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| 1 | Role of E3 ubiquitin ligases in lung cancer显示文摘E3 ubiquitin ligases are a large family of proteins that catalyze the ubiquitination of many protein substrates for targeted degradation by the 26S proteasome.Therefore,E3 ubiquitin ligases play an essential role in a variety of biological processes including cell cycle regulation,proliferation and apoptosis.E3 ubiquitin ligases are often found overexpressed in human cancers,including lung cancer,and their deregulation has been shown to contribute to cancer development.However,the lack of specific inhibitors in clinical trials is a major issue in targeting E3 ubiquitin ligases with currently only one E3 ubiquitin ligase inhibitor being tested in the clinical setting.In this review,we focus on E3 ubiquitin ligases that have been found deregulated in lung cancer.Furthermore,we discuss the processes in which they are involved and evaluate them as potential anti-cancer targets.By better understanding the mechanisms by which E3 ubiquitin ligases regulate biological processes and their exact role in carcinogenesis,we can improve the development of specific E3 ubiquitin ligase inhibitors and pave the way for novel treatment strategies for cancer patients. | Barbara C Snoek Leonie HAM de Wilt Gerrit Jansen Godefridus J Peters | 2013 | World Journal of Clinical Oncology2013，4，3： | 5 |
| 2 | Faster Recovery of Gastrointestinal Transit After Laparoscopy and Fast-Track Care in Patients Undergoing Colonic Surgery显示文摘 | Sjoerd van Bree Malaika Vlug Willem Bemelman Markus Hollmann Dirk Ubbink Koos Zwinderman Wouter de Jonge Susanne Snoek Karen Bolhuis Esmerij van der Zanden Frans The Roel Bennink Guy Boeckxstaens | 2011 | Gastroenterology2011，，3： | 2 |
| 3 | Monitoring of Individual Needs in Diabetes (MIND): baseline data from the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) MIND study显示文摘 | Snoek F J Kersch NY Eldrup E | 2011 | Diabetes Care2011，34，： | 1 |
| 4 | Patients' evaluation of the quality of diabetes care (PEQD):development and validation of new instrument显示文摘 | Snoek FJ | 2002 | Quality in Health Care2002，11，2： | 1 |
| 5 | In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity 显示文摘 | Andries K Dewindt B Snoeks J | 1992 | Antimicrob Agents Chemother1992，36，： | 1 |
| 6 | Colloidal assemblies modified by ion irradiation显示文摘 | Snoeks E Blaaderen A van | 2001 | Nuclear Instruments and Methods in Physics Research2001，，： | 1 |
| 7 | Adding Semantics to Detectors for Video Retrieval显示文摘 | Snoek C G M Huurnink B Hollink L | 2007 | IEEE Trans on Multimedia2007，9，5： | 1 |
| 8 | Farm and man- agement characteristics associated with boar taint 显示文摘 | Van Wagenberg C Snoek H Van der Fels J | 2013 | Animal: an international journal of animal bioscience2013，7，11： | 1 |
| 9 | The convergence angle of tooth preparations for complete crowns 显示文摘 | Leempoel PJ Lemmens LM Snoek PA | 1987 | J Prosthet Dent1987，58，4： | 1 |
| 10 | A dedicated applicator for light delivery and monitoring of PDT of intra-anal intraepithelial neoplasia显示文摘 | Bastiaan Kruijt Eric M. van der Snoek Henricus J.C.M. Sterenborg Arjen Amelink Dominic J. Robinson | 2010 | Photodiagnosis and Photodynamic Therapy2010，，1： | 1 |
| 11 | Design and optimization of 2D photonic crystal waveguides based on silicon显示文摘 | M.J.A. De Dood E. Snoeks A. Moroz A. Polman | 2002 | Optical and Quantum Electronics (-)2002，，1： | 1 |
| 12 | Concept-based video retrieval 显示文摘 | Snoek C G M Worring M | 2009 | Foundations and Trends in Information Retrieval2009，2，4： | 1 |
| 13 | Exaggerated IL -8 and IL - 6 responses to TNF - alpha by parainfluenza virus type 4 - in-fected NCI -H292 cells显示文摘 | ROGER T BRESSER P SNOEK M | 2004 | Am J Physiol Lung Cell Mol Physiol2004，287，5： | 1 |
| 14 | Arginine deficiency augments inflammatory mediator production by airway epithelial cells in vitro 显示文摘 | Fan X Y van den Berg A Snoek M | 2009 | Respir Res2009，10，： | 1 |
| 15 | Rates and risks for co-morbid depression in patients with type 2diabetes mellitus:results from a communitybased study显示文摘 | Pouwer F Beekman AT Nijpels G Dekker JM Snoek FJ Kostense PJ | 2003 | Diabetologia2003，46，7： | 1 |
| 16 | Concentration quenching in erbium implanted alkali silicate glasses显示文摘 | SNOEKS E KIK P G POLMAN A | 1996 | Opt Mater1996，5，3： | 1 |
| 17 | The Dutch Insulin Pump Study Group:A randomized trial of continuous subcutaneous insulin infusion and intensive injection therapy in type 1 diabetes for patients with long-standing poor glycemic control显示文摘 | DeVries JH Snoek FJ Kostense PJ | 2002 | Diabetes Care2002，25，： | 1 |
| 18 | Concept-based video relricval显示文摘 | Snoek C G M Worring M | 2009 | Trcnds Inf Retriev2009，4，2： | 1 |
| 19 | Evaluating color descriptors for object and scene recogni- tion显示文摘 | VAN DE SANDE K E A GEVERS T SNOEK C G M | 2010 | IEEE Transactions on Pattern Analysis and Ma- chine Intelligence2010，32，9： | 1 |
| 20 | A comprehensive examination ofheat transfer correlations suitable for reactor safety analy-sis显示文摘 | Groeneveld D Snoek C | 1986 | Multiphase Science and Technology1986，12，： | 1 |
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