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| 1 | Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis显示文摘补充 5a (C5a ) 被导致 neutrophils 的功能的缺陷在败血的致病含有;然而, C5a 受体的用途(C5aRs;C5aR 和 C5L2 ) 因为为败血的管理的 biomarkers 是不明确的。这研究在嗜中性的功能上在 neutrophils 和他们的效果上调查了 C5aR 和 C5L2 的动态表示。我们发现败血病人与健康、全身的煽动性的反应相比在 neutrophils 上显示了 C5aR 和 C5L2 的低表示层次症候群(先生) 题目,和这个表示模式与疾病严厉被相关。另外, C5aR 和 C5L2 的表示层次与败血病人的幸存被联系。在 vitro, C5a 的增加显著地从败血病人在 neutrophils 减少了 C5aR 和 C5L2 表示层次和 IL-8 生产。那些调查结果建议 C5aRs 的减少的表示为败血病人与 neutrophils 和差的预后的功能的缺陷被联系。总的来说,这些调查结果可以帮助作为早标记建立 C5aRs 表示层次预言败血的严厉。 | Ruonan Xu Fang Lin Chunmei Bao Huihuang Huang Chengcheng Ji Siyu Wang Lei Jin Lijian Sun Ke Li Zheng Zhang Fu-Sheng Wang | 2016 | Cellular & Molecular Immunology2016，13，1： | 10 |
| 2 | Fe5C2 nanoparticles as low-cost HER electrocatalyst:the importance of Co substitution显示文摘Constructing and understanding the doping effect of secondary metal in transition metal carbide(TMC)catalysts is pivotal for the design of low-cost hydrogen evolution reaction(HER) electrocatalysts. In this work, we developed a wet-chemistry strategy for synthesizing Co-modified Fe_5C_2 nanoparticles((Fe_(1-x)Cox)_5C_2 NPs) as highly active HER electrocatalysts in basic solution. The structure of(Fe_(1-x)Cox)_5C_2 NPs was characterized by X-ray diffraction(XRD), extended X-ray absorption fine structure spectra(EXAFS) and scanning/transmission electron microscopy(S/TEM), indicating that the isomorphous substitution of cobalt in the lattice of Fe_5C_2.(Fe_(0.75) Co_(0.25))_5C_2 exhibited the best HER activity(174 mV for j = -10 mA/cm^2). Computational calculation results indicate that Co provides the most active site for HER. X-ray adsorption spectra(XAS) studies further suggested that the electron transfer in Fe–C bonds are enhanced by the substitution of Co, which modulates the hydrogen adsorption on the adjacent electronic-enriched carbon, and therefore promotes HER activity. Our results affirm the design of lowcost bimetallic TMCs based HER catalysts. | Siwei Li Pengju Ren Ce Yang Xi Liu Zhen Yin Weizhen Li Hanjun Yang Jian Li Xiaoping Wang Yi Wang Ruochen Cao Lili Lin Siyu Yao Xiaodong Wen Ding Ma | 2018 | Science Bulletin2018，63，20： | 6 |
| 3 | High levels of circulating GM-CSF^(+) CD4^(+) T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study显示文摘Granulocyte colony-stimulating factor(GM-CSF),produced by CD4^(+)T cells,has recently been implicated in the pathogenesis of inflammatory diseases,such as multiple sclerosis and juvenile arthritis.However,the role of GM-CSF-producing CD4^(+)T cells in sepsis remains unknown.This study reports peripheral changes in GM-CSF-producing CD4^(+)T cells in septic patients and the possible underlying mechanism by which GM-CSF influences the outcome of sepsis.Forty-three septic patients,20 SIRS patients,and 20 healthy controls were enrolled in this study and followed for 28 days to assess mortality.We measured the peripheral frequency of GM-CSF^(+)CD4^(+)T cells and recorded their associated relationship with disease progression.Our data demonstrated that peripheral GM-CSF-producing CD4^(+)T cells were significantly higher in septic patients than in both SIRS patients and healthy controls.These cells exhibit a memory phenotype and impaired IFN-γ-secreting capacity in sepsis patients.Using a receiver operating curve analysis with 8.01%as a cut-off point,the percentage of GM-CSF^(+)CD4^(+)T cells could predict the outcome of septic patients.Combined with the increase in GM-CSF-producing CD4^(+)T cells,inflammatory cytokines IL-1βand IL-6 were also upregulated.Using an in vitro neutrophil model,we found that GM-CSF inhibited C3aR expression,while inducing IL-8 production.Furthermore,this effect was transferrable in plasma from sepsis patients and was attenuated by inhibition of GM-CSF using an anti-GM-CSF antibody.These results indicate that GM-CSF-producing CD4^(+)T cells may serve as a marker of sepsis severity.Thus,targeting GM-CSF overproduction may benefit sepsis patients. | Huihuang Huang Siyu Wang Tianjun Jiang Rong Fan Zheng Zhang Jinsong Mu Ke Li Yonggang Wang Lei Jin Fang Lin Jie Xia Lijian Sun Biao Xu Chengcheng Ji Jing Chen Juan Chang Bo Tu Bing Song Chao Zhang Fu-Sheng Wang Ruonan Xu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 4 | Changes of microbial composition during wastewater reclamation and distribution systems revealed by high- throughput sequencing analyses显示文摘这研究采用了 454-pyrosequencing 在二废水开垦和分发系统调查微生物引起、病原的社区。11972 个有效 16S rRNA 序列的一个总数从这二个开垦系统被获得,然后由使用 RDP 分类器指明了到相关分类等级。Chao 索引和香农差异索引证明微生物引起的社区的差异沿着废水开垦过程减少了。Proteobacteria 是在消毒以后的回收的水里的最主导的门,它分别地在二个系统占了 83% 和 88% 。包括 Clostridium, Escherichia, Shigella, Pseudomonas 和 Mycobacterium,人的机会主义的病原体被消毒过程选择并且充实。全部的氯和营养素(TOC, NH 3-N 和没有 3-N) 显著地在回收的水期间影响了微生物引起、病原的社区存储和分发过程。我们的结果显示消毒抵抗的病原体应该在回收的水里被控制,自从相对许多的增加在消毒以后的病原的细菌含有与回收的水联系的潜在的公共健康。 | Yiwen LIN Dan LI Siyu ZENG Miao HE | 2016 | Frontiers of Environmental Science & Engineering2016，10，3： | 5 |
| 5 | Effect of PdOx structure properties on catalytic performance of Pd/Ce0.67Zr0.33O2 catalyst for CO,HC and NOx elimination显示文摘Pd/Ce0.67Zr0.33O2 catalyst was pretreated in different atmosphere respectively, and characterized by CO chemical adsorption, XPS, HR-TEM, H2-TPR, Raman, OSC and in situ DRIFTS to investigate the effect of the structure properties of PdOx species on the catalytic performance for CO, HC and NOx elimination. The results show that Pd/CZ catalyst pretreated in air atmosphere has higher oxidation activity of HC due to having high Pd dispersion and strong interaction between PdOx and CZ support. Pd/CZ-H catalyst pretreated in reducing atmosphere exhibits better catalytic performance of NOx elimination because of having relatively big Pd particle size, more Pd species in metallic state and higher concentration of oxygen vacancies. While for the Pd/CZ-RG catalyst pretreated in reactant atmosphere, strong adsorption of HC species on the surface of catalysts would lead to a part of active sites being covered, which inhibits HC and NO conversions. | Ting Wang Xiaolin Guo Siyu Lin Renxian Zhou | 2019 | Journal of Rare Earths2019，37，7： | 4 |
| 6 | Quantification of viable bacteria in wastewater treatment plants by using propidium monoazide combined with quantitative PCR(PMA-qPCR)显示文摘The detection of viable bacteria in wastewater treatment plants(WWTPs) is very important for public health, as WWTPs are a medium with a high potential for waterborne disease transmission. The aim of this study was to use propidium monoazide(PMA) combined with the quantitative polymerase chain reaction(PMA-qPCR) to selectively detect and quantify viable bacteria cells in full-scale WWTPs in China. PMA was added to the concentrated WWTP samples at a final concentration of 100 μmol/L and the samples were incubated in the dark for 5 min, and then lighted for 4 min prior to DNA extraction and qPCR with specific primers for Escherichia coli and Enterococci, respectively. The results showed that PMA treatment removed more than 99% of DNA from non-viable cells in all the WWTP samples, while matrices in sludge samples markedly reduced the effectiveness of PMA treatment. Compared to qPCR, PMA-qPCR results were similar and highly linearly correlated to those obtained by culture assay, indicating that DNA from non-viable cells present in WWTP samples can be eliminated by PMA treatment, and that PMA-qPCR is a reliable method for detection of viable bacteria in environmental samples. This study demonstrated that PMA-qPCR is a rapid and selective detection method for viable bacteria in WWTP samples, and that WWTPs have an obvious function in removing both viable and non-viable bacteria. The results proved that PMA-qPCR is a promising detection method that has a high potential for application as a complementary method to the standard culture-based method in the future. | Dan Li Tiezheng Tong Siyu Zeng Yiwen Lin Shuxu Wu Miao He | 2014 | Journal of Environmental Sciences2014，26，2： | 4 |
| 7 | Comparison Analysis on Feasible Solutions for LTE Based Next-Generation Railway Mobile Communication System显示文摘Wireless communication technologies play an essential role in supporting railway operation and control. The current Global System for Mobile Communications-Railway(GSM-R) system offers a rich set of voice services and data services related with train control, but it has very limited multimedia service bearer capability. With the development of commercial wireless industry, Long-Term Evolution(LTE) mobile broadband technology is becoming the prevalent technology in most of commercial mobile networks. LTE is also a promising technology of future railway mobile communication systems. The 3rd Generation Partner Project(3 GPP) and China Communications Standards Association(CCSA) have proposed two feasible LTE based broadband trunking communication solutions: the 3 GPP Mission Critical Push to Talk(MCPTT) solution and B-TrunC solution. In this paper, we first introduce the development of railway mobile communications and LTE technology. The user requirements of future railway mobile communication system(FRMCS) are then discussed. We also analyze the suitability of the two LTE-based solutions for LTE based Next-Generation Railway Mobile Communication System(LTE-R) from different aspects. | SUN Bin DING Jianwen LIN Siyu WANG Wei CHEN Qiang ZHONG Zhangdui | 2019 | ZTE Communications2019，17，1： | 4 |
| 8 | Development of a new high resolution waveform migration location method and its applications to induced seismicity显示文摘Locating seismic events is a central task for earthquake monitoring.Compared to arrival-based location methods,waveformbased location methods do not require picking phase arrivals and are more suitable for locating seismic events with noisy waveforms.Among waveform-based location methods,one approach is to stack different attributes of P and S waveforms around arrival times corresponding to potential event locations and origin times,and the maximum stacking values are assumed to indicate the correct event location and origin time.In this study,to obtain a high-resolution location image,we improve the waveform-based location method by applying a hybrid multiplicative imaging condition to characteristic functions of seismic waveforms.In our new stacking method,stations are divided into groups;characteristic functions of seismic waveforms recorded at stations in the same group are summed,and then multiplied among groups.We find that this approach can largely eliminate the cumulative effects of noise in the summation process and thus improve the resolution of location images.We test the new method and compare it to three other stacking methods,using both synthetic and real datasets that are related to induced seismicity occurring in petroleum/gas production.The test results confirm that the new stacking method can provide higher-resolution location images than those derived from currently used methods. | SiYu Miao HaiJiang Zhang YuYang Tan Ye Lin | 2021 | Earth and Planetary Physics2021，5，6： | 3 |
| 9 | A near-infrared multifunctional fluorescent probe for hypoxia monitoring and tumor-targeted therapy显示文摘Hypoxia is one of the key characteristics of solid tumors. The over-expression of azoreductase resulting from hypoxia can be used as a target to visualize hypoxic levels and a trigger of the drug release system in tumor treatment. In this work, we developed a near-infrared fluorescent probe YLOD, composed of a near-infrared fluorophore, an azo bond, and an analogue of the anti-tumor drug melphalan. In the presence of azoreductase, YLOD displayed a red emission at 620 nm and released the anti-tumor drug concomitantly, thus achieving the integrated effects of hypoxic imaging and tumor treatment. Furthermore, YLOD successfully inhibited the growth of solid tumors during the tumor suppression experiments in nude mice. Considering all the results, YLOD emerges as a new fluorescence tool that can quickly determine the location and the edges of a tumor, showing concrete potential in clinical cancer treatment. | Yuxun Lu Jiajia Xu Zongyun Jia Siyu Kong Yimu Qiao Lin Li Qiong Wu Ying Zhou | 2022 | Chinese Chemical Letters2022，33，3： | 2 |
| 10 | The ChinaMAP reference panel for the accurate genotypeimputation in Chinese populations显示文摘Dear Editor,The genotype imputation is an efficient and pivotal approach to estimate the unobserved genotypes in the genomic data from the single nucleotide polymorphism(SNP)genotyping arrays or whole-genome sequencing(WGS).The fine mapping of variants in the genome-wide association study(GWAS)could be critically improved by the imputation with an optimal reference panel based on the population-specific haplotypes. | Lin Li Peide Huang Xiaohui Sun Siyu Wang Min Xu Sha Liu Zhimin Feng Qing Zhang Xiaoji Wang Xiaole Zheng Mengyao Dai Yufang Bi Guang Ning Yanan Cao Weiqing Wang | 2021 | Cell Research2021，31，12： | 2 |
| 11 | Embedding physics domain knowledge into a Bayesian network enables layer-by-layer process innovation for photovoltaics显示文摘Process optimization of photovoltaic devices is a time-intensive,trial-and-error endeavor,which lacks full transparency of the underlying physics and relies on user-imposed constraints that may or may not lead to a global optimum.Herein,we demonstrate that embedding physics domain knowledge into a Bayesian network enables an optimization approach for gallium arsenide(GaAs)solar cells that identifies the root cause(s)of underperformance with layer-by-layer resolution and reveals alternative optimal process windows beyond traditional black-box optimization.Our Bayesian network approach links a key GaAs process variable(growth temperature)to material descriptors(bulk and interface properties,e.g.,bulk lifetime,doping,and surface recombination)and device performance parameters(e.g.,cell efficiency).For this purpose,we combine a Bayesian inference framework with a neural network surrogate device-physics model that is 100×faster than numerical solvers.With the trained surrogate model and only a small number of experimental samples,our approach reduces significantly the time-consuming intervention and characterization required by the experimentalist.As a demonstration of our method,in only five metal organic chemical vapor depositions,we identify a superior growth temperature profile for the window,bulk,and back surface field layer of a GaAs solar cell,without any secondary measurements,and demonstrate a 6.5%relative AM1.5G efficiency improvement above traditional grid search methods. | Zekun Ren Felipe Oviedo Maung Thway Siyu I.P.Tian Yue Wang Hansong Xue Jose Dario Perea Mariya Layurova Thomas Heumueller Erik Birgersson Armin G.Aberle Christoph J.Brabec Rolf Stangl Qianxiao Li Shijing Sun Fen Lin Ian Marius Peters Tonio Buonassisi | 2020 | npj Computational Materials2020，，1： | 2 |
| 12 | A new PM_(2.5)-based CADR method to measure air infiltration rate of buildings显示文摘Air infiltration is an important way to exchange indoor air with outdoors.It significantly impacts energy consumption and air quality of buildings.Fine particles(PM_(2.5))in the outdoor atmosphere environment are a potential natural tracer for the measurement of air infiltration rate,especially in the long term field measurement.In this study,a PM_(2.5)-based method,named as CADR(clean air delivery rate)method,is developed to supplement traditional tracer gas method in order to make routine measurement in realistic environments possible and convenient.An air cleaner is installed indoors to reduce indoor PM_(2.5) concentration.Air infiltration is determined by fitting a model to the decreasing concentration data.Comparison with CO_(2) decay method in four different indoor environments gives a normalized mean error of 19%and a correlation coefficient of 0.80 for this method.This justifies the CADR method as a feasible option to measure air infiltration rate.Although subject to several constraints,the proposed method would facilitate field measurement under realistic conditions by being combined with current tracer gas methods. | Cong Liu Siyu Ji Fengjiao Zhou Qingbin Lin Yiqi Chen Xiaoliang Shao | 2021 | Building Simulation2021，14，3： | 1 |
| 13 | Indoor Positioning System Using Axis Alignment and Complementary IMUs for Robot Localization显示文摘An indoor positioning method for robots is presented to improve the precision of displacement measurement using only low-cost inertial measurement units(IMUs).Firstly,a high-fidelity displacement estimation for linear motion is proposed.A new robot motion model is designed as well as an axis alignment that only uses a single axis of the accelerometer.The integral error of velocity is eliminated by a new subsection calculation method.Two complementary IMUs are combined by assigning them different weights to obtain high accuracy displacement results.Secondly,an orientation estimation based on a fusion filter for the steering motion is proposed.Experiments show that the proposed method significantly improves the accuracy of linear motion measurement and is effective for the indoor positioning of a robot. | ZHOU Qinqin LEI Siyu YU Zhangguo LIN Hsien-I CHEN Xuechao ZHANG Weimin | 2017 | 机器人2017，39，3： | 1 |
| 14 | beta-CaSiO3/beta-Ca-3(P04)(2)composite materials for hard tissue repair:In vitro studies显示文摘 | Ni Siyu Lin Kaili Chang Jiang Chou Lee | 2008 | Journal of Biomedical Materials Research2008，85，1： | 1 |
| 15 | Advances, opportunities, and challenge for full-color emissive carbon dots显示文摘Carbon dots(CDs), novel luminescent zero-dimensional carbon nanomaterials, have been widely applied due to their low toxicity, optimal optical properties, and easy modification. However, the current controllable equipment and mechanism explanation of CDs are relatively vague and require urgent resolution.Full-color emission CDs, an essential CDs category, have attracted people’s attention given their light and color-tunable properties. In addition to a wider range of biological and optoelectronic device applications, full-color emission CDs have similar structures and significantly affected the fluorescence mechanism of CDs. At present, few studies have reported on the summary research of CDs emitted by its full color, which greatly limits the development of CDs mechanisms and applications. As such, the present review detailed the full-color CDs development status, to which a suitable method for preparing full-color CDs was presented and the existing fluorescence emission mechanism of full-color CDs was summarized.Herein, we comprehensively introduced full-color CDs applications in biology and optoelectronics. Finally,we made an outlook on the development and potential applications of full-color CDs. The present review aims to contribute novel insights and methods for understanding full-color CDs. | Xin Yang Xue Li Boyang Wang Lin Ai Guoping Li Bai Yang Siyu Lu | 2022 | Chinese Chemical Letters2022，33，2： | 1 |
| 16 | Unified simulation of hardening and softening effects for metals up to failure显示文摘Toward accurately simulating both hardening and softening effects for metals up to failure,a new finite strain elastoplastic J2-flow model is proposed with the yield strength therein as a function of the plastic work in the explicit form.With no need to identify any adjustable parameters,the uniaxial stress-strain response predicted from this new model is shown to automatically and accurately match any given data from monotonic uniaxial extension tests of bars.As such,the objectives in three respects are achieved for the first time,i.e.,(i)both the hardening and softening effects up to failure can be simulated in the sense of matching test data with no errors,(ii)the usual tedious implicit procedures toward identifying numerous unknown parameters need not be involved and can be totally bypassed,and(iii)the model applicability can be ensured in a broad sense for various metallic materials with markedly different transition effects from hardening to softening.With the new model,the complete response features of stretched bars and twisted tubes up to failure are studied,including the failure effects of bars under monotonic extension and tubes under monotonic torsion and,furthermore,the fatigue failure effects of bars under cyclic loading.The results show accurate agreement with the uniaxial data,and the results for both the shear stress and the normal stress at the finite torsion display realistic hardening-to-softening transition effects for the first time. | Siyu WANG Lin ZHAN Huifeng XI O.T.BRUHNS Heng XIAO | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，12： | 1 |
| 17 | Study of the mechanical property and in vitro biocompatibility of CaSiO3 ceramics显示文摘 | Lin Kaili Zhai Wanyin Ni Siyu | 2005 | Ceramics International2005，31，2： | 1 |
| 18 | Cupric oxide nanowires assembled by nanoparticles in situ with enhancing electrocatalytic oxidation of ascorbic acid显示文摘 | Chuanxi Wang Jie Liu Xing Huang Huanhuan Wang Youdan Zheng Li Lin Siyu Wang Song Chen Yong Jin | 2013 | Applied Surface Science2013，，： | 1 |
| 19 | Study on New Urbanization and Urban Ecological Security Assessment显示文摘Taking the relationship between new urbanization and urban ecological security protection as research object,based on pressure- status- response model,taking Gaochun( Gucheng Lake basin) and Zhangjiakou( Guanting Reservoir basin) as the examples,basin ecological security in its new urbanization process was evaluated. Based on the principle of comprehensiveness,representativeness and data availability,evaluation indexes were selected,and index system was established. Mathematical function of evaluation indexes was established,and security index of each evaluation indicator in index layer was determined. Using weighted average method,ecological security indexes in the two areas were obtained. On the basis of comparison and analysis,it is proposed that we must deal with urban ecological security problem in new urbanization process,thereby truly achieving ultimate value orientation of new urbanization construction oriented by people. | Lin Siyu Ma Zhong Shi Lei | 2015 | Meteorological and Environmental Research2015，6，7： | 1 |
| 20 | 新型可遗传编码的荧光探针实现在果蝇、斑马鱼和小鼠中快速特异地示踪多巴胺显示文摘文章简介多巴胺是神经系统中一种重要的单胺类神经递质,它介导了一系列重要的生理、病理过程。如何在自由活动的动物脑中特异、精准地示踪特定时间、区域的多巴胺释放是长期以来困扰神经科学家的技术难题。 | 孙芳妙 曾健智 井淼 Jingheng Zhou 冯杰思 Scott F.Owen 骆奕辰 Funing Li 王欢 Takashi Yamaguchi 雍自昊 Yijing Gao Wanling Peng Lizhao Wang Siyu Zhang Jiulin Du Dayu Lin Min Xu Anatol C.Kreitzer Guohong Cui 李毓龙 | 2019 | 科学新闻2019，0，2： | 1 |
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