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| 1 | Advances in diagnosis, treatment and palliation of pancreatic carcinoma: 1990-2010显示文摘Several advances in genetics, diagnosis and palliation of pancreatic cancer (PC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. PC is relatively common as it is the fourth leading cause of cancer related mortality. Most patients present with obstructive jaundice, epigastric or back pain, weight loss and anorexia. Despite improvements in diagnostic modalities, the majority of cases are still detected in advanced stages. The only curative treatment for PC remains surgical resection. No more than 20% of patients are candidates for surgery at the time of diagnosis and survival remains quite poor as adjuvant therapies are not very effective. A small percentage of patients with borderline non-resectable PC might benefit from neo-adjuvant chemoradiation therapy enabling them to undergo resection; however, randomized controlled studies are needed to prove the benefits of this strategy. Patients with unresectable PC benefit from palliative interventions such as biliary decompression and celiac plexus block. Further clinical trials to evaluate new chemo and radiation protocols as well as identification of genetic markers for PC are needed to improve the overall survival of patients affected by PC, as the current overall 5-year survival rate of patients affected by PC is still less than 5%. The aim of this article is to review the most recent high quality literature on this topic. | Chakshu Sharma Karim M Eltawil Paul D Renfrew Mark J Walsh Michele Molinari | 2011 | World Journal of Gastroenterology2011，17，7： | 28 |
| 2 | Novel concepts in radiation-induced cardiovascular disease显示文摘Radiation-induced cardiovascular disease(RICVD) is the most common nonmalignant cause of morbidity and mortality among cancer survivors who have undergone mediastinal radiation therapy(RT).Cardiovascular complications include effusive or constrictive pericarditis,cardiomyopathy,valvular heart disease,and coronary/vascular disease.These are pathophysiologically distinct disease entities whose prevalence varies depending on the timing and extent of radiation exposure to the heart and great vessels.Although refinements in RT dosimetry and shielding will inevitably limit future cases of RICVD,the increasing number of long-term cancer survivors,including those treated with older higher-dose RT regimens,will ensure a steady flow of afflicted patients for the foreseeable future.Thus,there is a pressing need for enhanced understanding of the disease mechanisms,and improved detection methods and treatment strategies.Newly characterized mechanisms responsible for the establishment of chronic fibrosis,such as oxidative stress,inflammation and epigenetic modifications,are discussed and linked to potential treatments currently under study.Novel imaging modalities may serve as powerful screening tools in RICVD,and recent research and expert opinion advocating their use is introduced.Data arguing for the aggressive use of percutaneous interventions,such as transcutaneous valve replacement and drug-eluting stents,are examined and considered in the context of prior therapeutic approaches.RICVD and its treatment options are the subject of a rich and dynamic body of research,and patients who are at risk or suffering from this disease will benefit from the care of physicians with specialty expertise in the emerging field of cardiooncology. | Jason R Cuomo Gyanendra K Sharma Preston D Conger Neal L Weintraub | 2016 | World Journal of Cardiology2016，8，9： | 17 |
| 3 | MicroRNAs:a new ray of hope for diabetes mellitus显示文摘Diabetes mellitus has become one of the most common chronic diseases,thereby posing a major challenge to global health.Characterized by high levels of blood glucose(hyperglycemia),diabetes usually results from a loss of insulin-producing β-cells in the pancreas,leading to a deficiency of insulin(type 1 diabetes),or loss of insulin sensitivity(type 2 diabetes).Both types of diabetes have serious secondary complications,such as microvascular abnormalities,cardiovascular dysfunction,and kidney failure.Various complex factors,such as genetic and environmental factors,are associated with the pathophysiology of diabetes.Over the past two decades,the role of small,single-stranded noncoding microRNAs in various metabolic disorders,especially diabetes mellitus and its complications,has gained widespread attention in the scientific community.Discovered first as an endogenous regulator of development in the nematode Caenorhabditis elegans,these small RNAs post-transcriptionally suppress mRNA target expression.In this review,we discuss the potential roles of different microRNAs in diabetes and diabetes-related complications. | Munish Kumar Sayantan Nath Himanshu K Prasad G D Sharma Yong Li | 2012 | Protein & Cell2012，3，10： | 14 |
| 4 | Autologous mobilized peripheral blood CD34^+ cell infusion in non-viral decompensated liver cirrhosis显示文摘AIM: To study the effect of mobilized peripheral blood autologous CD34 positive(CD34+) cell infusion in patients with non-viral decompensated cirrhosis.METHODS: Cirrhotic patients of non-viral etiology were divided into 2 groups based on their willingness to be listed for deceased donor liver transplant(DDLT)(control, n = 23) or to receive autologous CD34+ cell infusion through the hepatic artery(study group, n= 22). Patients in the study group were admitted to hospital and received granulocyte colony stimulating factor injections 520 μg/d for 3 consecutive days to mobilize CD34+ cells from the bone marrow. On day 4,leukapheresis was done and CD34+ cells were isolated using CliniMAC magnetic cell sorter. The isolated CD34+ cells were infused into the hepatic artery under radiological guidance. The patients were discharged within 48 h. The control group received standard of care treatment for liver cirrhosis and were worked up for DDLT as per protocol of the institute. Both groups were followed up every week for 4 wk and then every month for 3 mo.RESULTS: In the control and the study group, the cause of cirrhosis was cryptogenic in 18(78.2%) and16(72.72%) and alcohol related in 5(21.7%) and6(27.27%), respectively. The mean day 3 cell count(cells/μL) was 27.00 ± 20.43 with a viability of 81.84± 11.99%. and purity of 80%-90%. Primary end point analysis revealed that at 4 wk, the mean serum albumin in the study group increased significantly(2.83± 0.36 vs 2.43 ± 0.42, P = 0.001) when compared with controls. This improvement in albumin was,however, not sustained at 3 mo. However, at the end of3 mo there was a statistically significant improvement in serum creatinine in the study group(0.96 ± 0.33 vs 1.42 ± 0.70, P = 0.01) which translated into a significant improvement in the Model for End-Stage Liver Disease score(15.75 ± 5.13 vs 19.94 ± 6.68,P = 0.04). On statistical analysis of secondary end points, the transplant free survival at the end of 1 mo and 3 mo did not show any significant difference(P =0.60) when compared to the control group. There was no improvement in aspartate transaminase, alanine transaminase, and bilirubin at any point in the study population. There was no mortality benefit in the study group. The procedure was safe with no procedural or treatment related complications.CONCLUSION: Autologous CD 34+ cell infusion is safe and effectively improves liver function in the short term and may serve as a bridge to liver transplantation. | Mithun Sharma Padaki Nagaraja Rao Mitnala Sasikala Mamata Reddy Kuncharam Chimpa Reddy Vardaraj Gokak BPSS Raju Jagdeesh R Singh Piyal Nag D Nageshwar Reddy | 2015 | World Journal of Gastroenterology2015，21，23： | 9 |
| 5 | Interdependent regulation of intracellular acidification and SHP-1 in apoptosis显示文摘 | Thangaraju M Sharma K Liu D | 1999 | Cancer Res1999，59，： | 2 |
| 6 | 加巴喷丁和普瑞巴林用于治疗慢性瘙痒显示文摘瘙痒持续6周可定义为慢性瘙痒,慢性瘙痒是一种难以治疗的自主症状。当局部治疗和口服抗组胺药物对患者无效时,临床医师需考虑使用神经活性药物等其他治疗手段。加巴喷丁和普瑞巴林最初作为抗癫痫药物用于治疗神经性疼痛,如带状疱疹后遗神经痛、糖尿病性神经病变,这两种药物作用于痛觉和痒觉的信号传导途径,也被用于探索性治疗缓解慢性瘙痒。 | Matsuda KM Sharma D Schonfeld AR Kwatra SG 薛如君 张锡宝 | 2017 | 皮肤性病诊疗学杂志2017，24，4： | 2 |
| 7 | Carcinoma of the gallbladder显示文摘 | Sanjeev Misra Arun Chaturvedi Naresh C Misra Indra D Sharma | 2003 | Lancet Oncology2003，，3： | 2 |
| 8 | Salt-stress-induced proline accumulation in germinating embryos:Evidence suggesting a role of proline in seed germination显示文摘 | THAKUR M SHARMA A D | 2005 | Arid Environments2005，62，： | 1 |
| 9 | Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways 显示文摘 | Sharma D Saxena NK Vertino PM | 2006 | Endocr Relat Cancer2006，13，2： | 1 |
| 10 | Effect of surfactant on leaching of pendimethalin in Florida candler fine sand显示文摘 | Sharma S D Singh M | 2007 | Bull Environ Contam Toxicol2007，78，： | 1 |
| 11 | Isolation of arbuscular mycorrhizal fungi and Azotobacter chroococcum from local litchi orchards and evaluation of their activity in the air-layers system显示文摘 | SHARMA S D KUMAR P RAJ H | 2009 | Scientia Hortieulturae2009，123，： | 1 |
| 12 | A Novel Approach To Investigate the Uptake and Internalization of Escherichia coli O157:H7 in Spinach Cultivated in Soil and Hydroponic Medium 显示文摘 | Sharma M Ingram D T Patel J R | 2009 | J Food Protection2009，72，7： | 1 |
| 13 | The impact of impending corporate failure on the incidence and magnitude of discretionary accounting policy changes显示文摘 | Sharma D Peta A Stevenson | 1997 | British accounting Review1997，，29： | 1 |
| 14 | Conceptualizing risk assessment framework for impacts of climate change on water resources显示文摘 | Sharma D Bharat A | 2009 | Current Science2009，96，8： | 1 |
| 15 | Rapid flow cytometric analysisof the cell cycle in intact plant tissues显示文摘 | GALBRAITH D W HARKINS K R MADDOX J M AYRES N M SHARMA D P FIROOZABADY E | 1983 | Science1983，220，4601： | 1 |
| 16 | Coal extraction: enhancement through novel prior alkylation procedures at atmospheric pressure显示文摘 | Sharma D K Sarkar M K Mirza Z B | 1985 | Fuel1985，64，4： | 1 |
| 17 | In vitro propagation of an adult tree Wrightia lomentosa through enhanced axilliary branching显示文摘 | Purohit S D Kukda G Sharma P | 1994 | Plant Sci1994，103，： | 1 |
| 18 | Effect of tertiary multileaf collimator (MLC) on foetal dose during three-dimensional conformal radiation therapy (3DCRT) of a brain tumour during pregnancy显示文摘 | Sharma D S Jalali R Tambe C M | 2004 | Radiother Oncol2004，70，1： | 1 |
| 19 | Phase behavior and surface tensions of amphiphilic fluorinated random copolymer aqueous solutions显示文摘 | Sharma S C Acharya D P Garc'1a-Roman M | 2006 | Colloids and Surfaces A:Physicochem2006，28，1： | 1 |
| 20 | Influence of mixed probiotic on growth,feed conversion efficiency and incidence of diarrhoea in young calves显示文摘 | Raman M Sharma D D Malik R | 1998 | Indian Journal of Animal Nutrition1998，15，3： | 1 |
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