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| 1 | Effectiveness of probiotics in irritable bowel syndrome:Updated systematic review with meta-analysis显示文摘AIM:To investigate the efficacy of probiotics in irritable bowel syndrome(IBS) patients.METHODS:Pub Med,Cochrane library,Scopus,Google Scholar,and Clinicaltrial.gov databases were searched for literature published between September 2007 and December 2013.The applied Mesh terms were 'probiotics,' 'irritable bowel syndrome,' and 'irritable bowel syndrome treatment.' The collected data contained24 clinical trials,of which 15 were eligible for meta-analysis and nine were reviewed systematically.All studies were randomized placebo-controlled trials in patients with IBS that investigated the efficacy of probiotics in IBS improvement.The Jadad score was used to assess the methodological quality of trials.The quality scale ranges from 0 to 5 points,with a score ≤ 2 indicating a low quality report,and a score of ≥3 indicating a high quality report.Relative risk(RR),standardized effect size,and 95%CI were calculated using the Der Simonian-Laird method.The Cochran Q test was used to test heterogeneity with P < 0.05.Funnel plots were constructed and Egger's and BeggMazumdar tests were performed to assess publication bias.RESULTS:A total of 1793 patients were included in the meta-analysis.The RR of responders to therapies based on abdominal pain score in IBS patients for two included trials comparing probiotics to placebo was 1.96(95%CI:1.14-3.36;P = 0.01).RR of responders to therapies based on a global symptom score in IBS patients for two included trials comparing probiotics with placebo was 2.43(95%CI:1.13-5.21;P = 0.02).For adequate improvement of general symptoms in IBS patients,the RR of seven included trials(six studies) comparing probiotics with placebo was 2.14(95%CI:1.08-4.26;P = 0.03).Distension,bloating,and flatulence were evaluated using an IBS severity scoring system in three trials(two studies) to compare the effect of probiotic therapy in IBS patients with placebo,the standardized effect size of mean differences for probiotics therapy was-2.57(95%CI:-13.05--7.92).CONCLUSION:Probiotics reduce pain and symptom severity scores.The results demonstrate the beneficial effects of probiotics in IBS patients in comparison with placebo. | Tina Didari Shilan Mozaffari Shekoufeh Nikfar Mohammad Abdollahi | 2015 | World Journal of Gastroenterology2015，21，10： | 51 |
| 2 | Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis显示文摘AIM: To investigate the beneficial effect of the combination of butyrate, Lactobacillus casei, and L-carnitine in a rat colitis model.METHODS: Rats were divided into seven groups. Fourgroups received oral butyrate, L-carnitine, Lactobacillus casei and the combination of three agents for 10 consecutive days. The remaining groups included negative and positive controls and a sham group. Macroscopic, histopathological examinations, and biomarkers such as tumor necrosis factor-alpha(TNF-α) and interlukin-1β(IL-1β), myeloperoxidase(MPO), thiobarbituric acid reactive substances(TBARS), and ferric reduced ability of plasma(FRAP) were determined in the colon.RESULTS: The combination therapy exhibited a significant beneficial effect in alleviation of colitis compared to controls. Overall changes in reduction of TNF-α(114.66 ± 18.26 vs 171.78 ± 9.48 pg/mg protein, P < 0.05), IL-1β(24.9 ± 1.07 vs 33.06 ± 2.16 pg/mg protein, P < 0.05), TBARS(0.2 ± 0.03 vs 0.49 ± 0.04 μg/mg protein, P < 0.01), MPO(15.32 ± 0.4 vs 27.24 ± 3.84 U/mg protein, P < 0.05), and elevation of FRAP(23.46 ± 1.2 vs 15.02 ± 2.37 μmol/L, P < 0.05) support the preference of the combination therapy in comparison to controls. Although the monotherapies were also effective in improvement of colitis markers, the combination therapy was much better in improvement of colon oxidative stress markers including FRAP, TBARS, and MPO.CONCLUSION: The present combination is a suitable mixture in control of experimental colitis and should be trialed in the clinical setting. | Mahsa Moeinian Seyedeh Farnaz Ghasemi-Niri Shilan Mozaffari Amir Hossein Abdolghaffari Maryam Baeeri Mona Navaea-Nigjeh Mohammad Abdollahi | 2014 | World Journal of Gastroenterology2014，20，31： | 5 |
| 3 | New biologic therapeutics for ulcerative colitis and Crohn’s disease显示文摘 | Shilan Mozaffari Shekoufeh Nikfar Amir Hossein Abdolghaffari Mohammad Abdollahi | 2014 | Expert Opinion on Biological Therapy2014，，5： | 3 |
| 4 | A systematic review of the safety of probiotics显示文摘 | Tina Didari Sara Solki Shilan Mozaffari Shekoufeh Nikfar Mohammad Abdollahi | 2014 | Expert Opinion on Drug Safety2014，，2： | 3 |
| 5 | Melatonin, a Promising Supplement in Inflammatory Bowel Disease: A Comprehensive Review of Evidences显示文摘 | Shilan Mozaffari Mohammad Abdollahi | 2011 | Current Pharmaceutical Design2011，，38： | 2 |
| 6 | Structure and antioxidant activity study of sulfated acetamido-polysaccharide from Radix Hedysari显示文摘 | Zilong Dang Demei Feng Xiaohua Liu Tao Yang Long Guo Jin Liang Jiandi Liang Fangdi Hu Fang Cui Shilan Feng | 2013 | Fitoterapia2013，，： | 2 |
| 7 | Research progress on etiology of gestational diabetes mellitus显示文摘As a metabolic disorder during pregnancy,gestational diabetes mellitus (GDM) has an important effects on fetal development,neonatal health and maternal long-term health,and is one of the pregnancy complications with high incidence.It is of great significance that we have an accurate understanding of the etiology and risk factors of GDM for its prevention and control.GDM is a complex disease with multiple etiologies.Current studies have shown that the occurrence of GDM may be the result of combined effect of heredity and environment,but the exact etiology is still unclear.In this paper,we summarized the possible etiologies and risk factors of GDM,so as to understand the occurrence and development of GDM better and to provide possible references for prevention and further etiological studies of GDM. | Jiayue Zhang Shujuan Ma Chuhao Guo Sisi Long Shilan Wu Hongzhuan Tan | 2018 | Global Health Journal2018，2，4： | 2 |
| 8 | Iridold glucosides from phlomis rotata显示文摘 | Zhang Chengzhong Li Chong Feng Shilan | 1991 | Phytochemistry1991，30，12： | 1 |
| 9 | A planar- re? ective symmetry transform for 3d shapes显示文摘 | Podolak J Shilane P Golovinskiy A | 2006 | ACM Transaction on Graphics2006，25，3： | 1 |
| 10 | Cost-Effectiveness of Percutaneous Coronary Intervention in Patients With Stable Coronary Artery Disease and Abnormal Fractional Flow Reserve显示文摘 | William F. Fearon David Shilane Nico H.J. Pijls Derek B. Boothroyd Pim A.L. Tonino Emanuele Barbato Peter Jüni Bernard De Bruyne Mark A. Hlatky | 2013 | Circulation2013，，12： | 1 |
| 11 | The Princeton shape benchmark显示文摘 | SHILANE P MIN P KAZHDAN M | 2004 | Proceedings of Shape Modeling International2004，，： | 1 |
| 12 | A planarreflective symmetry transform for 3D shapes显示文摘 | Podolak J Shilane P Golovinskiy A | | 0，，03： | 1 |
| 13 | Distinctive Regions of 3D Surfaces显示文摘 | Shilane P Funkhouser T | 2007 | ACM Transactions on Graphics2007，26，2： | 1 |
| 14 | Incremental prognostic information from kidney function in patients with new onset coronary heart disease 显示文摘 | Hlatky MA Shilane D Chang TI | 2014 | Am Heart J2014，167，1： | 1 |
| 15 | Modeling by example 显示文摘 | Funkhouser T Kazhdan M Shilane P | 2004 | ACM Transactions on Graphics2004，23，3： | 1 |
| 16 | Modeling by example显示文摘 | Funkhouser T Kazhdan M Shilane P | 2004 | ACM Transactions on Graphics( TOG )2004，23，3： | 1 |
| 17 | Disfinctive regions of 3D surfaces显示文摘 | Shilane P Funkhouser T | 2007 | ACM Trans Graph2007，26，2： | 1 |
| 18 | Synthesis and swelling properties of pH-sensitive hydrogels based on ehitosan and poly ( methaerylic acid) semi-interpenetrating polymer network 显示文摘 | Chen Shilan Liu Mingzhu Jin Shuping et ai | 2005 | J Appl Polym Sci2005，98，4： | 1 |
| 19 | Procedural complications, rehospitalizations, and repeat procedures after catheter ablation for atrial fibrillation 显示文摘 | Shah RU Freeman JV Shilane D | 2012 | J Am Coil Cardiol2012，59，2： | 1 |
| 20 | A planar-reflective symmetry transform for 3D shapes 显示文摘 | PODOLAK J SHILANE P GOLOVINSKIY A | 2006 | AGM Trans on Graphics2006，25，： | 1 |
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