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| 1 | Systematic review and meta-analysis on the association of tuberculosis in Crohn's disease patients treated with tumor necrosis factor-α inhibitors(Anti-TNFα)显示文摘AIM To perform a meta-analysis on the risk of developing Mycobacterium tuberculosis(TB) infection in Crohn's disease(CD) patients treated with tumor necrosis factoralpha(TNFα) inhibitors.METHODS A meta-analysis of randomized, double-blind, placebocontrolled trials of TNFα inhibitors for treatment of CD in adults was conducted. Arcsine transformation of TB incidence was performed to estimate risk difference. A novel epidemiologically-based correction(EBC) enabling inclusions of studies reporting no TB infection cases in placebo and treatment groups was developed to estimate relative odds.RESULTS Twenty-three clinical trial studies were identified, including 5669 patients. Six TB infection cases were reported across 5 studies, all from patients receiving TNFα inhibitors. Eighteen studies reported no TB infection cases in placebo and TNFα inhibitor treatment arms. TB infection risk was significantly increased among patients receiving TNFα inhibitors, with a risk difference of 0.028(95%CI: 0.0011-0.055). The odds ratio was 4.85(95%CI: 1.02-22.99) with EBC and 5.85(95%CI: 1.13-30.38) without EBC.CONCLUSION The risk of TB infection is higher among CD patients receiving TNFα inhibitors. Understanding the immunopathogenesis of CD is crucial, since using TNFα inhibitors in these patients could favor mycobacterial infections, particularly Mycobacterium avium subspecies paratuberculosis, which ultimately could worsen their clinical condition. | Brent L Cao Ahmad Qasem Robert C Sharp Latifa S Abdelli Saleh A Naser | 2018 | World Journal of Gastroenterology2018，24，25： | 4 |
| 2 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 3 | The influence of the MAPK pathway on T cell lineage commitment显示文摘 | SHARP L L SCHWARZ D A BOTT C M | 1997 | Immunity1997，7，5： | 1 |
| 4 | Feasibility of a novel deformable image registration technique to facilitate elassifieation, targeting, and monitoring of tumor and normal tissue 显示文摘 | Brock K K Dawson L A Sharpe M B | 2006 | Int J Radiat Oneol Biol Phys2006，64，4： | 1 |
| 5 | Mucosal reactive oxygen species decrease virulence by disrupting Campylobacter jejuni phosphotyrosine signaling显示文摘 | CORCIONIVOSCHI N ALVAREZ L A SHARP T H | 2012 | Cell Host Microbe2012，12，1： | 1 |
| 6 | Determination of the isotopic composition ofammonium-nitrogen at the natural abundance level fromestuarine waters 显示文摘 | Velinsky D J Pennock J R Sharp J H Cifuentes L A Fogel M L | 1989 | Marine Chemistry1989，26，： | 1 |
| 7 | Improved Aerobic Col- ony Count Technique for Hydrophobic Grid Membrane Filters 显示文摘 | Parrington L J Sharpe A N Peterkin P I | 1993 | Applied and Environmental Microbiology1993，59，9： | 1 |
| 8 | Growth and'linkage of the East Tanka fault zone, Suez rift: Structural style and syn-rift stratigraphic response 显示文摘 | Jackson C A L Gawthorpe R L Sharp I A | 2002 | Journal of the Geological Society of London2002，159，： | 1 |
| 9 | Nitrogen Cycling in a Wheat Crop:Soil,Plant,and Aerial Nitrogen Transport显示文摘 | HARPER L A SHARPE R R LANGDALE G W | 1987 | Agronomy Journal1987，79，6： | 1 |
| 10 | Who defaults from colposcopy? A multi-centre, population-based, prospective cohort study of predic- tors of non-attendance for follow-up among women with low-grade ab- normal cervical cytology显示文摘 | Sharp L Cotton S Thornton A et at | 2012 | European Journal of Obstetrics & Gyne- cology and Reproductive Biology2012，165，2： | 1 |
| 11 | Nitrogen cyc- ling in swine production systems: Ammonia, nitrous oxide, and din-itrogen gas emissions 显示文摘 | Harper L A Sharpe R R Parkin T B | 2004 | J Environ Qual2004，33，4： | 1 |
| 12 | Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia显示文摘 | Sharp D Blinderman L Combs K A | 1993 | Nature1993，365，： | 1 |
| 13 | Chronic inter- mittent hypoxia increases sympathetic control of blood pressure: role of neuronal activity in the hypothalamic paraventricular nucle- us显示文摘 | Sharpe A L Calderon A S Andrade M A | 2013 | Am J Physiol Heart Circ Physiol2013，305，12： | 1 |
| 14 | Improved Im- munological Membrane Filter Method for Detection of Food- Borne Salmonella Strains 显示文摘 | Cerqueira-Campos M L Peterkin P I Sharpe A N | 1986 | Applied and Environmental Mi- crobiology1986，52，1： | 1 |
| 15 | Accuracy of finite element model-based multiorgan deformable image registration 显示文摘 | Brock K K Sharpe M B Dawson L A | 2005 | Medical Physics2005，32，6： | 1 |
| 16 | Wide bandwidth slow light using a Rarnan fiber amplifier 显示文摘 | SHARPING J E OKAWACHI Y GAETA A L | 2005 | OPTICS EXPRESS2005，13，16： | 1 |
| 17 | Fate of natural vegetation during urban development of rural landscape in southeastern Wisconsin显示文摘 | SHARPED M STEARNS F LEITNER L A | 1986 | Urban Ecol1986，9，： | 1 |
| 18 | Cylindrosper- mopsis racibarskii dominates under very low and high ni- trogen-to-phosphorus ratios 显示文摘 | Chislock M F Sharp K L Wilsona A E | 2014 | Water Research2014，49，： | 1 |
| 19 | The PD-1 pathway in tolerance and autoimmunity显示文摘 | Francisco L M Sage P T Sharpe A H | 2010 | Immunological Reviews2010，236，1： | 1 |
| 20 | Ear wax removal : a survey of current practice显示文摘 | Sharp J F Wilson J A Ross L | 1990 | BMJ1990，301，： | 1 |
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