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| 1 | Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer显示文摘Epidermal growth factor receptor(EGFR) has been an attractive target for treatment of epithelial cancers, including colorectal cancer(CRC). Evidence from clinical trials indicates that cetuximab and panitumumab(antiEGFR monoclonal antibodies) have clinical activity in patients with metastatic CRC. The discovery of intrinsic EGFR blockade resistance in Kirsten RAS(KRAS)-mutant patients led to the restriction of anti-EGFR antibodies to KRAS wild-type patients by Food and Drug Administration and European Medicine Agency. Studies have since focused on the evaluation of biomarkers to identify appropriate patient populations that may benefit from EGFR blockade. Accumulating evidence suggests that patients with mutations in EGFR downstream signaling pathways including KRAS, BRAF, PIK3CA and PTEN could be intrinsically resistant to EGFR blockade. Recent whole genome studies also suggest that dynamic alterations in signaling pathways downstream of EGFR leads to distinct oncogenic signatures and subclones which might have some impact on emerging resistance in KRAS wild-type patients. While anti-EGFR monoclonal antibodies have a clear potential in the management of a subset of patients with metastatic CRC, further studies are warranted to uncover exact mechanisms related to acquired resistance to EGFR blockade. | Zain A Sobani Ashwin Sawant Mikram Jafri Amit Keith Correa Ibrahim Halil Sahin | 2016 | World Journal of Clinical Oncology2016，7，5： | 3 |
| 2 | Infectious diseases in the aftermath of monsoon flooding in Pakistan显示文摘Pakistan is ranked 9th in terms of flood-affected countries worldwide.In the summer of 2010,the northern province of Khyber-Pakhtunkhwa received more than 312 mm of rain in a 56 hour period.This resulted in over 1 600 deaths across the region.In addition,over 14 million people were directly affected by this record-breaking deluge.Flood affected regions serve as ideal breeding grounds for pathogens,leading to the spread of diseases.The poor standards of hygiene in camps set up for individuals displaced by the floods also contribute to this.It is essential that those involved in relief efforts are aware of the epidemiology of diseases that have historically seen a sudden upsurge after natural disasters.Keeping this in mind,we conducted a simple review of literature.An extensive literature search was conducted using the PubMed data base and online search engines.Articles published in the last 20 years were considered along with some historical articles where a background was required.Seven major diseases were identified to increase substantially in the aftermath of natural disasters.They were then classified into acute and sub-acute settings.Diarrhea,skin&eye infections and leptospirosis were identified in the acute setting while malaria,leishmaniasis,respiratory infections and hepatitis were identified in the sub-acute setting. | Maryam Baqir Zain A Sobani Amyn Bhamani Nida Shahab Bham Sidra Abid Javeria Farook M Asim Beg | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，1： | 2 |
| 3 | Comparison of outcomes of enteralfeeding via nasogastric versus gastrostomy tubes in post operative patientswith a principle diagnosis of squamous call carcinoma of the oral cavity显示文摘 | Sobani ZU Ghaffar S Ahmed BN | 2011 | JPak Med Assoc2011，61，10： | 1 |
| 4 | Stem cells for spinal cord regeneration:Current status显示文摘 | Zain A Sobani Syed A | | 0，，： | 1 |
| 5 | long--term effects of the Mentlt device in Meniere' s disease: the Western Austrilian experience显示文摘 | Gunesh PR Sobani D Marcus DA | 2005 | J Laryngol Otol2005，119，： | 1 |
| 6 | Cranioplasty after decompressive craniectomy: An institutional audit and analysis of factors related to complications 显示文摘 | Sobani ZA Shamim MS Zafar SN | 2011 | Surg Neurol 1nt2011，2，： | 1 |
| 7 | Stem cel s for spinal cord regeneration:Current status显示文摘 | Sobani ZA Quadri SA Enam SA | | 0，，01： | 1 |
| 8 | Safety of untreated autologous cranioplasty after extracorporeal storage at - 26 degree celsius 显示文摘 | Tahir MZ Shamim MS Sobani ZA | 2013 | Br J Neurosurg2013，27，4： | 1 |
| 9 | Minimally invasive endoscopic selective parathyroidectomy 显示文摘 | Junaid M Sobani ZA Kazi M | 2012 | J Pak Med Assoe2012，62，4： | 1 |
| 10 | Cranioplasty after decompressive craniectomy: An institutional audit and analysis of factors related to complications显示文摘 | Sobani ZA Shamim MS Zafar SN | 2011 | Surg Neurol Int2011，2，： | 1 |
| 11 | Cranioplasty after decompressive craniectomy: An institutional audit and analysis of factors related to complications 显示文摘 | Sobani ZA Shamim MS Zafar SN | 2011 | Surg Neurol Int2011，2，： | 1 |
| 12 | Pediatric traumatic putamenal strokes: mecha- nisms and prognosis显示文摘 | Sobani ZA All A | 2011 | Surg Neurol Int2011，2，： | 1 |
| 13 | Long-term effects of the Menitti device in Meniere's disease: the Westerm austrilian experience显示文摘 | Cunesh PR Sobani D Marcus DA | 2005 | J Laryngolotol2005，119，： | 1 |
| 14 | Long-Termeffects of the Menittt device in Menieres disease:theWestern Austrilian experience显示文摘 | Gunesh P R Sobani D Marcus D A | 2005 | J Laryngol Otol2005，119，3： | 1 |
| 15 | Long-term effects of the Meniett device in Meniere's disease: the Western Australian experience 显示文摘 | Gunesh PR Sobani D Marcus DA | 2005 | J Laryngol Otol2005，119，5： | 1 |
| 16 | Successful management of aggressive fibromatosis of the neck u- sing wide surgical excision: a case report显示文摘 | SOBANI Z A JUNAID M KHAN M J | 2011 | J Med Case Rep2011，5，： | 1 |
| 17 | Establishment of a Comprehensive Epilepsy Center in Pakistan: Initial Experiences, Results, and Reflections显示文摘 | M. Zubair Tahir Zain A. Sobani S. A. Quadri S. Nizam Ahmed Mughis Sheerani Fowzia Siddiqui Warren W. Boling Syed Ather Enam Seyed M. Mirsattari | 2012 | Epilepsy Research and Treatment2012，，： | 1 |
| 18 | A case of cellulitis of the hands caused by a predatory bird attack显示文摘Many species have been drastically affected by rapid urbanization.Harris' s hawks from their natural habitat of open spaces and a supply of rodents,lizards and other small prey have been forced to change their natural environment adapting to living in open spaces in sub-and periurban areas.Specific areas include playgrounds,parks and school courtyards.The migration of this predatory species into these areas poses a risk to individuals,and especially the children are often attacked by claws,talons and beaks intentionally or as collateral damage while attacking rodent prey.In addition,the diverse micro-organisms harbored in the beaks and talons can result in wound infections,presenting a challenge to clinical management.Here we would like to present a case of an 80-year-old man with cellulitis of bom hands after sustaining minor injuries from the talons of a Harris s hawk and review the management options.We would also like to draw attention to the matter that,even though previously a rarity,more cases of injuries caused by birds of prey may be seen in hospital settings. | M Adil Abbas Khan Mohammed Farid Zain A Sobani Syed Nadir Ali Huzaifa Malick Maryam Baqir Hasanat Sharif M Asim Beg | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 0 |
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