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| 1 | Utilizing the ultrasensitive Schistosoma up-converting phosphor lateral flow circulating anodic antigen(UCP-LF CAA)assay for sample pooling-strategies显示文摘Background:Methodological applications of the high sensitivity genus-specific Schistosoma CAA strip test,allowing detection of single worm active infections(ultimate sensitivity),are discussed for efficient utilization in sample pooling strategies.Besides relevant cost reduction,pooling of samples rather than individual testing can provide valuable data for large scale mapping,surveillance,and monitoring.Method:The laboratory-based CAA strip test utilizes luminescent quantitative up-converting phosphor(UCP)reporter particles and a rapid user-friendly lateral flow(LF)assay format.The test includes a sample preparation step that permits virtually unlimited sample concentration with urine,reaching ultimate sensitivity(single worm detection)at 100%specificity.This facilitates testing large urine pools from many individuals with minimal loss of sensitivity and specificity.The test determines the average CAA level of the individuals in the pool thus indicating overall worm burden and prevalence.When requiring test results at the individual level,smaller pools need to be analysed with the pool-size based on expected prevalence or when unknown,on the average CAA level of a larger group;CAA negative pools do not require individual test results and thus reduce the number of tests.Results:Straightforward pooling strategies indicate that at sub-population level the CAA strip test is an efficient assay for general mapping,identification of hotspots,determination of stratified infection levels,and accurate monitoring of mass drug administrations(MDA).At the individual level,the number of tests can be reduced i.e.in low endemic settings as the pool size can be increased as opposed to prevalence decrease.Conclusions:At the sub-population level,average CAA concentrations determined in urine pools can be an appropriate measure indicating worm burden.Pooling strategies allowing this type of large scale testing are feasible with the various CAA strip test formats and do not affect sensitivity and specificity.It allows cost efficient stratified testing and monitoring of worm burden at the sub-population level,ideally for large-scale surveillance generating hard data for performance of MDA programs and strategic planning when moving towards transmission-stop and elimination. | Paul L.A.M.Corstjens Pytsje T.Hoekstra Claudia J.de Dood Govert J.van Dam | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 2 | Adrenomedullin me-diates vasodilation via CGRP receptors显示文摘 | Doods HN Wieland HA | 1994 | Life Sci1994，56，1： | 1 |
| 3 | Effects of price,brand,and store information on buyers’product evaluations显示文摘 | DOODS W B MONROE K B GREWAL D | 1991 | Journal of Marketing Research1991，28，： | 1 |
| 4 | Predicational of self -care:a test of Oremmodel显示文摘 | Dood MJ Dibble SL | 1993 | Oncology Nursing Forun1993，20，6： | 1 |
| 5 | Design and optimization of 2D photonic crystal waveguides based on silicon显示文摘 | M.J.A. De Dood E. Snoeks A. Moroz A. Polman | 2002 | Optical and Quantum Electronics (-)2002，，1： | 1 |
| 6 | IL-27 induces a Th1 immune response and susceptibility to xperimental arthritis显示文摘 | Cao Y Doodes PD Glant TT | 2008 | Immunol2008，180，2： | 1 |
| 7 | Spray enzymatic retting:A new method for processing flax fibers显示文摘 | Akin D Dood R Perkins W | 2000 | Textile Res2000，，70： | 1 |
| 8 | Theoretical study of photonic band gaps in woodpile crystals显示文摘 | B Gralak M Dood | 2003 | Physical Review E2003，67，6： | 1 |
| 9 | IL-27 induces a Th1 immune response and susceptibility to experimental arthritis 显示文摘 | Cao Y Doodes PD Giant TT | 2008 | J Immunol2008，180，2： | 1 |
| 10 | IL-27 induces a Thl immune response and susceptibility to experimental arthritis显示文摘 | Cao Y Doodes P Giant TT | | 0，，： | 1 |
| 11 | Erbium-implanted silica colloids with 80% luminescencequantum efficiency显示文摘 | DOOD M J A de POLMAN A | 2000 | Appl Phys Lett2000，76，25： | 1 |
| 12 | IL-27 induces a Thl immune response and susceptibility to experimental arthritis 显示文摘 | Cao Y Doodes P Glant TT | 2008 | J Immunol2008，180，8： | 1 |
| 13 | Development of Proteoglyean-lnduced Arthritis Is Independent of IL-17显示文摘 | DOODES P D CAO Y X HAMEL K M | 2008 | Immunol2008，181，： | 1 |
| 14 | Development of CGRP antagonists for the treatment of mi-graine显示文摘 | Doods H | 2001 | Curr Opin Investig Drugs2001，2，9： | 1 |
| 15 | Predieators of self-care: a test of Oran's model显示文摘 | Dood M J Dibble S L | 1993 | Oneology Nursing Forum1993，20，6： | 1 |
| 16 | Suppression of proteoglycan-induced arthritis by anti-CD20 B cell depletion therapy is mediated by reduction in autoantibodies and CD4+ T cell reactivity显示文摘 | HAMEL K DOODES P CAO Y | 2008 | J Immunol2008，180，7： | 1 |
| 17 | Tools for diagnosis, monitoring and screening of Schistosoma infections utilizinglateral- flow based assays and up converting phosphor labels 显示文摘 | Corstjens PL De Dood C J Kornelis D | 2014 | Parasitol- ogy2014，141，14： | 1 |
| 18 | BIIE0246,a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist显示文摘 | Cadieux A Doods H | 2000 | Br J Pharmacol2000，129，6： | 1 |
| 19 | Application of a circulating-cathodic-antigen (CCA) strip test and real-time PCR, in comparison with microscopy, for the detection of Schistosoma haenurtobium in urine samples from Ghana 显示文摘 | Obeng BB Aryeetey YA de Dood C J | 2008 | Ann Trop Med Parasitol2008，102，7： | 1 |
| 20 | Predicators of self-care:a test of Orem'model 显示文摘 | Dood MJ Dibble SL | 1993 | Oncology Nursing Forum1993，20，6： | 1 |
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