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| 1 | Use of Sargassum fusiforme Extract and its Bioactive Molecules to inhibit HIV Infection: Bridging Two Paradigms between Eastern and Western Medicine显示文摘AIDS is a global pandemic that has seen the development of novel and effective treatments to improve the quality of life of those infected and reduction in the spread of the disease. While great advancements have been made in HIV/AIDS therapeutics, there is still no cure or viable vaccine in development. The high rate of HIV-1 mutation contributing to virus immune escape, combined with increase in sexual transmission and the significant clinical therapeutics side effects of the currently available treatments highlights the need for novel therapeutics with broad anti-viral activity against both CXCR4(X4) and CCR5(R5)-tropic viruses. In our search for novel modalities against HIV infection, we investigated several aqueous extracts from Traditional Chinese Medicine(TCM) collection and identified Sargassum fusiforme(S. fusiforme) as a potent inhibitor of HIV infection. Following the Western approach of drug discovery and development, we isolated several bioactive molecules from S. fusiforme and determined their mechanism of action. TCM and Western approaches to disease treatment and drug development have been shown to be complementary to each other. The former provides a rich medicinal history for natural compounds that can have clinical impact on a variety of illnesses, while the latter enables the application of chemical informatics with rational drug design approach coupled to mechanistic underpinnings of such therapeutics. This multistep paradigm is demonstrated in the example of S. fusiforme as a treatment to prevent HIV infection, as described in this review. | Hui-jun Guo Yan-ze Liu Elena E.Paskaleva Manoj Arra Jeffrey S.Kennedy Alexander Shekhtman Mario Canki | 2014 | Chinese Herbal Medicines2014，6，4： | 3 |
| 2 | 非球面非零位横向剪切干涉检测与波前重建显示文摘本文分析了非球面非零位检测中3种典型的非球面度及其变化率、调整误差、回程误差以及干涉仪系统误差,提出了非球面度变化率是影响检测误差的主要因素,并给出了非球面非零位检测面形加工误差的确定方法.对基于Zernike多项式拟合的最小二乘法和系数转换法进行了对比研究,分析了剪切量和多项式拟合阶数对波前重建精度的影响,并给出了数值模拟结果.为了验证以上方法的可行性及检测精度,针对一单点金刚石车削的抛物面反射镜,利用顶点球作为测试波前进行非零位横向剪切干涉检测,并用最小二乘法进行波前重建.实验结果表明,在非球面度变化率最大的反射镜边缘处面形误差最大,达到0.203μm,研究结果为横向剪切干涉仪用于非球面加工过程中在位检测提供了技术支撑. | 王起维 董申 孙涛 韩成顺 Shekhtman V N | 2013 | 纳米技术与精密工程2013，11，3： | 3 |
| 3 | IL-6 media- ted degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase 显示文摘 | Dugan L L Ali S S Shekhtman G | 2009 | PLoS One2009，4，5： | 1 |
| 4 | Treat- ment of basilar tip aneurysms with horizontal PCA to PCA stent-assisted coiling: case series 显示文摘 | Blackburn SL Kadkhodayan Y Shekhtman E | 2013 | J Neurointerv Surg2013，5，3： | 1 |
| 5 | Formation of Alloys in Ti-V System in Hydride Cycle and Synthesis of Their Hydrides in Self-propagating High-temperature Synthesis Regime显示文摘 | AIeksanyan A G Dolukhanyan S K Shekhtman V S | 2011 | J Alloys Compd2011，509，： | 1 |
| 6 | Intraarterial injection of verapamil in treatment of cerebral vasospasm in a patient with acute subarachnoid hemorrhage from an aneurysm:case report显示文摘 | Mikeladze KG Eliava Sh Sh Shekhtman OD | 2013 | Zh Vopr Neirokhir Im N N Burdenko2013，77，4： | 1 |
| 7 | High Pressure Opera- tion of the Triple-GEM Detector in PureNe, Ar and Xe显示文摘 | Bondar A Buzulutskov A Shekhtman L | 2003 | Nuclear Instruments and Methods in Physics Research 4812003，481，： | 1 |
| 8 | The receptor for advanced glycation end products (RAGE) specifically rec- ognizes methylglyoxal-derived AGEs 显示文摘 | XUE J RAY R SHEKHTMAN A | 2014 | Biochemistry2014，53，20： | 1 |
| 9 | Tooth fillet profile optimization for gears with symmetric and asymmetric teeth显示文摘 | KAPELEVICH A SHEKHTMAN Y | 2009 | Gear Technology2009，26，7： | 1 |
| 10 | AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function显示文摘 | Dugan Laura L You Young-Hyun Ali Sameh S Diamond-Stanic Maggie Miyamoto Satoshi DeCleves Anne-Emilie Andreyev Aleksander Quach Tammy Ly San Shekhtman Grigory Nguyen William Chepetan Andre Le Thuy P Wang Lin Xu Ming Paik Kacie P Fogo Agnes | 2013 | Journal of Clinical Investigation2013，，11： | 1 |
| 11 | Mo- lecular mechanism of the chaperone function of mini-alpha- crystallin,a 19-residue peptide of human alpha-crystallin显示文摘 | BANERJEE PR PANDE A SHEKHTMAN A PANDE J | 2015 | Biochemistry2015，54，2： | 1 |
| 12 | Intra-arteri- al injection of verapamil in treatment of cerebral vasospasm in a patient with acute subarachnoid hemorrhage from an aneu-rysm: case report显示文摘 | Mikeladze KG Eliava ShSh Shekhtman OD | 2013 | Zh Vopr Neirokhir Im N N Burdenko2013，77，4： | 1 |
| 13 | The role of topoisomerase IV in partitioning bacterial replicons and the structure of catenated intermediates in DNA replication显示文摘 | Adams D E Shekhtman E M Zechiedrich E L | 1992 | Cell1992，71，2： | 1 |
| 14 | Complex transition metal hydrides and hydride-nitrides prepared by SHS. I. Systems involving nitrogen显示文摘 | A. G. Aleksanyan A. G. Akopyan V. M. Beibutyan O. P. Ter-Galstyan S. K. Dolukhanyan V. Sh. Shekhtman | 1999 | Powder Metallurgy and Metal Ceramics (-)1999，，1： | 1 |
| 15 | Gear Tooth Fillet Profile Optimization显示文摘 | Alex Kapelevich Yuriy Shekhtman | 2009 | Gear Solutions2009，，9： | 1 |
| 16 | Treat ment of basilar tip aneurysms with horizontal PCA to PCA stent assisted coiling:case series显示文摘 | Blackburn S L Kadkhodayan Y Shekhtman E | 2013 | J Neurointerv Surg2013，5，3： | 1 |
| 17 | Inside the living cell 显示文摘 | Burz D S Shekhtman A | 2009 | Naturef2009，458，： | 1 |
| 18 | Direct gear design: bending stress minimization 显示文摘 | Yurly V Shekhtman | 2003 | Gear Technology2003，，910： | 1 |
| 19 | Intra-arterial injection of verapamil in treatment of cerebral vasospasm in a patient with acute subarachnoid hemorrhage from an aneurysm:Case report显示文摘 | Mikeladze KG Eliava S Shekhtman OD | 2013 | Zh Vopr Neirokhir Im N N Burdenko2013，77，4： | 1 |
| 20 | Forward modelling and inversion of multi-souree TEM data显示文摘 | Oldenburg D W Haber E Shekhtman R | 2008 | Expanded Abstracts of 78^th Annual Internat SEG Mtg2008，，： | 1 |
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