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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Prospective, randomized controlled study to assess the role of dexmedeto-midine in patients with supratentorial tumors undergoing craniotomy under general anesthesia 显示文摘 | Soliman RN Hassan AR Rashwan AM | 2011 | Middle East J Anes- thesiol2011，2，： | 1 |
| 3 | Dysphagia,hoarseness,and unilateral true vocal fold motion impairment following anterior cervical diskectomy and fusion显示文摘 | Baron EM Soliman AM Simpson L | 2003 | Ann Otol Rhinol Laryngol2003，112，11： | 1 |
| 4 | Clinical and epidemi- ologic profile of breast cancer in Tanzania显示文摘 | Burson AM Soliman AS Ngoma TA | 2010 | Breast Dis2010，31，1： | 1 |
| 5 | Dysphagia,hoarseness,and unilateral true vocal fold motion impairment following anterior cervical diskectomy and fusion显示文摘 | Baron EM Soliman AM Gaughan JP | 2003 | Ann Otol Rhinol Laryngol2003，112，： | 1 |
| 6 | Assessment of left atrial volume and function by real-time three-dimensional echocardiography显示文摘 | Anwar AM Soliman OI Geleijnse ML | | 0，，02： | 1 |
| 7 | Assessment of left atrial ejection force in hypertrophic cardiomyopathyusing real-time three-dimensional echocardiography显示文摘 | Anwar AM Soliman OI Geleijnse ML | 2007 | Am Soc Echocardiogrl2007，20，6： | 1 |
| 8 | Assessment of mitral annulus size and function by real-time 3-dimensional echocardiography in cardiomyopathy:comparison with magnetic resonance imaging显示文摘 | Anwar AM Soliman OI Nemes A | | 0，，08： | 1 |
| 9 | Dysphagia, hoarse?ness, and unilateral true vocal fold motion impairment follow?ing anterior cervical disectomy and fusion 显示文摘 | Baron EM Soliman AM Simpson L | 2003 | Ann otol rhinol 1 aryn gol2003，112，11： | 1 |
| 10 | Prospec- tive,randomized study to assess the role of dexmedetomi- dine in patients with supratentorial tumors undergoing craniotomy under general anaesthesia显示文摘 | Soliman RN Hassan AR Rashwan AM | 2011 | Middle East J Anesthesiology2011，21，3： | 1 |
| 11 | Assessment of leftatrial volum and function by real-time three-dimensionalechocardiography显示文摘 | Anwar AM Soliman 01 Geleijnse ML | 2007 | Int J Cardiol2007，123，： | 1 |
| 12 | Prospective,randomized controlled study to assess the role of dexmedetomidine inpatients with supratentorial tumors undergoing craniotomy undergeneral anesthesia显示文摘 | Soliman RN Hassan AR Rashwan AM | 2011 | Middle East Anesthesiol2011，21，1： | 1 |
| 13 | Treatment of human Demodex folliculorum by camphor oil and metronidazole显示文摘 | Hassan AA Soliman M | 2004 | J Egypt Soc Parasitol2004，34，1： | 1 |
| 14 | Clinico-epidemiological study of human fascioliasis in an endemicfocus in Dakahlia Govemorate, Egypt显示文摘 | E1-Shazly AM Soliman M Gabr A | 2001 | J Egypt Soc Parasitol2001，31，2： | 1 |
| 15 | Prospective, randomized controlled study to assess the role of dexmedeto midine yn patients with supratentorial tumors undergoing cra- niotomy under general anesthesia显示文摘 | Soliman RN Hassan AR Rashsan AM | 2011 | Middle East J Anesthe siol2011，21，1： | 1 |
| 16 | Clinicoepidemiological study of human fasciolias in an endemic focus in dakahlia governorate,egypt显示文摘 | EL-SHAZLY AM SOLIMAN M GABR A | | 0，，03： | 1 |
| 17 | Superabsorbent polyacrylamide grafted carboxymethyl cellulose pH sensitive hydrogel: preparation and characterization 显示文摘 | Eldin MSM Omer AM Soliman EA | 2013 | Desalination and Water Treatment2013，51，1618： | 1 |
| 18 | Assessment of left atri- al volum and function by real-time three-dimensional eehoeardiog- raphy显示文摘 | Anwar AM Soliman OI Celeijnse ML | 2008 | Int J Cardioi2008，123，2： | 1 |
| 19 | Prospective, randomized controlled study to assess therole of dexmedetomidine in patients with supratentorialtumors undergoing craniotomy under general anesthesia 显示文摘 | Soliman RN Hassan AR Rashwan AM | 2011 | Middle East J Anesthesiol2011，21，1： | 1 |
| 20 | Prospective, ran- domized controlled study to assess the role of dexmedetomidine in patients with supratentorial tumors undergoing craniotomy under general anesthesia 显示文摘 | Soliman RN Hassan AR Rashwan AM | 2011 | Middle East journal of anaesthesiology2011，21，1： | 1 |
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