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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Diabetic retinopathy显示文摘 | Infeld D A O'Shea J G | 1998 | Postgrad Med J1998，74，： | 1 |
| 3 | Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptorβgene due to activation of Wnt/β-catenin protein signaling显示文摘 | O′SHEA P J KIM D W LOGAN J G | 2012 | J Biol Chem2012，287，17： | 1 |
| 4 | Physical and observational practice afford unique learning opportunities显示文摘 | SHEA C H WRIGHT D L WULF G | 2000 | J Motor Behavior2000，32，： | 1 |
| 5 | Meat-analysis of calcium supplementation for the prevention of postmenopausal osteoporosis 显示文摘 | SHEA B WELLS G GRANNEY A | 2002 | Endocr Rev2002，3，4： | 1 |
| 6 | Medical costs of ab- normal serum sodium levels显示文摘 | Shea A M Hammill B G Curtis L H | 2008 | J Am Soc Nephrol2008，19，4： | 1 |
| 7 | Distribution, seasonality and putative origin of the non-native red alga Bangia atropurpurea ( Bangiales, Rhodophyta) in the Laurentian Great Lakes显示文摘 | Shea T B Sheath R G Chhun A | 2014 | Journal of Great Lakes Research2014，40，1： | 1 |
| 8 | 3D magnetization-prepared trur-FISP: a new technique for imaging coronary arteries 显示文摘 | Deshpande VS Shea SM Laub G | 2001 | Magn Reson Med2001，46，3： | 1 |
| 9 | Ultrastructural changes in the theca interna during follicula atresia in sheep 显示文摘 | O'Shea J D Hay M F Gran D G | 1978 | Repord Fertil1978，54，： | 1 |
| 10 | Child-proof authentication for MIPv6 显示文摘 | Shea G Roe M | 2001 | ACM Computer Communications Review2001，31，2： | 1 |
| 11 | Germination and seeding development of swichgrass and smooth bromegrass exposed to 2,4,6-trinitrotoluene显示文摘 | PETERSON M HORST G L SHEA P J | 1998 | Environ Pollut1998，99，1： | 1 |
| 12 | The Automaticity of Complex Motor Skill Learning as a Function of Attentional Focus,Quarterly显示文摘 | Wulf G McNevin N H Shea C H | 2001 | Journal of Experimental Psychology2001，54，： | 1 |
| 13 | Interest rate term structure estimation with expo- nential splines:a note显示文摘 | SHEA G S | 1985 | The Journal of Finance1985，40，1： | 1 |
| 14 | 3D magnetizatiompre-pared true-FISP: a new technique for imaging coronary arteries显示文摘 | Deshpande VS Shea SM Laub G | 2001 | Magn Reson Med2001，16，3： | 1 |
| 15 | The dentist-patient relationship:perceived dentist behaviors that reduce patient anxiety and increase satisfaction显示文摘 | Corah N L O’Shea R M Bissell G D | 1988 | Jam Dent Assoc1988，116，1： | 1 |
| 16 | Thyroid hormone activates fibroblast growth factor receptor-1 in bone显示文摘 | Stevens DA Harvey CB Scott AJ O'Shea PJ Barnard JC Williams AJ Brady G Samarut J Chassande O Williams GR | | 0，，： | 1 |
| 17 | Development of AMSTAR: A measurement tool to assess systematic reviews 显示文摘 | SHEA B J GRIMSHAW J M WELLS G A | 2007 | BMC Med Res Methodol2007，7，10： | 1 |
| 18 | Defining the pediatrie spinal thoracoscopy leaning curve sixty-five consecutive cases显示文摘 | Newton P O Shea K G Granlund K F | 2002 | Spine2002，25，8： | 1 |
| 19 | Cereal grains, legumes, and weight management:a comprehensive review of the scientific evidence显示文摘 | Williams P. G Gafenauer S. J O'Shea J. E | | 0，，04： | 1 |
| 20 | The effects of kilovoltage on diagnostic accuracy in chest radiography显示文摘 | Evesz G Shea FJ and Kundel HL | 1982 | Radiology1982，142，： | 1 |
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