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| 1 | 疏肝和胃颗粒治疗肝胃郁热型反流性食管炎疗效观察显示文摘目的评价疏肝和胃颗粒治疗肝胃郁热型反流性食管炎的临床疗效。方法将94例肝胃郁热型反流性食管炎患者随机分为试验组和对照组,每组47例。试验组予生活饮食指导合疏肝和胃颗粒,对照组予生活饮食指导合奥美拉唑。两组疗程均为8周,观察临床疗效、临床症状积分以及胃镜下食管黏膜分级变化情况。结果入组患者94例均完成了8周疗程,其中疗程结束后实际完成胃镜复查76例。试验组临床及胃镜总有效率分别为95.74%、80.00%,对照组分别为76.60%、63.89%,试验组临床疗效及胃镜疗效均优于对照组(P<0.05)。两组治疗后,临床症状积分值均显著降低(P<0.05);组间治疗后临床症状积分差值比较,差异有统计学意义(P<0.05)。两组治疗后,胃镜下食管黏膜炎症分级均明显改善(P<0.05);组间治疗后比较,胃镜下食管黏膜炎症分级差异有统计学意义(P<0.05)。结论疏肝和胃颗粒可以明显提高肝胃郁热型反流性食管炎的临床疗效,改善临床症状,减轻食管黏膜炎症。 | 王阿会 朱生樑 周秉舵 王轶 李亚鼎 | 2021 | 上海中医药杂志2021，55，3： | 8 |
| 2 | Anti-apoptotic effect of banhasasim-tang on chronic acid reflux esophagitis显示文摘AIM To evaluate the anti-apoptotic effect of banhasasimtang(BHSST) on chronic acid reflux esophagitis(CARE) using a rat model.METHODS A surgically-induced CARE model was established in Sprague-Dawley rats. The modeled rats were divided into a treatment group or untreated group, and given BHSST(1 g/kg body weight per day) or water, respectively, for 15 consecutive days(n = 7 each group). Changes in expression of proteins related to nicotinamide adenine dinucleotide phosphate(NADPH) oxidase and apoptosis were assessed by western blotting. Changes in esophageal pathology were analyzed by gross and histological examinations.RESULTS The CARE exposure modeled rats showed increased levels of the NADPH oxidase subunit, NOX4 and p47 phox in the esophagus. The BHSST treatment completely resolved these CARE-related increases. The CARE rats also showed markers of cytokine stress, including elevated levels of TNF-α and reactive oxygen species as well as of the consequent increase in JNK activation, and subsequent decrease in pro-survival gene expression, such as of Bcl-2. BHSST treatment resolved the CARE-related changes. BHSST also exerted an antiapoptotic effect, as evidenced by altered expression of the apoptosis-related genes for bax, cytochrome c,and caspase 3. Finally, the BHSST treatment markedly ameliorated the CARE-related esophageal mucosal ulcerations. CONCLUSION In the rat model of CARE, BHSST can suppress development of esophageal mucosal ulceration via regulation of reactive oxygen species-dependent apoptosis. | Mi-Rae Shin Hyo-Jin An Bu-Il Seo Seong-Soo Roh | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
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