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| 1 | Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice显示文摘瞄准:增加的证据建议那 probucol,有抗氧化剂活动的一个类脂化合物阴沉的代理人,可能为有经由在胆固醇和 neuroinflammation 的减小的 hyperlipidemia 的 ischemic 击的治疗有用。在这研究,我们检验了 probucol 是否能在正常和 hyperlipidemic mice.Methods 经由 anti-neuroinflammatory 行动免于大脑 ischemic 损害:主要老鼠 microglia 和鼠科的 BV2 microglia 不为 3 h,和版本暴露于 lipopolysaccharide (LPS ) , PGE2, IL-1β并且在 NF-κ 的 IL-6,以及变化; B,表明小径的 MAPK 和 AP-1 被估计。ApoE 击倒老鼠被喂包含 0.004% 的一本高脂肪的食谱, 0.02% , 0.1%(wt/wt ) 为 10 个星期的 probucol 而正常 C57BL/6J 老鼠收到了 probucol (3, 10, 30 mg· kg -1·d-1, po ) 为 4 d。然后,所有老鼠通过中间的服的动脉吸藏(MCAO ) 受到焦点的服的局部缺血。神经病学的赤字被获得在外科以后的 24 h,然后大脑为测量服的梗塞尺寸和支持 inflammatory mediators.Results 的生产被移开:在对待 LPS 的 BV2 房间和主要 microglial 房间,有 probucol 的预告的处理(1, 5, 10 μ mol/L ) dose-dependently 禁止了版本没有, PGE2, IL-1β并且 IL-6,它发生在抄写铺平。而且, probucol 的禁止的行动与 NF-κ 的 downregulation 被联系;表明小径的 B, MAPK 和 AP-1。在有 MCAO 的正常鼠标, probucol 的管理前 dose-dependently 减少了梗塞卷和改进神经病学的功能。这些效果被支持 inflammatory 调停人的减少的生产伴随(iNOS, COX-2, IL-1, IL-6 ) 。在 ApoE 击倒,老鼠喂了一本高脂肪的食谱, 0.1% probucol 的管理前显著地减少了梗塞体积,改进了跟随 MCAO 的神经病学的赤字,并且减少全部胆固醇并且 LDL 胆固醇 levels.Conclusion:Probucol 禁止导致 LPS 的 microglia 激活并且改善在经由它的 anti-neuroinflammatory 行动的正常和 hyperlipidemic 老鼠的服的 ischemic 损害,建议那 probucol 为 ischemic 击和 hyperlipidemia 为病人的治疗有潜力与或在风险。 | Yeon Suk JUNG Jung Hwa PARK Hyunha KIM So Young KIM Ji Young HWANG Ki Whan HONG Sun Sik BAE Byung Tae CHOI Sae-Won LEE Hwa Kyoung SHIN | 2016 | Acta Pharmacologica Sinica2016，37，8： | 16 |
| 2 | Testing for unit roots in heterogeneous panels显示文摘 | Kyung So Im M.Hashem Pesaran Yongcheol Shin | 2003 | Journal of Econometrics2003，，1： | 2 |
| 3 | Cytoplasmic CD24 expression in advanced ovarian serous borderline tumors显示文摘 | Yoon-La Choi Seok-Hyung Kim Young Kee Shin Yun-Chul Hong Sun-Joo Lee So Young Kang Geunghwan Ahn | 2005 | Gynecologic Oncology2005，，2： | 2 |
| 4 | Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers显示文摘 | Jung Ho Kim So Hyun Shin Hyeong Ju Kwon Nam Yun Cho Gyeong Hoon Kang | 2009 | Virchows Archiv2009，，6： | 2 |
| 5 | Testing for unit roots in heterogeneous panels显示文摘 | Kyung So Im M.Hashem Pesaran Yongcheol Shin | 2003 | Journal of Econometrics2003，，1： | 2 |
| 6 | Calcium-dependent proteasome activation is required for axonal neurofilament degradation显示文摘Even though many studies have identified roles of proteasomes in axonal degeneration,the molecular mechanisms by which axonal injury regulates proteasome activity are still unclear.In the present study,we found evidence indicating that extracellular calcium influx is an upstream regulator of proteasome activity during axonal degeneration in injured peripheral nerves.In degenerating axons,the increase in proteasome activity and the degradation of ubiquitinated proteins were significantly suppressed by extracellular calcium chelation.In addition,electron microscopic findings revealed selective inhibition of neurofilament degradation,but not microtubule depolymerization or mitochondrial swelling,by the inhibition of calpain and proteasomes.Taken together,our findings suggest that calcium increase and subsequent proteasome activation are an essential initiator of neurofilament degradation in Wallerian degeneration. | Joo Youn Park So Young Jang Yoon Kyung Shin Duk Joon Suh Hwan Tae Park | 2013 | Neural Regeneration Research2013，8，36： | 2 |
| 7 | uPAR expression under hypoxic conditions depends on iNOS modulated ERK phosphorylation in the MDA-MB-231 breast carcinoma cell line显示文摘尿激 plasminogen 使活跃之物受体(uPAR ) 戏在癌症侵略和转移和 uPAR 表示的一个主要角色在各种各样的癌症类型与差的预后被相关。而且, uPAR 的表示在 hypoxic 条件下面被增加。氮的氧化物(没有) 并且它可诱导的氮的氧化物 synthase (i NOS ) 生产的代谢物是 hypoxic 应力的重要产品,并且可以不激活或调制细胞外的信号调整 kinase (英皇家空军之阶级最低之兵) 。这里,我们在 MDA-MB-231 人的乳癌房间线在 hypoxic 条件,和 i NOS 并且不的调节效果下面在 A, uPAR,和激活的英皇家空军之阶级最低之兵层次上面评估了。房间在 hypoxic 或 normoxic 孵卵器被孵化并且与 PD98059 对待(一个 MEK 1/2 禁止者,它废除英皇家空军之阶级最低之兵 phosphorylation ) 并且 aminoguanidine (选择 i NOS 禁止者) 。uPAR 表示,英皇家空军之阶级最低之兵 phosphorylation,并且在 A 上面,活动被发现在 hypoxic 条件下面被增加。而且当房间在 hypoxic 条件下面与 PD98059 被对待时, uPAR 低调整,而 aminoguanidine 显著地以一种剂量依赖者方式增加了英皇家空军之阶级最低之兵 phosphorylation。而且, aminoguanidine 增加了 uPAR 表示并且由 PD98059 阻止了 uPAR 表示的抑制。这些结果证明 uPAR 被组织缺氧导致,那增加的 uPAR 表情被英皇家空军之阶级最低之兵 phosphorylation 调停,它被 iNOS/NO 接着在 MDA-MB-231 房间调制。我们结束那 iNOS/NO 在下面经由英皇家空军之阶级最低之兵小径调整在 hypoxic 条件下面调整 uPAR 的表示。 | So Young Yoon Yoo Jung Lee Jae Hong Seo Hwa Jung Sung Kyong Hwa Park In Keun Choi Seok Jin Kim Sang Cheul Oh Chul Won Choi Byung Soo Kim Sang Won Shin Yeul Hong Kim Jun Suk Kim | 2006 | Cell Research2006，16，1： | 2 |
| 8 | Cardiac mucosa at the gastroesophageal junction:An Eastern perspective显示文摘AIM:To investigate the nature and origin of cardiac mucosa(CM).METHODS:Biopsy samples from sixty-one individuals were included in this study. The specimens were taken 'at','just below',or 'just above' the gastroesophageal junction,including the histologic squamocolumnar junction. Clinical data were obtained by reviewing electronic medical records for each patient. Patients with a history of stomach adenoma or carcinoma and esophageal carcinoma were excluded,and cases that were endoscopically suspicious of Barrett's esophagus or a polyp were also ruled out. Histologic and endoscopic reviews were performed blinded to the patient's clinical data. Histologic evaluation wasconducted by two pathologists,and endoscopic review was performed by a endoscopist with wide experience in the field. Histologically,the columnar epithelium of squamocolumnar junction,presence and severity of acute and chronic inflammation,atrophy,intestinal metaplasia,and presence of carditis were evaluated. Endoscopically,reflux esophagitis was evaluated by Los Angeles(LA) classification,hiatal hernias were classified by Hill grade,and gastroesophageal flap valves were assessed. RESULTS:Fifty-nine of the 61(96.7%) patients were Korean; 65.6%(40/61) of the patients underwent endoscopy according to the schedule of the National Health Insurance Program as a screening inspection. Of these,only 20.0%(8/40) of cases had reflux s y m p t o m s. C M w a s p r e s e n t i n 4 1 / 6 1( 6 7. 2 %) individuals,and its presence was associated with older age compared to oxyntocardiac mucosa/oxyntic mucosa(60.59 ± 2.02 years vs 51.55 ± 3.35 years; P = 0.018). The presence of CM was associated with endoscopic diagnosis of esophagitis according to the LA classification(P = 0.022). CM was associated with mononuclear cell infiltration and neutrophilic infiltration,which were statistically significant(P = 0.001,and P = 0.004,respectively). The inflammation of CM,'carditis',showed a statistically significant association with endoscopic diagnosis of reflux esophagitis according to the LA classification(P = 0.008). CONCLUSION:CM at the gastroesophageal junction is a common histologic finding in biopsy specimens,though not always present,and associated with gastroesophageal reflux disease and carditis severity. | Ahrong Kim Won-Young Park Nari Shin Hyun Jung Lee Young Keum Kim So Jeong Lee Cheong-Soo Hwang Do Youn Park Gwang Ha Kim Bong Eun Lee Hong-Jae Jo | 2015 | World Journal of Gastroenterology2015，21，30： | 2 |
| 9 | Tissue engineered regeneration of completely transected spinal cord using human mesenchymal stem cells显示文摘 | Kkot Nim Kang Da Yeon Kim So Mi Yoon Ju Young Lee Bit Na Lee Jin Seon Kwon Hyo Won Seo Il Woo Lee Ha Cheol Shin Young Man Kim Hyun Soo Kim Jae Ho Kim Byoung Hyun Min Hai Bang Lee Moon Suk Kim | 2012 | Biomaterials2012，，19： | 1 |
| 10 | Relationship between intravascular ultrasound parameters and fractional flow reserve in intermediate coronary artery stenosis of left anterior descending artery: Intravascular ultrasound volumetric analysis显示文摘 | Hyoung‐Mo Yang Seung‐Jea Tahk Hong‐Seok Lim Myeong‐Ho Yoon So‐Yeon Choi Byoung‐Joo Choi Xiong Jie Jin Gyo‐Seung Hwang Jin‐Sun Park Joon‐Han Shin | 2014 | Intervent2014，，3： | 1 |
| 11 | Recursive mean adjustment for unit root tests显示文摘 | Shin D W Beong Soo So | 2001 | Journal of Time Series Analysis2001，22，5： | 1 |
| 12 | Ultrastructural changes in the cochlea of the guinea pig after fast neutron irradiation 显示文摘 | Kim CS Shin SO | 1994 | Otolaryngology Head Neck Surg1994，110，4： | 1 |
| 13 | Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rabll trafficking of the alpha6beta4 integrin 显示文摘 | Yoon SO Shin S Mercurio AM | 2005 | Cancer Res2005，65，7： | 1 |
| 14 | Comparison of antiheat shock protein 70(antihsp70)and anti268 kD inner ear protein in the sera of patients with Meniere's disease显示文摘 | Shin SO Billings PB Keithley EM | 1997 | Laryngoscope1997，107，2： | 1 |
| 15 | Efficacy of the Disposcope end- oscope, a new video laryngoscope, for endotracheal intubafion in patients with cervical spine immobilisation by semirigid neck collar: comparison with the Macintosh laryngoscope using a simulation study on a manikin显示文摘 | Park SO Shin DH Lee KR | 2013 | Emerg Med J2013，30，4： | 1 |
| 16 | Multidetector row CT of various hepatic artery complications after living donor liver transplantation显示文摘 | So Yeon Kim Kyoung Won Kim Min Ju Kim Yong Moon Shin Moon-Gyu Lee Sung Gyu Lee | 2007 | Abdominal Imaging2007，，5： | 1 |
| 17 | Brassiere wearing and breast cancer risk:A systematic review and meta-analysis显示文摘AIM:To evaluate existing evidence for the association between different type of brassiere exposures and the risk of breast cancer.METHODS:Ovid Medline,CINAHL,Cochrane Data Base of Systematic Reviews,Pubmed,Scopus,Proquest,Sciencedirect,Wiley Online Library,WanF ang Data,Hong Kong Index to Chinese Periodicals,China Journal Net,Chinese Medical Current Contents,Chinese Biomedical Literature Database,China Academic Journals FullText database,Taiwan Electronic Periodical Services and HyR ead; reference lists of published studies; original research studies published in English or Chinese examining the association between type and duration of brassiere-wearing and breast cancer risk.Data were abstracted by a first reviewer and verified by a second.Study quality was rated according to predefined criteria.'Fair' or 'good' quality studies were included.Results were summarised by meta-analysis whenever adequate material was available.RESULTS:Twelve case-control studies were included in the review.Meta-analysis showed brassiere wearing during sleep was associated with a 1.3 times of increased risk.The odd ratio for more than 12 h of daily brassiere use in relation to breast cancer risk was 1.08(95%CI:1.01-1.14).CONCLUSION:The present review demonstrates insufficient evidence to establish a positive association between the duration and type of brassiere wearing and breast cancer.Further research is essential; specifically,a large-scale epidemiological study of a better design is needed to examine the association between various forms of brassiere exposure in detail and breast cancer risk,with adequate control of confounding variables. | Winnie KW So Dorothy NS Chan Yan Lou Kai-Chow Choi Carmen WH Chan Kristina Shin Ava Kwong Diana TF Lee | 2015 | World Journal of Meta-Analysis2015，3，4： | 1 |
| 18 | Endoscopic versus external reparir of orbital blowout fractures 显示文摘 | Jin HR Yeon JY Shin SO | 2007 | Otolaryngol Head Neck Surg2007，136，1： | 1 |
| 19 | Gaussian tests for seasonal unit roots based on Cauchy estimation and recursive mean adjustments显示文摘 | Dong Wan Shin Beong Soo So | 2000 | Journal of Econometrics2000，99，： | 1 |
| 20 | Ultrastructural changes in the cochlea of the guinca pig after fast neutron irradiation显示文摘 | Kim CS Shin SO | 1994 | Otolaryngol Head Neck Surg1994，110，4： | 1 |
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