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| 1 | Microglial migration mediated by ATP-induced ATP release from lysosomes显示文摘Microglia 是在中央神经系统充当活跃有免疫力的防卫的主要形式的高度能动的房间。由免除损坏房间的因素吸引了, microglia 向损坏或感染的地点被招募,在他们涉及退化、再生的回答和房间碎片的 phagocytotic 清理的地方。从损坏神经纸巾的 ATP 版本被建议了调停向损害的地点的 microglial 过程的快速的延期。然而, microglia 的远程的迁居的机制尚待被澄清。这里,我们发现在 microglia 的 lysosomes 响应各种各样的刺激包含丰富的 ATP 和展览 Ca 2+-dependent exocytosis。由建立一在 vitro 趋化性试金有效,我们证明从 microglia 的 释放endogenously 的 ATP 由 ATPγ 的本地 microinjection 被触发; S 为 microglia 的远程的趋化性是批评的,显著地在与导致 lysosome osmodialysis 的一个代理人或在房间对待的 microglia 被禁止的回答源于在 Rab 27a (灰老鼠)缺乏的老鼠,为能分泌的 lysosomes 的 trafficking 和 exocytosis 要求的小 GTPase 。这些结果建议 microglia 由通过 lysosomal exocytosis 自己释放 ATP 对细胞外的 ATP 作出回应,从而提供积极反馈机制为吸引远 microglia 移居向并且在损害的地点积累产生一个远程的细胞外的信号。 | Ying Dou Hang-jun wu Hui-quan Li Song Qin Yin-er Wang Jing Li Hui-fang LOU Zhong Chew Xiao-ming Li Qing-ming Luo Shumin Duan | 2012 | Cell Research2012，22，6： | 10 |
| 2 | Effects of annealing treatment on the microstructure and electrochemical properties of low-Co hydrogen storage alloys containing Cu and Fe显示文摘The effects of annealing treatment on the microstructure and electrochemical properties of low-Co LaNi 3.55 Mn 0.35 Co 0.20 Al 0.20 Cu 0.75 Fe 0.10 hydrogen storage alloys were investigated. X-ray diffraction (XRD) analysis indicated that annealing treatment remarkably reduced the lattice strain and defects, and increased the unit-cell volume. The optical microscope analysis showed that the as-cast alloy had a crass dendrite microstructure with noticeable composition segregation, which gradually disappeared with increasing annealing temperature, and the micro-structure changed to an equiaxed structure after annealing the alloy at 1233 K. The electrochemical tests indicated that the annealed alloys demonstrated much better cycling stability compared with the as-cast one. The capacity retention at the 100th cycle increased from 90.0% (as-cast) to 94.7% (1273 K). The annealing treatment also improved the discharge capacity. However, the high rate dischargeability (HRD) value of the annealed alloy slightly dropped, which was believed to be ascribed to the decreased exchange current density and the hydrogen diffusion coefficient in alloy bulk. | YANG Suxia LIU Zhiping HAN Shumin ZHANG Wei SONG Jianzheng | 2011 | Rare Metals2011，30，5： | 10 |
| 3 | Design and parameter optimization of flexible comb-type grass seed metering device显示文摘In order to optimize the structure schema of flexible comb-type grass seeder,the effects of combing teeth gap L,rotation speed of comb shaft N,seed metering device inclining angle α and groove strip inclining angle θ on the rate and uniformity of seeding were observed by test and analyzed,then the coefficient of seeding stability variation was explored in the simulating planting environment on the soil tank test bed based on the above four influencing factors,with Festuca arundinacea seeds as example.According to the results of regression analysis,the model fits well with the actual situation.L,N,α,and the interaction term of N and θ are significant,and the interaction term of θ and α is extremely significant.The analysis of interaction factor effect shows that the variation coefficient responds to the interaction of N and θ in the same manner as that responds to the interaction of θ and α,showing ‘saddle’ variation tendency.Suppose the acceptable maximum value of coefficient of seeding uniformity variation is 4%,then the inverse proportion relationship between factors is inferred according to the change trend of the above interaction factors and derivation of regression equation.Then the regression equation was simplified according to the inverse proportion equation,and four groups of parameters were obtained.Each parameter group was tested,and the test results agreed with the regression equation's predicting value,with the correlation coefficient 0.726.This research can provide reference for the development of seed metering devices and grass seeders. | Yang Song Zhang Shumin | 2015 | International Journal of Agricultural and Biological Engineering2015，8，1： | 5 |
| 4 | A New Understanding of Channel Patterns and Facies Models of the Shallow Lake Delta Facies of Fuyu Oil Reservoir in Songliao Basin,China显示文摘摘要:在 Songliao 盆的 Fuyu 水库,在那里发生一系列开发得好的古怪的浅湖三角洲外形,它能被划分到象上面的三角洲平原 subfacies,更低的三角洲平原 subfacies,和三角洲前面 subfacies 的如此的三。在他们之中,上面的三角洲平原 subfacies 主要种近似支流隧道;更低的三角洲平原 subfacies 主要增长远侧的。全部 Fuyu 水库主要开发了 7 种支流隧道模式:proximal/ 远侧的蜿蜒地流类型支流隧道,近似 / 远侧的低蜿蜒的类型支流隧道,近似 / 远侧的直类型支流隧道,和水下的支流隧道。在这些模式之中,近似、远侧的蜿蜒地流的类型支流隧道有点酒吧并且更好的排序和泥的低内容的更大的厚度;而且,他们是主要水库并且发生在 Quan-4th 的底部成员。水下的支流隧道的沙洲有更高的泥内容,并且用作更差的水库,并且主要发生在 Quan-4th 成员的顶。 | LI Yanping CHEN Shumin SONG Yongzhong ZHANG Erhua SHEN Jiagang ZHENG Jianbin | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 3 |
| 5 | Direct observation of chaotic resonances in optical microcavities显示文摘Optical microcavities play a significant role in the study of classical and quantum chaos.To date,most experimental explorations of their internal wave dynamics have focused on the properties of their inputs and outputs,without directly interrogating the dynamics and the associated mode patterns inside.As a result,this key information is rarely retrieved with certainty,which significantly restricts the verification and understanding of the actual chaotic motion.Here we demonstrate a simple and robust approach to directly and rapidly map the internal mode patterns in chaotic microcavities.By introducing a local index perturbation through a pump laser,we report a spectral response of optical microcavities that is proportional to the internal field distribution.With this technique,chaotic modes with staggered mode spacings can be distinguished.Consequently,a complete chaos assisted tunneling(CAT)and its time-reversed process are experimentally verified in the optical domain with unprecedented certainty. | Shuai Wang Shuai Liu Yilin Liu Shumin Xiao Zi Wang Yubin Fan Jiecai Han Li Ge Qinghai Song | 2021 | Light(Science & Applications)2021，10，8： | 3 |
| 6 | Optimizing pH-sensitive and time-dependent polymer formula of colonic pH-responsive pellets to achieve precise drug release显示文摘Time-sensitive and pH-dependent polymers are generally employed to prepare colon-site delivery system, and their coating thickness and order are very important in controlling the drug release. The traditional colon-site delivery systems consist of time-dependent polymers as inner layer and pH-sensitive polymers as outer layer. However, they suffer from low drug-loading rate and immature drug release. In this study, total alkaloids of sophora alopecuroides(TASA)-loaded pellets were prepared by extrusion-spheronization method and coated with Eudragit RS30D and Eudragit S100. Pellets using Eudragit RS30D as inner layer and Eudragit S100 as outer layer were named as ERS-ES100 TCO, while pellets with Eudragit S100 as inner layer and Eudragit RS30D as outer layer were ES100-ERS NCO. Both types of formulations with varying coating ratios and orders of Eudragit S100 and Eudragit RS30D were designed and prepared. The following in vitro drug release and SEM studies indicated that ERS-ES100 TCO(F2) with 12.8% Eudragit RS30D as inner layer and 21% Eudragit S100 as outer layer released up to 42% drug in 5 h. Interestingly, ES100-ERS NCO(F4) coated with 12.8% Eudragit S100 and 14.8% Eudragit RS30D showed optimal drug release in colon. In conclusion, ES100-ERS NCO colonic delivery system achieved reduced coating thickness and improved colonic targeting compared with traditional delivery system(ERS-ES100 TCO). In addition, the similarity factors( f 2) value of sophoridine and matrine for investigated formulation were within 50–100 and > 80, demonstrating that sophoridine and matrine in all formulations achieved a synchronous release. | Lijun Song Liping Liang Xiaoying Shi Honglang Chen Shumin Zhao Wenfeng Chen Ruoxia Zhou Wenchang Zhao | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 1 |
| 7 | Effect of La 2 O 3 -CaO composite additive on the hydrogen storage properties of Mg 2 Ni alloy显示文摘 | Jianzheng Song Shumin Han Ruidong Fu | 2014 | Materials Science & Engineering B2014，，： | 1 |
| 8 | Improvement of the chirality near avoided resonance crossing in optical microcavity显示文摘Chirality is one of the important phenomena at the vicinity of exceptional point(EP). The conventional understanding is that the chirality is determined by asymmetrical scattering efficiency(?), which reaches to zero only when the resonance approaches EP. Here we study the possibility to enhance the chirality in open systems with a more robust mechanism. By combining chirality with avoided resonance crossing, we show that the chirality and ? can be dramatically modified. Taking a spiral shaped annular cavity as an example, we show that the chirality of optical resonances can be significantly improved when two sets of chiral states approach each other. The imbalance between counterclockwise(CCW) components and clockwise(CW) components has been enhanced by more than an order of magnitude. Our research provides a new route to tailor and control the chirality in open systems. | SONG QingHai GU ZhiYuan ZHANG Nan WANG KaiYang YI Ning Bo XIAO ShuMin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，11： | 1 |
| 9 | Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausal Chinese women显示文摘Growth differentiation factor 11(GDF11) is an important circulating factor that regulates aging.However,the role of GDF11 in bone metabolism remains unclear.The present study was undertaken to investigate the relationship between serum GDF11 level,bone mass,and bone turnover markers in postmenopausal Chinese women.Serum GDF11 level,bone turnover biochemical markers,and bone mineral density(BMD) were determined in 169 postmenopausal Chinese women(47–78 years old).GDF11 serum levels increased with aging.There were negative correlations between GDF11 and BMD at the various skeletal sites.After adjusting for age and body mass index(BMI),the correlations remained statistically significant.In the multiple linear stepwise regression analysis,age or years since menopause,BMI,GDF11,and estradiol were independent predictors of BMD.A significant negative correlation between GDF11 and bone alkaline phosphatase(BAP) was identified and remained significant after adjusting for age and BMI.No significant correlation was noted between cross-linked N-telopeptides of type I collagen(NTX) and GDF11.In conclusion,GDF11 is an independent negative predictor of BMD and correlates with a biomarker of bone formation,BAP,in postmenopausal Chinese women.GDF11 potentially exerts a negative effect on bone mass by regulating bone formation. | Yusi Chen Qi Guo Min Zhang Shumin Song Tonggui Quan Tiepeng Zhao Hongliang Li Lijuan Guo Tiejian Jiang Guangwei Wang | 2016 | Bone Research2016，4，1： | 1 |
| 10 | Distributed Step-by-step Finite-time Consensus Design for Battery Energy Storage Devices with Droop Control显示文摘As all generators are distributed in different areas among large scale power systems,the cooperative manipulation of the multi-generator system cannot operate well without consideration of the distance information of the generators.A distributed step-by-step finite-time consensus scheme for the heterogeneous battery energy storage system(BESS)is proposed in this paper,where the coordinated consensus can come into reality within a limited time,which is appealing for the electrical engineering community.To be concrete,at first,all BESSs are classified into several clusters according to their locations,and in each cluster,there is an active leader in charge of information receiving from outside.Then,in order to coordinate the multi BESSs,five inputs,which are function oriented,were used to achieve energy level balancing,active/reactive power sharing,and the consensus of voltage and frequency of the multi BESSs.Furthermore,the frequency and voltage restoration to the nominal values of the main grid were made possible by the introduction of a virtual leader,which is actually an external leader.Compared with the centralized methods,this control scheme is entirely distributed,and each BESS only utilizes the information of its own and its neighbors.In addition,this control is robust to the load perturbation and the plug-and-play of the communication topology.Finally,some simulation experiments are executed on the modified IEEE 57-bus system to verify the suggested scheme. | Yalin Zhang Yunzhong Song Shumin Fei | 2023 | CSEE Journal of Power and Energy Systems2023，9，5： | 1 |
| 11 | Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma显示文摘Constitutively activated G proteins caused by specific mutations mediate the development of multiple malignancies. The mutated Gaq/11 are perceived as oncogenic drivers in the vast majority of uveal melanoma(UM) cases, making directly targeting Gaq/11 to be a promising strategy for combating UM. Herein, we report the optimization of imidazopiperazine derivatives as Gaq/11 inhibitors, and identified GQ262 with improved Gaq/11 inhibitory activity and drug-like properties. GQ262 efficiently blocked UM cell proliferation and migration in vitro. Analysis of the apoptosis-related proteins, extracellular signal-regulated kinase(ERK), and yes-associated protein(YAP) demonstrated that GQ262 distinctly induced UM cells apoptosis and disrupted the downstream effectors by targeting Gaq/11directly. Significantly, GQ262 showed outstanding antitumor efficacy in vivo with good safety at the testing dose. Collectively, our findings along with the favorable pharmacokinetics of GQ262 revealed that directly targeting Gaq/11 may be an efficient strategy against uveal melanoma. | Yang Ge Jun-Jie Deng Jianzheng Zhu Lu Liu Shumin Ouyang Zhendong Song Xiaolei Zhang Xiao-Feng Xiong | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 1 |
| 12 | Effect of La2O3-Ca O composite additive on the hydrogen storage properties of Mg2Ni alloy显示文摘 | Jianzheng Song Shumin Han Ruidong Fu | 2014 | Materials Science and Engineering:B2014，188，： | 1 |
| 13 | Mechanism of high-concentration electrolyte inhibiting the destructive effect of Mn(Ⅱ)on the performance of lithium-ion batteries显示文摘By optimizing electrolyte formulation to inhibit the deposition of transition metal ions(TMIs) on the surface of the graphite anode is an effective way to improve the electrochemical performance of lithium-ion batteries.At present,it is generally believed the formation of an effective interfacial film on the surface of the anode electrode is the leading factor in reducing the dissolution of TMIs and prevent TMIs from being embedded in the electrode.It ignores the influence of the solvation structures in the electrolyte system with different composition,and is not conducive to the design of the electrolyte formulation from the perspective of changing the concentration and the preferred solvent to inhibit the degradation of battery performance caused by TMIs deposition.In this work,by analyzing the special solvation structures of the high-concentra tion electrolyte,we study the main reason why high-concentration electrolyte inhibits the destructive effect of Mn(Ⅱ) on the electrochemical performance of LIBs.By combining the potentialresolved in-situ electrochemical impedance spectroscopy technology(PRIs-EIS) and density functional theory(DFT) calculation,we find that Mn(Ⅱ) mainly exists in the form of contact ions pairs(CIPs) and aggregates(AGGs) in high-concentration electrolyte.These solvation structures can reduce the destructive effect of Mn(Ⅱ) on battery performance from two aspects:on the one hand,it can rise the lowest unoccupied orbital(LUMO) value of the solvation structures of Mn(Ⅱ),thereby reducing the chance of its reduction;on the other hand,the decrease of Mn2+ions reduction can reduce the deposition of metallic manganese in the solid electrolyte interphase(SEI),thereby avoiding the continuous growth of the SEI.This study can be provided inspiration for the design of electrolytes to inhibit the destructive effect of TMls on LIBs. | Xiaoling Cui Jinlong Sun Dongni Zhao Jingjing Zhang Jie Wang Hong Dong Peng Wang Junwei Zhang Shumin Wu Linhu Song Ningshuang Zhang Chunlei Li Shiyou Li | 2023 | Journal of Energy Chemistry2023，，3： | 1 |
| 14 | Liquid-Crystal- Based Tunable High-Q Directional Random Laser from a Planar Random Microcavily 显示文摘 | Song Qinghai Xiao Shumin Zhou Xinchuan | 2007 | Optics Letters2007，32，4： | 1 |
| 15 | Random Lasing in Bone Tissue显示文摘 | Song Qinghai Xiao Shumin Xu Zhengbin | 2010 | Optics Letters2010，35，9： | 1 |
| 16 | Lanthanide-doped nanocrystals in high-Q microtoroids for stable on-chip white-light lasers显示文摘The plentiful energy states of lanthanide(Ln^(3+))-doped nanomaterials make them very promising for on-chip integrated white-light lasers.Despite the rapid progresses,the Ln^(3+)-based white upconversion emissions are strongly restricted by their low upconversion quantum efficiency and the color stability.Herein,we combine the CaF_(2):Yb_(35)Tm_(1.5)Er_(0.5)nanocrystals and the high-Q microtoroids,and experimentally demonstrate the chip-integrated stable white-light laser.By optimizing the sizes,density,and distributions of Ln^(3+)-doped nanocrystals,the Q factors of Ln^(3+)-doped microtoroids are maintained as high as 5×10^(5).The strong light matter interaction in high-Q microtoroids greatly enhances the upconversion emission and dramatically reduces the laser thresholds at 652 nm,545 nm,and 475 nm to similarly low values(1.89-2.10 m J cm^(-2)).Consequently,robust white-light microlaser has been experimentally achieved from a single microtoroid.This research has paved a solid step toward the chip-scale integrated broadband microlasers. | LIMIN JIN ZHUO LIU YUQI ZHANG YUNKAI WU YILIN LIU HUACHUN DENG QINGHAI SONG SHUMIN XIAO | 2022 | Photonics Research2022，10，7： | 1 |
| 17 | A candy-like photocatalyst by wrapping Co, N-co-doped hollow carbon sphere with ultrathin mesoporous carbon nitride for boosted photocatalytic hydrogen evolution显示文摘Hierarchical carbon material is used as a star cocatalyst in the field of photocatalysis due to its excellent catalytic properties. In this work, mesoporous carbon nitride sheet(MCNS) photocatalyst introduced nitrogen-doped hollow carbon spheres assembled with cobalt nanoparticles(Co@NHC) is synthesized by electrostatic adsorption. A series of characterizations are analyzed to display the structures, morphologies and optical properties of as-prepared materials. The photocatalytic activity of Co@NHC/MCNS material is evaluated with hydrogen evolution under visible light irradiation. The results indicate that 5 wt%Co@NHC/MCNS material reveals higher photocatalytic activity of hydrogen evolution rate of 3675 μmol/g with 4 h reaction time, which is 159 times than that of pure MCNS material. The carbon material with excellent charge transport properties can effectively accelerate the charge transfer from ultrathin MCNS to cobalt nanoparticles. The goal of improving the photocatalytic performance of Co@NHC/MCNS material is achieved. As a result, it provides a feasible and promised approach for doping transition metals to enhance photocatalytic activity. | Jinyuan Liu Shumin Zhu Bin Wang Ruizhe Yang Rong Wang Xingwang Zhu Yanhua Song Junjie Yuan Hui Xu Huaming Li | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 18 | Suppressing meta-holographic artifacts by laser coherence tuning显示文摘A metasurface hologram combines fine spatial resolution and large viewing angles with a planar form factor and compact size.However,it suffers coherent artifacts originating from electromagnetic cross-talk between closely packed meta-atoms and fabrication defects of nanoscale features.Here,we introduce an efficient method to suppress all artifacts by fine-tuning the spatial coherence of illumination.Our method is implemented with a degenerate cavity laser,which allows a precise and continuous tuning of the spatial coherence over a wide range,with little variation in the emission spectrum and total power.We find the optimal degree of spatial coherence to suppress the coherent artifacts of a meta-hologram while maintaining the image sharpness.This work paves the way to compact and dynamical holographic displays free of coherent defects. | Yaniv Eliezer Geyang Qu Wenhong Yang Yujie Wang Hasan Yılmaz Shumin Xiao Qinghai Song Hui Cao | 2021 | Light(Science & Applications)2021，10，7： | 0 |
| 19 | Short-Term Wind Power Prediction Based on ICEEMDAN-SE-LSTM Neural Network Model with Classifying Seasonal显示文摘Wind power prediction is very important for the economic dispatching of power systems containing wind power.In this work,a novel short-term wind power prediction method based on improved complete ensemble empirical mode decomposition with adaptive noise(ICEEMDAN)and(long short-term memory)LSTM neural network is proposed and studied.First,the original data is prepossessed including removing outliers and filling in the gaps.Then,the random forest algorithm is used to sort the importance of each meteorological factor and determine the input climate characteristics of the forecast model.In addition,this study conducts seasonal classification of the annual data where ICEEMDAN is adopted to divide the original wind power sequence into numerous modal components according to different seasons.On this basis,sample entropy is used to calculate the complexity of each component and reconstruct them into trend components,oscillation components,and random components.Then,these three components are input into the LSTM neural network,respectively.Combined with the predicted values of the three components,the overall power prediction results are obtained.The simulation shows that ICEEMDAN-SE-LSTM achieves higher prediction accuracy ranging from 1.57%to 9.46%than other traditional models,which indicates the reliability and effectiveness of the proposed method for power prediction. | Shumin Sun Peng Yu Jiawei Xing Yan Cheng Song Yang Qian Ai | 2023 | Energy Engineering2023，120，12： | 0 |
| 20 | Temporal-spatial Generation of Astrocytes in the Developing Diencephalon显示文摘tAstrocytes are the largest glial population in the mammalian brain.However,we have a minimal understanding of astrocyte development,especially fate specification in different regions of the brain.Through lineage tracing of the progenitors of the third ventricle(3V)wall via in-utero electroporation in the embryonic mouse brain,we show the fate specification and migration pattern of astrocytes derived from radial glia along the 3V wall.Unexpectedly,radial glia located in different regions along the 3V wall of the diencephalon produce distinct cell types:radial glia in the upper region produce astrocytes and those in the lower region produce neurons in the diencephalon.With genetic fate mapping analysis,we reveal that the first population of astrocytes appears along the zona incerta in the diencephalon.Astrogenesis occurs at an early time point in the dorsal region relative to that in the ventral region of the developing diencephalon.With transcriptomic analysis of the region-specific 3V wall and lateral ventricle(LV)wall,we identified cohorts of differentially-expressed genes in the dorsal 3V wall compared to the ventral 3V wall and LV wall that may regulate astrogenesis in the dorsal diencephalon.Together,these results demonstrate that the generation of astrocytes shows a spatiotemporal pattern in the developing mouse diencephalon. | Wentong Hong Pifang Gong Xinjie Pan Zhonggan Ren Yitong Liu Guibo Qi Jun-Liszt Li Wenzhi Sun Woo-Ping Ge Chun-Li Zhang Shumin Duan Song Qin | 2024 | Neuroscience Bulletin2024，40，1： | 0 |
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