|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effectiveness of probiotics in irritable bowel syndrome:Updated systematic review with meta-analysis显示文摘AIM:To investigate the efficacy of probiotics in irritable bowel syndrome(IBS) patients.METHODS:Pub Med,Cochrane library,Scopus,Google Scholar,and Clinicaltrial.gov databases were searched for literature published between September 2007 and December 2013.The applied Mesh terms were 'probiotics,' 'irritable bowel syndrome,' and 'irritable bowel syndrome treatment.' The collected data contained24 clinical trials,of which 15 were eligible for meta-analysis and nine were reviewed systematically.All studies were randomized placebo-controlled trials in patients with IBS that investigated the efficacy of probiotics in IBS improvement.The Jadad score was used to assess the methodological quality of trials.The quality scale ranges from 0 to 5 points,with a score ≤ 2 indicating a low quality report,and a score of ≥3 indicating a high quality report.Relative risk(RR),standardized effect size,and 95%CI were calculated using the Der Simonian-Laird method.The Cochran Q test was used to test heterogeneity with P < 0.05.Funnel plots were constructed and Egger's and BeggMazumdar tests were performed to assess publication bias.RESULTS:A total of 1793 patients were included in the meta-analysis.The RR of responders to therapies based on abdominal pain score in IBS patients for two included trials comparing probiotics to placebo was 1.96(95%CI:1.14-3.36;P = 0.01).RR of responders to therapies based on a global symptom score in IBS patients for two included trials comparing probiotics with placebo was 2.43(95%CI:1.13-5.21;P = 0.02).For adequate improvement of general symptoms in IBS patients,the RR of seven included trials(six studies) comparing probiotics with placebo was 2.14(95%CI:1.08-4.26;P = 0.03).Distension,bloating,and flatulence were evaluated using an IBS severity scoring system in three trials(two studies) to compare the effect of probiotic therapy in IBS patients with placebo,the standardized effect size of mean differences for probiotics therapy was-2.57(95%CI:-13.05--7.92).CONCLUSION:Probiotics reduce pain and symptom severity scores.The results demonstrate the beneficial effects of probiotics in IBS patients in comparison with placebo. | Tina Didari Shilan Mozaffari Shekoufeh Nikfar Mohammad Abdollahi | 2015 | World Journal of Gastroenterology2015，21，10： | 51 |
| 2 | A systematic review of the safety of probiotics显示文摘 | Tina Didari Sara Solki Shilan Mozaffari Shekoufeh Nikfar Mohammad Abdollahi | 2014 | Expert Opinion on Drug Safety2014，，2： | 3 |
| 3 | Low-temperature oxidation of some Turkish coals显示文摘 | Baris K Kizgut S Didari V | 2012 | Fuel2012，93，： | 1 |
| 4 | How a single residue in individual 13-thymosin/WH2 domains controls their functions in actin assembly 显示文摘 | Didary D Cantrelle FX Husson C | 2011 | EMBO J2011，31，4： | 1 |
| 5 | Phase IIdrugs under clinical investigation for the treatment ofchronic constipation显示文摘 | MOZAFFARI S DIDARI T NIKFAR S | 2014 | Expert Opin Investig Drugs2014，24，： | 1 |
| 6 | Low-temperature oxidation ofsome Turkish coals显示文摘 | BARIS K KIZGUT S DIDARI V | 2012 | Fuel2012，93，1： | 1 |
| 7 | Study of viral infections in infants with biliary atresia显示文摘 | Yaghobi R Didari M Gramizadeh B | | 0，，04： | 1 |
| 8 | Low-temperature oxidation of some Turkish coals显示文摘 | Baris K Kizgut S Didari V | 2012 | Fuel2012，93，3： | 1 |
| 9 | Phase II drugs under clinical investigation for the treatment of chronic consti- pation显示文摘 | MOZAFFARI S DIDARI T N1KFAR S | 2014 | Expert Opinion on Investigational Drugs2014，23，11： | 1 |
| 10 | Feasibility of periodic surface models to develop gas diffusion layers : A gas permeability study 显示文摘 | DIDARI S HARRIS T A L HUANG W | 2012 | International Journal of Hydrogen Energy2012，37，14： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员