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| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 3 | Prognostic value of baseline FDG uptake on PET-CT in esophageal carcinoma显示文摘AIM: To evaluate the influence of baseline maximum standardized uptake value(SUVmax) on survival in a cohort of patients, undergoing positron emission tomography-computed tomography(PET-CT) scan for esophageal carcinoma. METHODS: The pre-treatment SUVmax numeric reading was determined in patients with confirmed esophageal or junctional cancer having PET-CT scan during the time period 1st January 2007 until 31 st July 2012. A minimum follow up of 12 mo was required. Patients were subdivided into quartiles according to SUVmax value and the influence of SUVmax on survival was assessed using univariate and multivariate analysis. The following pre-treatment factors were investigated: patient characteristics, tumor characteristics and planned treatment. RESULTS: The study population was 271 patients(191male) with esophageal or junctional carcinoma. The median age was 65 years(range 40-85) and histologic subtype was adenocarcinoma in 197 patients and squamous carcinoma in 74 patients. The treatment intent was radical in 182 and palliative in 89 patients. SUVmax was linked to histologic subtype(P = 0.008), tumor site(P = 0.01) and Union for International Cancer Control(UICC) stage(P < 0.001). On univariate analysis, prognosis was significantly associated with SUVmax(P = 0.001), T-stage(P < 0.001) and UICC stage(P < 0.001). On multivariate analysis, only T-stage and UICC stage remained significant. CONCLUSION: Pretreatment SUVmax was not a useful marker in isolation for determining prognosis of patients with esophageal carcinoma. | Omar S Al-Taan Amar Eltweri David Sharpe Peter M Rodgers Sukhbir S Ubhi David J Bowrey | 2014 | World Journal of Gastrointestinal Oncology2014，6，5： | 2 |
| 4 | An evolutionary perspective on synonymous codon usage in unicellular organisms 显示文摘 | Sharp P M Li W H | 1986 | Journal of Molecular Evolution1986，24，12： | 1 |
| 5 | Use of cardiac troponin T in diagnosis and prognosis of cardiac events in patients on chronic haemodialysis显示文摘 | Conway B McLaughlin M Sharpe P | 2005 | Nephrol Dial Transplant2005，20，12： | 1 |
| 6 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 7 | Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel 显示文摘 | Cranage M Sharpe S Herrera C | 2008 | PLoS Med2008，5，8： | 1 |
| 8 | Production of hydrogen from chemical hydrides via hydrolysis with steam 显示文摘 | AIELLO R SHARP J H MATTHEWS M A | 1999 | International Journal of Hydrogen Energy1999，24，12： | 1 |
| 9 | Corticosteroid effects on blood gene expression in duchenne muscular dystrophy显示文摘 | Lit L Sharp FR Apperson M | 2009 | Pharmacogenomics J2009，9，6： | 1 |
| 10 | Fabrication of photonic crystals for the visible spectrum by holo1graphic lithography显示文摘 | CAMPBELL M SHARP D N HARRISON M T | 2000 | Nature2000，404，6773： | 1 |
| 11 | Rates of nucleotide substitution vary greatly among plant mitochondrial,chloroplast and nuclear DNAs显示文摘 | WOLFE K H LI W H SHARP P M | 1987 | Proc Natl Acad Sci USA1987，84，5： | 1 |
| 12 | Activities of several noveloxazolidinones against Mycobacterium tuberculosis in a murine model显示文摘 | Cynamon M H Klemens S P Sharpe C A | 1999 | Atimicrob AgentsChemother1999，43，： | 1 |
| 13 | Case study:a state space condition monitoring model for furnace erosion prediction and replacement显示文摘 | Christer A H Wang W Sharp J M | 1997 | European Journal of Operational Research1997，101，1： | 1 |
| 14 | The influence of the MAPK pathway on T cell lineage commitment显示文摘 | SHARP L L SCHWARZ D A BOTT C M | 1997 | Immunity1997，7，5： | 1 |
| 15 | Microbial life beneath a High Arctic glacier显示文摘 | Skidmore M L Foght J M Sharp M J | 2000 | Applied and Environmental Microbiology2000，66，8： | 1 |
| 16 | Feasibility of a novel deformable image registration technique to facilitate elassifieation, targeting, and monitoring of tumor and normal tissue 显示文摘 | Brock K K Dawson L A Sharpe M B | 2006 | Int J Radiat Oneol Biol Phys2006，64，4： | 1 |
| 17 | Expression and Regulation of Lhx6 and Lhx7, a Novel Subfami?ly of LIM Homeodomain Encoding Genes, Suggests a Role in Mammalian Head Development显示文摘 | GRIGORIOU M TUCKER A S SHARPE P T | 1998 | Development1998，125，11： | 1 |
| 18 | Plasma fibrinogen andcoronar y heart disease in elderly Japanese-American men 显示文摘 | Sharp D S Abbott R D Burchfied C M | 1996 | Arterioscler Thromb Vase Biol1996，16，2： | 1 |
| 19 | Telmisartan: a review of its use in hypertension显示文摘 | Sharpe M Jarvis B Goa KL | | 0，，： | 1 |
| 20 | Rates of chemical de- nudation and CO2 drawdown in a glacier-covered alpine catch- ment显示文摘 | Sharp M Tranter M Brown G H | 1995 | Geology1995，23，1： | 1 |
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