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| 1 | A novel phenol-bound pectic polysaccharide from Decalepis hamiltonii with multi-step ulcer preventive activity显示文摘AIM: To investigate H+, K+-ATPase inhibition, anti-H pylori , antioxidant, and the in vivo antiulcer potential of a pectic polysaccharide from Swallow root (Decalepis hamiltonii; SRPP). METHODS: SRPP, with known sugar composition [rhamnose: arabinose: xylose: galactose in the ratio of 16:50:2:32 (w/w), with 141 mg/g of uronic acid] was examined for anti-ulcer potency in vivo against swim/ ethanol stress-induction in animal models. Ulcer index, antioxidant/antioxidant enzymes, H+, K+-ATPase and gastric mucin levels were determined to assess the anti- ulcer potency. Anti-H pylori activity was also determined by viable colony count and electron microscopic studies. RESULTS: SRPP, containing phenolics at 0.12 g GAE/g, prevented stress-induced gastric ulcers in animal models by 80%-85%. Down regulation of gastric mucin 2-3 fold, antioxidant/antioxidant enzymes and upregulation of 3 fold of H+, K+-ATPase in ulcerous animals were normalized upon treatment with SRPP. Histopathological analysis revealed protection to the disrupted gastric mucosal layer and epithelial glands. SRPP also inhibited H+, K+-ATPase in vitro, at an IC50 of 77 μg/mL as opposed to that of 19.3 μg/mL of Lansoprazole and H pylori growth at Minimum Inhibitory Concentration (MIC) of 150 μg/mL. In addition, free radical scavenging (IC50-40 μg/mL) and reducing power (3200 U/g) activities were also observed. CONCLUSION: SRPP, with defined sugar composition and phenolics, exhibited multi-potent free radical scavenging, antioxidant, anti-H pylori, inhibition of H+, K+-ATPase and gastric mucosal protective activities. In addition, SRPP is non-toxic as opposed to other known anti-ulcer drugs, and therefore may be employed as a potential alternative for ulcer management. | BM Srikanta MN Siddaraju Shylaja M Dharmesh | 2007 | World Journal of Gastroenterology2007，13，39： | 6 |
| 2 | Control of autoimmune arthritis by herbal extracts and their bioactive components显示文摘Autoimmune diseases such as rheumatoid arthritis (RA) cause significant morbidity and loss of productivity. Many potent conventionally used drugs are available for these diseases, but their prolonged use is accompanied by severe adverse effects besides a high cost.Therefore, there is an unmet need for effective but less expensive medications for RA and other autoimmune diseases. Natural plant products belonging to the traditional systems of medicine, such as the traditional Chinese medicine and Indian Ayurvedic medicine, offer a vast and promising resource in this regard. However, herbal medicinal products are often poorly characterized for their composition as well as mechanisms of action. We review here the results of our systematically performed studies aimed at defining the anti-arthritic activity of three herbal extracts, namely, modified Huo-luo-xiao-ling dan (HLXL), Celastrus aculeatus Merr., and polyphenolic fraction of green tea (Camellia sinensis), as well as a purifiedcompound Celastrol, a bioactive component of Celastrus. Specifically, we examined the effects of these herbal products on the immunological, biochemical and molecular biological effector pathways in autoimmune arthritis. We have also reviewed here related studies on these herbal products by other investigators. Taken together, we suggest further testing of these herbal products in RA patients. | Shivaprasad H.Venkatesha Brian Astry Siddaraju M.Nanjundaiah Hong R.Kim Rajesh Rajaiah Yinghua Yang Li Tong Hua Yu Brian M.Berman Kamal D.Moudgil | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，2： | 2 |
| 3 | Inhibition of gastric H ^+ , K^+ - ATPase and Helicobacter pylori growth by phenolic antioxidants of curcuma amada显示文摘 | Siddaraju MN Dharmesh SM | 2007 | J Agri Food Chem2007，55，18： | 1 |
| 4 | Inhibition of gastric H^+ , K^+ - ATPasc and Helieobacter priori growth by phenolic antioxidants of zingiber officinale 显示文摘 | Siddaraju MN Dharmesh SM | 2007 | Mol Nutr Food Res2007，51，3： | 1 |
| 5 | Immunohistochemical distinction between mesothelial and adenocarcinoma cells in serous effusions: a combination panel-based approach with a brief review of the literature显示文摘 | Murugan P Siddaraju N Habeebullah S | 2009 | Indian J Pathol Microbiol2009，52，2： | 1 |
| 6 | Internal derangementof temporomandibular joint : an evaluation of effect ofcorticosteroid injection compared with injection of sodiumhyaluronate after arthrocentesis 显示文摘 | Giraddi GB Siddaraju A Kumar B | 2012 | J Maxillofac Oral Surg2012，11，3： | 1 |
| 7 | Role of pro-angiogenic marker galectin-3 in follicular neoplasms of thyroid显示文摘 | Manivannan P Siddaraju N Jatiya L | 2012 | Indian J Biochem Biophys2012，49，5： | 1 |
| 8 | Cytologic aspeets of T-cell acute lymphoblastic leukemia presenting as a massive pericardial effusion: a case report显示文摘 | Basu D Siddaraju N Muruqan ST | 2009 | Acta Cytol2009，53，3： | 1 |
| 9 | Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines显示文摘 | Shivaprasad H. Venkatesha Brian Astry Siddaraju M. Nanjundaiah Hua Yu Kamal D. Moudgil | 2012 | Bioorganic & Medicinal Chemistry2012，，17： | 1 |
| 10 | Inhibition of gastric H+,K+-ATPase and helicobacteRpylori growth by phenolic antioxidants of curcuma amada显示文摘 | Siddaraju MN Dharmesh SM | 2007 | J Agri Food Chem2007，55，18： | 1 |
| 11 | Developing an in vitro screening assay platform for evaluation of antifibrot- ic drags using precision-cut liver slices 显示文摘 | Sadasivan SK Siddaraju N Khan KM | 2015 | Fibrogenesis Tissue Repair2015，8，1： | 1 |
| 12 | Role of eerebrospinal flu- id cytology in carcinomatous meningitis masquerading as tu berculoma显示文摘 | Toi PCh Siddaraju N Ganesh RN | 2013 | J Cytol2013，30，3： | 1 |
| 13 | Role of cerebrospinal fluid cytol- ogy in carcinomatous meningitis masquerading as tuberculoma显示文摘 | Tol PC Siddaraju N Ganesh RN | 2013 | Journal of Cytology2013，30，3： | 1 |
| 14 | Review Immunohisto- chemical distinction between mesothelial and adenocarcinoma cells in serous effusions: a combination panel- based approach with a brief re- view of the literature 显示文摘 | Murugan P Siddaraju N Habeebullah S | 2009 | Indian J Pathol Microbiol2009，52，2： | 1 |
| 15 | Cytologic aspects of T-cell acute lymphoblastic leukemia presenting as a massive pericardial effusion: a case report显示文摘 | Basu D Siddaraju N Murugan P | 2009 | Acta Cytol2009，53，3： | 1 |
| 16 | Immunohisto- chemical distinction between mesothelial and adenocarcinoma cells in serous offusions:a combination panel-based approach with abrief review of the literature 显示文摘 | Murugan P siddaraju N Habeebullah S | 2009 | Indian J Patholmicrobiol2009，52，2： | 1 |
| 17 | Role of pro-angiogenic marker Galectin-3 in follicular neoplasms of thyroid显示文摘 | Manivannan P Siddaraju N Jatiya L | 2012 | Indian J Biochem Biophys2012，49，5： | 1 |
| 18 | Inhibition of gastric H + , K + - AT- Pase and helicobacter pylori growth by phenolic antioxidants of cur- cuma amada 显示文摘 | Siddaraju MN Dharmesh SM | 2007 | J Agri Food Chem2007，55，18： | 1 |
| 19 | Immunohisto- chemical distinction between mesothelial and adenocarcinoma cells in serous effusions: a combination panel-based approach with a brief review of the literature显示文摘 | Murugan P Siddaraju N Habeebullah S | 2009 | Indian J Pathol Microbiol2009，52，2： | 1 |
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