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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Spectral selectivity in infrared thermal detection显示文摘A review is made of the physics and technology of spectrally selective thermal detectors,especially those operating at non-cryogenic temperatures.The background radiation noise fluctuations are rederived for arbitrary spectral characteristics.Infrared absorption due to phonons and free carriers is discussed followed by a review of published works on artificial infrared absorption materials such as patterned grids,nanoparticles,plasmonic structures,metamaterials and others.Subsequently,the literature of the spectral characteristics of broadband thermal detectors and spectrally selective thermal detectors is reviewed.Finally,the authors speculate on the directions that future research and development in the area will take regarding architectures,sensitivity and spectral characteristics. | Joseph J Talghader Anand S Gawarikar Ryan P Shea | 2012 | Light(Science & Applications)2012，1，1： | 6 |
| 3 | Alcoholic liver disease显示文摘 | O'Shea RS Dasarathy S McCullough AJ | | Hepatology0，，： | 2 |
| 4 | 颈动脉硬化进展与病程≥10年的高血压治疗之间的关系:多种族动脉粥样硬化研究显示文摘尚未有前瞻性多种族队列对抗高血压药物类别和动脉硬化进展的相关性进行研究。该研究所有受试者基线均患高血压,定义为血压≥140/90 mm Hg(1mm Hg=0.133kPa)或服用降压药物治疗。在5个时间点评估药物的服用情况和血压水平。通过超声在基线时和平均随访(9.4±0.5)年后测定右颈总动脉的杨氏弹性模量和扩张系数。 | Gepner AD Tedla Y Colangelo LA Tattersall MC Korcarz CE Kaufman JD Liu K Burke GL Shea S Greenland P Stein JH 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 5 | Propofol increasesagonist efficacy at the GABAA receptor显示文摘 | O′Shea S M Wong L C Harrison N L | 2000 | Brain Research2000，852，2： | 1 |
| 6 | Halide salts acceleratedegradation of high explosives by zerovalent iron 显示文摘 | Kim J S Shea P J Yang J E ef al | 2007 | Environmental Pollution2007，147，3： | 1 |
| 7 | Hyperinsulinemia and risk of Alzheimer disease显示文摘 | Luchsinger JA Tang MX Shea S | 2004 | Neurology2004，63，7： | 1 |
| 8 | The use of medial and lateral surgical approaches for the treatment of tibial plafond fractures 显示文摘 | CHEN L O'SHEA K EARLY J S | 2007 | J Orthop Trauma2007，21，3： | 1 |
| 9 | Adaptations in cortical and trabecular bone in response to mechanical loading with and without weight bearing显示文摘 | WARNER S E SHEA J E MILLER S C | 2006 | Calcif Tissue Int2006，79，6： | 1 |
| 10 | Pilot -scale treatment of RDX-contaminated soil with zerovalent iron显示文摘 | Comfort S D Shea P J Machacek T A | 2003 | J Environ Qual2003，32，： | 1 |
| 11 | But watch out for the weather-factors affecting adherence to progressive resistance exercise for persons with COPD 显示文摘 | O'Shea S D Taylor N F Paratz J D | 2007 | J Cardiopulm Rehabil Prey2007，27，3： | 1 |
| 12 | Remediating munitionscontaminated soil with zerovalent iron and cationic surfactants显示文摘 | Park J Comfort S D Shea P J | 2004 | J Environ Qual2004，33，： | 1 |
| 13 | Surface stress effects on the resonance properties o{ cantilever sen- sors显示文摘 | Lu P Lee H P Lu C O Shea S J | 2005 | Physical Review B2005，72，8： | 1 |
| 14 | Frequency coupling and energy trapping in mesa-shaped muhichannel quartz crystal microbalances显示文摘 | Shen F Lu P O'Shea S J | 2004 | Sens and Actuators A2004，111，： | 1 |
| 15 | Base-excision repair of oxidativeDNA damage显示文摘 | David SS O'Shea VL Kundu S | 2007 | Nature2007，447，7147： | 1 |
| 16 | Socioeconomic position, race/ethnicity, and inflammation in the multi-ethnic study of ath- erosclerosis显示文摘 | Ranjit N Diez-Roux AV Shea S | 2007 | Circulation2007，116，21： | 1 |
| 17 | Microcantilever- based biosensors显示文摘 | Moutin A M O'Shea S J Welland M E | 2000 | Uhramicroscopy2000，82，： | 1 |
| 18 | Alcoholic liver dis- ease显示文摘 | Robert S O' Shea Sfinivasan Dasarathy | 2010 | Hepatology2010，51，： | 1 |
| 19 | Sex differences in the use of implantable cardioverter-defibrillators for primary and secondary prevention of sudden cardiac death显示文摘 | Curtis L H Al-Khatib S M Shea A M | | 0，，： | 1 |
| 20 | The use of uncementedextensively porous-coated femoral componentsin the management of Vancouver B2 and B3 periprostheticfemoral fractures显示文摘 | O'Shea K Quinlan J F Kutty S | | 0，，12： | 1 |
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