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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Effect of Thermal Treatment on the Properties of TEMPO Oxidized Cellulose Film for the Flexible Substrate of Solar Cell显示文摘The 2,2,6,6-tetramethylpiperidine-1-oxyl(TEMPO)oxidized cellulose film(TOCF)has been attempted to be used as a substrate in electronic and optoelectronic devices,but the changes in the TOCF properties before and after annealing treatment have usually been neglected during device fabrication.In this study,TOCF was treated in different atmospheres(air,vacuum,and N2)and at different temperatures,and the properties were investigated.The results indicate that the optical properties are slightly affected by atmosphere and temperature;only slight transmittance loss and haze increase have been observed when TOCF is exposed to an air atmosphere at temperatures of above 120℃.In contrast to the slight effects on the optical properties,cellulose degradation and a loss of film strength have been observed regardless of the atmosphere used when placed at temperatures of above 100℃.Specifically,TOCF was exposed to air,followed by N2 and vacuum atmospheres.Additional Fourier transform infrared(FT-IR)and nuclear magnetic resonance(NMR)results showed that increasing the temperature had no significant effect on the structure of TOCF.Therefore,the annealing temperature should be controlled at a temperature of lower than 100℃and a vacuum atmosphere is preferred. | Changmei Lin Hui Zhang Qidu Deng Liulian Huang Xiaojuan Ma Shilin Cao | 2020 | Paper And Biomaterials2020，5，3： | 2 |
| 3 | Preparation of Starch-Fatty Acid Modified Clay and Its Application in Packaging Paper显示文摘 | Cao Shilin Song Delong Deng Yulin | 2011 | Industrial & Engineering Chemistry Research2011，50，9： | 1 |
| 4 | Preparation of starch-fatty acid modified clay and its application in packaging papers显示文摘 | Shilin Cao Delong Song Yulin Deng | 2011 | In- dustrial & Engineering Chemistry Research2011，50，9： | 1 |
| 5 | Preparation of Starch Fatty Acid Modi-fied Clay and Its Application in Packaging Papers显示文摘 | Cao Shilin Song Delong | 2011 | Industrial& Engineering Chemistry Research2011，50，： | 1 |
| 6 | Structural design of a practical suspen-dome 显示文摘 | Zhang Zhihong Cao Qingshuai Dong Shilin Fu Xueyi | 2008 | International Journal Advanced Steel Construction2008，4，4： | 1 |
| 7 | Structural design of a practical suspendome 显示文摘 | Zhang Zhihong Cao Qingshui Dong Shilin Fu Xueyi | 2008 | Advanced Steel Construction2008，4，4： | 1 |
| 8 | Preparation of Starch a Fatty Acid Modified Clay and Its Application in Packaging Papers 显示文摘 | Cao Shilin Song Delong Deng Yulin | 2011 | Ind Eng Chem Res2011，50，： | 1 |
| 9 | Structural Characteristics of Cellulose and Xylan during in vitro Fermentation by Pig Fecal Bacteria显示文摘In this study,cellulose and xylan were in vitro fermented by pig fecal bacteria.Rapid fermentation(40 h) and extended fermentation(eight weeks)were performed.The properties and ultra-structure changes of post-fermented solid residues were studied.In the end effluent,acetic acid,propionic acid,and butyric acid were observed to be the principal short-chain fatty acids(SCFAs) produced by anaerobic fermentation.Xylan was more accessible to bacteria than cellulose,leading to higher SCFA and lactic acid production.In addition,the crystalline structure of cellulose changed,leading to 16.3% and42.1% increases in crystallinity index for rapid and extended fermentation,respectively.Through this research,a systematic and advanced method to study the degradation chemistry of cellulose and xylan during fermentation was developed. | Ling Meng ShiLin Cao XiaoJuan Ma LiHui Chen LiuLian Huang Fang Huang | 2016 | Paper And Biomaterials2016，1，2： | 0 |
| 10 | Laparoscopic vs open radical resection in management of gallbladder carcinoma:A systematic review and meta-analysis显示文摘BACKGROUND Radical resection offers the only hope for the long-term survival of patients with gallbladder carcinoma(GBC)above the T1b stage.However,whether it should be performed under laparoscopy for GBC is still controversial.AIM To compare laparoscopic radical resection(LRR)with traditional open radical resection(ORR)in managing GBC.METHODS A comprehensive search of online databases,including Medline(PubMed),Cochrane Library,and Web of Science,was conducted to identify comparative studies involving LRR and ORR in GBCs till March 2023.A meta-analysis was subsequently performed.RESULTS A total of 18 retrospective studies were identified.In the long-term prognosis,the LRR group was comparable with the ORR group in terms of overall survival and tumor-free survival(TFS).LRR showed superiority in terms of TFS in the T2/tumor-node-metastasis(TNM)Ⅱstage subgroup vs the ORR group(P=0.04).In the short-term prognosis,the LRR group had superiority over the ORR group in the postoperative length of stay(POLS)(P<0.001).The sensitivity analysis showed that all pooled results were robust.CONCLUSION The meta-analysis results show that LRR is not inferior to ORR in all measured outcomes and is even superior in the TFS of patients with stage T2/TNMⅡdisease and POLS.Surgeons with sufficient laparoscopic experience can perform LRR as an alternative surgical strategy to ORR. | Shilin He Tu-Nan Yu Jia-Sheng Cao Xue-Yin Zhou Zhe-Han Chen Wen-Bin Jiang Liu-Xin Cai Xiao Liang | 2023 | World Journal of Clinical Cases2023，11，27： | 0 |
| 11 | Lignin extraction and recovery in hydrothermal pretreatment of bamboo显示文摘A significant amount of lignin and hemicellulose are dissolved in the hydrothermal treatment of biomass.The hemicellulose can be recovered and utilized for value-added products.The dissolved lignin can undergo depolymerization and condensation reactions,and interferes with the separation and purification process for hemicellulose recovery.This paper investigated the behavior of the lignin extracted from the hydrothermal pretreatment of bamboo and its contributions to the physical characteristics of the hydrolysate.It was found that the turbidity of the hydrolysate was strongly associated with the lignin fragments and suspended long chain hemicelluloses.As the lignin depolymerization and condensation reactions occurred simultaneously,the dissolved lignin fractions in the hydrolysate increased first and then decreased.The molecular weight(MW)of the dissolved lignin fragments ranged from 3342~5611 g/mol,with mainly guaiacyl(G)and syringyl(S)unit in the structure. | Xin Zheng Xiaojuan Ma Lihui Chen Liulian Huang Shilin Cao Joseph Nasrallah | 2016 | Journal of Bioresources and Bioproducts2016，1，3： | 0 |
| 12 | Spatial Pattern and Heterogeneity of Port & Shipping Service Enterprises in the Yangtze River Delta,2002–2016显示文摘Using the ‘theoretical hypothesis—empirical study—case verification' method, this paper studies the spatial distribution and differentiation of port & shipping service enterprises(PSSE), as well as the variation process and underlying mechanism in the Yangtze River Delta(YRD). First, through inductive and deductive reasoning, we propose the following hypothesis: the regional distribution of different types of PSSE would show different spatial agglomeration-decentralization tendency; and there would be distinct regional differentiation in the industrial structure of the enterprises. Second, based on data obtained from enterprises, empirical research is conducted using Gini coefficient and spatial interpolation simulation methods. Results show that: 1) The overall enterprise distribution is decentralized within a city. 2) Different types of enterprises show different spatial agglomeration-decentralization tendencies. At 3000 m×3000 m grid scale, there is an agglomeration tendency along seas and rivers in the spatial distribution of enterprises. Shanghai has been identified consistently as a hot spot. 3) There is significant regional differentiation in 12 port cities with respect to the industrial structures of enterprises. Finally, the transportization and the increase of shipping service demand, the globalization and the expansion of multinational corporate activities, the hierarchization and the cooperation among port cities as well as the decentralization and the behavioral difference between the central and local states can be seen as main driving mechanism of the spatial phenomenon. | CAO Youhui JIANG Ziran YE Shilin WU Wei LIANG Shuangbo | 2019 | Chinese Geographical Science2019，29，3： | 0 |
| 13 | Reproductive Behaviors and Pairing Modes of Odontotermes fomosanus(Shiraki)Alates显示文摘[Objectives] To study the reproductive behaviors and the effect of different pairing modes on the developmental status of incipient colonies' of Odontotermes fomosanus( Shiraki). [Methods]We observed the reproductive behaviors of male alates,female alates and mated alates respectively. Male and female alates had 9 pairing modes and founded 170 incipient colonies under laboratory conditions. The effect of pairing mode on incipient colonies' developmental status was analyzed. [Results]Two peaking hours of mating activity within the daily circadian rhythm of alate activity appeared from 09: 00 to 10: 00,and from 21: 00 to 22: 00,respectively. Courtship behavior before mating consisted of touching with antennae,connecting into a ring( head-to-end),and licking. The reproductive behavior( calling,pairing,tandem,mating and oviposition) of nestmate pairs was different to that of non-nestmate pairs. The pairing time of non-nestmate pairs was significantly longer than that of alates paired with siblings( P < 0. 05). The non-swarming alates could mate with swarming or non-swarming alates and lay fertile eggs which hatched successfully. However,the survival rate of colonies founded by non-swarming alates was very low. The death rate of incipient colonies was in the range of 0. 61%- 0. 99% after three months,while the death rate of the colonies founded by swarming alates was in the range of 0. 22%- 0. 58%. Females that had been experimentally prevented from mating could lay eggs,but the eggs did not hatch. [Conclusion] There are two distinct hourly peaks of mating activity within each 24 hour period. Incipient colonies founded by outbreeding have the highest probability of survival. | Ji Shilin Ji Baozhong Liu Shuwen Cao Dandan Liu Jiajia Yang Jinjin Zhang Xinwei Zhao Zhengping Wang Liping Ehsan SOLEYMANINEJADIAN | 2014 | Plant Diseases and Pests2014，5，6： | 0 |
| 14 | Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state显示文摘During homeostasis and after injury,adult muscle stem cells(MuSCs)activate to mediate muscle regeneration.However,much remains unclear regarding the heterogeneous capacity of MuSCs for self-renewal and regeneration.Here,we show that Lin28a is expressed in embryonic limb bud muscle progenitors,and that a rare reserve subset of Lin28a^(+)Pax7^(-)skeletal MuSCs can respond to injury at adult stage by replenishing the Pax7^(+)MuSC pool to drive muscle regeneration.Compared with adult Pax7^(+)MuSCs,Lin28a^(+)MuSCs displayed enhanced myogenic potency in vitro and in vivo upon transplantation.The epigenome of adult Lin28a^(+)MuSCs showed resemblance to embryonic muscle progenitors.In addition,RNA-sequencing revealed that Lin28a^(+)MuSCs co-expressed higher levels of certain embryonic limb bud transcription factors,telomerase components and the p53 inhibitor Mdm4,and lower levels of myogenic differentiation markers compared to adult Pax7^(+)MuSCs,resulting in enhanced self-renewal and stress-response signatures.Functionally,conditional ablation and induction of Lin28a^(+)MuSCs in adult mice revealed that these cells are necessary and sufficient for efficient muscle regeneration.Together,our findings connect the embryonic factor Lin28a to adult stem cell self-renewal and juvenile regeneration. | Peng Wang Xupeng Liu Ziyue Yao Yu Chen Lanfang Luo Kun Liang Jun-Hao Elwin Tan Min-Wen Jason Chua Yan-Jiang Benjamin Chua Shilin Ma Liping Zhang Wenwu Ma Shuqing Liu Wenhua Cao Luyao Guo Lu Guang Yuefan Wang He Zhao Na Ai Yun Li Chunwei Li Ruiqi Rachel Wang Bin Tean Teh Lan Jiang Kang Yu Ng Shyh-Chang | 2023 | Cell Research2023，33，9： | 0 |
| 15 | The Metasequoia genome and evolutionary relationships among redwoods显示文摘Redwood trees(Sequoioideae),including Metasequoia glyptostroboides(dawn redwood),Sequoiadendron giganteum(giant sequoia),and Sequoia sempervirens(coast redwood),are threatened and widely recognized iconic tree species.Genomic resources for redwood trees could provide clues to their evolutionary relationships.Here,we report the 8-Gb reference genome of M.glyptostroboides and a comparative analysis with two related species.More than 62%of the M.glyptostroboides genome is composed of repetitive sequences.Clade-specific bursts of long terminal repeat retrotransposons may have contributed to genomic differentiation in the three species.The chromosomal synteny between M.glyptostroboides and S.giganteum is extremely high,whereas there has been significant chromosome reorganization in S.sempervirens.Phylogenetic analysis of marker genes indicates that S.sempervirens is an autopolyploid,and more than 48%of the gene trees are incongruent with the species tree.Results of multiple analyses suggest that incomplete lineage sorting(ILS)rather than hybridization explains the inconsistent phylogeny,indicating that genetic variation among redwoods may be due to random retention of polymorphisms in ancestral populations.Functional analysis of ortholog groups indicates that gene families of ion channels,tannin biosynthesis enzymes,and transcription factors for meristem maintenance have expanded in S.giganteum and S.sempervirens,which is consistent with their extreme height.As a wetland-tolerant species,M.glyptostroboides shows a transcriptional response to flooding stress that is conserved with that of analyzed angiosperm species.Our study offers insights into redwood evolution and adaptation and provides genomic resources to aid in their conservation and management. | Fangfang Fu Chi Song Chengjin Wen Lulu Yang Ying Guo Xiaoming Yang Ziqiang Shu Xiaodong Li Yangfan Feng Bingshuang Liu Mingsheng Sun Yinxiao Zhong Li Chen Yan Niu Jie Chen Guibin Wang Tongming Yin Shilin Chen Liangjiao Xue Fuliang Cao | 2023 | Plant Communications2023，4，6： | 0 |
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