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| 1 | Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis显示文摘 | Yan Li Qiupeng Zheng Chunyang Bao Shuyi Li Weijie Guo Jiang Zhao Di Chen Jianren Gu Xianghuo He Shenglin Huang | 2015 | Cell Research2015，25，8： | 323 |
| 2 | Correlation analysis between vegetation coverage and climate drought conditions in North China during 2001–2013显示文摘Climate change is one of the most important factors that affect vegetation distribution in North China. Among all climatic factors, drought is considered to have the most significant effect on the environment. Based on previous studies, the climate drought index can be used to assess the evolutionary trend of the ecological environment under various arid climatic conditions. It is necessary for us to further explore the relationship between vegetation coverage(index) and climate drought conditions. Therefore, in this study, based on MODIS-NDVI products and meteorological observation data, the Palmer Drought Severity Index(PDSI) and vegetation coverage in North China were first calculated. Then, the interannual variations of PDSI and vegetation coverage during 2001–2013 were analyzed using a Theil-Sen slope estimator. Finally, an ecoregion perspective of the correlation between them was discussed. The experimental results demonstrated that the PDSI index and vegetation coverage value varied over different ecoregions. During the period 2001–2013, vegetation coverage increased in the southern and northern mountains of North China, while it showed a decreasing trend in the Beijing-Tianjin-Tangshan City Circle area and suburban agricultural zone located in Hebei Province and Henan Province). Over 13 years, the climate of the northeastern part of North China became more humid, while in the southern part of North China, it tended to be dry. According to the correlation analysis results, 73.37% of North China showed a positive correlation between the vegetation coverage and climate drought index. A negative correlation was observed mainly in urban and suburban areas of Beijing, Tianjin, Hebei Province, and Henan Province. In most parts of North China, drought conditions in summer and autumn had a strong influence on vegetation coverage. | GONG Zhaoning ZHAO Shuyi GU Jinzhi | 2017 | Journal of Geographical Sciences2017，27，2： | 38 |
| 3 | Sedimentary hydrodynamic study of sand bodies in the upper subsection of the 4th Member of the Paleogene Shahejie Formation in the eastern Dongying Depression, China显示文摘Petroleum is produced from a beach-bar sand reservoir in the upper subsection of the 4th member of the Paleogene Shahejie Formation(Es4s) in the eastern Dongying Depression, penetrated by many wells in the Guangli-Qingnan area and this subsection still has further exploration potential. Using drilling and logging data, we analyzed the sand body types, emphasizing the sedimentary characteristics of the beach-bar sand bodies. Combining these data with the concepts of lacustrine and oceanic hydrodynamics, we explain the formation and distribution of the beach-bar sands in the eastern Dongying Depression. The connectivity between beach-bar sand bodies within each individual hydrodynamic zone is better than that between sand bodies in any two adjacent zones. The tempestite sand bodies developed in this area are characterized by typical storm deposits and are located at the bottoms of the beachbar sand bodies. They grade upward to normal shore and shallow-lacustrine beaches and bars. We also propose a new simple method to estimate the paleo-water depth using the thicknesses of the bar sand bodies in parasequences combined with the principle of hydrodynamic zonation. Based on the distribution of the beach-bar sands in parasequence set 3, we infer that the paleo-wind direction was from the north with an average paleo-wind force of 6 when the major beach-bar sand bodies formed. | Jiang Zaixing Liang Shuyi Zhang Yuanfu Zhang Shanwen Qin Lanzhi Wei Xiaojie | 2014 | Petroleum Science2014，11，2： | 16 |
| 4 | Effect of substrate COD/N ratio on performance and microbial community structure of a membrane aerated biofilm reactor显示文摘Two parallel carbon-membrane aerated biofilm reactors were operated at well-defined conditions to investigate the effect of substrate COD/N ratios on the performance and microbial community structure of the bioreactor.Results showed that at substrate COD/N of 5,organic and nitrogen could be eliminated simultaneously,and COD removal degree,nitrification and denitrification efficiency reached 85%,93% and 92%,respectively.With increasing substrate COD/N ratios,the specific oxygen utilization rates of nitrifying bacteria in biofilm were found to decrease,indicating that nitrifying population became less dominant.At substrate COD/N ratio of 6,excessive heterotrophs inhibited the activity of nitrifying bacteria greatly and thus led to poor nitrification process.With the help of fluorescence in situ hybridization(FISH),Nitrosomonas and Nitrosospira were identified as dominant ammonia-oxidizing bacteria in the biofilm at substrate COD/N of 0,whereas only Nitrosospira were detected in the biofilm at COD/N ratio of 5.Nitrospira were present as dominant nitrite-oxidizing bacteria in our study.Confocal laser scanning microscopy images revealed that at substrate COD/N ratio of 0 nitrifying bacteria existed throughout the biofilm and that at COD/N ratio of 5 they were mainly distributed in the inner layer of biofilm. | Huijun Liu Fenglin Yang Shuyi Shi Xincheng Liu | 2010 | Journal of Environmental Sciences2010，22，4： | 9 |
| 5 | ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy显示文摘Ample clinical evidence suggests a high incidence of cardiovascular events in Alzheimer’s disease(AD),although neither precise etiology nor effective treatment is available.This study was designed to evaluate cardiac function in AD patients and APP/PS1 mutant mice,along with circulating levels of melatonin,mitochondrial aldehyde dehydrogenase(ALDH2)and autophagy.AD patients and APP/PS1 mice displayed cognitive and myocardial deficits,low levels of circulating melatonin,ALDH2 activity,and autophagy,ultrastructural,geometric(cardiac atrophy and interstitial fibrosis)and functional(reduced fractional shortening and cardiomyocyte contraction)anomalies,mitochondrial injury,cytosolic mtDNA buildup,apoptosis,and suppressed autophagy and mitophagy.APP/PS1 mutation downregulated cyclic GMP-AMP synthase(cGAS)and stimulator of interferon genes(STING)levels and TBK1 phosphorylation,while promoting Aβaccumulation.Treatment with melatonin overtly ameliorated unfavorable APP/PS1-induced changes in cardiac geometry and function,apoptosis,mitochondrial integrity,cytosolic mtDNA accumulation(using both immunocytochemistry and qPCR),mitophagy,and cGAS-STING-TBK1 signaling,although these benefits were absent in APP/PS1/ALDH2−/−mice.In vitro evidence indicated that melatonin attenuated APP/PS1-induced suppression of mitophagy and cardiomyocyte function,and the effect was negated by the nonselective melatonin receptor blocker luzindole,inhibitors or RNA interference of cGAS,STING,TBK1,and autophagy.Our data collectively established a correlation among cardiac dysfunction,low levels of melatonin,ALDH2 activity,and autophagy in AD patients,with compelling support in APP/PS1 mice,in which melatonin rescued myopathic changes by promoting cGAS-STING-TBK1 signaling and mitophagy via an ALDH2-dependent mechanism. | Shuyi Wang Lin Wang Xing Qin Subat Turdi Dongdong Sun Bruce Culver Russel JReiter Xiaoming Wang Hao Zhou Jun Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 6 | Mucinous colorectal adenocarcinoma:clinical pathology and treatment options显示文摘Mucinous colorectal adenocarcinoma is a distinct subtype of colorectal cancer(CRC)characterized by the pres-ence of abundant extracellular mucin which accounts for at least 50%of the tumor volume.Mucinous colorectal adenocarcinoma is found in 10%-20%of CRC patients and occurs more commonly in female and younger patients.Moreover,mucinous colorectal adenocarcinoma is more frequently located in the proximal colon and diagnosed at an advanced stage.Based on its molecular context,mucinous colorectal adenocarcinoma is associated with the over-expression of mucin 2(MUC2)and mucin 5AC(MUC5AC)proteins.At the same time,it shows higher mutation rates in the fundamental genes of the RAS/MAPK and PI3K/Akt/mTOR pathways.Mucinous colorectal adenocarcinoma also shows higher rates of microsatellite instability(MSI)than non-mucinous colorectal adenocarcinoma which might correlate it with Lynch syndrome and the CpG island methylator phenotype.The prognosis of mucinous colorectal adenocarcinoma as to non-mucinous colorectal adenocarcinoma is debatable.Further,the impaired responses of mucinous colorectal adenocarcinoma to palliative or adjuvant chemotherapy warrant more studies to be performed for a specialized treatment for these patients.In this review,we discuss the molecular background and histopathol-ogy of mucinous colorectal adenocarcinoma,and provide an update on its prognosis and therapeutics from recent literatures. | Cong Luo Shuyi Cen Guojun Ding Wei Wu | 2019 | Cancer Communications2019，39，1： | 8 |
| 7 | Facile growth of homogeneous Ni(OH)2 coating on carbon nanosheets for high-performance asymmetric supercapacitor applications显示文摘 | Mingjiang Xie Zhicheng Xu Shuyi Duan Zhengfang Tian Yu Zhang Kun xiang Ming Lin Xuefeng Guo Weiping Ding | 2018 | Nano Research2018，11，1： | 8 |
| 8 | Synthesis of ordered mesoporous carbonaceous materials and their highly efficient capture of uranium from solutions显示文摘An extremely effortless method was applied for successful synthesis of mesoporous carbonaceous materials(MCMs) using well-ordered mesoporous silica as template. Various characterizations(scanning electron microscopy(SEM), transmission electron microscopy(TEM), X-ray diffraction(XRD), Fourier transform infrared spectroscopy(FT-IR), Raman, X-ray photoelectron spectroscopy(XPS), Brunner-Emmet-Teller(BET) and Zeta potential) confirmed that MCMs had large surface area, uniform pore size distribution, and abundant oxygen-containing functional groups. The batch techniques were employed to study U(VI) adsorption on MCMs under a wide range of experiment conditions. The adsorption kinetics of U(VI) onto MCMs were well-fitted by pseudo-second-order kinetic model, indicating a chemisorption process. The excellent adsorption capacity of MCMs calculated from the Langmuir model was 293.95 mg g^(-1) at pH 4.0. The FT-IR and XPS analyses further evidenced that the binding of U(VI) onto MCMs was ascribed to the plentiful adsorption sites(–OH and –COOH groups) in the internal mesoporous structure, which could efficiently trap guest U(VI) ions. The results presented herein revealed that MCMs were ideal adsorbents in the efficient elimination of uranium or other lanthanides/actinides from aqueous solutions, which would play an important role in environmental pollution management application. | Chenlu Zhang Xing Li Zhongshan Chen Tao Wen Shuyi Huang Tasawar Hayat Ahmed Alsaedi Xiangke Wang | 2018 | Science China Chemistry2018，61，3： | 8 |
| 9 | ZrC-ZrB_2-SiC ceramic nanocomposites derived from a novel single-source precursor with high ceramic yield显示文摘For the first time, ZrC-ZrB_2-SiC ceramic nanocomposites were successfully prepared by a single-source-precursor route, with allylhydridopolycarbosilane(AHPCS),triethylamine borane(TEAB),and bis(cyclopentadienyl) zirconium dichloride(Cp_2 ZrCl_2) as starting materials. The polymer-to-ceramic transformation and thermal behavior of obtained single-source precursor were characterized by means of Fourier transform infrared spectroscopy(FT-IR) and thermal gravimetric analysis(TGA). The results show that the precursor possesses a high ceramic yield about 85% at 1000 ℃.The phase composition and microstructure of formed ZrC-ZrB_2-SiC ceramics were investigated by means of X-ray diffraction(XRD) and high resolution transmission electron microscopy(HRTEM).Meanwhile, the weight loss and chemical composition of the resultant ZrC-ZrB_2-SiC nanocomposites were investigated after annealing at high temperature up to 1800 ℃. High temperature behavior with respect to decomposition as well as crystallization shows a promising high temperature stability of the formed ZrC-ZrB_2-SiC nanocomposites. | Zhaoju YU Xuan LV Shuyi LAI Le YANG Wenjing LEI Xingang LUAN Ralf RIEDEL | 2019 | Journal of Advanced Ceramics2019，8，1： | 8 |
| 10 | Variations in carbon isotopic composition in the subcontinental lithospheric mantle beneath the Yangtze and North China Cratons:Evidence from in-situ analysis of diamonds using SIMS显示文摘The components and evolution of subcontinental lithospheric mantle beneath the North China Craton and the Yangtze Craton is a current topic in the geological study of China and the carbon isotopic composition of diamond is one of the most direct probes into cratonic lithospheric mantle processes.In this paper,in-situ SIMS(Secondary Ion Mass Spectrometry) techniques were used to analyze the carbon isotope compositions at different internal growth zones of diamonds from Shandong and Liaoning in the North China Craton and Hunan in the Yangtze Craton.It was found that the carbon isotopic range of diamonds from the North China Craton are rather distinct from those of the Yangtze Craton;the former has a range of 6.0‰ to 2.0‰(relative to VPDB) with an average value of 3.0‰ in their core areas,which is consistent with global peridotitic diamonds;the diamonds from the Yangtze Craton,however,have a carbon isotopic range from 8.6‰ to 3.0‰ with an average value of 7.4‰ in their core areas,being more consistent with global eclogitic diamonds.The variations of carbon isotope ratios between different internal growth zones in individual diamonds were different in the three diamond localities studied.There was a clear correlation between changes in carbon isotopic composition and phases of diamond dissolution and new growth,while no correlation was observed between δ13C and internal inclusions.The variations suggest that the carbon isotopic compositions of mantle fluids were changing during the process of diamond crystallization,and that the heterogeneity of the carbon isotopic composition in mantle carbon reservoirs was a more important factor than carbon isotope fractionation in controlling the carbon isotopic compositions and their variation in diamonds.In addition,the preliminary results of in-situ nitrogen analyses demonstrated that the variation of carbon isotopic compositions between the core and outer growth zones does not correlate with nitrogen abundances,implying either that diamonds crystallized in an open environment or that the carbon isotopic composition and nitrogen contents in mantle fluids were controlled by other,not yet understood factors.The experimental results provide hints that the isotopic composition of carbon and its original sources were different in metasomatic fluids controlling diamond formation in the mantle beneath the North China Craton and the Yangtze Craton. | CHEN Hua QIU ZhiLi LU TaiJin STERN Richard STACHEL Thomas SUN Yuan ZHANG Jian KE Jie PENG ShuYi QIN SheCai | 2013 | Chinese Science Bulletin2013，58，1： | 7 |
| 11 | Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells显示文摘各种各样的干细胞类型在对待光敏电阻器为他们的潜在的申请被测试了退化疾病,例如视网膜炎 pigmentosa (RP ) 和年龄相关的有斑点的退化(AMD ) 。仅仅胚胎的干细胞(转换字符) 到目前为止被显示了产生恢复光敏电阻器缺乏的老鼠的轻反应的功能的光敏电阻器房间,但是仍然有肿瘤形成的一些担心。在这研究,我们有成功地有教养的 Nestin + Sox2 + Pax6 + multipotent 从成年老鼠视网膜的网膜的干细胞(RSC ) ,它能够生产恢复跟随移植的光敏电阻器缺乏的 rd1 异种老鼠的轻反应的功能的光敏电阻器房间。在他们面对 FGF 和 EGF 为超过 35 个段落被扩展了以后,有教养的 RSC 仍然维持稳定的增长和区别潜力。在合适的区别条件下面,他们能区分进在成年视网膜发现的所有主要网膜的房间类型。更重要地,他们能高效地在优化区别条件下面区分进光敏电阻器房间。直到慢慢地堕落的 rd7 异种的 subretinal 空间的后面的移植看,导出 RSC 的光敏电阻器房间与居民一起集成到视网膜,词法上类似于的内长的光敏电阻器和形成的 synapases 网膜的神经原。当移植了进光敏电阻器缺乏的 rd1 异种老鼠的眼睛时,一个 RP 模型,导出 RSC 的光敏电阻器能部分恢复轻反应,显示那些导出 RSC 的光敏电阻器是功能的。最后,为在移植光敏电阻器的眼睛的肿瘤形成没有证据。因此,这研究证明了从成年视网膜孤立的 RSC 有生产能潜在地恢复光敏电阻器房间的损失在 RP 和 AMD 引起的失去的视觉的功能的光敏电阻器房间的潜力。 | Tianqing Li Michelle Lewallen Shuyi Chen Wei Yu Nian Zhang Ting Xie | 2013 | Cell Research2013，23，6： | 7 |
| 12 | Energy-saving PPM schemes for WSNs显示文摘Energy conservation is a critical problem in recently-emerging wireless sensor networks (WSNs). Pulse position modulation (PPM), as an exploring-worthy modulation format for energy efficiency, is tailored for WSNs into two schemes, mono-mode PPM and multi-mode PPM, in this paper. Resorting to an idealized system model and a practical system model, which combine the power consumptions in transmission and reception modules of nodes with the idealized and realistic battery characteristics, the battery energy efficiencies of mono-mode PPM and multi-mode PPM are evaluated and compared. To minimize the battery energy consumption (BEC), these schemes are further optimized in terms of constellation size M for a link in path-loss channels. Our analytical and numerical results show that considerable energy can be saved by multi-mode PPM; and the optimization performances of these schemes are noticeable at various communication distances though their optimization properties are different. | TANG QiuLing YANG LiuQing QIN TuanFa ZHANG ShuYi | 2008 | Science in China(Series F)2008，51，5： | 7 |
| 13 | Radial acceleration estimation within one pulse echo based on Hough-ambiguity transformation显示文摘The information of acceleration of a highly maneuverable target can be helpful to enhancing the performance of the tracker and facilitating the classification of targets.However,the current radars cannot provide information on the acceleration of the target in signal processing.Conventionally,acceleration is estimated by using Kalman filtering in several pulse echoes.There are limitations and shortcomings in this method because of its low precision.This paper proposes a Hough-ambiguity transformation(HAT) method for estimating the acceleration within one pulse.Simulations results validate the effectiveness of the proposed algorithm under several conditions with different pulse durations,signal to noise ratios(SNR),searching steps and searching radii respectively.Simulation results also show that the performance of the proposed method is superior to that of other methods. | WANG GuoHong JIA ShuYi DU WenChao | 2010 | Science China(Information Sciences)2010，53，9： | 7 |
| 14 | Effect of Ti-V-Nb-Mo addition on microstructure of high chromium cast iron显示文摘The effects of trace additions of multi-alloying elements(Ti,Nb,V,Mo)on carbides precipitation and as- cast microstructure of eutectic high chromium cast iron containing 2.85wt.%C and 31.0wt.%Cr were investigated from thermodynamic and kinetic considerations.The thermodynamic calculations show that Ti and Nb exist in the multi-alloying system in the forms of TiC and NbC.The formation of VC during the solidification is not feasible from the thermodynamic consideration.XRD analysis shows that the V exists in alloy compounds(VCr2C2,VCrFe8).The first precipitated high melting point particles(TiC,NbC)can act as the heterogeneous substrate of M7C3 carbides, which results in significant refinement of the M7C3 carbides.After the addition of alloying elements,C atom diffusion is hindered due to the strong affinities of the strong carbide forming elements for carbon,which decreases the growth rate of carbides.The combined roles of the increase of nucleation rate and the decrease of carbides growth rate lead to the finer microstructure. | Ma Youping Li Xiulan Liu Yugao Zhou Shuyi Dang Xiaoming | 2012 | China Foundry2012，9，2： | 6 |
| 15 | FGF1^(△HBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression显示文摘As a classically known mitogen,fibroblast growth factor 1(FGF1)has been found to exert other pleiotropic functions such as metabolic regulation and myocardial protection.Here,we show that serum levels of FGF1 were decreased and positively correlated with fraction shortening in diabetic cardiomyopathy(DCM)patients,indicating that FGF1 is a potential therapeutic target for DCM.We found that treatment with a FGF1 variant(FGF1^(△HBS))with reduced proliferative potency prevented diabetes-induced cardiac injury and remodeling and restored cardiac function.RNA-Seq results obtained from the cardiac tissues of db/db mice showed significant increase in the expression levels of anti-oxidative genes and decrease of Nur77 by FGF1AHBS treatment.Both in vivo and in vitro studies indicate that FGF1^(△HBS) exerted these beneficial effects by markedly reducing mitochondrial fragmentation,reactive oxygen species(ROS)generation and cytochrome c leakage and enhancing mitochondrial respiration rate and β-oxidation in a 5;AMP-activated protein kinase(AMPK)/Nur77-dependent manner,all of which were not observed in the AMPK null mice.The favorable metabolic activity and reduced proliferative properties of FGF1^(△HBS) testify to its promising potential for use in the treatment of DCM and other metabolic disorders. | Dezhong Wang Yuan Yin Shuyi Wang Tianyang Zhao Fanghua Gong Yushuo Zhao Beibei Wang Yuli Huang Zizhao Cheng Guanghui Zhu Zengshou Wang Yang Wang Jun Ren Guang Liang Xiaokun Li Zhifeng Huang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 6 |
| 16 | Fouling community characteristics in subtropical coastal waters of the southwestern East China Sea显示文摘A fouling study was conducted in coastal waters southwest of the East China Sea between December 2013 and November 2014. A total of 84 species of fouling organisms belonging to 69 genera, 49 families, and 10 phyla were recorded over the entire year. The community composition was dominated by coastal warm-water species belonging to typical subtropical inner bay communities. The prosperous stage of settlement lasted from April to September, and the adhesion strength of the fouling organisms was the highest in summer. Sessile suspension feeders constituted the main core of settlement for the fouling community. Amphibalanus reticulatus was the most dominant and representative species of fouling organism, and other dominant species included Caprella equilibra, Ectopleura crocea, Anthopleura nigrescens, Stylochus ijimai, Spirobranchus kraussii, Crassostrea angulata, Perna viridis, Jassa falcata, Stenothoe valida, Sphaerozius nitidus, and Biflustra grandicella. The individuals in the fouling community showed a mutual dependence or constraint relationship due to competition for settlement space and food, and they exhibited a particular spatiotemporal distribution in accordance with adaptation to environmental factors. Temperature was the most important environmental factor determining the geographic distribution of fouling organisms. The temperature characteristics of species essentially reflect the differences in the fouling community composition in various climate zones. The species number, settlement stage, and settlement rate of fouling organisms are closely related to water temperature. Local natural environmental conditions(salinity, water currents, light, etc.) as well as human activity(such as aquaculture production) are all important factors affecting the settlement of fouling organisms. | LIN Heshan WANG Jianjun LIU Wei LIU Kun ZHANG Shuyi HE Xuebao HUANG Yaqin LIN Junhui MOU Jianfeng ZHENG Chengxing YAN Tao | 2017 | Acta Oceanologica Sinica2017，36，10： | 6 |
| 17 | Basin Fluid Mineralization during Multistage Evolution of the Lanping Sedimentary Basin,Southwestern China显示文摘Lanping 沉积的盆后来经历了五阶段的进化晚古生代:海洋大陆转变(对晚古生代早中间 -- 三叠纪) ;intracontinental 裂缝盆(晚中间 -- 对早侏罗记三叠纪) ;下面弄歪的盆(到迟了的侏罗记的中间) ;低岬盆(白垩纪) ;并且罢工滑倒盆(新生代) 。Ag-Cu polymetallic 矿石存款的三种主要基因类型,包括重做热水沉积,沉积热水地重做并且热水的静脉类型,被认为是在特定的沉积构造的进化阶段的盆液体活动的产品。不同进化阶段的构造差别在形成交通,移植方向和盆液体的炮兵阵地进程的机制导致了可观的差异,因此在矿化作用式样以及在矿石沉积物的基因类型引起差别。 | GU Xuexlang ZHANG Yongmei DONG Shuyi TANG Juxing | 2007 | Acta Geologica Sinica(English Edition)2007，81，6： | 5 |
| 18 | Correlation between echolocation calls and morphological features among three kinds of bats显示文摘The correlation between echolocation sound and morphological features of 18 species of bats, which are subordinated to 3 families including rhinolophidae, hipposideridae and vespertilionidae is studied. Pearson's correlation and regression analysis are adopted to analyze the correlations between noseleaf width (NW) and forearm length (FAL), NW and dominant frequency (DF), FAL and DF. The results show a positive correlation between NW and FAL and a negative correlation between NW and DF in Rhinolophidae. In each family, there is a negative correlation between FAL and DF. Some species have a higher or lower frequency than predicted one according to their body size. There are significant differences of the regression equation of FAL and DF among the three families. For the bats with the same body size, the order in frequency is: hipposiderid bats> rhinolophid bats> vespertilionid bats. The mechanism of interrelationship between FAL and DF of bats, the reason why these deviations occur in correlativity of the three families and the mechanism of the interaction between morphological, physiological and ecological characteristics are discussed. | FENG Jiang , CHEN Min, LI Zhenxin, ZHANG Shuyi, ZHAO Huihua and ZHOU Jiang(1. Environmental Science Department, Northeast Normal University, Changchun 130024, China 2. Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China 3. Biology Department, Guizhou Normal University, Guiyang 550000, China) | 2002 | Progress in Natural Science:Materials International2002，12，9： | 4 |
| 19 | Sliding-mode-disturbance-observer-based adaptive neural control of uncertain discrete-time systems显示文摘Dear editor,For real-world control systems,there are often system uncertainties caused by modeling errors,disturbances caused by external unknown environments,and saturation caused by physical limitations of the actuator.The above-mentioned problems can not only degrade the performance of the controlled object,but also result in system instability.However,the issues of system uncertainties,input saturation,and external disturbances have seldom been considered in combination in the existing research on the control of continuous-time and discrete-time systems[1–5].In recent years,the utilization of digital computers and samplers in actual control plants has made the controller design based on discrete-time system representation more reasonable than that based on continuoustime representation.Thus,this study presents the design method of a discrete-time adaptive neural(DTAN)tracking control scheme for uncertain discrete-time multi-input and multi-output(MIMO)nonlinear systems with external disturbances and input saturation based on a discretetime sliding mode disturbance observer(SMDO). | Shuyi SHAO Mou CHEN | 2020 | Science China(Information Sciences)2020，63，4： | 4 |
| 20 | Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy显示文摘Given the opposing effects of Akt and AMP-activated protein kinase(AMPK)on metabolic homeostasis,this study examined the effects of deletion of Akt2 and AMPKα2 on fat diet-induced hepatic steatosis.Akt2–Ampkα2 double knockout(DKO)mice were placed on high fat diet for 5 months.Glucose metabolism,energy homeostasis,cardiac function,lipid accumulation,and hepatic steatosis were examined.DKO mice were lean without anthropometric defects.High fat intake led to adiposity and decreased respiratory exchange ratio(RER)in wild-type(WT)mice,which were ablated in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.High fat intake increased blood and hepatic triglycerides and cholesterol,promoted hepatic steatosis and injury in WT mice.These effects were eliminated in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.Fat diet promoted fat accumulation,and enlarged adipocyte size,the effect was negated in DKO mice.Fat intake elevated fatty acid synthase(FAS),carbohydrate-responsive element-binding protein(CHREBP),sterol regulatory element-binding protein 1(SREBP1),peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α),peroxisome proliferator-activated receptor-α(PPARα),PPARγ,stearoyl-CoA desaturase 1(SCD-1),phosphoenolpyruvate carboxykinase(PEPCK),glucose 6-phosphatase(G6Pase),and diglyceride O-acyltransferase 1(DGAT1),the effect was absent in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.Fat diet dampened mitophagy,promoted inflammation and phosphorylation of forkhead box protein O1(FoxO1)and AMPKα1(Ser^(485)),the effects were eradicated by DKO.Deletion of Parkin effectively nullified DKO-induced metabolic benefits against high fat intake.Liver samples from obese humans displayed lowered microtubule-associated proteins 1A/1B light chain 3B(LC3B),Pink1,Parkin,as well as enhanced phosphorylation of Akt,AMPK(Ser^(485)),and FoxO1,which were consolidated by RNA sequencing(RNAseq)and mass spectrometry analyses from rodent and human livers.These data suggest that concurrent deletion of Akt2 and AMPKα2 offers resilience to fat diet-induced obesity and hepatic steatosis,possibly through preservation of Parkin-mediated mitophagy and lipid metabolism. | Shuyi Wang Jun Tao Huaguo Chen Machender R.Kandadi Mingming Sun Haixia Xu Gary D.Lopaschuk Yan Lu Junmeng Zheng Hu Peng Jun Ren | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 4 |
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