recipient and donor genotypes were tested for association with graft-versus-host disease(GVHD)by statistical methods including Cox regression analysis.We found a significant association between the IL-10 promoter haplotype polymorphisms at positions-1082,-819 and-592 with the occurrence of severe(grades Ⅲ–Ⅳ)acute GVHD(aGVHD).Recipients with the haplotype GCC had a statistically significant decreased risk of severe aGVHD(hazard risk(HR)50.20,95% confidence interval(CI):0.06–0.67)in comparison with patients with other IL-10 haplotypes(P50.008).Transplant-related mortality at 1 year was significantly lower in recipients with this haplotype(HR50.17,95% CI:0.012–0.320)versus other IL-10 haplotypes(P=0.03),whereas overall survival was not influenced by IL-10 haplotype polymorphisms.In multivariate analysis,the presence of the IL-10 GCC haplotype was found as the only variable associated with a statistically significant decreased hazard of severe aGVHD development(P=0.02,HR50.21,95% CI:0.05–0.78).These results suggest that pediatric patients possessing the IL-10 GCC haplotype may be protected from the occurrence of severe aGVHD in the setting of matched sibling HSCT. | Evgenios Goussetis Ioanna Varela Ioulia Peristeri Vasiliki Kitra Kleopatra Spanou Olga Moraloglou Anna Paisiou Sofia Karatasaki Alexandra Soldatou Nikki Constantinidou Stelios Graphakos | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 6 | 在不含酒精的脂肪肝疾病和尖锐 ischemic 击严厉和结果之间的协会显示文摘 AIM:To evaluate the association of nonalcoholic fatty liver disease(NAFLD)with acute ischemic stroke severity and in-hospital outcome.METHODS:We prospectively studied all patients who were admitted in our Department with acute ischemic stroke between September 2010 and August 2012(n=415;39.5%males,mean age 78.8±6.6 years).The severity of stroke was assessed with the National Institutes of Health Stroke Scale(NIHSS)score at admission.NALFD was defined as serum alanine aminotransferase and/or aspartate aminotransferase levels above the upper limit of normal in the absence of other causes of elevated aminotransferases levels[chronic hepatitis B or C,drug toxicity,increased alcohol consumption(>21 and>14 drinks per week in men and women,respectively),cholestatic diseases or rhabdomyolysis].The outcome was assessed with the modified Rankin scale(mRS)score at discharge and in-hospital mortality.Adverse outcome was defined as mRS score at discharge≥2.Dependency at discharge was defined as mRS score between 2 to 5.RESULTS:NAFLD was present in 7.7%of the study population.Patients with NAFLD had lower serum high-density lipoprotein cholesterol and higher triglyceride levels than patients without NAFLD(P<0.05 for both comparisons).Demographic data,the prevalence of other cardiovascular risk factors and the prevalence of established CVD did not differ between the two groups.At admission,the NIHSS score did not differ between patients with and without NAFLD(6.3±6.4and 8.8±9.6,respectively;P=NS).At discharge,the mRS score did not differ between the two groups(1.9±2.2 and 2.6±2.2 in patients with and without NAFLD,respectively;P=NS).Rates of dependency at discharge were also similar in patients with and without NAFLD(36.8%and 55.0%,respectively;P=NS)as were the rates of adverse outcome(42.9%and58.6%,respectively;P=NS).In-hospital mortality rates also did not differ between the 2 groups(8.0%and 7.0%in patients with and without NAFLD,respectively;P=NS).CONCLUSION:The presence of NAFLD in patients admitted for acute ischemic stroke does not appear to be associated with more severe stroke or with worse in-hospital outcome. | Konstantinos Tziomalos Vasilios Giampatzis Stella D Bouziana Marianna Spanou Maria Papadopoulou Athinodoros Pavlidis Stavroula Kostaki Andreas Bozikas Christos Savopoulos Apostolos I Hatzitolios | 2013 | World Journal of Hepatology2013，5，11： | 2 |
| 7 | Using cool paving materials to improve mieroclimate of urban areas-design realization and results of the flisvos proieet 显示文摘 | Santamouris M Gaitani N Spanou A | 2012 | Building and Environment2012，53，： | 1 |
| 8 | Flavonoid glycosides isolatedfrom unique legume plant extracts as novel inhibitors of xanthine oxidase显示文摘 | Spanou C Veskoukis A S Kerasioti T | 2012 | Plos One2012，7，3： | 1 |
| 9 | Antioxidant and chemopreventive properties of polyphenolic compounds derived from Greek legume plant extracts显示文摘 | Spanou C Bourou G Dervishi A | 2008 | Joumal of Agricultural and Food Chemistry2008，56，16： | 1 |
| 10 | Relationship between mean blood glucose and glycated haemoglobin in Type 2 diabetic patients显示文摘 | Makris K Spanou L Rambaouni-Antoneli A | 2008 | Diabetic Medicine2008，25，12： | 1 |
| 11 | Ni/nano-TiO2composite electrodeposits:textural and structural modifications显示文摘 | SPANOU S PAVLATOU E A SPYRELLIS N | 2009 | Electrochimica Acta2009，54，9： | 1 |
| 12 | The evaluation of benign glottic lesions:rigid telescopic stroboscopy versus suspension microlaryngoscopy显示文摘 | Spanou K Zeitels SM | 2007 | J Voice2007，21，1： | 1 |
| 13 | Self cleaning behavior of Ni/nano-TiO2metal matrix composites显示文摘 | Spanou S Kontos A I Siokou A | 2013 | Electrochimica Acta2013，105，： | 1 |
| 14 | Effects of Greek legume plant extracts on xanthine oxidase, catalase and superox- ide dismutase activities显示文摘 | Spanou C 1 Veskoukis A S Stagos D | 2012 | Journal of Physiology and Biochemis- try2012，68，： | 1 |
| 15 | Involvement of drug-specific T cells in acute drug-induced interstitial nephritis显示文摘 | Spanou Z Keller M Britschgi M | | 0，，： | 1 |
| 16 | Effect of prior treatment with different statins on stroke severity and functional outcome at discharge in patients with acute ischemic stroke显示文摘 | Konstantinos Tziomalos Vasilios Giampatzis Stella D. Bouziana Marianna Spanou Athinodoros Pavlidis Maria Papadopoulou Chrysoula Boutari Dimitra Magkou Christos Savopoulos Apostolos I. Hatzitolios | 2013 | Int J Stroke2013，，7： | 1 |
| 17 | Evolution of the Oomycete Chitin Synthase genes显示文摘 | Skandalis N Spanou Z Badreddine I | 2009 | Phytopathologia Mediterranea2009，48，2： | 1 |
| 18 | Is there a relationship between mean blood glucose and glycated hemoglobin 显示文摘 | Makris K Spanou L | 2011 | 5:1572- 15832011，5，： | 1 |
| 19 | Preparedf Ni/nano -TiO2 composite coatings prepared by direct and pulse current electroplating 显示文摘 | SPANOU S KONTOS A I SIOKOU A | 2015 | Journal of Material Engi- neering and Performance2015，24，2： | 1 |
| 20 | Rapid downregulation of innate cells, interleukin - 12 and interlankin -23 in generalized pustular psoriasis with infiiximab in combination with acitretin 显示文摘 | Tang MM Spanou Z Tang H | 2012 | Dermatology2012，225，4： | 1 |
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