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| 1 | Properties and evaluation of amidoxime-based UHMWPE fibrous adsorbent for extraction of uranium from seawater显示文摘An amidoxime-based ultra-high molecular weight polyethylene(UHMWPE)fibrous adsorbent was successfully prepared by γ-irradiation-induced graft copolymerization of acrylonitrile(AN)and acrylic acid(AA),followed by amidoximation.The grafting of AN and AA on the UHMWPE fiber and the amidoximation of the grafted fiber were confirmed by Fourier transform infrared spectroscopy,scanning electron microscopy,and thermogravimetric analysis.The mechanical property of the original and modified UHMWPE fibers was compared by single-filament strength test.The adsorption property of the UHMWPE fibrous adsorbent was evaluated by adsorption test in uranyl nitrate solution and seawater.The surface of the modified UHMWPE fibers was covered by the grafting layer and became rough.The tensile strength of the amidoxime-based UHMWPE fibrous adsorbent was influenced by the absorbed dose and hydrochloric acid elution,but was independent of the grafting yield and amidoximation.The uranium adsorption amount of the amidoxime-based UHMWPE fibrous adsorbent after immersing in seawater for 42 days was 2.3 mg-U/g. | XING Zhe HU JiangTao WANG MouHua ZHANG WenLi LI ShiNeng GAO QianHong WU GuoZhong | 2013 | Science China Chemistry2013，56，11： | 17 |
| 2 | Indirectly extruded biodegradable Zn-0.05wt%Mg alloy with improved strength and ductility: In vitro and in vivo studies显示文摘As compared to permanent orthopedic implants for load-bearing applications, biodegradable orthopedic implants have the advantage of no need for removing after healing, but they suffer from the 'trilemma' problem of compromising among sufficiently high mechanical properties, good biocompatibility and proper degradation rate conforming to the growth rate of new bones. In the present work, in vitro and in vivo studies of a Zn-0.05 wt%Mg alloy(namely, Zn-0.05 Mg alloy) were conducted with pure Zn as a control. The Zn-0.05 Mg alloy is composed of a small amount of Mg_2 Zn11 phase embedded in the refined Zn matrix with an average grain size of ~20 μm. The addition of 0.05 wt% Mg into Zn significantly increases the ultimate tensile strength up to 225 MPa and the elongation to fracture to 26%, but has little influence on the in vitro degradation rate. Both Zn and Zn-0.05 Mg alloy exhibit homogeneous in vitro degradation with a rate of about 0.15 mm/year. Based on the cytotoxicity evaluation, Zn and Zn-0.05 Mg alloy do not induce toxicity to L-929 cells, indicating that they have little toxicity to the general functions of the animal. An in vivo biocompatibility study of Zn and Zn-0.05 Mg alloy samples by placing them in a rabbit model for 4.12 and 24 weeks, respectively did not show any inflammatory cells, and demonstrated that new bone tissue formed at the bone/implant interface, suggesting that Zn and Zn-0.05 Mg alloy promote the formation of new bone tissue. The in vivo degradation of Zn and Zn-0.05 Mg alloy does not bring harm to the important organs and their cell structures. More interestingly, Zn and Zn-0.05 Mg alloy exhibit strong antibacterial activity against Escherichia coli and Staphylococcus aureus. The above results clearly demonstrate that the Zn-0.05 Mg alloy could be a potential biodegradable orthopedic implant material. | Chi Xiao Liqing Wang Yuping Ren Shineng Sun Erlin Zhang Chongnan Yan Qi Liu Xiaogang Sun Fenyong Shou Jingzhu Duan Huang Wang Gaowu Qin | 2018 | Journal of Materials Science & Technology2018，34，9： | 11 |
| 3 | Preparation and biodistribution of ^(99)Tc^m-PIDP as bone imaging agent显示文摘A novel zoledronic acid derivative,1-hydroxy-2-(2-propyl-1H-imidazol-1-yl)ethane-1,1-diyldiphosphonic acid (PIDP), was synthesized by three-step reactions from 2-propyl-1H-imidazole. It was labeled with 99Tcm in conditions of 0.1 mg SnCl2.2H2O at pH 6.0 and 99TcmO4? in aqueous solution for 20 min at room temperature. The labeling yield and radiochemical purity of 99Tcm-PIDP are both higher than 95%. The biodistribution results show that the bone uptake is up to 8.47% ID/g which is the maximum of bone uptake at 30 min after injection of 99Tcm-PIDP in mice. The pharmacokinetic parameters can be estimated from the exponential equation of C=59.565e-11.307t+2.069e-1.211t. The clear bone image of rabbit was obtained at 120 min after injection of 99Tcm-PIDP. The results indicate that 99Tcm-PIDP has highly selective uptake in the skeletal and low uptake, rapid clearance in soft tissues, so it would be a potential novel bone imaging agent. | CHEN Chuanqing LUO Shineng LIN Jianguo YANG Min YE Wanzhong QIU Ling SANG Guangming XIA Yongmei | 2009 | Nuclear Science and Techniques2009，20，5： | 6 |
| 4 | Expression profiles of miRNAs in human pancreatic cancer cell lines显示文摘目的将开始由微数组技术在人的胰腺的癌症房间线分析 miRNAs 表示侧面的差别。743 根探针全部的方法 A 根据人,老鼠,和老鼠的已知的 miRNAs 序列被设计。miRNAs 微数组被生产,它的可靠被验证。全部的 RNA 被提取, miRNAs 与胰腺的癌症房间衬里的人(SW1990, Capan-2, BxPC-3, Aspc-1,和 Panc1 ) 和不朽的人被分开胰腺的管上皮的房间线 H6C7。他们用 T4 RNA ligase 被标记,当时是有微数组的 hybridized。通过数组扫描和分析,在胰腺的癌症的 miRNAs 表达式侧面被获得。结果被北弄污和 RT-PCR 验证。与胰腺的癌症有关的 63 miRNAs 全部的结果 A 被发现是在 5 根胰腺的癌症房间线表示的差别,包括 25 下面调整并且 38 起来调整的 miRNAs。mir-21 和 let-7 的表情也被证实。结果建议了侧面能在胰腺的癌症房间被发现的那 miRNAs 表情的结论。 | Shineng Zhang Haijun Zuo Zhong Yu Fengting Huang Wa Zhong | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，2： | 3 |
| 5 | Syntheses of haptens and hapten-protein conjugates for insecticide propoxur and cyhalothrin显示文摘A facile procedure was described for the hapten design of the N-methylcarbamate insecticide propoxur.Two new haptens of propoxur(hapten 1a and hapten 1b) were synthesized by introducing appropriate spacers in the pesticide aromatic moiety of the analyte molecular structure.First,the propoxur reacted with nitric acid to yield the intermediate product.Then hapten 1a was prepared via the reduction of the intermediate product,and hapten 1b was formed by the acylation of hapten 1a with succinic anhydride.In addition,we have also developed a simple method to prepare hapten 2 for the pyrethroid insecticide cyhalothrin,which only requires two steps including the reactions of nitration and reduction.Three haptens were coupled to carrier proteins to prepare the corresponding artificial antigens.The molecular structures of these three haptens were identified by 1H NMR and MS,and those of the artificial antigens were confirmed by UV-vis. | Sang, GuangMing Luo, ShiNeng Lin, JianGuo Qiu, Ling Chen, ChuanQing Yang, HaiLin Xia, YongMei | 2010 | Science China Chemistry2010，53，5： | 3 |
| 6 | Insulinoma imaging with glucagon-like peptide-1 receptor targeting probe 18 F-FBEM–Cys 39 -exendin-4显示文摘 | Yuping Xu Donghui Pan Qing Xu Chen Zhu Lizhen Wang Fei Chen Runlin Yang Shineng Luo Min Yang | 2014 | Journal of Cancer Research and Clinical Oncology2014，，9： | 1 |
| 7 | Preparation and preliminary biological evaluation of ^(99)Tc^m-TADP as bone imaging agent显示文摘TADP, 2-(1H-1,2,4-triazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid, was synthesized by three step reactions from the raw material 1H-1,2,4-triazole. Tcm-TADP was prepared with 5 mg TADP at pH 7.0 by joining 99 99TcmO4 with SnCl2·2H2O in aqueous solution for 10 min at room temperature. Both labeling yield and radiochemical - purity of Tcm-TADP were more than 95%. The biodistribution in rats and bone scan in rabbits were also studied. The 99 uptake of organ was expressed as %ID/g. The results showed that the bone uptake is up to 17.17%ID/g which is the maximum of bone uptake at 30 min after injection of Tcm-TADP in rats, bone-to-muscle and bone-to-blood uptake 99 ratios were 61.32 and 13.21, respectively. The clear bone image of rabbit was obtained at 120 min after injection of 99Tcm-TADP and clearance in soft tissue was visible. The preparation of 99Tcm-TADP was convenient and 99Tcm-TADP exhibited high uptake in bone, and it would be a potential new bone imaging agent. | YAN Xiaohong LUO Shineng NIU Guosai YE Wanzhong YANG Min WANG Hongyong XIA Yongmei | 2008 | Nuclear Science and Techniques2008，19，3： | 1 |
| 8 | Study on the reaction kinetics of ^(99)Tc^m-labeled BIDP显示文摘A novel zoledronic acid derivative,1-hydroxy-2-(2-butyl-1H-imidazole-1-yl)-ethylidene-l,l- diphosphonic acid(BIDP),was synthesized and labeled with ^(99)Tc^m.The detailed kinetic study on the labeling reaction between BIDP and ^(99)Tc^m was carried out.The results indicated that the reaction rate constants k were 0.0258,0.0268, 0.0305,0.0323,0.0351 and 0.0384 min^(-1)at 0℃,5℃,10℃,15℃,20℃and 25℃,respectively.From the Arrhenius equation k=A·e^(-E_Δ/(RT)),the activation energy E_a of the labeling reaction was calculated to be 10.45 kJ/mol.And the correlation between k and temperature(T)was also deduced as In k=-1258.8×(l/T)+0.9531.In addition,it was found that in order to get a high radiolabeling yield(RLY)(>90%),the reaction temperature must be up to 12℃. | LIN Jianguo WANG Yan LUO Shineng QIU Ling ZHAI Haozhen | 2011 | Nuclear Science and Techniques2011，22，3： | 0 |
| 9 | MAT1-siRNA体外转染抑制胰腺癌细胞增殖和侵袭能力的研究(英文)显示文摘目的将在人的胰腺的癌症房间由小干扰 RNA 观察 MAT1 基因的基因 silencing 的可行性。方法 BxPC-3 房间是用提出与的化学上综合的双搁浅的 RNA 的 transfected 脂肪一些。MAT1 的基因表示分别地是由 RT-PCR 和西方的污点的 assayed。房间增长试金被在 Trypan 排除以后数活着的房间执行。房间侵略能力被 Boyden 房间模型决定。结果 BxPC-3 房间的 MAT1 mRNA 和蛋白质表示与控制组相比由小干扰 RNA 是显著地下面调整的。MAT1 mRNA 的表示被 55.2% 和 64.3% 分别地在 24 h 和 48 h 减少(P <
0.01 ) 。BxPC-3 房间的房间增长和侵略能力显著地被禁止(P <
0.01 ) 。结果由 siRNA 建议 MAT1 的那基因 silencing 的结论能禁止房间增长和 BxPC-3 房间的侵略,它可以是在人的胰腺的癌症的基因治疗的一个目标。 | Shineng Zhang Jianping Liu Fengqin Xu Yiwen Wanga Wa Zhong Shizhen Yuan | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，5： | 0 |
| 10 | Semi-automated synthesis,validation and microPET imaging of ^(18)F-FP-DTBZ as a vesicular monoamine transporter ligand显示文摘This work was to develop a semi-automated synthesis of 18F-9-fluoropropyl-9-desmethyl-DTBZ (18F-FP-DTBZ) and validate its potential as a vesicular monoamine transporter 2 (VMAT2) ligand.18F-FP-DTBZ was synthesized by a semi-automated procedure in a 21-35% yield without decay correction and with a radiochemical purity of >98%.Bioistribution in rats exhibited a favorable brain uptakes of the ligand (0.31±0.04 ID% at 60min post injection,n=8).The highest radioactivity located in VMAT2 enriched striatal tissue.The target-to-nontarget ratio (striatum/cerebellum,ST/CB) was 4.81±0.84.Blocking studies implied that striatum uptake could be blocked by DTBZ (a VMAT2 inhibitor) but could not by CFT (a dopamine transporter inhibitor).MicroPET imaging with 18F-FP-DTBZ in normal rats gave high quality images in which high radioactivity were observed in the striatal tissue.Time-and-activity curves revealed good retention in the target (striatum) and rapid clearance in the background (cerebellum),which resulted in a maximum ST/CB ratio of 5.08±0.81 (n=3) in 80-120min.By contrast,the 6-hydroxydopamine unilateral lesioned rats gave asymmetrical striata images with higher 18F-FP-DTBZ concentration on the unlesioned side (unlesioned-ST/CB=5.21±0.38,n=3) than the lesioned (lesioned-ST/CB=2.34±0.51).The results validated that 18F-FP-DTBZ is a favorable PET ligand binding to VMAT2. | CHEN Zhengping LIU Chunyi LI xiaomin TANG Jie TAN Cheng HUANG Hongbo YU Huixin LUO Shineng | 2012 | Nuclear Science and Techniques2012，23，1： | 0 |
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