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| 1 | 卒中存活者体力活动和锻炼建议:美国心脏协会/美国卒中协会针对医疗专业人员的声明显示文摘目的这份科学声明为卒中存活者的体力活动和锻炼建议提供了一份证据纵览。证据提示,卒中存活者会经历体力下降(physical deconditioning)并导致久坐的生活方式。因此,本更新版科学声明旨在为医务人员提供全面的指导,使其更好地理解体力活动的益处,并为卒中存活者各个恢复阶段的锻炼方案提供推荐意见。方法写作组成员由美国心脏协会(American Heart Association,AHA)卒中委员会的科学声明监督委员会和AHA手稿监督委员会任命。作者利用系统文献综述,参考公开发表的临床和流行病学研究、发病率和死亡率报告、临床与公共卫生指南、权威声明、个人文件以及专家意见,对现有的证据进行总结并指出目前的知识空白。结果卒中后体力活动不足非常普遍。大量证据明确支持对卒中存活者进行运动训练,包括有氧运动和力量训练。运动训练能改善功能能力、日常生活活动的执行能力以及生活质量,同时降低随后的心血管事件风险。卒中存活者的体力活动目标和锻炼方案需个体化制定以最大限度地增高长期依从性。结论写作组给出的推荐是,体力活动和锻炼方案应融入卒中存活者的治疗。卒中存活者体力活动的推动应强调低到中等强度的有氧活动、增强肌肉力量、减少久坐的生活方式以及对卒中二级预防的危险因素管理。 | Sandra A. Billinger Ross Arena Julie Bemhardt Janice J. Eng Barry A. Franklin Cheryl Mortag Johnson Marilyn MacKay-Lyons Richard F. Macko Gillian E. Mead Elliot J. Roth Marianne Shaughnessy Ada Tang 孙新亭 张通 | 2014 | 国际脑血管病杂志2014，22，10： | 80 |
| 2 | XRCC1 and DNA polymerase β in cellular protection against cytotoxic DNA single-strand breaks显示文摘 | Julie K Horton Mary Watson Donna F Stefanick Daniel T Shaughnessy Jack A Taylor Samuel H Wilson | 2008 | Cell Research2008，18，1： | 17 |
| 3 | 如何撰写循证临床综述显示文摘传统临床综述不同于系统评价和Meta分析。临床综述是在广泛讨论某一主题时选择性评价医学文献;非定量系统评价则全面评价医学文献,收集并综合所有相关信息以形成最佳诊疗方案;而Meta分析(即定量系统评价)是采用严格的统计学方法分析汇总的研究资料,以回答某一具体的临床问题。本文旨在为《美国家庭医生》撰写循证临床综述提供指南。首先,主题应与家庭医疗实践相关,并能引起普遍兴趣。接着,用表格列出综述的继续医学教育目标。描述文献检索过程,列举循证医学评价的多种来源,如Cochrane协作网、BMJ临床证据网或InfoRetriever网。尽可能使用与发病率、病死率或生活质量相关的临床结局证据及基于初级保健人群研究的证据。向《美国家庭医生》投稿时,应根据以下标准划分支持重要建议的证据级别:A级,随机对照试验(RCT)、Meta分析;B级,其它证据;C级,共识/专家意见。最后,还应提供一份要点总结表。 | Jay Siwek Margaret L. Gourlay David C. Slawson Allen F. Shaughnessy 刘雪梅(译) 钱楠(译) 林东涛(审校) 刁骧(审校) | 2006 | 中国循证医学杂志2006，6，8： | 8 |
| 4 | 新鲜冰冻血浆、冷沉淀和冷上清使用指南显示文摘摘要
FFP、冷沉淀和冷上清的临床适应症(见第10节)
单一凝血因子缺乏(10.1) | Duguid J O'Shaughnessy D F Atterbury C 洪缨 | 2004 | 国外医学(输血及血液学分册)2004，27，5： | 6 |
| 5 | Advanced Irrigation Engineering: Precision and Precise显示文摘 | Terry A. Howell Steven R. EveR Susan A. O' Shaughnessy Paul D. Colaizzi Prasanna H. Gowda | 2012 | Journal of Agricultural Science and Technology(A)2012，2，1： | 3 |
| 6 | 乳腺癌预后相关分子标记物的研究进展显示文摘 | O’Shaughnessy J A. 柴凡 姜军 范林军 | 2007 | 中华乳腺病杂志(电子版)2007，1，3： | 3 |
| 7 | Shoot and root traits in drought tolerant maize(Zea mays L.) hybrids显示文摘This study aimed to investigate the differences in shoot and root traits, and water use and water use efficiency(WUE) in drought tolerant(DT) maize(Zea mays L.) hybrids under full and deficit irrigated conditions. A two-year greenhouse study was conducted with four hybrids(one conventional hybrid, 33D53AM, two commercial DT hybrids, P1151 AM, N75H, and an experimental hybrid, Exp HB) grown under two water regimes(I_(100) and I_(50), referring to 100 and 50% of evapotranspiration requirements). Under water stress, the hybids P1151 AM, N75, and Exp HB showed more drought tolerance and had either greater shoot dry weight or less dry weight reduction than the conventional hybrid(33 D53 AM). However, these three hybrids responded to water stress using different mechanisms. Compared with the conventional hybrid, the two commercial DT hybrids(P1151 AM and N75H) had a smaller leaf area, shoot dry weight, and root system per plant. As a result, these hybrids used less water but had a higher WUE compared with the conventional hybrid. In contrast, the experimental hybrid(ExpHB) produced more shoot biomass by silking stage at both irrigation levels than all other hybrids, but it had relatively lower WUE. The hybrids demonstrated different drought response mechanisms that may require different irrigation management strategies. More investigation and validation are needed under field conditions and in different soil types. | ZHAO Jin XUE Qing-wu Kirk E Jessup HOU Xiao-bo HAO Bao-zhen Thomas H Marek XU Wen-wei Steven R Evett Susan A O'Shaughnessy David K Brauer | 2018 | Journal of Integrative Agriculture2018，17，5： | 3 |
| 8 | 紫杉醇洗脱支架与血管内近距离放射疗法治疗裸金属支架内再狭窄的比较:TAXUSVISR随机试验显示文摘Context: Restenosis within bare-metal stents is often treated with repeat percutaneous coronary intervention, although subsequent recurrence rates are high, with vascular brachytherapy(VBT) affording the best results. The effectiveness of drug-eluting stents in this setting has not been established. Objective: To investigate the safety and efficacy of the polymer-based, slow-release paclitaxel-eluting stent in patients with restenotic lesions after prior stent implantation in native coronary arteries. Design, Setting, and Patients: Prospective, multicenter, randomized trial conducted between June 6, 2003, and July 16, 2004, at 37 North American academic and community-based institutions in 396 patients with in-stent restenosis of a previously implanted bare-metal coronary stent(vessel diameter, 2.5-3.75 mm; lesion length, ≤ 46 mm). Interventions: Patients were randomly assigned to undergo angioplasty followed by VBT with a β source(n=201) or paclitaxel-eluting stent implantation(n=195). Clinical and angiographic follow-up at 9 months was scheduled in all patients. Main Outcome Measure: Ischemia-driven target vessel revascularization at 9 months. Results: Diabetes mellitus was present in 139 patients(35.1% ). Median reference vessel diameter was 2.65 mm and median lesion length was 15.3 mm. In the VBT group, new stents were implanted in 22 patients(10.9% )and in the paclitaxel-eluting stent group, multiple stents were required in 57 patients(29.2% ), with median stent length of 24 mm. Follow-up at 9 months was complete in 194 patients in the VBT group and 191 patients in the paclitaxel-eluting stent group(96.5% and 97.9% , respectively). For VBT and paclitaxel-eluting stents, respectively, the number of events and 9-month rates for ischemic target lesion revascularization were 27(13.9% ) vs 12(6.3% )(relative risk [RR], 0.45; 95% confidence interval [CI], 0.24-0.86; P=.01); for ischemic target vessel revascularization, 34(17.5% ) vs 20(10.5% )(RR, 0.60; 95% CI, 0.36-1.00; P=.046); and for overall major adverse cardiac events, 39(20.1% ) vs 22(11.5% )(RR, 0.57; 95% CI, 0.35-0.93; P=.02), with similar rates of cardiac death or myocardial infarction(10 [5.2% ] vs 7 [3.7% ]; RR, 0.71; 95% CI, 0.28-1.83; P=.48) and target vessel thrombosis(5 [2.6% ] vs 3 [1.6% ]; RR, 0.61; 95% CI, 0.15-2.50; P=.72). Angiographic restenosis at 9 months was 31.2% (53 of 170 patients) with VBT and 14.5% (25 of 172 patients) with paclitaxel-eluting stents(RR, 0.47; 95% CI, 0.30-0.71; P< .001). Conclusion: Treatment of bare-metal in-stent restenotic lesions with paclitaxel-eluting stents rather than angioplasty followed by VBT reduces clinical and angiographic restenosis at 9 months and improves event-free survival. Trial Registration: ClinicalTrials. gov Identifier: NCT00287573. | Stone G. W. Ellis S. G. O'Shaughnessy C. D. 任付先(译) 杜媛(校) | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，8： | 3 |
| 9 | One-Year Clinical Results With the Slow-Release, Polymer-Based, Paclitaxel-Eluting TAXUS Stent: The TAXUS-IV Trial显示文摘 | Gregg W. Stone Stephen G. Ellis David A. Cox James Hermiller Charles O’Shaughnessy James Tift Mann Mark Turco Ronald Caputo Patrick Bergin Joel Greenberg Jeffrey J. Popma Mary E. Russell | 2004 | Circulation: Journal of the American Heart Association2004，，16： | 2 |
| 10 | N-methyl-D-aspartate and brain-derived neurotrophic factor induce distinct profiles of extracellular signal-regulated kinase,mitogen-and stress-activated kinase,and ribosomal s6 kinase phosphorylation in cortical neurons显示文摘 | Rakhit S Clark CJ O'shaughnessy T C | 2005 | Mol Pharmacol2005，67，4： | 1 |
| 11 | Deep subsurface electronic defect image contrast and resolution amplification in Si wafers using infrared photo carrier radiometry 显示文摘 | BATISTA J MANDELIS A SHAUGHNESSY D | 2004 | Applied Physics Letters2004，85，10： | 1 |
| 12 | Randomized phase Ⅱ study of weekly irinotecan/carboplatin with or without cetuximab in patients with metastatic breast cancer ( abstract 308 ) 显示文摘 | O' Shaughnessy J Weckstein DJ Vukelja SJ | 2007 | Breast Cancer Res Treat2007，106，1： | 1 |
| 13 | Total hip arthroplas- ty in patients with dwarfism显示文摘 | Chiavetta JB Parvizi J Shaughnessy WJ | 2004 | J Bone Joint Surg Am2004，2，： | 1 |
| 14 | An experilnental study of the creep of rayon显示文摘 | O'Shaughnessy M T | 1948 | Textile Res J1948，18，： | 1 |
| 15 | Properties of neurons in the trigeminal nucleus caudalis responding to noxious dural and fa- cial stimulation 显示文摘 | Bolton S O' Shaughnessy CT Goadsby PJ | 2005 | Brain Res2005，1046，： | 1 |
| 16 | Chronic wound pathogenesis and current treatment strategies:a unifying hypothesis显示文摘 | Mustoe TA O'Shaughnessy K Kloeters O | | 0，，7： | 1 |
| 17 | A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1 显示文摘 | Shaughnessy JD Jr Zhan F Burington BE | 2007 | Blood2007，109，6： | 1 |
| 18 | Infraredphotocarrier radiometry of semiconductors: Physicalprinciples, quantitative depth profilometry, and scanningimaging of deep subsurface electronic defects显示文摘 | MANDELIS A BATISTA J SHAUGHNESSY D | 2003 | Phys RevB2003，67，20： | 1 |
| 19 | Guide linesfor the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant显示文摘 | Duguid J OI Shaughnessy DF Atterbury C | 2004 | Br J Haematol2004，126，5： | 1 |
| 20 | Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study显示文摘 | Cortes J O'Shaughnessy J Loesch D | 2011 | Lancet2011，377，9769： | 1 |
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