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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 3 | Residual and sublethal effects of fenpyroximate and pyridaben on the instantaneous rate of increase of Tetranychus urticae显示文摘 | Kim M Sim C Shin D Y | 2006 | Crop Protection2006，25，6： | 1 |
| 4 | Concepts of plant biotic stress: Some insights into the stress physiology of virus-infected plant from the perspective of photosynthesis 显示文摘 | Balachandran S Hurry V M Kelley S E Osmond C B Robinson S A Rohozinski J Seaton G G R Sims D A | 1997 | Physiologia Plantarum1997，100，： | 1 |
| 5 | Anti-solvent co-crystallization of carbamazepine and saccharin显示文摘 | Wang I C Lee M J Sim S J | 2013 | Int J Pharm2013，450，： | 1 |
| 6 | Supercritical carbon dioxide extraction efficiency for carotenes from carrots by RSM显示文摘 | Balaban M O Sims C A | 1996 | Journal of Food Science1996，61，75： | 1 |
| 7 | Relationships between soil test phosphorus, soluble phosphorus, and phosphorus saturation in Delaware soils显示文摘 | Pautler M C Sims J T | 2000 | Soil Science Society of American Journal2000，64，76： | 1 |
| 8 | Solid-phase combinatorial synthesis of 5-arylalkylidene rhodanine显示文摘 | Sim M M | 2000 | Tetrahedron Lett2000，41，： | 1 |
| 9 | Job Stressors and Satisfaction in the Nursing Staff of a Critical Unit显示文摘 | Simón M G Blesa A M Bermejo P C | 2005 | Enferm Intensiva2005，16，1： | 1 |
| 10 | Fate of polycyclic aromatic compounds(PNA's)in soil-plant systems显示文摘 | Sims R C Overcash M R | 1983 | Residue Rev1983，88，： | 1 |
| 11 | Nutrient removal in a pilot and full scale constructed wetland, Putrajaya city, Malaysia 显示文摘 | SIM C H YUSOFF M K SHUTES B | 2008 | Journal of Envimmnental Management2008，88，2： | 1 |
| 12 | A common novel CYP2C 19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants显示文摘 | Sim S C Risinger C Dahl M L | 2006 | Clin Pharmacol Ther2006，79，1： | 1 |
| 13 | Electroosmotic properties of microfluidic channels composed of poly ( dimethylsiloxane) 显示文摘 | Ren Xueqin Baehman M Sims C | 2001 | Journal of Chromatography B2001，762，2： | 1 |
| 14 | Effects of fabrication procedures on fatigue resistance of welded joints in steel ortho- tropic decks显示文摘 | CHARLES S SIM H B UANG C M | 2009 | Journal of Bridge Engineering2009，14，5： | 1 |
| 15 | Wireless technologies for telemedicine 显示文摘 | NG H S SIM M L TAN C M | 2006 | BT Technology Journal2006，24，2： | 1 |
| 16 | Understanding the origin of the 535 nm emission band in oxidized poly(9,9- dioctylfluorene) : The essential role of inter-chain/inter-segment interactions显示文摘 | Sims M Bradley D D C Ariu M | 2004 | Adv Func Mater2004，14，8： | 1 |
| 17 | Fast neutron interrogation system development for the detection of explosive materials显示文摘 | Sim C M Kim Y K Kim T J | 2010 | Nuclear Instruments and Methods in Physics Research A2010，615，： | 1 |
| 18 | Optimization of carrot Juice color and cloud stability显示文摘 | Sims C A Balaban M O Matthews R F | 1993 | J Food Sci1993，58，： | 1 |
| 19 | Versatile transfer of a- ligned carbon nanotubes with polydimethylsiloxane as the inter- mediate显示文摘 | Zhu Y W Lim X D Sim M C | 2008 | Nanotechnology2008，19，32： | 1 |
| 20 | The use of digitally reconstructed radiographs for three-dimensional treatment planning and CT-simulation 显示文摘 | GALVIN J M SIMS C DOMINIAK G | 1995 | Int J Radiat Oncol Biol Phys1995，31，4： | 1 |
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