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| 1 | Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis显示文摘嗜曙红血球(曙光女神) 长在层次造血的系统被看作了结束阶段受动器房间。证据的众多的线建议了那个曙光女神是关于各种各样的煽动性或有免疫力的反应的开始,繁殖和规定的多功能的白血球,特别在过敏疾病。最近的研究证明了那个曙光女神也为骨头髓血浆房间的维护和 B 房间的区别被要求。然而,曙光女神是否贡献造血的干细胞(HSC ) 的规定,仍然保持不清楚动态平衡。这里,我们证明曙光女神由在野类型的老鼠损害 HSC 静止和体质能力破坏 HSC 动态平衡后面的 ovalbumin (卵) 挑战并且甚至由引起骨头髓 HSC 在 Cd3-Il-5 转基因的老鼠的失败和疲劳。HSC 的损害维护和功能与导致曙光女神的氧化还原作用不平衡(增加的氧化 phosphorylation 和减少的抗氧化剂层次) 被联系。用集体 spectrometry,更重要地,我们决定 CCL-6 在嗜曙红血球过多下面在高水平被表示。我们证明 CCL-6 为损害 HSC 动态平衡导出曙光女神、负责。有趣地,有特定的抵销抗体的 CCL-6 的阻塞,当在质问卵的老鼠加重嗜曙红血球过多航线发炎时,恢复了 HSC 的体质能力。因此,我们的学习在 HSC 动态平衡揭示 Eos/CCL-6 的意外功能。 | Chao Zhang, Fei Li, Xufei Du, Man Luo, Wen Hua, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen Weiwei Yi, Hu Wang, Zhenyu Ju Hu Wang, Zhenyu Ju Ping Wu, Chao Peng, Catherine CL Wong James J Lee Songmin Ying Songmin Ying Huahao Shen | 2018 | Cell Research2018，28，3： | 6 |
| 2 | Flexible and reusable cap-like thin Fe2O3 film for SERS applications显示文摘Cap-like α-Fe2O3 films are fabricated and deposited onto quartz fabric by using radio frequency magnetron sputtering and annealing.The treated fabric sample in this study shows highly sensitive surface-enhanced Raman scattering (SERS) and excellent flexibility,reproducibility and stability.In addition,the sample can be recovered after a washing process with an organic solvent and repeatedly used.The sensitive SERS performance is attributed to chemical enhancement through a charge transfer process.Moreover,the SERS performance is also found to be dependent on the light coupling effect.When the light absorbance rate of the α-Fe2O3 films increases at a wavelength near that of laser light,the film shows excellent sensitivity due to light coupling effect. | Jiangtao Xu Xiaoting Li Yuxiang Wang Ronghui Guo Songmin Shang Shouxiang Jiang | 2019 | Nano Research2019，12，2： | 3 |
| 3 | Poly- methylmethacrylate-carbon nanotubes Composites Pre- pared by Microemulsion Polymerization for Gas Sensor 显示文摘 | Shang Songmin Li Liang Yang Xiaoming | 2009 | Composites Science and Technology2009，69，78： | 1 |
| 4 | Facile preparation of graphene nanoribbon filled silicone rubber nanocomposiie with improved thermal and mechanical properties显示文摘 | Gan Lu Shang Songmin Yuen Chunwah Marcus eL al | 2015 | Composites:Part B2015，，69： | 1 |
| 5 | Physical properties of silk fibroin/eellulose blend films regenerated from the hy- drophilic Ionic liquid 显示文摘 | SHANG Songmin ZHU Lei PAN Jintu | 2011 | Carbohydr Polym2011，86，2： | 1 |
| 6 | View-invariant Gait Authentication Based on Silhouette Contours Analysis and View Estimation显示文摘In this paper, we propose a novel view-invariant gait authentication method based on silhouette contours analysis and view estimation. The approach extracts Lucas-Kanade based gait flow image and head and shoulder mean shape(LKGFI-HSMS)of a human by using the Lucas-Kanade s method and procrustes shape analysis(PSA). LKGFI-HSMS can preserve the dynamic and static features of a gait sequence. The view between a person and a camera is identified for selecting the target s gait feature to overcome view variations. The similarity scores of LKGFI and HSMS are calculated. The product rule combines the two similarity scores to further improve the discrimination power of extracted features. Experimental results demonstrate that the proposed approach is robust to view variations and has a high authentication rate. | Songmin Jia Lijia Wang Xiuzhi Li | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，2： | 1 |
| 7 | Fabrication and characterization of free-standing polypyrrole/graphene oxide nanocomposite paper显示文摘 | Lanyan Li Keqiang Xia Liang Li Songmin Shang Qingzhong Guo Guoping Yan | 2012 | Journal of Nanoparticle Research2012，，6： | 1 |
| 8 | Facial synthesis of polypyrrole/silver nanocomposites at the water ionic liquid interface and their electrochemical properties 显示文摘 | Yang Xiaoming Li Liang Shang Songmin | 2010 | Mater Lett2010，64，17： | 1 |
| 9 | In- vestigation on the electrical response behaviors of multiwalled carbon nanotube/polyurethane composite in organic solvent vapors显示文摘 | SHANG Songmin ZENG Wei TAO Xiaoming | 2012 | Sensors and Actuators B: Chemical2012，，12： | 1 |
| 10 | Foam Dyeing for Developing the Wan-out Effect on Cotton Knitted Fabrics with Pigment 显示文摘 | Songmin Shang Enling Hu Patrick Poon | 2011 | RJTA2011，15，1： | 1 |
| 11 | Eosinophil-derived chemokine(hCCL 15/23,mCCL6)interacts with CCR1 to promote eosinophilic airway inflammation显示文摘Eosinophils are terminally differentiated cells derived from hematopoietic stem cells(HSCs)in the bone marrow.Several studies have confirmed the effective roles of eosinophils in asthmatic airway pathogenesis.However,their regulatory functions have not been well elucidated.Here,increased C-C chemokine ligand 6(CCL6)in asthmatic mice and the human orthologs CCL15 and CCL23 that are highly expressed in asthma patients are described,which are mainly derived from eosinophils.Using Cc/6 knockout mice,further studies revealed CCL6-dependent allergic airway inflammation and committed eosinophilia in the bone marrow following ovalbumin(OVA)challenge and identified a CCL6-CCR1 regulatory axis in hematopoietic stem cells(HSCs).Eosinophil differentiation and airway inflammation were remarkably decreased by the specific CCR1 antagonist BX471.Thus,the study identifies that the CCL6-CCR1 axis is involved in the crosstalk between eosinophils and HSCs during the development of allergic airway inflammation,which also reveals a potential therapeutic strategy for targeting G protein-coupled receptors(GPCRs)for future clinical treatment of asthma. | Xufei Du Fei Li Chao Zhang Na Li Huaqiong Huang Zhehua Shao Min Zhang Xueqin Zhan Yicheng He Zhenyu Ju Wen Li Zhihua Chen Songmin Ying Huahao Shen | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 12 | Physical properties of silk fibroin/ cellulose blend films regenerated from the hydrophilic ionic liquid 显示文摘 | Shang Songmin Zhu Lei Fan | 2011 | Carbohydr Polym2011，86，2： | 1 |
| 13 | Evaluation of Farmland Drainage Water Quality by Fuzzy–Gray Combination Method显示文摘The complex relationships between indicators and water conditions cause fuzzy and gray uncertainties in evaluation of water quality. Compared to conventional single-factor evaluation methods, the combination evaluation method can consider these two uncertainties to produce more objective and reasonable evaluation results. In this paper, we propose a combination evaluation method with two main parts:(1) the use of fuzzy comprehensive evaluation and gray correlation analysis as submodels with which to consider the fuzzy and gray uncertainties and(2) the establishment of a combination model based on minimum bias squares. In addition, using this method, we evaluate the water quality of a ditch in a typical rice–wheat system of Yixing city in the Taihu Lake Basin during three rainfall events. The results show that the ditch water quality is not good and we found the chemical oxygen demand to be the key indicator that affects water quality most significantly. The proposed combination evaluation method is more accurate and practical than single-factor evaluation methods in that it considers the uncertainties of fuzziness and grayness. | Xiaoling Wang Songmin Li Yuling Yan Xiaotong Zheng Fuchao Zhang | 2019 | Transactions of Tianjin University2019，25，1： | 1 |
| 14 | Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing显示文摘Common fragile sites(CFSs)are genomic loci prone to the formation of breaks or gaps on metaphase chromosomes.They are hotspots for chromosome rearrangements and structural variations,which have been extensively implicated in carcinogenesis,aging,and other pathological processes.Although many CFSs were identified decades ago,a consensus is still lacking for why they are particularly unstable and sensitive to replication perturbations.This is in part due to the lack of high-resolution mapping data for the vast majority of the CFSs,which has hindered mechanistic interrogations.Here,we seek to map human CFSs with high resolution on a genome-wide scale by sequencing the sites of mitotic DNA synthesis(MiDASeq)that are specific for CFSs.We generated a nucleotide-resolution atlas of MiDAS sites(MDSs)that covered most of the known CFSs,and comprehensively analyzed their sequence characteristics and genomic features.Our data on MDSs tallied well with long-standing hypotheses to explain CFS fragility while highlighting the contributions of late replication timing and large transcription units.Notably,the MDSs also encompassed most of the recurrent double-strand break clusters previously identified in mouse neural stem/progenitor cells,thus bridging evolutionarily conserved break points across species.Moreover,MiDAseq provides an important resource that can stimulate future research on CFSs to further unravel the mechanisms and biological relevance underlying these labile genomic regions. | Fang Ji Hongwei Liao Sheng Pan Liujian Ouyang Fang Jia Zaiyang Fu Fengjiao Zhang Xinwei Geng Xinming Wang Tingting Li Shuangying Liu Madiha Zahra Syeda Haixia Chen Wen Li Zhihua Chen Huahao Shen Songmin Ying | 2020 | Cell Research2020，30，11： | 1 |
| 15 | Highly transparent and infrared reflective AZO/Ag/AZO multilayer film prepared on PET substrate by RF magnetron sputtering显示文摘 | Dagang Miao Shouxiang Jiang Songmin Shang Zhuoming Chen | 2014 | Vacuum2014，，： | 1 |
| 16 | Vapor-phase polymerization of pyrrole on flexible substrate at low temperature and its application in heat generation显示文摘 | Shang Songmin Yang Xiaoming Tao Xiaoming | 2010 | Polym Int2010，59，2： | 1 |
| 17 | LPS-induced mitochondrial DNA synthesis and release facilitate RAD50-dependent acute lung injury显示文摘Dear Editor,ATP-binding cassette(ABC)-ATPase(RAD50),together with meiotic recombination 11 homolog 1(MRE11)subunits,to form MRE11-RAD50 complex,plays important roles in recognition of double-stranded DNA(dsDNA)and initiation of consequent inflammatory cascade1.Acute lung injury(ALI)and acute respiratory destress syndrome(ARDS)are systemic uncontrolled inflammation and life-threatening.However,the function of the DNA sensor in ALI/ARDS remains poorly defined.Here we investigated functions of RAD50 using mouse primary macrophages and conditionally RAD50 knockout mice in vitro and in a lipopolysaccharide(LPS)-induced lung injury model. | Xueqin Zhan Rui Cui Xinwei Geng Jiaqian Li Yunlian Zhou Lulu He Chao Cao Chao Zhang Zhimin Chen Songmin Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 0 |
| 18 | Dual-Driven Hemostats Featured with Puncturing Erythrocytes for Severe Bleeding in Complex Wounds显示文摘Achieving rapid hemostasis in complex and deep wounds with secluded hemorrhagic sites is still a challenge because of the difficulty in delivering hemostats to these sites.In this study,a Janus particle,SEC-Fe@CaT with dual-driven forces,bubble-driving,and magnetic field–(MF–)mediated driving,was prepared via in situ loading of Fe_(3)O_(4) on a sunflower sporopollenin exine capsule(SEC),and followed by growth of flower-shaped CaCO3 clusters.The bubble-driving forces enabled SEC-Fe@CaT to self-diffuse in the blood to eliminate agglomeration,and the MF-mediated driving force facilitated the SEC-Fe@CaT countercurrent against blood to access deep bleeding sites in the wounds.During the movement in blood flow,the meteor hammer-like SEC from SEC-Fe@CaT can puncture red blood cells(RBCs)to release procoagulants,thus promoting activation of platelet and rapid hemostasis.Animal tests suggested that SEC-Fe@CaT stopped bleeding in as short as 30 and 45 s in femoral artery and liver hemorrhage models,respectively.In contrast,the similar commercial product Celox™required approximately 70 s to stop the bleeding in both bleeding modes.This study demonstrates a new hemostat platform for rapid hemostasis in deep and complex wounds.It was the first attempt integrating geometric structure of sunflower pollen with dual-driven movement in hemostasis. | Haoyu Qiu Guangqian Lan Weiwei Ding Xinyu Wang Wenyi Wang Dahua Shou Fei Lu Enling Hu Kun Yu Songmin Shang Ruiqi Xie | 2022 | Research2022，，4： | 0 |
| 19 | A prodrug nanoplatform via esterification of STING agonist and IDO inhibitor for synergistic cancer immunotherapy显示文摘Cancer immunotherapy has made significant progress in the last few decades,revolutionizing oncology.However,low patient response rates and potential immune-related adverse events continue to be major clinical challenges.Cancer nanomedicine,by virtue of its regulated delivery and modular flexibility,has shown the potential to strengthen antitumor immune responses and sensitize tumors to immunotherapy.In this study,we developed tumor microenvironment(TME)responsive nanomedicine to achieve specific and localized amplification of the immune response in tumor tissue in a safe and effective manner,while simultaneously reducing immune-related side effects.We synthesized the TME responsive prodrug by coupling MSA-2,a stimulator of interferon genes(STING)agonist,and NLG-919,an indoleamine 2,3 dioxygenase(IDO)inhibitor.The prodrug was assembled into nanoparticles to enhance the solubility and bioavailability.By synthesizing a TME responsive prodrug,we aim to explore the therapeutic efficacy of combined regimen(STING agonist and IDO inhibitor)for cancer,and reduce the unwanted side effects of STING agonism on normal tissues.Free prodrug and nanoparticles were characterized by mass spectrometry,dynamic light scattering(DLS),and transmission electron microscopy(TEM).Following that,we investigated the tumor accumulation,anti-tumor activity,and toxicity in vitro and in vivo.Prodrug nanoparticles demonstrated the ability to inhibit the tumor growth and activate antitumor immune response by modulating immune cells populations in tumor microenvironment.The TME responsive nanomedicine provided an effective tool for precise targeting,promoting antitumor immunity,and efficient tumor growth inhibition with safety.Outcomes of this study may have implications for future clinical trials. | Madiha Zahra Syeda Tu Hong Min Zhang Yanfei Han Xiaoling Zhu Songmin Ying Longguang Tang | 2022 | Nano Research2022，15，10： | 0 |
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