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| 1 | 记忆门诊的微出血患病率和严重程度研究显示文摘Objective: To determine prevalence and severity of microbleeds (MBs) in a large cohort of patients attending a memory clinic. Methods: The authors consecutively included patients attending their memory clinic between January 2002 and April 2005. They analyzed prevalence and number of MBs according to demographic, diagnostic, and MRI data. Results: The authors included 772 patients (53%men, age 66 ±11). One hundred twenty-seven patients (17%) exhibited at least one MB. The prevalence differed according to diagnostic groups (p < 0.0001): Sixty-five percent of patients with vascular dementia exhibited MBs vs 18%of Alzheimer disease patients, 20%of mild cognitive impairment patients, and 10%of patients with subjective complaints. The presence of MBs was associated with age, white matter hyperintensities, lacunar infarcts, and infarcts. Conclusion: The prevalence of microbleeds (MBs) in a large cohort of patients attending a memory clinic is higher than previously described in community samples and lower than reported in stroke patients. This finding of a relatively high proportion of MBs in Alzheimer disease and mild cognitive impairment provides further evidence for the involvement of vascular factors in neurodegenerative diseases such as Alzheimer disease. | Cordonnier C. Van Der Flier W.M. Sluimer J.D. P. Scheltens 王鹏 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 8 |
| 2 | 记忆临床病人全脑萎缩率和认知功能损害的纵向MR研究显示文摘目的前瞻胜地研究轻度认知功能障碍(MCI)和阿尔茨海默病(AD)的全脑萎缩率及其与认知功能损害的关系,研究已有基础脑容量与全脑萎缩率,但尚未痴呆的病人发展为痴呆的概率。方法本研究经学术审查委员会批准并取得所有病人书面的知情同意。65例AD病人(女38例,男27例;年龄52~81岁),45例MCI病人(女22例,男23例;年龄56~80岁),27例有主观症状的病人(女12例。男15例;年龄50~87岁),以及10名健康人(女6例,男4例;年龄53-80岁)作为对照纳入研究。2次MR检查时间间隔为(1.8±0.7)a。采用3DT1WI(1.0T,单块采集,168层, | J.D. Sluimer W.M. van der Flier G.B. Karas N.C. Fox P. Scheltens F.Barkhof 郭雪梅(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 2 |
| 3 | Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis显示文摘 | Xianghai Liao Judith C. Sluimer Ying Wang Manikandan Subramanian Kristy Brown J. Scott Pattison Jeffrey Robbins Jennifer Martinez Ira Tabas | 2012 | Cell Metabolism2012，，4： | 1 |
| 4 | Computer analysis of computed tomography scans of the lung: A survey显示文摘 | Sluimer I Schilham A Prokop M | 2006 | IEEE Transactions on Medical Imaging2006，25，4： | 1 |
| 5 | Computer analysis of computed tornography scans of the lung a survey显示文摘 | Sluimer I Schilham A Prokup M | 2006 | IEEE Trans Med Imaging2006，25，4： | 1 |
| 6 | Angiotensin con- verting enzyme and vascular remodeling显示文摘 | Heeneman S Sluimer JC Daemen MJ | 2007 | Circ Res2007，101，44： | 1 |
| 7 | Effect of garlic on vancomycinresistant enterococci显示文摘 | Sluimer J Stobberingh E | 1999 | Antimicrob Agents Chemother1999，43，12： | 1 |
| 8 | Macrophage autophagy plays a protective role in advanced atherosclerosis显示文摘 | Liao X Sluimer JC Wang Y | 2012 | Cell Metab2012，15，4： | 1 |
| 9 | Hippocampal atrophy rates in Alzheimer disease,Added value over whole brain volume measures显示文摘 | Henneman W J Sluimer J D Barnes J | 2009 | Neurology2009，72，3： | 1 |
| 10 | Toward automated segmentation of the pathological lung in CT显示文摘 | Sluimer I Prokop M van Ginneken B | 2005 | IEEE Transactions on Medical Imaging2005，24，8： | 1 |
| 11 | Incidence of cerebral Mi- crobleeds:a longitudinal study in a memory clinic population 显示文摘 | Goos JD Henneman WJ Sluimer JD | 2010 | Neurology2010，74，： | 1 |
| 12 | Amnestic mild cognitive impairment:structural MR imaging findings predictive of conversion to Alzheimer disease显示文摘 | Karas GB Sluimer J Goekoop R | 2008 | AJNR2008，29，： | 1 |
| 13 | Joint recovery programme VerSUS usual cam:an emonomie evaluation of a clinical pathway forjoint replaeement surgery显示文摘 | Brunenberg DE Vansteyn MJ Sluimer jc | | 0，，10： | 1 |
| 14 | Angiotensin - converting enzyme and vascular remodeling 显示文摘 | Heeneman S Sluimer JC Daemen MJ | 2007 | Circ Res2007，101，： | 1 |
| 15 | Angiotensin - converting enzyme and vascular remodeling显示文摘 | Heeneman S Sluimer JC Daemen MJ | 2007 | Circ Res2007，101，8： | 1 |
| 16 | Joint recovery program versus usual care :an economic evaluation of a clinical pathway for joint replacement surgery显示文摘 | Brunen berg D E van Steyn MJ Sluimer JC | 2005 | Med Care2005，43，10： | 1 |
| 17 | Computer analysis of computed tomography scans of the lung:a survey显示文摘 | SLUIMER I SCHILHAM A PROKOP M | 2006 | IEEE Trans on Medical Imaging2006，25，4： | 1 |
| 18 | Hy- poxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angio- genesis显示文摘 | Sluimer Judith C Gasc Jean-Marie van Wanroij Job L | 2008 | J Am Coil Cardiol2008，51，13： | 1 |
| 19 | Macrophage autophagy plays a protective role in advanced atherosclerosis 显示文摘 | Liao X Sluimer JC Wang Y | 2012 | Cell Metab2012，15，4： | 1 |
| 20 | Novel concepts in atherogenesis:angiogenesis and hypoxia in atherosclerosis显示文摘 | Sluimer JC Daemen MJ | 2009 | The Journal of Pathology2009，218，1： | 1 |
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