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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Body mass is a poor predictor of peak plantar pressure in diabetic men 显示文摘 | Cavanagh PR Sims DS Sanders LJ | 1991 | Diabetes Care1991，14，8： | 1 |
| 3 | Body mass is a poor predictor of peak plantar pressure in diabetic men显示文摘 | CAVANAGH PR SIMS DS Jr SANDERS LJ | 1991 | Diabetes Care1991，14，8： | 1 |
| 4 | Current management of acute myocardi al infarction:Experience from the Korea acute myocardial infarc tion registry显示文摘 | Sim DS Jeong MH Kang JC | 2010 | J Cardiol2010，56，1： | 1 |
| 5 | Identification of an an- tithrombotic allosteric modulator that acts through helix 8 of PAR1 显示文摘 | DOWAL L SIM DS DILKS JR | 2011 | ProcNatlAcadSci USA2011，108，7： | 1 |
| 6 | The relationship among Nterminal pro-B-type natriuretic peptide,high-sensitivity C-reactive protein and infarct size in patients with acute ST-elevation myocardial infarction显示文摘 | Sim DS Ahn Y Kim YH | 2015 | Korean Circ J2015，45，4： | 1 |
| 7 | ARRY-334543 Re- verses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2 显示文摘 | Wang DS Patel A Sim HM | 2014 | J Cell Bio- chem2014，115，8： | 1 |
| 8 | Manual Thrombus Aspira- tion is not Associated with Reduction in Infarct Size As- sessed by Delayed Enhancement MDCT 显示文摘 | Sim DS Kim YH Lee D | 2012 | Circulation2012，126，19： | 1 |
| 9 | Body Mass is A Poor Predictor of Peak Plantar Pressure in Diabetic Men显示文摘 | Cavanagh PR Sims DS Jr Sanders LJ | 1991 | Diabetes Care1991，14，8： | 1 |
| 10 | Influence of uric acid and gamma-glutamyhransferase on total antioxidant capacity and oxida- tive stress in patients with metabolic syndrome 显示文摘 | Sim~o AN Dichi JB Barbosa DS | 2008 | Nutrition2008，24，78： | 1 |
| 11 | Body mass is a poor predictor of peak plantar pressure in diabetic men显示文摘 | Cavanagh PR Sims DS Jr Sanders LJ | 1991 | Diabetes Care1991，14，： | 1 |
| 12 | Novel inflammatory biomarkers in acutecoronary syndrome 显示文摘 | Sim DS Ahn Y | 2013 | Korean J Intern Med2013，28，2： | 1 |
| 13 | Current management of acute myocardial infarction:experience from the Korea Acute Myocardial Infarction Registry显示文摘 | Sim DS Jeong MH Kang JC | 2010 | J Cardiol2010，56，1： | 1 |
| 14 | Plantar sensory threshold in the ulcerative foot显示文摘 | Birke JA Sims DS | | 0，，03： | 1 |
| 15 | Expression and characterizationof synthetic heat-labile enterotoxin B subuint and hemagglutinin-neuraminidase-neutralizing epitope fusion protein in Escherichiacoli and tobacco chloroplasts显示文摘 | Sim JS Pak HK Kim DS | 2009 | Plant Mol Biol Rep2009，27，3： | 1 |
| 16 | Cel adhesion biomaterial based on mussel adhesive protein fused with RGD peptide显示文摘 | Hwang DS Sim SB Cha HJ | | 0，，28： | 1 |
| 17 | Reliable porcine coronary model of chronic total occlusion using copper wire stents and bioabsorbable levo-polylactie acid polymer显示文摘 | Sim DS Jeong MH Cha KR | 2012 | J Cardiol2012，60，6： | 1 |
| 18 | Differences in clinical outcomes between patients with ST-elevation versus non-ST-elevation acute myocardial infarction in korea显示文摘 | Sim DS Kim JH Jeong MH | 2009 | Korean Circ J2009，39，8： | 1 |
| 19 | Cel adhesion biomaterial based on mussel adhesive protein fused with RGD peptide显示文摘 | Hwang DS Sim SB Cha HJ | | 0，，28： | 1 |
| 20 | Body mass is a poor predictor of peak plantar pressure in diabetic men显示文摘 | Cavanagh PR Sims DS Jr Sanders LJ | 1991 | Diabetes Care1991，14，： | 1 |
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