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295篇 您的检索式：作者名="Shields P"

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	题名	作者	年代	出处	被引量
1	Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.	Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon	2005	Hepatobiliary & Pancreatic Diseases International2005，4，1：	12
2	Solidstate characterization of chlodiazepoxide polymorphs显示文摘	SINGH D MARSHALL P V SHIELDS L	1998	J Pharm Science1998，87，5：	1
3	Simulations of ductile fracture in an idealized ship grounding scenario using phenomenological damage and cohesive zone models 显示文摘	Woelke P B Shields M D Abboud N N	2013	Computational Materials Science2013，80，：	1
4	Dustbathing by broiler chickens: A comparison of preference for four different substrates显示文摘	Shields S J J P Garner J A Meneh	2004	Appl Anim Behav Sci2004，87，：	1
5	Blastomere morphology as a predictive measure of fish eggviability显示文摘	Shields R J Brown N P Bromage N R	1997	Aquaculture1997，155，：	1
6	Lung Injury in Acute Pancreatitis: Mechanisms, Prevention, and Therapy显示文摘	Shields C J Winter D C Redmond H P	2002	Curr Opin Crit Care2002，8，2：	1
7	Partial lamellar sclerouvectomy for ciliary body and choroidal tumors显示文摘	SHIELDS J A SHIELDS C L SHAH P	1991	Ophthalmology1991，98，：	1
8	Mutations of NFKBIA,encoding Ikappa B alpha,are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases显示文摘	Lake A Shield LA Cordano P	2009	Int J Cancer2009，125，6：	1
9	Effect of sand and wood --shavings beddingon the behavior of broiler ehiekens显示文摘	Shields S J J P Garner J A Mench	2005	Poultry Science2005，84，：	1
10	Broadband moth-eyeantireflection coatings fabricated by low-cost nanoimprinting 显示文摘	CHEN Q HUBBARD G SHIELDS P A	2009	ApplPhys Lett2009，94，26：	1
11	Managing diabetic nephropathy 显示文摘	Shields J Maxwell A P	2010	Clin Med2010，10，5：	1
12	Residence Time Distributions Of Shallow Basins显示文摘	Thackston E L F Shields D Schroeder P R	1987	Journal of Environmental Engineering1987，113，6：	1
13	Urinary heparan sulphate proteoglyean excretion is abnormal in insulin dependent diabetes显示文摘	SHIELD J P CARRADUS M STONE J E	1995	Ann Clin Biochem1995，32，6：	1
14	Mycotic pneumonia in mariculture reared green turtles显示文摘	Jacobson E R Gaskin J M Shields R P	1979	Am Vet Med Assoc1979，175，：	1
15	Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver显示文摘	Shields P L Morland C M Salmon M	1999	J Immunol1999，163，11：	1
16	Diagenetic constraints on the use of ceriumanomalies as palaeoseawater redox proxies: An isotopicand REE study of Cambrian phosphorites 显示文摘	Shields G Stille P	2001	Chem Geol2001，175，12：	1
17	Outcome of lamivudine resistant hepatitis B virus infection in the liver transplant recipient显示文摘	Pillay D Shields P etal	2000	Gut2000，46，1：	1
18	Complications of motility peg placement for the hydroxyapatite orbital implant 显示文摘	Edelstein C Shields CL De Potter P Shields JA	1997	Ophthalmology1997，，：	1
19	Mutagens from heated Chinese and US cooking oils显示文摘	Shields P G Xu G X Blot W J		0，，：	1
20	Relative Income, Happiness, and Utility : an Explanation for the Easterlin Paradox and Other Puzzles 显示文摘	Clark A Frijters P Shields M	2008	Journal of Economic Literature2008，46，1：	1

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