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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | A double crosslinking MXene/cellulose nanofiber layered film for improving mechanical properties and stable electromagnetic interference shielding performance显示文摘With the discovery of the two-dimensional(2D) MXene, it shows a great application potential in the field of electromagnetic interference(EMI) shielding, but the mechanical brittleness and easy oxidation of MXene limit its wide application. For this reason, a double crosslinking strategy is provided to solve the above problems in a nacre-like “brick-mortar” layered MXene/cellulose nanofiber(MXene/CNF) film.Typically, the film was firstly suffered by dopamine modification, then was further reinforced by secondary Ca^(2+)bridging, so as to obtain excellent mechanical properties and antioxidative EMI shielding performance. Comparing with the single crosslinking, the double crosslinking strategy reveals a higher efficiency in improving the mechanical property. The mechanical strength and toughness of the double crosslinking MXene/CNF film can increase to 142.2 MPa and 9.48 MJ/m^(3), respectively. More importantly, while achieving good mechanical properties, the MXene composite film still holds a very stable EMI shielding performance of more than 44.6 dB when suffering from the oxidation treatment of hightemperature annealing, showing excellent anti-oxidation ability and environment tolerance. Therefore,this work provides a universal but effective double crosslinking strategy to solve the mechanical brittleness and easy oxidation of MXene-based composites, thus showing a huge potential in flexible EMI shielding applications. | Shilu Luo Tiantian Xiang Jingwen Dong Fengmei Su Youxin Ji Chuntai Liu Yuezhan Feng | 2022 | Journal of Materials Science & Technology2022，，34： | 4 |
| 3 | OsSERK1 regulates rice development but not immunity to Xanthomonas oryzae pv. oryzae or Magnaporthe oryzae显示文摘Somatic embryogenesis receptor kinase(SERK)proteins play pivotal roles in regulation of plant development and immunity. The rice genome contains two SERK genes,OsSerk1 and OsSerk2. We previously demonstrated that OsSerk2 is required for rice Xa21-mediated resistance to Xanthomonas oryzae pv. oryzae(Xoo) and for normal development. Here we report the molecular characterization of OsSerk1. Overexpression of OsSerk1 results in a semi-dwarf phenotype whereas silencing of OsSerk1 results in a reduced angle of the lamina joint. OsSerk1 is not required for rice resistance to Xoo or Magnaporthe oryzae. Overexpression of Os Serk1 in OsSerk2-silenced lines complements phenotypes associated with brassinosteroid(BR) signaling defects, but not the disease resistance phenotype mediated by Xa21. In yeast, OsSERK1 interacts with itself forming homodimers, and also interacts with the kinase domains of OsSERK2 and BRI1, respectively.OsSERK1 is a functional protein kinase capable of auto-phosphorylation in vitro. We conclude that, whereas OsSERK2 regulates both rice development and immunity, OsSERK1 functions in rice development but not immunity to Xoo and M. oryzae. | Shimin Zuo Xiaogang Zhou Mawsheng Chen Shilu Zhang Benjamin Schwessinger Deling Ruan Can Yuan Jing Wang Xuewei Chen Pamela C.Ronald | 2014 | Journal of Integrative Plant Biology2014，56，12： | 4 |
| 4 | Host nucleotide polymorphism in hepatitis B virusassociated hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is etiologically linked with hepatitis B virus(HBV) and is the leading cause of death amongst 80% of HBV patients. Among HBV affected patients, genetic factors are also involved in modifying the risk factors of HCC. However, the genetic factors that regulate progression to HCC still remain to be determined. In this review, we discuss several single nucleotide polymorphisms(SNPs) which were reportedly associated with increased or reduced risk of HCC occurrence in patients with chronic HBV infection such as cyclooxygenase(COX)-2 expression specifically at COX-2-1195G/A in Chinese, Turkish and Egyptian populations, tumor necrosis factor α and the three most commonly studied SNPs: PAT-/+, Lys939Gln(A33512C, rs2228001) and Ala499Val(C21151T, rs2228000). In genome-wide association studies, strong associations have also been found at loci 1p36.22, 11q22.3, 6p21(rs1419881, rs3997872, rs7453920 and rs7768538), 8p12(rs2275959 and rs37821974) and 22q11.21. The genes implicated in these studies include HLA-DQB2, HLA-DQA1, TCF19, HLA-C, UBE2L3, LTL, FDX1, MICA, UBE4 B and PG. The SNPs found to be associated with the above-mentioned genes still require validation in association studies in order to be considered good prognostic candidates for HCC. Screening of these polymorphisms is very beneficial in clinical experiments to stratify the higher or lower risk for HCC and may help in designing effective and efficient HCC surveillance programs for chronic HBV-infected patients if further genetic vulnerabilities are detected. | Shilu Mathew Hany Abdel-Hafiz Abbas Raza Kaneez Fatima Ishtiaq Qadri | 2016 | World Journal of Hepatology2016，8，10： | 4 |
| 5 | A Novel Cooperative Multi-Stage Hyper-Heuristic for Combination Optimization Problems显示文摘A hyper-heuristic algorithm is a general solution framework that adaptively selects the optimizer to address complex problems.A classical hyper-heuristic framework consists of two levels,including the high-level heuristic and a set of low-level heuristics.The low-level heuristics to be used in the optimization process are chosen by the high-level tactics in the hyper-heuristic.In this study,a Cooperative Multi-Stage Hyper-Heuristic(CMS-HH)algorithm is proposed to address certain combinatorial optimization problems.In the CMS-HH,a genetic algorithm is introduced to perturb the initial solution to increase the diversity of the solution.In the search phase,an online learning mechanism based on the multi-armed bandits and relay hybridization technology are proposed to improve the quality of the solution.In addition,a multi-point search is introduced to cooperatively search with a single-point search when the state of the solution does not change in continuous time.The performance of the CMS-HH algorithm is assessed in six specific combinatorial optimization problems,including Boolean satisfiability problems,one-dimensional packing problems,permutation flow-shop scheduling problems,personnel scheduling problems,traveling salesman problems,and vehicle routing problems.The experimental results demonstrate the efficiency and significance of the proposed CMS-HH algorithm. | Fuqing Zhao Shilu Di Jie Cao Jianxin Tang Jonrinaldi | 2021 | Complex System Modeling and Simulation2021，1，2： | 3 |
| 6 | Composition demixing effect on cathodic arc ion plating显示文摘The composition demixing effect has been found often in alloy coatings deposited by cathodic arc ion plating using variousalloy cathode targets. The characteristics of composition demixing phenomena were summarized. Beginning with the ionization zonenear the surface of the cathode target, a physical model in terms of the ions generated in the ionization zone and their movement in theplating room modified by bias electric field was proposed. Based on the concept of electric charge state, the simulation calculation ofthe composition demixing effect was carried out. The percentage of atoms of an element in coating and from the alloy target was de-monstrated by direct comparison. The influences of the composition change of the alloy target and the bias electric field on the compo-sition demixing effect were discussed in detail. It is also proposed that the average charge states of the elements may be used to calcu-late the composition demixing effect and to design the composition of the alloy target. | Jun Zhang Li Li Lipeng Zhang Shilu Zhao Qiang Guo | 2006 | Journal of University of Science and Technology Beijing2006，13，2： | 3 |
| 7 | Hepatitis C virus and neurological damage显示文摘Chronic hepatitis C virus(HCV) infection exhibits a wide range of extrahepatic complications, affecting various organs in the human body. Numerous HCV patients suffer neurological manifestations, ranging from cognitive impairment to peripheral neuropathy. Overexpression of the host immune response leads to the production of immune complexes, cryoglobulins, as well as autoantibodies, which is a major pathogenic mechanism responsible for nervous system dysfunction. Alternatively circulating inflammatory cytokines and chemokines and HCV replication in neurons is another factor that severely affects the nervous system. Furthermore, HCV infection causes both sensory and motor peripheral neuropathy in the mixed cryoglobulinemia as well as known as an important risk aspect for stroke. These extrahepatic manifestations are the reason behind underlying hepatic encephalopathy and chronic liver disease. The brain is an apt location for HCV replication, where the HCV virus may directly wield neurotoxicity. Other mechanisms that takes place by chronic HCV infection due the pathogenesis of neuropsychiatric disorders includes derangement of metabolic pathways of infected cells, autoimmune disorders, systemic or cerebral inflammation and alterations in neurotransmitter circuits. HCV and its pathogenic role is suggested by enhancement of psychiatric and neurological symptoms in patients attaining a sustained virologic response followed by treatment with interferon; however, further studies are required to fully assess the impact of HCV infection and its specific antiviral targets associated with neuropsychiatric disorders. | shilu mathew muhammed faheem sara m ibrahim waqas iqbal bisma rauff kaneez fatima ishtiaq qadri | 2016 | World Journal of Hepatology2016，8，12： | 3 |
| 8 | Aerosol pollution in a megacity of southwest China inferred from variation characteristics of sulfate-δ^34S and water-soluble inorganic compositions in TSP显示文摘Daytime and nighttime aerosol samples for total suspended particles (TSP) were collected in Chengdu from 12 to 23 January 2013 (winter) and 10 to 21 August 2014 (summer). The mass concentrations of TSP, major inorganic ions, and stable sulfur isotope ratios were determined. Clear winter-summer variatio n inT SPwas observed;the mass concentrations ofTSPin summerwere below levels defi ned by the Chinese National Ambient Air Quality Standard (GB3095-2012), whereas winter TSP levels exceeded the standard by 2-4 times. Overall, the sum of SO4^2-, NO3^-, and NH4^+ concentmtions represented the highest contribution to water-soluble ionic components, which showed similar trends to TSP mass. According to correlations among major ions, the major compounds in TSP were likely to be (NH4)2SO4, NH4NO3, CaCl2,and KCl in both sampling times, and CaSO4 and Ca(NO3)2 were also present in summer. The NO3 /SO42^- ratios ranged from 0.57 to 1.28 (average 0.85 ± 0.16) in winter and 0.5 to 0.93 (average 0.66 ±0.11) in summer, indicating stationary source ernissi ons (coal bur ning) were more im porta nt sources than the vehicle exhaust. The relationship between SO4^2- and δ^34S indicated the sulfate sources were affected by the low sulfur isotope value of biogenic sulfur release in summer, and the high sulfur isotope value of coal in winter. As a whole, the mixture of coal burning and vehicle exhaust represent the major TSP sources in Chengdu in the study period, and biogenic sulfur also contributes to TSP in summer. | Zhou Yang Xiaodong Li Shilu Wang Qinkai Li Jun Huang Gaoyang Cui | 2019 | Particuology2019，17，2： | 3 |
| 9 | 牙本质过敏症激光治疗对髓腔温度的影响显示文摘目的比较功率相同的Nd:YAP激光、Nd:YAG激光和半导体激光治疗牙本质过敏症时的髓腔温度变化,初步评价3种激光治疗牙本质过敏症的安全性.方法收集完好的第三磨牙50颗,制备牙本质过敏症离体牙模型.将样本随机分为Nd:YAP激光组(n=15)、Nd:YAG激光组(n=15)、半导体激光组(n=15)、空白对照组(n=5).每个实验组又根据激光功率分为0.9W、1.4W及1.8W3个亚组,每组5个样本,实验中用对应激光参数进行照射并用热电偶测温仪记录髓腔温度变化;对照组不做任何处理.激光照射后,每组随机取1个样本并用扫描电镜观察牙本质小管形态.结果采用不同功率激光照射牙体时,各组髓腔温度均有升高,其中Nd:YAP激光组髓腔温升最小,半导体激光组次之,Nd:YAG激光组髓腔温升最高但仍小于能够引起牙髓坏死的温度(5.5℃).扫描电镜结果显示,不同功率激光照射后,Nd:YAG激光组与半导体激光组中大部分牙本质小管管径缩窄,甚至熔融闭锁,且效果优于Nd:YAP激光组.结论采用Nd:YAP激光、Nd:YAG激光以及半导体激光治疗牙本质过敏症时会引起髓腔温度的升高,但温升小于5.5℃,不会对牙髓组织造成不可逆性的损伤.Nd:YAG激光和半导体激光具有更好的牙本质小管封闭效果,比Nd:YAP激光更适合激光牙本质脱敏治疗. | 范林林 邹朝晖 Barsha Joshi 梁潇月 Shilu Bhattachan | 2018 | 国际生物医学工程杂志2018，41，2： | 3 |
| 10 | Poverty and malaria in the Yunnan province, China显示文摘Poverty and malaria appear to have an intertwined link.This paper aims to define the relationship between poverty and malaria in Yunnan,China,and to make recommendations for future research in this important area.Data on malaria prevalence and the population’s income in each county between 2005 and 2010 were obtained from the Yunnan Center for Disease Control and Prevention and the Yunnan Bureau of Statistics,respectively.Geographic mapping shows an apparent spatial convergence of poverty and the incidence of malaria at a county level,and suggests that poverty may be one of the drivers of malaria transmission in Yunnan.Future research should focus on:1.measuring and quantifying the relationship between poverty and the malaria burden at the individual,community,county and regional level in Yunnan;and 2.developing the GIS-based spatial decision support system(SDSS)framework in malaria endemic areas,particularly along the border areas in Yunnan. | Yan Bi Shilu Tong | 2014 | Infectious Diseases of Poverty2014，3，1： | 2 |
| 11 | Characteristics of U-pattern distribution of high-concentration ^(210)Pb in surface air at central Guizhou,China显示文摘A better understanding of the variation of 210Pb concentrations in the surface air is the key to trace lake sedimentation and catchment erosion, to establish and vali-date the global diffusion model of contaminants, and to as-sess the impact of natural radiation on the ecological system. Basing on the study progresses of the sedimentation, the at-mospheric model and the unique environmental background in the Yunnan-Guizhou Plateau, and starting from December 20, 2001, we made use of a 500 NE Type aerosol sampler to collect filter samples, once a week in the past consecutive two years, in the surface air at Mt. Guanfeng, Guiyang City, China. Synchronous detailed γ -energy spectrometric obser-vations of 210Pb concentrations at both Chinese and U.S. laboratories have shown that the average monthly 210Pb concentration displays a regular U-patterns distribution of annual variations, with high values appearing in winter and low values in late spring and summer. The average annual 210Pb concentrations are estimated to be 2.77±0.63 mBq/m3, about 4 times the average maximum concentrations reported from quite a number of monitoring stations throughout the world. The possible factors affecting the sources of 210Pb in the surface air in the central part of Guizhou Province are: Release of 222Rn from the U-Ra series enriched in the soils; chemical weathering of carbonate rocks; the exploitation, processing and utilization of coal and phosphorous resources. The principal factor controlling the high 210Pb concentrations in the surface air in the central Guizhou and their annual U-pattern distribution is the release of 222Rn. The average monthly 210Pb concentrations show a good negative power- function relationship with increasing precipitation and also show a good negative linear-function relationship with the rise of air temperature in month grouping. Group No.1 (June to November) reflects a relatively low release of 222Rn from soils in relatively high temperature seasons; Group No.2 (December to May) mirrors a relatively high release of 222Rn from soils in relatively low temperature seasons. The average monthly 210Pb concentrations simulated in terms of the pre-cipitation and air temperature are in good consistency with the measured values, revealing that the regular U-pattern distribution characteristics of 210Pb concentrations in the surface air in the central Guizhou are controlled predomi-nantly by regional precipitation and air temperature. Meanwhile, it is also indicated that the magnitude of varia-tion of air temperature and precipitation within the same year also constrains the ratio of high values over low values of average monthly 210Pb concentrations. On a month time scale, precipitation and air temperature are a main factor affecting the release of 222Rn from soils (rocks). In this aspect strong evidence has been obtained. | WAN Guojiang YANG Wei WANG Shilu WAN Enyuan WU Fengchang S.N.LEE WANG Changsheng HUANG Ronggui | 2005 | Chinese Science Bulletin2005，50，16： | 2 |
| 12 | Chitosan Removes Toxic Heavy Metal Ions from Cigarette Mainstream Smoke显示文摘This study investigated the removal of heavy metal ions from cigarette mainstream smoke using chitosan.Chitosan of various deacetylation degrees and molecular weights were manually added to cigarette filters in different dosages.The mainstream smoke particulate matter was collected by a Cambridge filter pad,digested by a microwave digestor,and then analyzed for contents of heavy metal ions,including As(III/V),Pb(II),Cd(II),Cr(III/VI) and Ni(II),by graphite furnace atomic absorption spectrometry(GFAAS).The results showed that chitosan had a removal effect on Pb(II),Cd(II),Cr(III/VI) and Ni(II).Of these,the percent removal of Ni(II) was elevated with an increasing dosage of chitosan.Chitosan of a high deace tylation degree exhibited good binding performance toward Cd(II),Cr(III/VI) and Ni(II),though with poor efficiency for Pb(II).Except As(III/V),all the tested metal ions showed similar tendencies in the growing contents with an increasing chitosan molecular weight.Nonetheless,the percent removal of Cr(III/VI) peaked with a chitosan molecular weight of 200 kDa,followed by a dramatic decrease with an increasing chitosan molecular weight.Generally,chitosan had different removal effects on four out of five tested metal ions,and the percent removal of Cd(II),Pb(II),Cr(III/VI) and Ni(II) was approximately 55%,45%,50%,and 16%,respectively.In a word,chitosan used in cigarette filter can remove toxic heavy metal ions in the mainstream smoke,improve cigarette safety,and reduce the harm to smokers. | ZHOU Wen XU Ying WANG Dongfeng ZHOU Shilu | 2013 | Journal of Ocean University of China2013，12，3： | 2 |
| 13 | Ambient air pollution, climate change, and population health in China显示文摘 | Haidong Kan Renjie Chen Shilu Tong | 2011 | Environment International2011，，： | 2 |
| 14 | Separation and purification of phosphatidylcholine and phosphatidylethanolamine from soybean degummed oil residues by using solvent extraction and column chromatography显示文摘 | Weinong Zhang Haibo He Yuqi Feng Shilu Da | 2003 | Journal of Chromatography B2003，，2： | 2 |
| 15 | Assessing the vulnerability of ecoenvironmental health to climate change 显示文摘 | Shilu T Peter M Gerry F | 2010 | International Journal of Environmental Research and Public Health2010，，7： | 1 |
| 16 | Improving cooking and eating quality of Xieyou57, an elite indica hybrid rice, by marker- assisted selection of the Wx locus显示文摘 | NI Dahu ZHANG Shilu CHEN Sheng | 2011 | Euphytica2011，179，2： | 1 |
| 17 | Climate variability and transmission of Japanese encephalitis in eastern China显示文摘 | Peng BI Shilu T | 2003 | Vector-borne Zoonot Dis2003，3，3： | 1 |
| 18 | Scheduling-and-control codesign for a collection of networked control systems with uncertain delays显示文摘 | Dai Shilu Lin Hal Ge S S | 2010 | IEEE Transactions on Control Systems Technology2010，18，1： | 1 |
| 19 | Long -term exposure to gaseous air pollutants and cardio - respiratory mortality in Brisbane, Australia 显示文摘 | Xiao Yu Wang Wenbiao Hu Shilu Tong et al | 2009 | Geospatial Health2009，3，2： | 1 |
| 20 | 显示文摘 | Wang Shilu Liu Wanshun Han Baoqin | 2009 | Applied Surface Science2009，255，： | 1 |
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