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| 1 | Current and future applications of in vitro magnetic resonance spectroscopy in hepatobiliary disease显示文摘原子磁性的回声光谱学允许细胞的生物化学和新陈代谢的学习,在整个身体在活体内并且在更高的磁场力量在试管内。因为这种技术非侵略、非选择,磁性的回声光谱学方法论广泛地在生物化学和药被使用了。房间,身体液体和纸巾的在试管内磁性的回声光谱学研究在医药生物化学被使用了调查 pathophysiological 过程,更最近,这种技术被医生使用了决定疾病畸形在活体内。这个加亮的话题说明在试管内的潜力在学习肝胆管系统的磁性的回声光谱学。在恶意、非恶意的肝疾病和胆汁作文的学习的磁性的回声光谱学学习的在试管内质子和磷的角色被讨论,特别地与关联词在活体内的参考整个身体的磁性的回声光谱学应用。在摘要,磁性的回声光谱学技术能在到内在的 pathophysiological 过程的疾病严厉和指针上提供非侵略的生物化学的信息。磁性的回声光谱学为疾病简历标记,以及估计的治疗学的反应作为一个屏蔽工具保持潜在的诺言。 | I Jane Cox Amar Sharif Jeremy FL Cobbold Howard C Thomas Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，30： | 10 |
| 2 | Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encepha-lopathy显示文摘肝的脑病(他) 普通 neuro 精神病学的畸形,它从肝细胞失败或 portosystemic 与肝疾病和结果复杂化病人的功课正在推延。表明他是广泛地可变的并且从温和无临床症状的骚乱包含一个系列到深昏迷。研究兴趣集中于传播导出勇气的毒素的角色,特别地氨,胀大的大脑的开发和在导致全球 CNS 消沉和混乱功能的服的 neurotransmitter 系统的变化。直到最近,服的功能的直接调查有在人是困难的。然而,当磁性的回声光谱学( 1H 太太)检测的质子在大脑生物化学变化时,新磁性的回声成像( MRI )技术在大脑体积( coregistered MRI )和损害大脑功能( fMRI )提供对变化的评价的一个非侵略的工具,包括服的 osmolytes 的直接测量,例如 myoinositol ,充斥管理对细胞的动态平衡内在的过程的使挫折和夫酸安,包括细胞内部的水的累积。这些细胞内部的 osmolytes 的集中与 hyperammonaemia 改变。有 neuropsychiatric 缺陷并且自从先生系列的严厉的检测太太的代谢物畸形相互关联向正常术后疗法回来,技术可能具有在客观耐心的监视并且在估计各种各样的治疗政体的有效性的使用。 | VP Bob Graver M Alex Dresner Daniel M Forton Serena Counsell David J Larkman Nayna Patel Howard C Thomas Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，19： | 8 |
| 3 | 血浆游离DNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)显示文摘Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain injury.Prediction of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free DNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma DNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher DNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma DNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma DNA levels were independently associated with death( P < 0. 001). In conclusion,high cell-free DNA concentration was a predictor of short-term mortality following severe TBI. | Rodrigues Filho EM1 Simon D Ikuta N Klovan C Dannebrock F de Oliveira CO Regner A | 2014 | 中华神经外科疾病研究杂志2014，13，3： | 6 |
| 4 | Cholangiocarcinoma显示文摘 | Shahid A Khan Howard C Thomas Brian R Davidson Simon D Taylor-Robinson | 2005 | The Lancet . 2005 (9493)2005，，： | 3 |
| 5 | Role of microbubble ultrasound contrast agents in the non-invasive assessment of chronic hepatitis C-related liver disease显示文摘长期地感染丙肝病毒的病人经常得长期的肝疾病,对肝损伤的严厉的评价在认为病毒的根除是治疗以前被要求。这篇文章检验从标准答案肝活体检视当前可得到的各种各样的评价方法到血清学的标记和成像。超声是在临床的实践的最广泛地使用的成像形式之一并且已经是为肝疾病的一个首要的诊断工具。Microbubble 超声对比代理人允许更高的分辨率要获得的图象和对要执行的微脉管的变化的功能的评价。在确定的这些代理人的角色肝的损害的状态作为与丙肝在病人决定肝疾病的阶段和等级的一个可行方法被讨论。尽管当前限制了到专家中心,提高对比的超声将不可避免地在临床的背景增加的微水泡的可获得性。 | Scott Grier Adrian KP Lim Nayna Patel Jeremy FL Cobbold Howard C Thomas Isobel J Cox Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，22： | 2 |
| 6 | Quantitative Gas-Chromatographic Determination of Pentaerythritol and its By-Products by Direct Oximation and then Silyation of Aqueous Solutions显示文摘 | Simon C D Comninos H Cornish L | 1993 | Journal of Chromatographic Science1993，31，6： | 2 |
| 7 | Cholangiocarcinoma显示文摘 | Shahid A Khan Howard C Thomas Brian R Davidson Simon D Taylor-Robinson | 2005 | The Lancet2005，，9493： | 2 |
| 8 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 9 | P0tential of low- molecular chitosan as a DNAdelivery system : biocompatility, bo- dydistribution and ability to complex and protect DNA显示文摘 | Simon C W R Hanno V J K Ruth D | 1999 | Inter- national Journal of Pharrnacentics1999，178，： | 1 |
| 10 | Molecular and morphologic characterization of a Cryptosporidium genotype identified in lemurs显示文摘 | Alexandre J Silva D Simone C | 2003 | Vet Parasitol2003，111，4： | 1 |
| 11 | Redifferentiation therapy with retinoids: therapeutic option for advanced follicular and papillary carcinoma显示文摘 | Koehrle J Reiners C | 1998 | Wold J Surg1998，22，： | 1 |
| 12 | Hypoxia, HIFs, and cardiovascular development显示文摘 | Simon M C Ramircz-Bergeron D Mack F | 2003 | Cold Spring Harb Symp Quant Biol2003，67，： | 1 |
| 13 | Development and potential role of type-2 sodium-glucose transporter inhibitors for management of type 2 diabetes 显示文摘 | Timothy C H Simon W D | 2011 | Diabetes Ther2011，2，3： | 1 |
| 14 | Clinical evidence for a detrimen-tal effect on uterine receptive If high serum oestradiol concentrationsin high and normal responder patients 显示文摘 | Simon C Cano F Valbuena D | 1995 | Hum Reprod1995，，： | 1 |
| 15 | A review of ac- celerated carbonation technology in the treatment of cement- based materials and sequestration 'of CO2 显示文摘 | Fernandez Bertos M Simons S J R Hills C D | 2004 | Journal of Hazard- ous Materia/s2004，112，3： | 1 |
| 16 | An adaptive optical flow technique for person tracking systems 显示文摘 | Simon D Vinod C Sridha S | 2007 | Pattern Recognition Letters2007，28，10： | 1 |
| 17 | Open systems: panoramic views of gene expression 显示文摘 | Green C D Simons J F Taillon B E | 2001 | Journal of Immunological Methods2001，250，12： | 1 |
| 18 | Characterization of 14 microsatellite markers for genetic analysis and cultivar identification of walnut显示文摘 | Dangl GS Woeste K Aradhya MK Koehmstedt A simon C Potter D Leslie CA.McGranahan G | | 0，，： | 1 |
| 19 | An analytical solution for the transient response of saturated porous elastic solids显示文摘 | SIMON B R ZIENKIEWICZ O C PAUL D K | 1984 | International Journal for Numerical and Analytical Methods in Geomechanics1984，8，： | 1 |
| 20 | Tight bounds on the information rate of secret sharing schemes显示文摘 | Blundo C Santis A D Simone R D | 1997 | Designs Codes and Cryptography1997，11，2： | 1 |
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