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	题名	作者	年代	出处	被引量
1	血浆游离DNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)显示文摘Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain injury.Prediction of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free DNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma DNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher DNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma DNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma DNA levels were independently associated with death( P < 0. 001). In conclusion,high cell-free DNA concentration was a predictor of short-term mortality following severe TBI.	Rodrigues Filho EM1 Simon D Ikuta N Klovan C Dannebrock F de Oliveira CO Regner A	2014	中华神经外科疾病研究杂志2014，13，3：	6
2	TNFalpha and its receptors in psoriatic skin,before and after treatment with etanercept显示文摘	Caldarola G De Simone C Carbone A Tulli A Amerio P Feliciani C	2009	Int J Immunopathol Pharmacol2009，22，4：	1
3	查看详情显示文摘	Mijatovic T De Nève N Bruyère C Simon G Dewelle J Van Quaquebeke E Van Der A.E Van Vynckt F Lefranc F Kiss R		0，，：	1
4	Effects of microcystin-LR on development of medaka fish embryos ( Oryzias latipes )显示文摘	Claire Jacquet Violette Thermes Amaury de Luze Simone Puiseux-Dao Cécile Bernard Jean-Stéphane Joly Franck Bourrat Marc Edery	2003	Toxicon2003，，2：	1
5	Two-phase n-butenes dimerization by nickel complexes in molten salt media显示文摘	Dupont J de Souza R F	1998	Appl Catal A:General1998，775，：	1
6	Gut liver axis:a new point of attack to treat chronic liver damage? 显示文摘	Loguereio C De Simone T Federico A	2002	Am J Gastroenterol2002，97，8：	1
7	A functional role forSmad7 in sustaining colon cancer cell growth and survival 显示文摘	Stolfi C De Simone V Colantoni A	2014	Cell Death Dis2014，5，：	1
8	Three-dimensional Color Doppler Reconstruction of Intracardic Blood Flow in Patients with Different Heart Valve Disease显示文摘	DE SIMONE R GLOMBITZA G VAHL C F	2000	Am J Cardiol2000，86，：	1
9	Numerical and Experimental Characterization ~f a Natural Gas Engine with Partially Stratified Charge Spark Igni- tion显示文摘	Chan E C Davy M H de Simone G	2011	Journal of Engineering for Gas Turbines and Power2011，133，：	1
10	A functional role for smad 7 in sustaining colon cancer cell growth and survival 显示文摘	Stolfi C De simone V Colantoni A	2014	Cell Death Dis2014，20，5：	1
11	The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells 显示文摘	Caballero-Franco C Keller K De Simone C	2007	Am J Physiol Gastrointest Liver Physiol2007，292，1：	1
12	Use of the Escherich-ia coli (3-Glucuronidase (gusA) gene as a reporter gene for analy-zing promoters in lactic acid bacteria显示文摘	PLATTEEUW C SIMONS G DE VOS WM	1994	Appl Environ Microbiol1994，60，2：	1
13	Microwave ablation: principles and applications 显示文摘	Simon C J Dupuy DE Mayo- Smith WW	2005	Radiographics2005，25，：	1
14	Ehancement of host resistance against Salmonellatyphimurium infection by a diet supplement with yogurt显示文摘	De Simone C Tzantzoglou S Baldinelli L	1988	Immunopharmacol Immunotoxical1988，10，3：	1
15	Wallerian degeneration of the pontocerebellar fibers 显示文摘	De Simone T Regna-Gladin C Carriero MR	2005	Am J Neuroradiol2005，26，5：	1
16	Granular cell tumor of the breast : Clinical and pathologic characteristics of a rare case in a 14-year-old girl显示文摘	De Simone N Aggon A Christy C	2011	J Clin Oncol2011，29，22：	1
17	Wallerian de- generationof the pontocerebellar fibers 显示文摘	De Simone T Regna Gladin C Carriero MR	2005	AJNR Am J Neurora- dio12005，26，5：	1
18	Diet, but not oral probiotics, effectively reduces urinary oxalate excretion and calci- um oxalate supersaturation显示文摘	Lieske J C Tremaine W J de Simone	2010	Kidney Int2010，78，7：	1
19	Carbonic anhydrase IX:Bio- chemical and crystallographic characterization of a novel anti- tumor target 显示文摘	de SIMONE G SUPURAN C T	2010	Biochim Biophys Aeta2010，1804，2：	1
20	Walleriandegeneration of the pontocerebe\|lar fibers显示文摘	De Simone T Regna Gladin C Carriero MR	2005	Am J Neuroradiol2005，26，5：	1

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