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| 1 | Effects of Helicobacterpyloriinfection on gastric emptying rate in patients with non-ulcer dyspepsia显示文摘AIM: The pathogenesis of delayed gastric emptying in patients with non-ulcer dyspepsia (NUD) remains unclear. We aimed to examine whether gastric emptying rate in NUD patients was associated with Helicobacterpylori(Hpylori) infection and whether it was affected by eradication of the infection. METHODS: Gastric emptying rate of a mixed solid-liquid meal was assessed by the paracetamol absorption method in NUD patients and asymptomatic controls (n=-17). Hpylori status was assessed by serology and biopsy urease test. Hpylori-positive NUD patients (n=-23) received 10-day triple eradication therapy. H pylori status was re-assessed by biopsy urease test four weeks later, and if eradication was confirmed, gastric emptying rate was re-evaluated. RESULTS: Thirty-three NUD patients and 17 controls were evaluated. NUD patients had significantly delayed gastric emptying compared with controls. The mean maximum plasma paracetamol concentration divided by body mass (Cmax/BM) was 0.173 and 0.224 mg/L.kg respectively (P=0.02), the mean area under plasma paracetamol concentration-time curve divided by body mass (AUC/BM) was 18.42 and 24.39 mg.min/L.kg respectively (P=-0.01). Gastric emptying rate did not differ significantly between H pylori-positive and H pylori-negative NUD patients. The mean Cmax/BM was 0.172 and 0.177 mg/Ukg respectively (P=-0.58), the mean AUC/BM was 18.43 and 18.38 rag.min/L.kg respectively (P=0.91). Among 14 NUD patients who were initially H pylori-positive, confirmed eradication of the infection did not significantly alter gastric emptying rate. The mean Cmax/BM was 0.171 and 0.160 mg/Ukg before and after Hp eradication, respectively (P=0.64), the mean AUC/BM was 17.41 and 18.02 mg.min/Ukg before and after eradication, respectively (P=-0.93). CONCLUSION: Although gastric emptying is delayed in NUD patients compared with controls, gastric emptying rate is not associated with H pylori status nor it is affected by eradication of the infection. | Grigoris I Leontiadis George I Minopoulos Efstratios Maltezos Stamatia Kotsiou Konstantinos I Manolas Konstantinos Simopoulos Dimitrios Hatseras | 2004 | World Journal of Gastroenterology2004，10，12： | 9 |
| 2 | Essential fatty acids in health and chronic disease 显示文摘 | Simopoulos AP | 1999 | Am J Clin Nutr1999，，： | 1 |
| 3 | Olfac- tion-associated quality of life in chronic rhinosinusitis显示文摘 | Simopoulos E Katotomichelakis M Gouveris H | 2012 | Adaptation and Laryngoscope2012，122，7： | 1 |
| 4 | Purslane : a plant source of omega - 3 fatty acids and melatonin 显示文摘 | Simopoulos AP Tan DX Manchester LC | 2005 | J Pineal Res2005，39，3： | 1 |
| 5 | Unit commitment by an enhanced simulated annealing algorithm显示文摘 | Simopoulos D N Kavatza S D Vournas C D | 2006 | IEEE Trans on Power Systems2006，21，1： | 1 |
| 6 | Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation:nutritional implications for chronic diseases显示文摘 | Simopoulos AP | 2006 | Biomed Pharmacother2006，60，： | 1 |
| 7 | Unit commitment by an enhanced simulated annealing algorithm显示文摘 | Simopoulos D N Kavatza S D Vournas C D | 2006 | IEEE Trans on Power Systems2006，21，1： | 1 |
| 8 | Risk factors for conversion of laparoscopic cholecystectomy to open cholecystectomy显示文摘 | SIMOPOULOS C BOTAITIS S POLYCHRONIDIS A | 2005 | Surg Endosc2005，19，7： | 1 |
| 9 | c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1 alpha dependent显示文摘 | Giatromanolaki A Koukourakis M I Simopoulos C | 2004 | Clin Cancer Res2004，10，23： | 1 |
| 10 | Risk factors for conversion of laparoscopic cholecystectomy to open cholecystectomy显示文摘 | C. Simopoulos S. Botaitis A. Polychronidis G. Tripsianis A. J Karayiannakis | 2005 | Surgical Endoscopy2005，，7： | 1 |
| 11 | Common purslane:a sourceof omega-3 fatty acids and antioxidants显示文摘 | Simopoulos AP Norman HA Gillaspy JE | 1992 | J-Am-Nutr1992，11，4： | 1 |
| 12 | Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases显示文摘 | A P Simopoulos | 2006 | Biomedicine & Pharmacotherapy2006，，60： | 1 |
| 13 | Lactate dehydrogenase 5 (LDH-5) relates to up-regulated hypoxia inducible factor pathway and metastasis in col- orectal cancer显示文摘 | Koukourakis MI Giatromanolaki A Simopoulos C | 2005 | Clinical Exp Metastasis2005，22，1： | 1 |
| 14 | Mucocele of the appendix: a report of five cases显示文摘 | M. Pitiakoudis A. K. Tsaroucha K. Mimidis A. Polychronidis G. Minopoulos C. Simopoulos | 2004 | Techniques in Coloproctology2004，，2： | 1 |
| 15 | Omega - 3 fatty acids in inflammation and au- toimmune diseases显示文摘 | SIMOPOULOS A P | 2002 | J Am Coil Nutr2002，21，： | 1 |
| 16 | Egg yolk as a source of long-chain polyunsatured fatty acids in infant feeding显示文摘 | Simopoulos A P Salem N | 1991 | Am J Clin Nutr1991，55，： | 1 |
| 17 | Risk factors for conversion of laparoscopic cholecystectomy to open cholecystecoty 显示文摘 | Simopoulos C Botaitis S Polychronidis A | 2005 | Surg Endosc2005，19，7： | 1 |
| 18 | Summary of the NATO advanced research workshop on dietary ω3 and ω6 fatty acids: biological effects and nutritional essentiality 显示文摘 | Simopoulos A P | 1989 | J Nutr1989，119，： | 1 |
| 19 | Omega-3 fatty acids in inflammation and autoimmune diseases显示文摘 | Simopoulos AP | 2002 | JAm Coll Nutr2002，21，6： | 1 |
| 20 | The importance of the omega-6/ omega 3 fatty acid ratio in cardiovascular disease and other chronic diseases显示文摘 | SIMOPOULOS A P | 2008 | Exp Biol Med(Maywood)2008，233，67： | 1 |
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