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| 1 | Multiple interferences suppression with space-polarization null-decoupling for polarimetric array显示文摘The adaptive digital beamforming technique in the space-polarization domain suppresses the interference with forming the coupling nulls of space and polarization domain.When there is the interference in mainlobe,it will cause serious mainlobe distortion,that the target detection suffers from.To overcome this problem and make radar cope with the complex multiple interferences scenarios,we propose a multiple mainlobe and/or sidelobe interferences suppression method for dual polarization array radar.Specifically,the proposed method consists of a signal preprocessing based on the proposed angle estimation with degree of polarization(DoP),and a filtering criterion based on the proposed linear constraint.The signal preprocessing provides the accurate estimated parameters of the interference,which contributes to the criterion for null-decoupling in the space-polarization domain of mainlobe.The proposed method can reduce the mainlobe distortion in the space-polarization domain while suppressing the multiple mainlobe and/or sidelobe interferences.The effectiveness of the proposed method is verified by simulations. | LU Yawei MA Jiazhi SHI Longfei QUAN Yuan | 2021 | Journal of Systems Engineering and Electronics2021，32，1： | 5 |
| 2 | Effectiveness and safety of Ginkgo biloba extract(GBE50)in the treatment of dizziness caused by cerebral arteriosclerosis:a multi-center,double-blind,randomized controlled trial显示文摘OBJECTIVE:To evaluate the effectiveness and safety of Ginkgo biloba extract(GBE50)in the treatment of dizziness caused by cerebral arteriosclerosis.METHODS:This was a multi-center,double-blind,double-dummy,positive-controlled,parallel randomized controlled clinical trial with 1∶1 allocation.We recruited 404 patients with dizziness caused by cerebral arteriosclerosis(blood stasis symptom pattern)in 10 hospitals in China.GBE50 group received GBE50 and Naoxinqing tablet(NXQ)of mimetic agent,control group received NXQ and GBE50 of mimetic agent.The main outcome was Traditional Chinese Medicine(TCM)symptom pattern score of blood stasis after 6 weeks.The secondary outcomes were changes in the dizziness handicap inventory(DHI)score,vertigo visual analogue scale(VAS)score,the university of California vertigo questionnaire(UCLA-DQ)score and single-item symptom score of TCM from baseline to 2,4 and 6 weeks.Safety indicators included the incidence of adverse events,severe adverse events and laboratory examination including blood routine,liver function,renal function,and so forth.RESULTS:The total effective rate of TCM symptom pattern score in the GBE50 group after 6 weeks of treatment was higher than that in the control group,the difference in rate was statistically significant(92.67%vs 83.07%,P=0.004).Compared with the control group,there was no difference in the incidence of adverse reactions(9.95%vs 14.85%,P=0.136).CONCLUSION:The treatment of dizziness caused by cerebral arteriosclerosis with GBE50 is effective,safe and reliable. | SHA Rina TANG Lu DU Yawei WU Shengxian SHI Huawei ZOU Hongxin ZHANG Xuran DONG Xinglu ZHOU Li | 2022 | Journal of Traditional Chinese Medicine2022，42，1： | 5 |
| 3 | Glucagon-like peptide 1 reverses myocardial hypertrophy through cAMP/PKA/RhoA/ROCK2 signaling显示文摘Myocardial hypertrophy is a major pathological and physiological process during heart failure.Glucagon-like peptide 1(GLP-1)is a glucagon incretin hormone released from the gut endocrine L-cells that has protective effects on various cardiovascular diseases,in eluding hyperte nsion,atherosclerosis,and myocardial hypertrophy.However,the protective mechanisms of GLP-1 in myocardial hypertrophy remain unclear.Here,we showed that the GLP-1 agonist liraglutide and dipeptidyl peptidase 4 inhibitor alogliptin decreased heart weight and cardiac muscle cell volume in spontaneously hypertensive rats(SHR).In H9C2 cell hypertensive models induced by angiotensin II,GLP-1 treatment reduced myocardial cell volume,inhibited the expressions of atrial natriuretie peptide,brain/B-type natriuretic peptide,p-myosin heavy chain,RhoA,and ROCK2,and decreased MLC and MYPT1 phosphorylation.When H9C2 cells were treated with H89,a PKA inhibitor,the inhibitory effect of GLP-1 disappeared,while the inhibitory role was enhaneed under the treatment of Y-27632,a ROCK2 inhibitor.These results suggested that GLP-1 might reverse myocardial hypertrophy through the PKA/RhoA/ROCK2 signaling pathway. | Shaohua Fan Qianfeng Xiong Xin Zhang Lihui Zhang Yawei Shi | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 2 |
| 4 | PC4 serves as a negative regulator of skin wound healing in mice显示文摘Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role of PC4 in skin wound healing through PC4 knock-in mouse model.Methods:A PC4 knock-in mouse model(PC4^(+/+))with a dorsal full-thickness wound was used to investigate the biological functions of PC4 in skin wound healing.Quantitative PCR,Western blot analysis and immunohistochemistry were performed to evaluate the expression of PC4;Sirius red staining and immunofluorescence were performed to explore the change of collagen deposition and angiogenesis.Proliferation and apoptosis were detected using Ki67 staining and TUNEL assay.Primary dermal fibroblasts were isolated from mouse skin to perform cell scratch experiments,cck-8 assay and colony formation assay.Results:The PC4^(+/+)mice were fertile and did not display overt abnormalities but showed an obvious delay in cutaneous healing of dorsal skin.Histological staining showed insufficient re-epithelialization,decreased angiogenesis and collagen deposition,increased apoptosis and decreased cell proliferation in PC4^(+/+)skin.Our data also showed decreased migration rate and proliferation ability in cultured primary fibroblasts from PC4^(+/+)mice in vitro.Conclusions:This study suggests that PC4 might serve as a negative regulator of skin wound healing in mice. | Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 1 |
| 5 | Glucagon-like peptide-1 attenuates cardiac hypertrophy via the AngII/AT1R/ACE2 and AMPK/mTOR/p70S6K pathways显示文摘Glucagon-like peptide-1(GLP-1),a novel type of glucose-lowering agent,has been reported to exert cardioprotective effects.However,the cardioprotective mechanism of GLP-1 on spontaneous hypertension-induced cardiac hypertrophy has not been fully elucidated.In this study,we revealed that liraglutide or alogliptin treatment ameliorated spontaneous hypertension-induced cardiac hypertrophy,as evidenced by decreased levels of cardiac hypertrophic markers(atrial natriuretic peptide,brain natriuretic peptide,andβ-myosin heavy chain),as well as systolic blood pressure,diastolic blood pressure,mean arterial pressure,and histological changes.Both drugs significantly reduced the levels of angiotensin II(AngII)and AngII type 1 receptor(AT1R)and upregulated the levels of AngII type 2 receptor(AT2R)and angiotensin-converting enzyme 2(ACE2),as indicated by a reduced AT1R/AT2R ratio.Simultaneously,treatment with liraglutide or alogliptin significantly increased GLP-1 receptor expression and adenosine monophosphate-activated protein kinase(AMPK)phosphorylation and downregulated the phosphorylation of mammalian target of rapamycin(mTOR),p70 ribosomal S6 protein kinase,and eukaryotic translation initiation factor 4E binding protein 1 in spontaneous hypertension rats.Furthermore,our data demonstrated that the AMPK inhibitor compound C or mTOR activator MHY1485 inhibited the anti-hypertrophic effect of GLP-1.In summary,our study suggests that liraglutide or alogliptin protects the heart against cardiac hypertrophy by regulating the expression of AngII/AT1R/ACE2 and activating the AMPK/mTOR pathway,and GLP-1 agonist can be used in the treatment of patients with cardiac hypertrophy. | Jing Wang Shaohua Fan Qianfeng Xiong Yu Niu Xin Zhang Junnan Qin Yawei Shi Lihui Zhang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 1 |
| 6 | Perchlorate in sewage sludge, rice, bottled water and milk collected from different areas in China显示文摘 | Yali Shi Ping Zhang Yawei Wang Jianbo Shi Yaqi Cai Shifen Mou Guibin Jiang | 2007 | Environment International2007，，7： | 1 |
| 7 | Study on the contamination of heavy metals and their correlations in mollusks collected from coastal sites along the Chinese Bohai Sea显示文摘 | Yawei Wang Lina Liang Jianbo Shi | 2005 | Environment International2005，31，： | 1 |
| 8 | Efficient adsorptive removal of dibenzothiophene from model fuel over heteroatom-doped porous carbons by carbonization of an organic salt显示文摘 | Shi Yawei Liu Guozhu Wang Li | 2015 | Chem Eng J2015，259，： | 1 |
| 9 | Study on the contamination of heavy metals and their correlations in mollusks collected from coastal sites along the Chinese Bohai Sea显示文摘 | WANG Yawei LIANG Lina SHI Jianbo | 2005 | Environmental International2005，31，8： | 1 |
| 10 | Presence of organophosphate flame retardants(OPEs)in different functional areas in residential homes in Beijing,China显示文摘The production and application of organophosphate esters(OPEs)have dramatically increased in recent years due to their use as a replacement for brominated flame retardants.In this study,13 OPEs(∑_(13)OPEs)were analyzed in indoor air samples from kitchens and living rooms in 14 residential homes in Beijing,China.The concentrations of ∑_(13)OPEs in kitchen air samples(mean:13 ng/m^(3))were significantly(p<0.05)higher than in living room air samples(5.0 ng/m^(3)).In addition,paired window surface organic film samples were collected and analyzed to investigate film-air partitioning,exhibiting a mean concentration of ∑_(13)OPEs of 4100 ng/m^(2).The congener profiles showed that tris(2-chloroisopropyl)phosphate(TCPP)was the predominant compound in both window film samples(48%)and the corresponding indoor air sample(56%).The estimated daily intakes(EDI)of OPEs via indoor air inhalation were 2.8 and 1.4 ng/kg/day for infants and adults,respectively,both of which are below the reference dose values(RfDs).Overall,these findings indicate that OPEs in the indoor air environment of residential homes in Beijing are not likely to pose a health risk to the general population. | Kun Lv Lu Bai Boyu Song Xindong Ma Minmin Hou Jie Fu Yali Shi Yawei Wang Guibin Jiang | 2022 | Journal of Environmental Sciences2022，34，5： | 1 |
| 11 | Intermolecular disulfide bond in the dimerization of S-periaxin mediated by Cys88 and Cys139显示文摘Periaxin 在哺乳动物的 Schwann 房间和透镜纤维房间被表示,并且为联系细胞骨架的蛋白质在一幅屏幕被识别了。Charcot-Marie-Tooth 4F 被 periaxin 基因的损失或变化引起。也就是, periaxin 基因编码二蛋白质 isoforms L-periaxin 和 S-periaxin。S-periaxin 包含 147 氨基酸残余并且有一个 N 终端 PDZ 领域。在这份报纸, S-periaxin 被报导是通过有它在温和氧化条件下面的 Cys88 和 Cys139 残余的分子间的二硫化物契约的形成的 homodimerized。S-periaxin 更暗淡的共有原子价被西方的污点分析和双分子的荧光互补分析也观察。S-periaxin dimerization 形成能被细胞的氧化还原作用变化调整。这些结果把可能的机制提供给 periaxin 建筑群,复杂稳定性的改进,和在细胞外的矩阵和细胞骨架之间的一个连接的建立的形成。 | Yan Yang Yemei Ren Yawei Shi | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 1 |
| 12 | Perchlorate in sewage sludge,rice,bottled water and milk collected from different areas in China显示文摘 | Shi Yali Zhang Ping Wang Yawei | 2007 | Environment International2007，33，： | 1 |
| 13 | Zinc binding site inPICK1 is dominantly located at the CPC motif of its PDZ domain显示文摘 | SHI Yawei ZHANG Lei YUAN Jingming | 2008 | JNeurochem2008，106，3： | 1 |
| 14 | MicroRNA‐191, by promoting the EMT and increasing CSC‐like properties, is involved in neoplastic and metastatic properties of transformed human bronchial epithelial cells显示文摘 | Wenchao Xu Jie Ji Yuan Xu Yawei Liu Le Shi Yi Liu Xiaolin Lu Yue Zhao Fei Luo Bairu Wang Rongrong Jiang Jianping Zhang Qizhan Liu | 2015 | Carcinog2015，，1： | 1 |
| 15 | Occurrence of perfluorinated compounds in fish from Qinghai-Tibetan Plateau显示文摘 | Yali Shi Yuanyuan Pan Ruiqiang Yang Yawei Wang Yaqi Cai | 2009 | Environment International2009，，1： | 1 |
| 16 | Perchlorate in sewage sludge, rice, bottled water and milk collected from different areas in China显示文摘 | Shi YaLi Zhang Ping Wang Yawei | 2007 | Environment International2007，33，7： | 1 |
| 17 | Perchlorate in sewage sludge, rice, bottled water and milk collected from different areas in China显示文摘 | Yali Shi Ping Zhang Yawei Wang Jianbo Shi Yaqi Cai Shifen Mou Guibin Jiang | 2007 | Environment International2007，，7： | 1 |
| 18 | UTI: a double-function inhibitor isolated from naked flax seeds显示文摘Acute glucose fluctuation during the postprandial period causes a risk fo r type 2 diabetes m ellitus(T2DM).a-Glucosidase inhibitors have been approved as therapeutic agents fo r diabetes.In the present study,a protein w ith a-glucosidase inhibitory activity from Flax(Linum usitatissimum)seeds was isolated using a one-step purification w ith Q-Sepharose4B colum n,follow ed by Sephacryl S-200 size-exclusion chromatography.It was identified as a trypsin inhibitor,named L.usitatissimum trypsin inh ibito r(LUTI).The half maximal inhibitory concentration(IC50)of LUTI was 113.92 pM fo r a-glucosidase and 6.17 pM for trypsin.Lineweaver-Burk kinetic experim ent showed that the protein exhibited tw o distinct inhibitory modes,a com petitive inh ibito r type for a-glucosidase and a non-com petitive type fo r trypsin.The interaction between LUTI and aglucosidase was detected through gel filtration chromatography and dynam ic light scattering.Increased glucose consum ption and lactic acid production were also observed fo llo w in g LUTI treatm ent in Caco-2 and HepG2 cells.LUTI inhibits not only the activity of trypsin but also the activity of a-glucosidase.It is expected that LUTI w ill become an oral hypoglycem ic polypeptide drug fo r T2DM. | Lei Wang Yinglu Chen Feng Wu Shasha Wu Xiaojun Hu Yawei Shi | 2019 | Acta Biochimica et Biophysica Sinica2019，51，10： | 0 |
| 19 | Sirt6通过表观遗传调控Wnt信号通路控制造血干细胞的稳态显示文摘Wnt信号通路对造血干细胞稳态的维持是至关重要的,但Wnt信号在造血干细胞中的表观遗传调控规律仍然是未知的。 | 汪虎 Daojun Diao Zhencan Shi Xudong Zhu Yawei Gao Shaorong Gao Xiaoyu Liu You Wu K.Lenhard Rudolph Guanghui Liu Tangliang Li 鞠振宇 | 2017 | 科学新闻2017，19，4： | 0 |
| 20 | Design and evaluation of chitosan-amino acid thermosensitive hydrogel显示文摘Chitosan/glycerophosphate thermosensitive hydrogel crosslinked physically was a potential drug delivery carrier;however, long gelation time limits its application. Here, chitosan-amino acid (AA) thermosensitive hydrogels were prepared from chitosan (CS), αβ-glycerophosphate (GP), and L-lysine (Lys) or L-glutamic acid (Glu). The prepared CS-Lys/GP and CS-Glu/GP hydrogel showed good thermosensitivity and could form gels in a short time. The optimal parameters of CS-Lys/GP hydrogel were that the concentration of CS-Lys was 2.5%, the ratio of CS/Lys was 3.5/1.0, the ratio of CS-Lys/GP was 4.5/1.0. The optimal parameters of CS-Glu/GP hydrogel were that the concentration of CS-Glu was 3.0%, the ratio of CS/Glu was 2.0/1.0, and the ratio of CS-Glu/GP was 4.0/1.5. Chitosan-amino acid (CS-AA) thermosensitive hydrogel had a three-dimensional network structure. The addition of model drug tinidazole (TNZ) had no obvious effect on the structure of hydrogel. The results of infrared spectroscopy showed that there were hydrogen bonds between amino acids and chitosan. In vitro release results showed that CS-Lys/GP and CS-Glu/GP thermosensitive hydrogels had sustained release effects. Thus, the chitosan-amino acid thermosensitive hydrogels hold great potential as a sustained release drug delivery system. | Jianan Tong Huiyun Zhou Jingjing Zhou Yawei Chen Jing Shi Jieke Zhang Xinyu Liang Tianyuan Du | 2022 | Marine Life Science & Technology2022，4，1： | 0 |
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