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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Brain metastases as preventive and therapeutic targets显示文摘 | Steeg PS Camphausen KA Smith QR | 2011 | 中国神经肿瘤杂志2011，9，1： | 16 |
| 3 | Laboratory diagnosis of CHS infection with HSV by PCR performed with CSF specimens 显示文摘 | Mitchell PS Espy M J Smith TF | 1997 | J Clin Microbiol1997，35，11： | 2 |
| 4 | American Association of Clinical Endocrinologists' Guidelines for Management of Dyslipidemia and Prevention ofAtherosclerosis显示文摘 | JeUinger PS Smith DA Mehta AE et at | 2012 | Endocr Pract2012，18，1： | 1 |
| 5 | Urea cycle disorders:clinical presentation outside the newborn period 显示文摘 | Smith W Kishnani PS Lee B | 2005 | Crit CareClin2005，21，4： | 1 |
| 6 | The double crush syndrome: a common occurrence in cyclists with ulnar nerve neuropathy-a case-control study显示文摘 | Smith TM Sawyer SF Sizer PS | 2008 | Clin J Sport Med2008，18，1： | 1 |
| 7 | The use of mini-CEX in UK foun- dation training six years following its introduction: Lessons still to be learned and the benefit of formal teaching re- garding its utility 显示文摘 | Weston PS Smith CA | 2014 | Med Teach2014，36，2： | 1 |
| 8 | Treadmill training post stroke: arethere any secondary benefits? A pilot study显示文摘 | Smith PS Thompson M | 2008 | Clin Rehabil2008，22，1011： | 1 |
| 9 | Surgical management of adult inferior turbinate hypertrophy:a systematic review of the evidence显示文摘 | Batra PS Seiden AM Smith TL | 2009 | Laryngoscope2009，119，9： | 1 |
| 10 | p57(KIP2) expression in normal islet cells and in hy- perinsulinism of infancy 显示文摘 | Kassem SA Ariel I Thornton PS Hussain K Smith V Lindley KJ | 2001 | Diabetes2001，50，12： | 1 |
| 11 | Patterning self-assembled monolayers 显示文摘 | Smith RK Lewis PA Weiss PS | 2004 | Prog Surf Sci2004，75，12： | 1 |
| 12 | Randomized clinical tri-al of an implantable drug delivery system compared withcomprehensive medical management for refractory cancerpain : impact on pain,drug - related toxicity,and survival显示文摘 | Smith TJ Staats PS Deer T | 2002 | J Clin Oncol2002，20，19： | 1 |
| 13 | Comparing measures of acute bowel toxicity in patients with prostate cancer treated with external beam radiation therapy显示文摘 | Muanza TM Albert PS Smith S | 2005 | Int J Radiat Oncol Biol Phys2005，62，9： | 1 |
| 14 | Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity,and survival显示文摘 | Smith T J Staats PS Deer T | 2002 | J Clin Oncol2002，20，： | 1 |
| 15 | Integrative research review of risk behaviors among adolescents in rural,suburban,and urban areas显示文摘 | Fahs PS Smith BE Atav AS | 1999 | J Adolesc Health1999，24，4： | 1 |
| 16 | Unusual subcutaneous mixed tumor exhibiting adipose, fibroblastic, and epithelial components 显示文摘 | Smith PS McClure J | 1982 | J Clin Pathol1982，35，： | 1 |
| 17 | Hyperspectral vegetation indices and their relationships with agricultural crop characteristics显示文摘 | Thenkabail PS Smith RB de Pauw E | | 0，，： | 1 |
| 18 | 5'-methylthioadenosine metabolism and methionine synthesis in mammalian cells grown in cuture显示文摘 | Backlund PS Jr Smith RA | | 0，，： | 1 |
| 19 | E-cadherin phosphorylation by protein kinase D1/protein kinase C{mu} is associated with altered cellular aggregation and motility in prostate cancer显示文摘 | Jaggi M Rao PS Smith DJ | 2005 | Cancer Res2005，65，2： | 1 |
| 20 | An evaluation of image-guided technologies in the placement of percutaneous iliosacral screws显示文摘 | Smith HE Yuan PS Sasso R | 2006 | Spine2006，31，2： | 1 |
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