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	题名	作者	年代	出处	被引量
1	Personalized chemotherapy in clear cell adenocarcinoma of the urethra:A case report显示文摘BACKGROUND Clear cell adenocarcinoma of the urethra is a rare type of aggressive cancer with a poor prognosis.Clear cell carcinoma of the urethra represents less than 0.02%of all malignancies in women.Adenocarcinomas account for 10%of female urethral carcinomas,of which 40%are the clear cell variant.Determining the presence or absence of certain mutations through genetic testing may predict whether a patient with cancer may benefit from a particular chemotherapy regimen.CASE SUMMARY A 40-year-old woman presented with a 3-year history of slow urinary flow and a 3-mo history of urinary urgency and frequency as well as gross hematuria.An abdominal and pelvic computed tomography scan demonstrated enlarged lymph nodes in the abdomen and pelvis.A biopsy of a left inguinal lymph node microscopically confirmed a metastatic adenocarcinoma of the urethra.Specialized genetic testing determined personalized chemotherapy.She was treated successfully with a non-platinum-based chemotherapy consisting of paclitaxel and bevacizumab.Following 3 cycles of paclitaxel and bevacizumab,she attained significant clinical improvement,and response by FDG-Positron emission tomography(PET)imaging showed a definite improvement in size and metabolic activity.She achieved complete response after 6 cycles of therapy by PET scan.The patient concluded 11 cycles of paclitaxel and bevacizumab,and a subsequent PET scan confirmed progression of metastatic disease.The patient was then treated with two cycles of doxorubicin after which a PET scan revealed a mixed response to the treatment.CONCLUSION We report the first case of a patient with metastatic clear cell adenocarcinoma of the urethra who underwent personalized chemotherapy after testing for cancer gene alterations.Our unique case represents the safe and effective use of nonplatinum-based chemotherapy in clear cell adenocarcinoma of the urethra.	Lisa B E Shields Arash Rezazadeh Kalebasty	2020	World Journal of Clinical Oncology2020，11，4：	3
2	Multiple heparin binding domains of respiratory syncytial virus G mediate binding to mammalian cells显示文摘	Shields B Mills J Ghildyal R	2003	Arch Virol2003，148，10：	1
3	The Evolution of Social Structure in the Iterated Prisoner's Dilemma显示文摘	Lomborg B Nucleus Shield	1996	American Sociological Review1996，61，：	1
4	Malignant hepatic angiomvolipoma:report of a case and review of literature显示文摘	Nguyen TT Gorman B Shields D		0，，05：	1
5	Simulations of ductile fracture in an idealized ship grounding scenario using phenomenological damage and cohesive zone models 显示文摘	Woelke P B Shields M D Abboud N N	2013	Computational Materials Science2013，80，：	1
6	Development length of glassfiber reinforced polymer bars in concrete 显示文摘	Wambeke B W Shield C K	2006	ACIStructural Journal2006，103，1：	1
7	Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression显示文摘	Krantz S B Shields M A Dangi-Garimella S		0，，01：	1
8	A phase Ⅱ study of carboplatin and paclitaxel in esophageal cancer显示文摘	EL-RAYES B F SHIELDS A ZALUPSKI M	2004	Ann Oncol2004，15，6：	1
9	Moral Growth Among Athletes and Nonathletes: A Comparative Analysis 显示文摘	BREDEMEIER B SHIELDS D	1986	J Genetic Psy1986，147，：	1
10	Another reovaluation of combined cataract and glaucoma surgery显示文摘	Shields M B	1993	Am J Ophthalmol:1993，115，6：	1
11	A UK perspective on intensive hatchery rearing methods for Atlantic halibut (Hippoglossus hippoglossus)显示文摘	Gara B Gillespie M J S	1999	Aquaculture1999，176，：	1
12	Ischemic conditioning shows a time-dependant influence on the fate of the gastric conduit after minimally invasive esophagectomy显示文摘	Veeramootoo D Shore AC Shields B	2010	Surg Endosc2010，24，5：	1
13	Glaucoma and systemic diseases 显示文摘	SALIM S SHIELDS M B	2010	Surv Ophthalmol2010，55，：	1
14	Variability in eaptan residues in apples from a Canadian orchard显示文摘	RAWN D F QUADE S C SHIELDS J B	2007	Food Additives and Contaminants2007，24，2：	1
15	Ischemic conditioning shows a time-dependant influence on the fate of the gastric conduit af- ter minimally invasive esophagectomy显示文摘	Veeramootoo D Shore AC Shields B	2010	Surg Endosc2010，24，5：	1
16	Adverse effects associated with highdose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion 显示文摘	Shields L B Raque G H Glassman S D	2006	Spine2006，31，5：	1
17	The complete image-source method for the prediction of sound distribution in non-diffuse enclosed spaces 显示文摘	Dance S M Shield B M	1997	Journal of Sound and Vibration1997，201，3：	1
18	Imaging proliferation in vivo withFLT and positron emission tomography显示文摘	SHIELDS A F GRIERSON J R DOHMEN B M	1998	Nat Med1998，4，11：	1
19	Phase Ⅱ study of capecitabine,irinotecan,and celecoxib in advanced colorectal cancer 显示文摘	El-Rayes B F Shields A F Vaishampayan U	2004	Proc Am Soc Clin Oncol2004，22，14：	1
20	Variations in 87Sr/86Sr ratios of calcites in Chinese loess:A proxy for chemicalal weathering associated with the East Asian summer monsoon显示文摘	Yang J D Chen J An Z S Shields G Tao X C Zhu H B Ji J F Chen Y	2000	Palaeogeography Palaeoclimatology Palaeoecology2000，157，：	1

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