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| 1 | Variations of geochemical compositions and the paleoclimatic significance of a loess-soil sequence from Garzê County of western Sichuan Province,China显示文摘The West Sichuan Plateau is located in the southeast margin of the Tibetan Plateau, where the climate is mainly influenced by the Indian southwest summer monsoon and the Tibetan Plateau monsoon. In this study, detailed geochemical analysis has been carried out on Ganzisi loess-paleosol sequence in Ganzê County of western Sichuan Province. The results indicate that Ganzê loess and paleosol have experienced the incipient stage of chemical weathering in dust source regions, characterized by the decomposition of plagioclase which caused the depletion of mobile elements Na and Ca. The post-depositional chemical weathering is characterized by carbonate dissolution and oxidation of Fe2+. The variations of some geochemical indexes (such as CIA values, Na/K and Fe2+/ Fe3+ ratios) in Ganzisi loess-paleosol sequence indicate a gradually decreased chemical weathering intensity in the dust source regions and deposition areas since 1.15 Ma BP consistent with the general increase of global ice volume, reflecting that the arid trend since 1.15 Ma BP in the southeast Tibetan Plateau is a regional response to the global climate change. The geochemical indexes in this section also reveal an obvious drying step occurred at about 250 ka BP in this region. We interpret this drying step as a result of decreased influence of the Indian southwest summer monsoon. This decrease in monsoon moisture is probably attributable to the uplift of the southeast margin of the Tibetan Plateau at about 250 ka BP. | QIAO YanSong ZHAO ZhiZhong WANG Yan FU JianLi WANG ShuBing JIANG FuChu | 2009 | Chinese Science Bulletin2009，54，24： | 13 |
| 2 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 3 | Magnetostratigraphic and paleoclimatic studies on the Red Earth Formation from the Chengdu Plain in Sichuan Province,China显示文摘Two red earth sections from the Chengdu Plain in Sichuan Province are dated using geomagnetic methods. The Brunhes/Matuyama (B/M) reversal boundary is recognized within the upper parts of the two sections,and the Jaramillo normal subzone occurs in the middle-lower parts of the vermiculated red soil (VRS),which indicate that the parent material for the VRS deposited in the middle Quaternary. Sedimentologic and geochemical studies suggest that the Chengdu Clay and part of the parent material for the VRS are of aeolian origin. Pollen analysis indicates that the Chengdu Plain was mainly covered by needle-leaved forest with a cool to cool temperate humid climate when the parent material for the VRS deposited. The relatively cool to cool temperate climatic condition in the Chengdu Plain in the middle Quaternary,which may be caused by the uplift of the Tibetan Plateau,was a response to the geo-environmental changes of global significance. | ZHAO ZhiZhong QIAO YanSong WANG Yan FU JianLi WANG ShuBing LI ChaoZhu YAO HaiTao JIANG FuChu | 2007 | Science China Earth Sciences2007，50，6： | 7 |
| 4 | Breeding and molecular cytogenetic identification of wheat-Thinopyrum intermedium addition lines resistant to powdery mildew显示文摘Wheat-related species Th. intermedium was used to cross with common wheat Yannong 15. In the self progenies of the hybrid, two addition lines, II -1-7-1 and II -3-3-2, stable in cytology, were developed by cytology and powdery mildew resistance identification. Their chromosome number were 2n = 44 and formed 22 bivalents at PMC MI. In F1 of the two addition lines crossing with Yannong 15, there appeared about one univalent at PMC MI, respectively. Resistance identification in greenhouse and field using the No. 15 and mixed strains of E. gramnis f. sp. tritici showed that they were immune to powdery mildew. Chromosome number and resistance identification using the F2 single plants of the addition line crossing with Yannong 15 indicated that the resistant gene was located on the alien chromosomes. In situ hybridization using St and E genomic DNA as probe showed that the added chromosome in the two addition lines probably came from the E genome of Th. intermedium, which indicated that a pair of E genome | Shubing Liu Honggang Wang | 2002 | Chinese Science Bulletin2002，47，22： | 7 |
| 5 | Characteristics of the phytoplankton community and bioaccumulation of heavy metals during algal blooms in Xiangjiang River (Hunan,China)显示文摘The frequency of algal blooms has increased in the mid and downstream reaches of the Xiangjiang River (Hunan,China),one of the most heavily polluted rivers in China.We identified the bloom-forming species in a bloom that occurred mid-late September 2010.In addition,we determined the extent of metal bioaccumulation in the algae and measured the toxicity of the algae using a mouse bioassay.Water samples were collected at upstream (Yongzhou),midstream (Hengyang),and downstream (Zhuzhou,Xiangtan,and Changsha) sites.The dominant species was Aulacoseira granulata,formerly known as Melosira granulata.The heaviest bloom occurred at Xiangtan and Changsha,where the number of A.granulata peaked at 1.3×10 5 filaments L 1 and chlorophyll a at 0.04 mg L 1.Concentrations of Al,Fe,and Mn were 4.4 10 3,768.4,and 138.7 mg kg 1 dry weight in the phytoplankton.The bioaccumulation factor was 4.0×10 5,7.7×10 5,and 3.2×10 3,respectively.The heavy metal Pb had the greatest tendency to bioaccumulate among the highly toxic heavy metals,with a concentration of 19.2 mg kg 1 dry weight and bioaccumulation factor of 9.6×10 3.The mouse bioassay suggested the bloom was toxic.The LD 50 was 384 mg kg 1 and all surviving mice lost weight during the first 72 h after exposure.Our results demonstrate that blooms of A.granulata in rivers contaminated with heavy metals pose a threat to freshwater ecosystems and human health.Thus,measures should be taken to control eutrophication and heavy metal pollution in such rivers. | LI Jie PENG FuLi DING DongBo ZHANG ShuBing LI DeLiang ZHANG Ting | 2011 | Science China(Life Sciences)2011，54，10： | 6 |
| 6 | Geochemical Characteristics of Eolian Deposits in the Chengdu Plain of Sichuan Province and the Implications for Provenance显示文摘In this study Chengdu Red Earth(CRE)from the Chengdu Plain(CP),Sichuan province,was analyzed for its elemental(major and trace elements)and isotopic(Sm-Nd)geochemistry and compared with Pleistocene loess and paleosol samples from the Chinese Loess Plateau(CLP)in Northern China.The geochemical composition of CRE is similar to north China loess,and also resembles the average UCC.This indicates that CRE,as loess deposits in Northern China,was derived from well-mixed sedimentary protoliths that have undergone numerous upper crustal recycling processes.However,obvious differences in the geochemical characteristics of CRE and the north China loess are also revealed in our results.For chemically stable elements,CRE has higher Ti,Zr,Hf and lowerΣREE,Ba contents in comparison with loess samples from the CLP.Further analysis shows that CRE has higher TiO2/Al2O3,SiO2/Al2O3,Ba/Rb and lower Ce/Yb,Eu/Yb,LaN/YbN andΣLREE/ΣHREE ratios.In Sm-Nd isotopic geochemistry,Sm and Nd content and theεNd(0)value in CRE are significantly higher than those in north China loess.The higher TiO2content in CRE coincided with a high background concentration of Ti in the Sichuan Basin and the surrounding regions.The lowerΣREE and higher Sm,Nd,εNd(0)values are related to the wide distribution of basalt in the southwest Sichuan Basin.The elemental and isotopic geochemistry of CRE indicates that eolian materials in the CP predominantly come from the Sichuan Basin and the surrounding regions,which differs from loess deposits in the CLP. | TAN Yuanlong QIAO Yansong ZHAO Zhizhong WANG Yan QI Lin FU Jianli LIU Zongxiu YAO Haitao WANG Shubing JIANG Fuchu | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 3 |
| 7 | Late Cenozoic Sedimentary Evolution of Pagri-Duoqing Co graben, Southern End of Yadong-Gulu Rift, Southern Tibet显示文摘The north trending rifts in southern Tibet represent the E-W extension of the plateau and confirming the initial rifting age is key to the study of mechanics of these rifts. Pagri-Duoqing Co graben is located at southern end of Yadong-Gulu rift, where the late Cenozoic sediments is predominately composed of fluvio-lacustrine and moraine. Based on the sedimentary composition and structures, the fluviolacustrine could be divided into three facies, namely, lacustrine, lacustrine fan delta and alluvial fan. The presence of paleo-currents and conglomerate components and the provenance of the strata around the graben indicate that it was Tethys Himalaya and High Himalaya. Electron spin resonance(ESR) dating and paleo-magnetic dating suggest that the age of the strata ranges from ca. 1.2 Ma to ca. 8 Ma. Optically stimulated luminescence(OSL) dating showed that moraine in the graben mainly developed from around181-109 ka(late Middle Pleistocene). Combining previous data about the Late Cenozoic strata in other basins, it is suggested that 8-15 Ma may be the initial rifting time. Together with sediment distribution and drainage system, the sedimentary evolution of Pagri could be divided into four stages. The graben rifted at around 15-8 Ma due to the eastern graben-boundary fault resulting in the appearance of a paleolake.Following by a geologically quiet period about 8-2.5 Ma, the paleolake expanded from east to west at around 8-6 Ma reaching its maximum at ca. 6 Ma. Then, the graben was broken at about 2.5 Ma. At last,the development of the glacier separated the graben into two parts that were Pagri and Duoqing Co since the later stages of the Middle Pleistocene. The evolution process suggested that the former three stages were related to the tectonic movement, which determined the basement of the graben, while the last stage may have been influenced by glacial activity caused by climate change. | HA Guanghao WU Zhonghai HE Lin WANG Shubing | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 3 |
| 8 | Initial Rifting Age of the Nearly N–S Rifts in Southern Tibetan Plateau:New Evidence from the Age limit of the Early Sediments显示文摘Objective The nearly parallel N–S-trending rifts in southern Tibet represent the E–W extension of the Tibet Plateau.Most data which constrained the age of the extensional deformation come from isotopic dating of the dikes probably related to the activity of the nearly N–S faulting and micas from hydrothermal activity and the lowtemperature thermochronology of plateau uplift. | HA Guanghao WU Zhonghai HE Lin WANG Shubing | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 2 |
| 9 | Comparison of Mastoscopic and Conventional Axillary Lymph Node Dissection in Breast Cancer: Long-term Results From a Randomized, Multicenter Trial显示文摘 | Chengyu Luo Wenbin Guo Jie Yang Qiuru Sun Wei Wei Suhua Wu Shubing Fang Qingliang Zeng Zhensheng Zhao Fanjie Meng Xuandong Huang Xianlan Zhang Ruihua Li Xiufeng Ma Chaoying Luo Yun Yang | 2012 | Mayo Clinic Proceedings2012，，12： | 1 |
| 10 | Quantitative trait loci for resistance to pre-harvest sprouting in US hard white winter wheat Rio Blanco显示文摘 | Liu Shubing Cai Shibin Robert Graybosch | 2008 | Theor Appl Genet2008，117，5： | 1 |
| 11 | Antioxidant activity of brown pigment and extracts from black sesame seed (Sesamum indicum L) 显示文摘 | Juan Xu Shubing Chen Qiuhui Hu | 2005 | Food Chemistry2005，91，1： | 1 |
| 12 | Experimentalstudy of ultrasound-modulated scattering light using differentfrequencies ultrasound probes 显示文摘 | ZHU Lili RAN Shubing LI Zhifang | 2012 | Proc SPIE2012，8553，85： | 1 |
| 13 | luminescence of RE^2+ (RE=Sm, Yb) in barium octoborate 显示文摘 | Qinghua Zeng Zhiwu Pei Shubing Wang | 1999 | Materials Research Bulletin1999，34，1213： | 1 |
| 14 | Discovery of the anti-influenza A virus activity of SB216763 and cyclosporine A by mining infected cells and compound cellular signatures显示文摘In this study,SB216763 and cyclosporine A were identified as anti-influenza A virus(IAV)agents by tran-scriptome signature reversion(TSR)analysis through deep mining of the cellular transcriptome of hu-man airway and lung cell lines infected with 3 strains of IAV and the chemical perturbations library.A synergistic effect of SB216763 and cyclosporine A against influenza A was disclosed by quantification of the network-based relationship,which was validated in vitro.Along with burgeoning omics approaches,transcriptome-based drug development is flourishing,which provides a novel insight into antivirals dis-covery with comprehensive cellular transcriptional information of disease and chemical perturbations in multicomponent intervention.This strategy can be applied as a new approach in discovering multitar-get antiviral agents from approved drugs,clinical compounds,natural products or other known bioactive compounds. | Ke Tang You Wu Shubing Chen Yijing Xin Ying Guo | 2022 | Chinese Chemical Letters2022，33，5： | 1 |
| 15 | Simplified pesticide multiresidues analysis in fish by low-temperature cleanup and solidphase extraction coupled with gas hromatography/mass spectrometry显示文摘 | CHEN Shubing YU Xuejua HE Xiaoyu | 2009 | Food Chemistry2009，113，： | 1 |
| 16 | Valence Change and Luminescence of Divalent Samarium in Strontium Borates显示文摘The valence change of samarium from trivalent to divalent state in strontium borates (SrB6O10)prepared in air was observed. The high resolution spectra of Sm2+ in matrix were studied between 10 K and 300 K. The results showed that three crystallographic sites for Sm2+ were available in the host. Energy transfer among these sites was possible. The vibronic transition of 5D0-7F0 of Sm2+ was studied at room temperature and the Huang-Rhys factor S was calculated. Due to the thermal population, 5D1 -7F0 transition at room temperature was | Qinghua ZENG Zhiwu PEI Shubing WANG and Qiang SU(Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China) To whom correspondence should be addressedE-mail: zengqh@ns. | 1999 | Journal of Materials Science & Technology1999，15，5： | 1 |
| 17 | Formation of the Yellow River, inferred from loess-palaeosol sequence in Mangshan and lacustrine sediments in Sanmen Gorge, China 显示文摘 | Jiang Fuchu Fu Jianli Wang Shubing | 2007 | Quaternary International2007，175，： | 1 |
| 18 | Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells显示文摘 | Hua Jiang ChunHui Hou ShuBing Zhang HengYue Xie WeiYing Zhou QiHuang Jin XiaoDong Cheng RuoLan Qian XueJun Zhang | 2007 | European Journal of Pharmacology2007，，2： | 1 |
| 19 | Virus-like particle vaccine by intranasal vaccination elicits protective immunity against respiratory syncytial viral infection in mice显示文摘呼吸 syncytial 病毒(RSV ) 是在婴儿和孩子的更低的呼吸感染的一个领先的原因,但是仍然没有可得到的准许的疫苗。在这份报告,我们基于 Bac-to-Bac baculovirus 表达式系统开发了像病毒的粒子(VLP ) 疫苗,由一个流行性感冒病毒矩阵(M1 ) 组成蛋白质和 RSV 熔化蛋白质(F) 或 glycoprotein (G) 。这些 RSV VLP 被西方的污点分析和电子显微镜学识别。有 RSV-F VLP, RSV-G VLP,或两个的 intranasally 使免疫的女 BALB/c 老鼠(i.n ) 对 RSV 显示出病毒特定的抗体回答。全部的 IgG, IgG1, IgG2a,和 mucosal IgA 与 RSV-F 正 RSV-G VLP 在老鼠被检测,揭示细胞的有势力和 mucosal 免疫者回答。而且,我们发现这些混合 RSV VLP 对实时 RSV 挑战授与提高的保护,在病毒的复制和组织病理学说的变化的明显的变细与病毒的感染联系了的肺的出现重要减少。这些结果证明由 intranasal 种痘的 RSV-F 正 RSV-G VLP 是保证使用棉花老鼠和首领模型的进一步的评估的一个有希望的疫苗的候选人。 | Mengying Cai Cheng Wang Yufeng Li Hongjing Gu Sujing Sun Yueqiang Duan Chengcai Lai Keyu Wang Xiaolan Yang Li Xing Peirui Zhang Zhaohai Wang Shaogeng Zhang Xiaodong Guo Shubing Liu Yigang Tong Xiliang Wang Penghui Yang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 1 |
| 20 | Luminescence of RE2+ (RE=Sm, Yb) in barium Octaborate 显示文摘 | Zeng Qinghua Pei Zhiwu Wang Shubing | 1999 | Materials Research Bulletin1999，34，1213： | 1 |
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