|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Encapsulating peritoneal sclerosis显示文摘Encapsulating peritoneal sclerosis(EPS) is a debilitating condition characterized by a fibrocollagenous membrane encasing the small intestine, resulting in recurrent small bowel obstructions. EPS is most commonly associated with long-term peritoneal dialysis, though medications, peritoneal infection, and systemic inflammatory disorders have been implicated. Many cases remain idiopathic. Diagnosis is often delayed given the rarity of the disorder combined with non-specific symptoms and laboratory findings. Although cross-sectional imaging with computed tomography of the abdomen can be suggestive of the disorder, many patients undergo exploratory laparotomy for diagnosis. Mortality approaches 50% one year after diagnosis. Treatment for EPS involves treating the underlying condition or eliminating possible inciting agents(i.e. peritoneal dialysis, medications, infections) and nutritional support, frequently with total parenteral nutrition. EPSspecific treatment depends on the disease stage. In the inflammatory stage, corticosteroids are the treatment of choice, while in the fibrotic stage, tamoxifen may be beneficial. In practice, distinguishing between stages may be difficult and both may be used. Surgical intervention, consisting of peritonectomy and enterolysis, is timeconsuming and high-risk and is reserved for situations in which conservative medical therapy fails in institutions with surgical expertise in this area. Herein we review the available literature of the etiology, pathogenesis, diagnosis, and treatment of this rare, but potentially devastating disease. | Christopher J Danford Steven C Lin Martin P Smith Jacqueline L Wolf | 2018 | World Journal of Gastroenterology2018，24，28： | 13 |
| 2 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 3 | Peptide combinatorial libraries identify TSC2 as a death - associated protein kinase (DAPK) death domain - binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling 显示文摘 | Stevens C Lin Y Harrison B | 2009 | JBiolChem2009，284，1： | 1 |
| 4 | A fast scalable implementation of the two-dimensional triangular discrete element method on GPU platform显示文摘 | LIN ZHANG STEVEN F QUIGLEY ANDREW H C CHAN | 2013 | Advances in Engineering Software2013，，6061： | 1 |
| 5 | Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death显示文摘 | Lin Y Hupp TR Stevens C | 2010 | FEBSJ2010，277，1： | 1 |
| 6 | Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis显示文摘 | Lin Y Stevens C Hupp T | 2007 | J Biol Chem2007，282，16： | 1 |
| 7 | Peptide combinatorial li braries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulato ry role for DAPK in mTORC1 signaling显示文摘 | Stevens C Lin Y Harrison B | 2009 | J Biol Chen2009，284，1： | 1 |
| 8 | Pep-tide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling显示文摘 | Stevens C Lin Y Harrison B | 2009 | Biol Chem2009，284，1： | 1 |
| 9 | Death-associated protein kinase (DAPK) and signal transduction:additional roles beyond cell death显示文摘 | Lin Y Hupp TR Stevens C | 2010 | FEBS J2010，277，1： | 1 |
| 10 | A germ line mutation in the death domain of DAPK-1 inactivates ERK-induced apoptosis 显示文摘 | Stevens C Lin Y Sanehez M | 2007 | JBiol Chem2007，282，13： | 1 |
| 11 | Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death 显示文摘 | Lin Y Hupp T R Stevens C | 2010 | FEBS J2010，277，1： | 1 |
| 12 | Death-associated protein kinase (DAPK) and signal transduction:additional roles beyond cell death显示文摘 | Lin Y Hupp TR Stevens C | 2010 | FEBS J2010，277，1： | 1 |
| 13 | Adherence to Quality Indicators and Survival in Patients With Breast Cancer显示文摘 | Skye H. Cheng C Jason Wang Jin-Long Lin Cheng-Fang Horng Mei-Chun Lu Steven M. Asch Lee H. Hilborne Mei-Ching Liu Chii-Ming Chen Andrew T. Huang | 2009 | Medical Care2009，，2： | 1 |
| 14 | Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death do- main-binding protein and reveal a stimulatoiy role for DAPK in mTORC1 signaling显示文摘 | Stevens C Lin Y Harrison B | 2009 | J Biol Chem2009，284，1： | 1 |
| 15 | Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling 显示文摘 | Stevens C Lin Y Harrison B | 2009 | J Biol Chem2009，284，1： | 1 |
| 16 | Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death显示文摘 | Lin Y Hupp T R Stevens C | 2010 | FEBS J2010，277，1： | 1 |
| 17 | Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling 显示文摘 | Stevens C Lin Y Harrison B | 2009 | J Biol Chem2009，284，1： | 1 |
| 18 | Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis 显示文摘 | Lin Y Stevens C Hupp T | 2007 | J Biol Chem2007，282，16： | 1 |
| 19 | An alternative transcript from the death-associated protein kinase 1 locus encoding a small protein in selectively mediates membrane blebbing显示文摘 | Lin Y Stevens C Hrstka R | | 0，，10： | 1 |
| 20 | Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase(DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling显示文摘 | Stevens C Lin Y Harrison B | | 0，，01： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员