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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Evaluation of the use of prairie grasses for stimulating polycyclic aromatic hydrocarbon treatment in soil显示文摘 | Aprill W R C Sims | 1990 | Chemosphere1990，20，： | 2 |
| 3 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 4 | Macroeconomics and reality 显示文摘 | SIMS C A | 1980 | Econometrica1980，48，5： | 1 |
| 5 | Macroeconomics and Reality显示文摘 | Sims C A | 1980 | Econometrica1980，，48： | 1 |
| 6 | Phosphorus loss in agricultural drainage: Historical perspective and current research显示文摘 | Sims J T Simard R R Joern B C | 1998 | Journal of Environmental Quality1998，27，： | 1 |
| 7 | Characteristics of basalt fiber as a strengthening material for concrete structures 显示文摘 | Sim J Park C Moon D Y | 2005 | Composites Part B2005，36，： | 1 |
| 8 | Toward conceptualizing and measuring cognitive structures显示文摘 | Kanwar Rajesh Jerry C Olson and Laura S Sims | 1981 | Advances in Consumer Research1981，8，： | 1 |
| 9 | Money, Income and Causality 显示文摘 | Sims C | 1972 | American Economic Review1972，62，1： | 1 |
| 10 | Complement activation and protein adsorption by carbon nanotubes显示文摘 | Salvador-Morales C Flahaut E Sim E Sloan J Green ML Sim RB | | 0，，03： | 1 |
| 11 | Residual and sublethal effects of fenpyroximate and pyridaben on the instantaneous rate of increase of Tetranychus urticae显示文摘 | Kim M Sim C Shin D Y | 2006 | Crop Protection2006，25，6： | 1 |
| 12 | Nonmehing-flesh trait in peaches is not related to low ethylene production rates显示文摘 | Brovelli E A Brecht J K Sherman W B Sims C A | 1999 | HortScience1999，34，： | 1 |
| 13 | Catalase and superoxide dismutase-2 enhance survival and protect ovaries during overwintering diapause in the mosquito Culex pipiens显示文摘 | Sim C Denlinger DL | 2011 | J Insect Physiol2011，57，5： | 1 |
| 14 | Concepts of plant biotic stress: Some insights into the stress physiology of virus-infected plant from the perspective of photosynthesis 显示文摘 | Balachandran S Hurry V M Kelley S E Osmond C B Robinson S A Rohozinski J Seaton G G R Sims D A | 1997 | Physiologia Plantarum1997，100，： | 1 |
| 15 | 显示文摘 | Butler P E Cao Y L | 1998 | Plast Reconstr Swry1998，10，6： | 1 |
| 16 | Characteristics of basalt fiber as a strengthening material for concrete structures 显示文摘 | Sim J S Park C W Moon D Y | 2005 | Composites Part B2005，，36： | 1 |
| 17 | cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily显示文摘 | Sims JE March C J Cosman D | 1988 | Scienee1988，241，4865： | 1 |
| 18 | Characteristics of basalt fiber as a strengthening material for concrete structure 显示文摘 | SIM J PARK C MOON D Y | 2005 | Composites : Part B Engineering2005，，36： | 1 |
| 19 | Macroecomonics and Reality 显示文摘 | Sims C | 1980 | Econometrica1980，48，1： | 1 |
| 20 | A parametric formulation of the generalized spectral subtraction method 显示文摘 | Sim B L Tong Y C Chang J S | 1998 | IEEE Trans on Speech and Audio Pro- cessing1998，6，4： | 1 |
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