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| 1 | Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion显示文摘The recent outbreak of coronavirus disease(COVID-19)caused by SARS-CoV-2 infection in Wuhan,China has posed a serious threat to global public health.To develop specific anti-coronavirus therapeutics and prophylactics,the molecular mechanism that underlies viral infection must first be defined.Therefore,we herein established a SARS-CoV-2 spike(S)protein-mediated cell-cell fusion assay and found that SARS-CoV-2 showed a superior plasma membrane fusion capacity compared to that of SARS-CoV.We solved the X-ray crystal structure of six-helical bundle(6-HB)core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit revealing that several mutated amino acid residues in the HR1 domain may be associated with enhanced interactions with the HR2 domain.We previously developed a pan-coronavirus fusion inhibitor,EK1,which targeted the HR!domain and could inhibit infection by divergent human coronaviruses tested,including SARS-CoV and MERS-CoV.Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM,about 241-and 149-fold more potent than the original EK1 peptide,respectively.EK1C4 was also highly effective against membrane fusion and infection of other human coronavirus pseudoviruses tested,including SARS-CoV and MERS-CoV,as well as SARSr-CoVs,and potently inhibited the replication of 5 live human coronaviruses examined,including SARS-CoV-2.Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection,suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. | Shuai Xia Meiqin Liu Chao Wang Wei Xu Qiaoshuai Lan Siliang Feng Feifei Qi Linlin Bao Lanying Du Shuwen Liu Chuan Qin Fei Sun Zhengli Shi Yun Zhu Shibo Jiang Lu Lu | 2020 | Cell Research2020，30，4： | 81 |
| 2 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 3 | Characterization of the receptor-binding domain(RBD)of 2019 novel coronavirus:implication for development of RBD protein as a viral attachment inhibitor and vaccine显示文摘The outbreak of Coronavirus Disease 2019(COVID-19)has posed a serious threat to global public health,calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),also known as 2019 novel coronavirus(2019-nCoV).The CoV spike(S)protein plays the most important roles in viral attachment,fusion and entry,and serves as a target for development of antibodies,entry inhibitors and vaccines.Here,we identified the receptor-binding domain(RBD)in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2(ACE2)receptors.SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and,hence,attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells,thus inhibiting their infection to host cells.SARS-CoV RBD-specific antibodies could crossreact with SARS-CoV-2 RBD protein,and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2,suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection. | Wanbo Tai Lei He Xiujuan Zhang Jing Pu Denis Voronin Shibo Jiang Yusen Zhou Lanying Du | 2020 | Cellular & Molecular Immunology2020，17，6： | 35 |
| 4 | A novel coronavirus (2019-nCoV) causing pneumonia-associated respiratory syndrome显示文摘By the end of 2019,the World Health Organization(WHO)was informed about an outbreak of pneumonia of unknown etiology in Wuhan,China.Some patients were linked to a seafood market,suggesting animal-to-human transmission,but,soon,human-tohuman transmission was confirmed.The pathogen was promptly identified as a novel coronavirus belonging to lineage B betacoronaviruses that also include severe acute respiratory syndrome coronavirus(SARS-CoV),which caused a pandemic in China in 2002/2003,and bat SARS-like coronaviruses. | Shibo Jiang Shuai Xia Tianlei Ying Lu Lu | 2020 | Cellular & Molecular Immunology2020，17，5： | 33 |
| 5 | Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein显示文摘Very recently,a novel coronavirus,2019-nCoV,emerged in Wuhan,China and then quickly spread worldwide,resulting in>17,388 confirmed cases and 361 deaths as of 3 February 2020,thus calling for the development of safe and effective therapeutics and prophylatics.1,2 Similar to severe acute respiratory syndrome(SARS)-CoV,2019-nCoV belongs to lineage B betacoronavirus,and it has the ability to utilize human angiotensin-converting enzyme 2(ACE2)as a receptor to infect human cells. | Shuai Xia Yun Zhu Meiqin Liu Qiaoshuai Lan Wei Xu Yanling Wu Tianlei Ying Shuwen Liu Zhengli Shi Shibo Jiang Lu Lu | 2020 | Cellular & Molecular Immunology2020，17，7： | 27 |
| 6 | Lymph node metastasis in early gastric cancer显示文摘 | Chen Rong He Qingsheng Cui Jianxin Bian Shibo Chen Lin | 2014 | Chinese Medical Journal2014，，3： | 15 |
| 7 | Fields experiments in North China show no decrease in winter wheat yields with night temperature increased by 2.0-2.5°C显示文摘The trends of daily maximum and minimum temperature in global warming indicated that the daily minimum temperature (Tmin) has risen more than twice as fast as the daily maximum temperature (Tmax) during the 20th century. Most researchers have focused on how the crops respond to daily mean temperature, whereas few controlled experiments were carried out to investigate how the crops respond to the Tmin rise. In particular, no experiment research has reported on how crops respond to the higher night temperature, which was the main trend in the climate warming. Taking winter wheat as the test crop, we investigated how the winter wheat growth and yields responded to the higher night temperature. In the field experiments, infrared heaters were used to increase higher night temperature (HNT) by about 2.5°C in contrast to the normal night temperature (CK) in two whole growth durations of winter wheat in 2008-2009 and 2009-2010 in North China. The results indicated that, compared to the CK treatment, winter wheat yield did not decline in HNT treatment, which increased temperatures by 2.0 2.5°C in both Warmer year (WY) and Colder year (CY). Furthermore, winter wheat yield in CY increased significantly in HNT treatment. HNT treatment in CY could significantly promote tillering and increase the effective panicles, which increased grain yield significantly (by more than 30% compared with CK). HNT treatment in CY contributed to an increase in the effective panicles and Kernels significantly, although making a significant reduction in 1000-grain weight, but did not lead to the yield decline. Under the HNT treatment, the whole growth duration of the winter wheat was shortened and the phenological dates were earlier except for the beginning of overwintering; the beginnings of the overwintering phase were postponed substantially and the ends of the overwintering phase were ahead of date compared to CK, which shortened the duration of overwintering considerably. We draw on our own studies to show examples of higher night temperature impact on winter wheat in a relatively cold year and relatively warm year in North China. Our results refer to winter wheat in North China, not all main winter wheat producing regions, in Huang-Huai and Southwest of China. Some uncertainties of our predictions derive from fast progress in crop breeding, the variability of climate, and the role of adaptive actions in the future. As expected, the adaptation measures should be considered to cope with the impacts of global warming on crops, and further research and assessments should be conducted. | FANG ShiBo TAN KaiYan REN SanXue ZHANG XinShi ZHAO JunFang | 2012 | Science China Earth Sciences2012，55，6： | 13 |
| 8 | Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus显示文摘 | Naru Zhang Rudragouda Channappanavar Cuiqing Ma Lili Wang Jian Tang Tania Garron Xinrong Tao Sumaiya Tasneem Lu Lu Chien-Te K Tseng Yusen Zhou Stanley Perlman Shibo Jiang Lanying Du | 2016 | Cellular & Molecular Immunology2016，13，2： | 12 |
| 9 | The First Disease X is Caused by a Highly Transmissible Acute Respiratory Syndrome Coronavirus显示文摘Based on the announcement of the World Health Organization(WHO) in 2018, the Wuhan pneumonia caused by an unknown etiology should be recognized as the first Disease X. Later, the pathogen was identified to be a novel coronavirus denoted 2019-nCoV, which has 79.5% and 96% whole genome sequence identify to SARS-CoV and bat SARS-related coronavirus(SARSr-CoV-RaTG13), respectively, suggesting its potential bat origin. With high human-to-human transmission rate(R0), 2019-nCoV has quickly spread in China and other countries, resulting in 34,953 confirmed cases and 725 deaths as of 8 February 2020, thus calling for urgent development of therapeutics and prophylactics. Here we suggest renaming 2019-nCoV as 'transmissible acute respiratory syndrome coronavirus(TARS-CoV)' and briefly review the advancement of research and development of neutralizing antibodies and vaccines targeting the receptor-binding domain(RBD) and viral fusion inhibitors targeting the heptad repeat 1(HR1) domain in spike protein of 2019-nCoV. | Shibo Jiang Zheng-Li Shi | 2020 | Virologica Sinica2020，35，3： | 11 |
| 10 | A novel strategy for rapid construction of libraries of full-length antibodies highly expressed on mammalian cell surfaces显示文摘一个万用的哺乳动物的显示器系统的开发为有高亲密关系的功能的人的抗体的选择是必要的。这里,我们为能高效地在哺乳动物的房间表面上被表示的全身的抗体图书馆的快速的建设描述了新奇策略。通用向量 pDGB-HC-TM 被插入唯一的序列为兴趣的基因的突然发生在里面和突然发生外面由限制 endonucleases BsmBI, SfiI,和 BstXI 认出了的多重克隆的地点构造。 Cytomegalovirus 倡导者,为在许多哺乳动物的房间的蛋白质的高表示的一个通常使用的倡导者,被用来从导出血小板的生长驾驶插入的抗体基因和一个 transmembrane 领域的表示因素受体在框架被熔化到重链的C终点一致区域到抗体在哺乳动物的房间表面上表示了的锚。用这策略,我们构造了一个全身的人的抗体显示图书馆。DNA 顺序分析和表示分析显示图书馆构造了有 6.58 e 的组合可表现的、可检测的差异 ???汩 l 吗?? | Ye Zhou Zhen-Rui Chen Chang-Zheng Li Wei He Shuwen Liu Shibo Jiang Wen-Li Ma Wanlong Tan Chen Zhou | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 11 |
| 11 | Integrated removal of NO and mercury from coal combustion flue gas using manganese oxides supported on TiO_2显示文摘A catalyst composed of manganese oxides supported on titania(MnO_x/TiO_2) synthesized by a sol–gel method was selected to remove nitric oxide and mercury jointly at a relatively low temperature in simulated flue gas from coal-fired power plants. The physico-chemical characteristics of catalysts were investigated by X-ray fluorescence(XRF), X-ray diffraction(XRD), and X-ray photoelectron spectroscopy(XPS) analyses, etc. The effects of Mn loading,reaction temperature and individual flue gas components on denitration and Hg^0 removal were examined. The results indicated that the optimal Mn/Ti molar ratio was 0.8 and the best working temperature was 240°C for NO conversion. O_2 and a proper ratio of [NH_3]/[NO]are essential for the denitration reaction. Both NO conversion and Hg^0 removal efficiency could reach more than 80% when NO and Hg^0 were removed simultaneously using Mn0.8 Tiat 240°C.Hg^0 removal efficiency slightly declined as the Mn content increased in the catalysts. The reaction temperature had no significant effect on Hg^0 removal efficiency. O_2 and HCl had a promotional effect on Hg^0 removal. SO2 and NH_3were observed to weaken Hg^0 removal because of competitive adsorption. NO first facilitated Hg^0 removal and then had an inhibiting effect as NO concentration increased without O_2, and it exhibited weak inhibition of Hg^0 removal efficiency in the presence of O_2. The oxidation of Hg^0 on Mn O x/TiO_2 follows the Mars–Maessen and Langmuir–Hinshelwood mechanisms. | Shibo Zhang Yongchun Zhao Zonghua Wang Junying Zhang Lulu Wang Chuguang Zheng | 2017 | Journal of Environmental Sciences2017，29，3： | 11 |
| 12 | Antenna Selection and Power Allocation Design for 5G Massive MIMO Uplink Networks显示文摘Massive MIMO is one of the key technologies in future 5G communications which can satisfy the requirement of high speed and large capacity. This paper considers antenna selection and power allocation design to promote energy conservation then provide good quality of service(QoS) for the whole massive MIMO uplink network. Unlike previous related works, hardware impairment, transmission efficiency, and energy consumption at the circuit and antennas are involved in massive MIMO networks. In order to ensure the QoS, we consider the minimum rate constraint for each user and the system, which increases the complexity of power allocation problem for maximizing energy and spectral efficiency in massive MIMO system. To this end, a quantum-inspired social emotional optimization(QSEO) algorithm is proposed to obtain the optimal power control strategy in massive MIMO uplink networks. Simulation results assess the great advantages of QSEO which previous strategies do not have. | Hongyuan Gao Yumeng Su Shibo Zhang Ming Diao | 2019 | China Communications2019，16，4： | 10 |
| 13 | Powder injection molding of pure titanium显示文摘An improved wax-based binder was developed for powder injection molding of pure titanium. A critical powder loading of 69 vol.% and a pseudo-plastic flow behavior were obtained by the feedstock based on the binder. The injection molding, debinding, and sintering process were studied. An ideal control of carbon and oxygen contents was achieved by thermal debinding in vacuum atmosphere (10-3 Pa). The mechanical properties of as-sintered specimens were less than those of titanium made by the conventional press-sintering process. Good shape retention and ±0.04 mm dimension deviation were achieved. | GUO Shibo DUAN Bohua HE Xinb QU Xuanhui | 2009 | Rare Metals2009，28，3： | 9 |
| 14 | The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin显示文摘Dear Editor,The rapid spread of SARS-CoV-2(also known as 2019-nCoV and HCoV-191),a novel lineage B betacoronavirus(βCoV),has caused a global pandemic of coronavirus disease(COVID-19).It has been speculated that RRAR,a unique furin-like cleavage site(FCS)in the spike protein(S),which is absent in other lineage BβCoVs,such as SARS-CoV,is responsible for its high infectivity and transmissibility. | Shuai Xia Qiaoshuai Lan Shan Su Xinling Wang Wei Xu Zezhong Liu Yun Zhu Qian Wang Lu Lu Shibo Jiang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 8 |
| 15 | Abnormal expression of bHLH3 disrupts a flavonoid homeostasis network,causing differences in pigment composition among mulberry fruits显示文摘Mulberry fruits with high concentrations of anthocyanins are favored by consumers because of their good taste,bright color,and high nutritional value.However,neither the regulatory mechanism controlling flavonoid biosynthesis in mulberry nor the molecular basis of different mulberry fruit colors is fully understood.Here,we report that a flavonoid homeostasis network comprising activation and feedback regulation mechanisms determines mulberry fruit color.In vitro and in vivo assays showed that MYBA-bHLH3-TTG1 regulates the biosynthesis of anthocyanins,while TT2L1 and TT2L2 work with bHLH3 or GL3 and form a MYB-bHLH-WD40(MBW)complex with TTG1 to regulate proanthocyanidin(PA)synthesis.Functional and expression analyses showed that bHLH3 is a key regulator of the regulatory network controlling mulberry fruit coloration and that MYB4 is activated by MBW complexes and participates in negative feedback control of the regulatory network to balance the accumulation of anthocyanins and proanthocyanidins.Our research demonstrates that the interaction between bHLH3 and MYB4 in the homeostasis regulatory network ensures that the fruits accumulate desirable flavonoids and that this network is stable in pigmentrich mulberry fruits.However,the abnormal expression of bHLH3 disrupts the balance of the network and redirects flavonoid metabolic flux in pale-colored fruits,resulting in differences in the levels and proportions of anthocyanins,flavones,and flavonols among differently colored mulberry fruits(red,yellow,and white).The results of our study reveal the molecular basis of the diversity of mulberry fruit colors. | Han Li Zhen Yang Qiwei Zeng Shibo Wang Yiwei Luo Yan Huang Youchao Xin Ningjia He | 2020 | Horticulture Research2020，7，1： | 8 |
| 16 | RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response显示文摘The pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has posed serious threats to global health and economy,thus calling for the development of safe and effective vaccines.The receptorbinding domain(RBD)in the spike protein of SARS-CoV-2 is responsible for its binding to angiotensin-converting enzyme 2(ACE2)receptor.It contains multiple dominant neutralizing epitopes and serves as an important antigen for the development of COVID-19 vaccines.Here,we showed that immunization of mice with a candidate subunit vaccine consisting of SARS-CoV-2 RBD and Fc fragment of human IgG,as an immunopotentiator,elicited high titer of RBD-specific antibodies with robust neutralizing activity against both pseudotyped and live SARS-CoV-2 infections.The mouse antisera could also effectively neutralize infection by pseudotyped SARS-CoV-2 with several natural mutations in RBD and the IgG extracted from the mouse antisera could also show neutralization against pseudotyped SARS-CoV and SARS-related coronavirus(SARSr-CoV).Vaccination of human ACE2 transgenic mice with RBD-Fc could effectively protect mice from the SARS-CoV-2 challenge.These results suggest that SARS-CoV-2 RBD-Fc has good potential to be further developed as an effective and broad-spectrum vaccine to prevent infection of the current SARS-CoV-2 and its mutants,as well as future emerging SARSr-CoVs and re-emerging SARS-CoV. | Zezhong Liu Wei Xu Shuai Xia Chenjian Gu Xinling Wang Qian Wang Jie Zhou Yanling Wu Xia Cai Di Qu Tianlei Ying Youhua Xie Lu Lu Zhenghong Yuan Shibo Jiang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 17 | Identification of HBsAg-specific antibodies from a mammalian cell displayed full-length human antibody library of healthy immunized donor显示文摘肝炎 B 免疫球蛋白(HBIG ) 在肝炎 B 的管理是重要的病毒(HBV ) 感染。试图作为 HBIG 的一种选择开发 recombinant monoclonal 抗体,我们报导 HBV 表面抗原(HBsAg ) 的成功的鉴定从在哺乳动物的房间上显示的一个全身的人的抗体图书馆的特定的抗体出现。把一个生来地使免疫的施主的外部血 mononuclear 房间的全部的 RNA 用作模板,抗体全部剧目被放大。联合四方法的结扎和 Flp 调停 recombinase 的集成(Flp 在里面) 系统,我们构造了每个房间在显示了一个种仅仅抗体分子的一个哺乳动物的基于房间的、充分人的、全身的抗体显示图书馆。由屏蔽使用激活荧光的房间排序的房间图书馆(FACS ) ,八个房间克隆显示那房间表面上的 HBsAg 特定的抗体被识别。抗体基因的 DNA 顺序分析揭示了三唯一的抗体。FACS 数据显示了那荧光灯表示(FSE ) 的力量,荧光灯绑定(FSB ) 的力量和相对有约束力的能力(RBA ) 都在他们之中是不同的。这些结果由使用我们的抗体表明了那哺乳动物的显示和屏蔽站台,我们能成功地从一个使免疫的全身的抗体图书馆识别抗原特定的抗体。因此,这个平台为治疗学的抗体的开发是很有用的。 | Chang-Zheng Li Zhong-Kun Liang Zhen-Rui Chen Hai-Bo Lou Ye Zhou Zhe-Huan Zhang Fei Yu Shuwen Liu Yuanping Zhou Shuguang Wu Wenling Zheng Wanlong Tan Shibo Jiang Chen Zhou | 2012 | Cellular & Molecular Immunology2012，9，2： | 7 |
| 18 | Mg-Zn-Y-Nd coated with citric acid and dopamine by layer-by-layer self-assembly to improve surface biocompatibility显示文摘Magnesium alloy has been generally accepted as an important biodegradable material on cardiovascular stent development for a long time. However, its limited biocompatibility, especially delayed endothelialization process restricts its further application. In this contribution, we modified the Mg-Zn-Y-Nd alloy surface with citric acid and dopamine via a layer-by-layer self-assembly assay, aiming at improving the biocompatibility of the magnesium alloy. The citric acid/dopamine(CA/PDA) layer exhibited a remarkable suppression of platelet activation/aggregation and thrombosis under 15 dyn/cm2 blood flowing. Inhibition on vascular smooth muscle cells growth and macrophages attachment/activation were also observed on this layer. In particular, the CA/PDA layer presented a promoted property for the vascular endothelial cells growth and spreading compared with the bare magnesium alloy, suggesting the pro-endotelialized function. In conclusion, this research may support potential application on surface modification of magnesium alloy based cardiovascular stents for better biocompatibility. | CHEN Li LI JingAn CHANG JiaWei JIN ShiBo WU Di YAN HaoHao WANG XiaoFeng GUAN ShaoKang | 2018 | Science China(Technological Sciences)2018，61，8： | 7 |
| 19 | Mechanical properties and expansion coefficient of Mo-Cu composites with different Ni contents显示文摘Mo-Cu composites were fabricated by powder metallurgy with addition of various Ni contents.The effect of Ni contents on mechanical and thermal properties of Mo-Cu composites was investigated.The results show that mechanical and thermal properties of Mo-Cu composites are greatly affected by the addition of Ni contents.The composite powders with Ni addition exhibits high sinterability.The sintering temperature is greatly decreased and the comprehensive properties of Mo-Cu composites are obviously improved.Mo-Cu composites with a content of 1.5 wt.% Ni have relative density 99.2%,bending strength 1057.9 MPa,hardness 72.5 HRA,electronic resistivity 1.28×10^(-7)Ω·m^(-1),thermal conductivity 139 W.m^(-1).K^(-1),and lower coefficient of thermal expansion 7.4×10^(-6)K^(-1).Mo-Cu composites have homogeneous and fine microstructure.The fracture mechanism is ductile fracture. | Guo, Shibo Kang, Qiping Cai, Chunbo Qu, Xuanhui | 2012 | Rare Metals2012，31，4： | 7 |
| 20 | Design of hierarchical, three-dimensional free-standing single-atom electrode for H2O2 production in acidic media显示文摘Electrochemical reduction of molecular O2 to hydrogen peroxide(H2O2)offers a promising solution for water purification and environmental remediation.Here,we design a hierarchical free-standing single-Co-atom(with Co-N4 coordination)electrode for oxygen reduction reaction(ORR)via a two-electron pathway to make H2O2 in acidic media.The current density of the single-Co-atom electrode reached 51 mA/cm2 at 0.1 V vs reversible hydrogen electrode,lasting for more than 10 hours of continuous operation with H2O2 selectivity greater than 80%.Toward practical application,the single-Co-atom electrode was directly used to assemble an electrochemical cell to produce H2O2 at a rate of 676 mol/kgcat/h with a cell voltage of about 1.6 V. | Jincheng Zhang Hongbin Yang Jiajian Gao Shibo Xi Weizheng Cai Junming Zhang Ping Cui Bin Liu | 2020 | Carbon Energy2020，2，2： | 6 |
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