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| 1 | ABCD^(2) risk score does not predict the presence of cerebral microemboli in patients with hyper-acute symptomatic critical carotid artery stenosis显示文摘Introduction:ABCD^(2) risk score and cerebral microemboli detected by transcranial Doppler(TCD)have been separately shown to the predict risk of recurrent acute stroke.We studied whether ABCD2 risk score predicts cerebral microemboli in patients with hyper-acute symptomatic carotid artery stenosis.Participants and methods:We studied 206 patients presenting within 2 weeks of transient ischaemic attack or minor stroke and found to have critical carotid artery stenosis(≥50% ).86 patients(age 70±1(SEM:years),58 men,83 Caucasian)had evidence of microemboli;72(84% )of these underwent carotid endarterectomy(CEA).120 patients(age 72±1 years,91 men,113 Caucasian)did not have microemboli detected;102(85% )of these underwent CEA.Data were analysed using X2 and Mann–Whitney U tests and receiver operating characteristic(ROC)curves.Results:140/206(68% :95% CI 61.63 to 74.37)patients with hyper-acute symptomatic critical carotid stenosis had an ABCD2 risk score≥4.There was no significant difference in the NICE red flag criterion for early assessment(ABCD^(2) risk score≥4)for patients with cerebral microemboli versus those without microemboli(59/86 vs 81/120 patients:OR 1.05 ABCD2 risk score≥4(95% CI 0.58 to 1.90,p=0.867)).The ABCD2 risk score was<4 in 27 of 86(31% :95% CI 21 to 41)embolising patients and in 39 of 120(31% :95% CI 23 to 39)without cerebral microemboli.After adjusting for pre-neurological event antiplatelet treatment(APT),area under the curve(AUC)of ROC for ABCD2 risk score showed no prediction of cerebral microemboli(no pre-event APT,n=57:AUC 0.45(95% CI 0.29 to 0.60,p=0.531);preevent APT,n=147:AUC 0.51(95% CI 0.42 to 0.60,p=0.804)).Conclusions:The ABCD2 score did not predict the presence of cerebral microemboli or carotid disease in over one-quarter of patients with symptomatic critical carotid artery stenosis.On the basis of NICE guidelines(refer early if ABCD2≥4),assessment of high stroke risk based on ABCD2 scoring may lead to inappropriate delay in urgent treatment in many patients. | Mahmud Saedon Charles E Hutchinson Christopher H E Imray Donald R J Singer | 2017 | Stroke & Vascular Neurology2017，2，2： | 6 |
| 2 | Nitropropionic acid of succinate dehydrogenase by 3-nitropropionate 显示文摘 | Coles C J Edmondson D E Singer T P | 1979 | J Biol Chem1979，54，： | 1 |
| 3 | Neutrophil gelatinase- associated lipocalin: pathophysiology and clinical applica- tions显示文摘 | Cardio - re- conference of Eur Heart J Singer E Marko L Paragas N | 2013 | Acta Physiol (Oxf)2013，207，4： | 1 |
| 4 | The sleep disorders invcnroty an instrument for studiees of sleep disturbancc in persons with Alzheimets disease 显示文摘 | TRACTEN BENG R E SINGER C M CUMMINGS J L | 2003 | J Sleep Res2003，12，4： | 1 |
| 5 | Greatly enhanced second-order nonlinear optical susceptibilities in doner-acceptor organic molecules显示文摘 | Katz H E Singer K D Sohn J E | 1987 | J Am Chem Soc1987，109，21： | 1 |
| 6 | Inactivation of succinate dehydrogenase by 3-nitropropionate显示文摘 | COLES C J EEMONDSON D E SINGER T P | 1979 | J Biol Chem1979，254，： | 1 |
| 7 | Recurrence of re- peat- induced point mutation (RIP) in Neurospora crassa 显示文摘 | Cambareri E B Singer M J Selker E U | 1991 | Genetics1991，127，4： | 1 |
| 8 | Successful removal of an entire lung for carcinoma of the bronchus显示文摘 | Graham E A Singer J J | 1933 | JAMA1933，101，： | 1 |
| 9 | The cyanoacrylate topical skin adhesives显示文摘 | Singer A J Quinn J V Hollander J E | 2008 | The American Journal of Emergency Medicine2008，26，4： | 1 |
| 10 | Experimental cholestasis due to alpha-naphthylisothiocyanate (ANIT) 显示文摘 | Goldfarb S Singer E J Popper H | 1962 | Am J Pathol1962，40，： | 1 |
| 11 | Empathic Neural Responses are Modulated by the PerceivedFairness of Others 显示文摘 | Singer T Seymour B 0 ’ Doherty J P Stephan K E Dolan R J FrithC D | 2006 | Nature2006，，439： | 1 |
| 12 | Antithrombotic therapy for atrial fibrillation: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guide- lines显示文摘 | You J J Singer D E Howard P A | 2012 | Chest2012，141，2： | 1 |
| 13 | Second harmonic generation in poled polymer films显示文摘 | SINGER K D SOHN J E LALAMA S L | 1986 | Appl Phys Let1986，49，： | 1 |
| 14 | The silent grief:psychosocial aspects ofpremature ovarian failure 显示文摘 | D Singer E Mann M S Hunter J Pitkin N Panay | 2011 | Climacteric:the journal of the International Menopause Society2011，14，4： | 1 |
| 15 | Single versus multiple probe blocks of P300-based concealed information tests for self-referring versus incidentally obtained information显示文摘 | ROSENFELD J P SHUE E SINGER E | 2007 | Biological Psychology2007，74，3： | 1 |
| 16 | Fast neurotransmitter release triggered by Ca influx through AMPA-type glutamate receptors显示文摘 | Chávez A E Singer J H Diamond J S | | 0，，7112： | 1 |
| 17 | Non-target screening with high-resolution mass spectrometry:Critical review using a collaborative trial on water analysis显示文摘 | SCHYMANSKI E L SINGER H P SLOBODNIK J | 2015 | Analytical and Bioanalytical Chemistry2015，407，21： | 1 |
| 18 | Prenatal drug exposure and selective attention in preschoolers 显示文摘 | Noland JS Singer LT Short E J | 2005 | Neurotoxicol Teratol2005，27，3： | 1 |
| 19 | CCI3 genotype and current depression increase risk of HIV - associated dementia 显示文摘 | LEVINE A J SINGER E J SINSHEIMER J S | 2009 | Neurobehav HIV ned2009，1，： | 1 |
| 20 | Adrenal function in sepsis: The retrospective corticus cohort study显示文摘 | Lipiner-Friedman D Sprung C L Laterre P F Weiss Y Goodman S V Vogeser M Briegel J Keh D Singer M Moreno R Bellissant E Annane D | 2007 | Critical Care Medicine2007，35，4： | 1 |
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