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| 1 | A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome显示文摘精子 DNA 损坏在不肥沃的人之中是流行的并且被知道影响自然复制。然而,帮助繁殖结果上的精子 DNA 损坏的影响仍然保持争论。这里,我们在精子 DNA 损坏上进行了研究的元分析(由 SCSA, TUNEL, SCD,或彗星试金估计了) 并且在从 MEDLINE, EMBASE,和 PUBMED 数据库的 IVF 或 ICSI 处理以后的临床的怀孕寻找这分析。我们识别了 41 篇文章(与 56 研究的一个总数) 包括 16, IVF 学习, 24 ICSI 研究,并且 16 混合了(IVF + ICSI ) 学习。这些研究测量了 DNA 损坏(由四试金之一:23 SCSA, 18 TUNEL, 8 SCD,和 7 彗星) 并且包括了 8068 个处理周期(3734 IVF, 2282 ICSI,和 2052 混合 IVF + ICSI ) 的一个总数。联合或 1.68 (95% CI:1.49-1.89;P <0.0001 ) 显示那精子 DNA 损坏影响临床的怀孕追随者 IVF 或 ICSI 处理。另外,联合或 IVF 的估计(16 估计,或 = 1.65;95% CI:1.34-2.04;P <0.0001 ) , ICSI (24 估计,或 = 1.31;95% CI:1.08-1.59;P = 0.0068 ) ,并且混合 IVF + ICSI 学习(16 估计,或 = 2.37;95% CI:1.89-2.97;P <0.0001 ) 也是统计上重要的。在建议精子 DNA 损坏在临床的怀孕追随者 IVF 或 ICSI 处理上有否定效果的存在文学有足够的证据。 | Luke Simon Armand Zini Alina Dyachenko Antonio Ciampi Douglas T Carrell | 2017 | Asian Journal of Andrology2017，19，1： | 38 |
| 2 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 3 | A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform显示文摘 | Bence Sipos Simone M?ser Holger Kalthoff Virag T?r?k Matthias L?hr Günter Kl?ppel | 2003 | Virchows Archiv2003，，5： | 4 |
| 4 | Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Donald Lloyd-Jones Robert Adams Mercedes Carnethon Giovanni De Simone T Bruce Ferguson Katherine Flegal Earl Ford Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Daniel Lackland Lynda L | 2009 | Circulation2009，，3： | 4 |
| 5 | Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway显示文摘BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually.Fibrosis develops from recurrent liver injury but the molecular mechanisms are not fully understood.Recently,the TLR4-MyD88 signaling pathway has been reported to contribute to fibrosis.Extracellular histones are ligands of TLR4 but their roles in liver fibrosis have not been investigated.AIM To investigate the roles and potential mechanisms of extracellular histones in liver fibrosis.METHODS In vitro,LX2 human hepatic stellate cells(HSCs)were treated with histones in the presence or absence of non-anticoagulant heparin(NAHP)for neutralizing histones or TLR4-blocking antibody.The resultant cellular expression of collagen I was detected using western blotting and immunofluorescent staining.In vivo,the CCl4-induced liver fibrosis model was generated in male 6-week-old ICR mice and in TLR4 or MyD88 knockout and parental mice.Circulating histones were detected and the effect of NAHP was evaluated.RESULTS Extracellular histones strongly stimulated LX2 cells to produce collagen I.Histone-enhanced collagen expression was significantly reduced by NAHP and TLR4-blocking antibody.In CCl4-treated wild type mice,circulating histones were dramatically increased and maintained high levels during the duration of fibrosisinduction.Injection of NAHP not only reduced alanine aminotransferase and liver injury scores,but also significantly reduced fibrogenesis.Since the TLR4-blocking antibody reduced histone-enhanced collagen I production in HSC,the CCl4 model with TLR4 and MyD88 knockout mice was used to demonstrate the roles of the TLR4-MyD88 signaling pathway in CCl4-induced liver fibrosis.The levels of liver fibrosis were indeed significantly reduced in knockout mice compared to wild type parental mice.CONCLUSION Extracellular histones potentially enhance fibrogenesis via the TLR4–MyD88 signaling pathway and NAHP has therapeutic potential by detoxifying extracellular histones. | Zhi Wang Zhen-Xing Cheng Simon T Abrams Zi-Qi Lin ED Yates Qian Yu Wei-Ping Yu Ping-Sheng Chen Cheng-Hock Toh Guo-Zheng Wang | 2020 | World Journal of Gastroenterology2020，26，47： | 3 |
| 6 | Use of APHRODITE Rain Gauge-Based Precipitation and TRMM 3B43 Products for Improving Asian Monsoon Seasonal Precipitation Forecasts by the Superensemble Method显示文摘 | Yatagai Akiyo Krishnamurti T N Kumar Vinay Mishra A K Simon Anu | 2014 | Journal of Climate2014，，3： | 2 |
| 7 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 8 | Task conflict and relationship conflict in top management teams: the pivotal role of intragroup trust 显示文摘 | SIMONS T L R S PETERSON | 2000 | Journal of Applied Psychology2000，85，1： | 1 |
| 9 | Reuse of effluent water2Benefits and risks显示文摘 | Simon T | 2006 | Agricultural Water Management2006，80，13： | 1 |
| 10 | Emotion processing in three systems:The medium and the message显示文摘 | SIMONS R DETENBER B H ROEDEMA T M | 1999 | Psychophysiology1999，36，5： | 1 |
| 11 | Superficial siderosis of the CNA:selective central myelin vulnerability and paripheral myelin sparing demonstrated by MRI显示文摘 | Grisoli M Maccagnano T Simone De | 2007 | Eur J Neurol2007，14，： | 1 |
| 12 | Central mucoepidermoid carcinoma of mandible-A case report and review of the literature 显示文摘 | Simon D Somanathan T Ramdas K | 2003 | World J Surg Oncol2003，1，1： | 1 |
| 13 | Outer Mem- brane Proteins and DNA profiles in strains of Haemophilus parasuis recovered from systemic and res- piratory sites 显示文摘 | Alvaro R Simone O Montserrat T | 2001 | J Clin Microbiol2001，，22： | 1 |
| 14 | 查看详情显示文摘 | Mijatovic T De Nève N Bruyère C Simon G Dewelle J Van Quaquebeke E Van Der A.E Van Vynckt F Lefranc F Kiss R | | 0，，： | 1 |
| 15 | 查看详情显示文摘 | Simon T Kroger A Somsen C Dlouhy A Eggeler G | | 0，，： | 1 |
| 16 | Extending and implementing the stable model semantics显示文摘 | Simons P Niemel(A)a I Soininen T | | 0，，1： | 1 |
| 17 | Usefulness of femin-A and C- reactive protein concentrations for prediction of outcome in acute coronary syndromes (from the French Registry of Acute ST-Eleva- tion Non-ST-Elevation Myocardial Infarction ) 显示文摘 | Lim P Moutereau S Simon T | 2013 | Am J Cardiol2013，111，1： | 1 |
| 18 | Euro- pean hernia society guidelines on the treatment of inguinal hernia in adult patients显示文摘 | SIMONS MP AUFENSCKER T BAY-NIELSEN M | 2009 | Hernia2009，13，4： | 1 |
| 19 | Locked nailing for the treat- ment of displaced articular fractures of the calcaneus:description of a new procedure with caJcanail显示文摘 | Goldzak M Mittlmeier T Simon P | 2012 | Eur J Orthop Surg Trauma- tol2012，22，： | 1 |
| 20 | Genetic determinants of response to clopidogrel and cardiovascular events 显示文摘 | Simon T Verstuyft C Mary-Kranse M | 2009 | N Engl J Med2009，360，4： | 1 |
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