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| 1 | Role of E3 ubiquitin ligases in lung cancer显示文摘E3 ubiquitin ligases are a large family of proteins that catalyze the ubiquitination of many protein substrates for targeted degradation by the 26S proteasome.Therefore,E3 ubiquitin ligases play an essential role in a variety of biological processes including cell cycle regulation,proliferation and apoptosis.E3 ubiquitin ligases are often found overexpressed in human cancers,including lung cancer,and their deregulation has been shown to contribute to cancer development.However,the lack of specific inhibitors in clinical trials is a major issue in targeting E3 ubiquitin ligases with currently only one E3 ubiquitin ligase inhibitor being tested in the clinical setting.In this review,we focus on E3 ubiquitin ligases that have been found deregulated in lung cancer.Furthermore,we discuss the processes in which they are involved and evaluate them as potential anti-cancer targets.By better understanding the mechanisms by which E3 ubiquitin ligases regulate biological processes and their exact role in carcinogenesis,we can improve the development of specific E3 ubiquitin ligase inhibitors and pave the way for novel treatment strategies for cancer patients. | Barbara C Snoek Leonie HAM de Wilt Gerrit Jansen Godefridus J Peters | 2013 | World Journal of Clinical Oncology2013，4，3： | 5 |
| 2 | Monitoring of Individual Needs in Diabetes (MIND): baseline data from the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) MIND study显示文摘 | Snoek F J Kersch NY Eldrup E | 2011 | Diabetes Care2011，34，： | 1 |
| 3 | In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity 显示文摘 | Andries K Dewindt B Snoeks J | 1992 | Antimicrob Agents Chemother1992，36，： | 1 |
| 4 | Farm and man- agement characteristics associated with boar taint 显示文摘 | Van Wagenberg C Snoek H Van der Fels J | 2013 | Animal: an international journal of animal bioscience2013，7，11： | 1 |
| 5 | Dispersion and absorption in magnetic ferrites at frequencies above one Mc/s显示文摘 | SNOEK J L | 1948 | Physica (Amsterdam)1948，204，14： | 1 |
| 6 | Spectral representations for convolutional neural networks 显示文摘 | Rippel O Snoek J Adams R P | 2015 | Advances in Neural Information Processing Systems2015，28，1： | 1 |
| 7 | Psychological counselling in problematic diabetes: does it help? 显示文摘 | SNOEK F J SKINNER T C | 2002 | Diabet Med2002，19，4： | 1 |
| 8 | Disability after severe head in- jury: observations on the use of the Glasgow ~utcome Scale显示文摘 | Jennett B Snoek J Bond M R et aI | 1981 | JNeurol Neurosurg Psychiatry1981，44，4： | 1 |
| 9 | Dispersion and Absorption in Magnetic Ferrites at Fre- quencies Above One Mc/s 显示文摘 | Snoek J L | 1948 | Physica1948，14，4： | 1 |
| 10 | Dispersion and absorption in magnetic ferrites at frequencies above one Mc/s 显示文摘 | Snoek J L | 1948 | Physica Amsterdam1948，，14： | 1 |
| 11 | A 7- year follow-up of sacral anterior root stimulation for blad- der control in patients with a spinal cord injury: quality of life and users' experiences显示文摘 | Vastenholt J M Snoek G J Buschman H P | 2003 | Spinal Cord2003，41，7： | 1 |
| 12 | 显示文摘 | Snoek J L | 1948 | Physlca1948，4，： | 1 |
| 13 | Effeet of small quantities of carbon and nitrogen on the elastic and plastie properties of iron 显示文摘 | Snoek J L | 1941 | Physica VIII1941，8，7： | 1 |
| 14 | Gyromagnetic Resonance in Ferrites显示文摘 | Snoek J L | 1947 | Nature1947，160，： | 1 |
| 15 | Optical doping of silicon with erbium by ion implantation显示文摘 | Polman A Custer J S Snoeks E | 1993 | J Nim Phys1993，80，1： | 1 |
| 16 | Postoperative ileus involves interleukin-1 receptor signaling in enteric glia 显示文摘 | Stoffels B Hupa K J Snoek S A | 2014 | Gastroenterology2014，146，1： | 1 |
| 17 | A 7-year follow-up of sacral anterior root stimulation for bladder control in patients with a spinal cord injury:quality of life and users experiences显示文摘 | Vastenholt KM Snoek G J Buschman HP | 2003 | Spinal Cord2003，41，7： | 1 |
| 18 | Automated detection of unusual events on stairs显示文摘 | Snoek J Hoey J Stewart L | 2009 | Image and Vision Computing2009，27，： | 1 |
| 19 | Effect of Small Quantities of Carbon and Nitrogen on the Elastic and Plastic Properties of Iron 显示文摘 | Snoek J L | 1941 | Physica1941，8，7： | 1 |
| 20 | Compar- ing compact codebooks for visual categorization 显示文摘 | Van GEMERT J C SNOEK C G M VEENMAN C J SMEULDERS A W M GEUSEBROEK J M | 2010 | Computer Vision and Image Understanding2010，114，4： | 1 |
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