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| 1 | Establishing the presence or absence of chronic kidney disease:Uses and limitations of formulas estimating the glomerular filtration rate显示文摘The development of formulas estimating glomerular filtration rate(eG FR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease(CKD),which is based on e GFR values and albuminuria.This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course. Disagreements between creatinine-based and cystatin-based e GFR values and between e GFR values and measured GFR have been reported in various cohorts. These disagreements are the consequence of variations in the rate of production and in factors, other than GFR, affecting the rate of removal of creatinine and cystatin C. The disagreements create limitations for all e GFR formulas developed so far. The main limitations are low sensitivity in detecting early CKD in several subjects, e.g., those with hyperfiltration, and poor prediction of the course of CKD. Research efforts in CKD are currently directed towards identification of biomarkers that are better indices of GFR than the current biomarkers and,particularly, biomarkers of early renal tissue injury. | Ahmed Alaini Deepak Malhotra Helbert Rondon-Berrios Christos P Argyropoulos Zeid J Khitan Dominic SC Raj Mark Rohrscheib Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Methodology2017，7，3： | 7 |
| 2 | Fluid balance concepts in medicine:Principles and practice显示文摘The regulation of body fluid balance is a key concern in health and disease and comprises three concepts. The first concept pertains to the relationship between total body water(TBW) and total effective solute and is expressed in terms of the tonicity of the body fluids. Disturbances in tonicity are the main factor responsible for changes in cell volume, which can critically affect brain cell function and survival. Solutes distributed almost exclusively in the extracellular compartment(mainly sodium salts) and in the intracellular compartment(mainly potassium salts) contribute to tonicity, while solutes distributed in TBW have no effect on tonicity. The second body fluid balance concept relates to the regulation and measurement of abnormalities of sodium salt balance and extracellular volume. Estimation of extracellular volume is more complex and error prone than measurement of TBW. A key function of extracellular volume, which is defined as the effective arterial blood volume(EABV), is to ensure adequate perfusion of cells and organs. Other factors, including cardiac output, total and regional capacity of both arteries and veins, Starling forces in the capillaries, and gravity also affect the EABV. Collectively, these factors interact closely with extracellular volume and some of them undergo substantial changes in certain acute and chronic severe illnesses. Their changes result not only in extracellular volume expansion, but in the need for a larger extracellular volume compared with that of healthy individuals. Assessing extracellular volume in severe illness is challenging because the estimates of this volume by commonly used methods are prone to large errors in many illnesses. In addition, the optimal extracellular volume may vary from illness to illness, is only partially based on volume measurements by traditional methods, and has not been determined for each illness. Further research is needed to determine optimal extracellular volume levels in several illnesses. For these reasons, extracellular volume in severe illness merits a separate third concept of body fluid balance. | Maria-Eleni Roumelioti Robert H Glew Zeid J Khitan Helbert Rondon-Berrios Christos P Argyropoulos Deepak Malhotra Dominic S Raj Emmanuel I Agaba Mark Rohrscheib Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2018 | World Journal of Nephrology2018，7，1： | 3 |
| 3 | Endothelin-1 in the human prostate tissue levels ,source of production and isometric tension studies 显示文摘 | Langenstror P Tang R Shapiro E | 1993 | J Urol1993，149，6： | 1 |
| 4 | The effect of section of the medial collateral ligament on force generated in the anterior cruciate ligament 显示文摘 | Shapiro M S Markolf K L Finerman G A M Mitchell P W | 1991 | Journal of Bone and Joint Surgery1991，72，： | 1 |
| 5 | Cross cascade activation of ERKs and ternary complex factors by Rho family proteins显示文摘 | Frost JA Steen H Shapiro P | 1997 | EMBO J1997，16，64： | 1 |
| 6 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 7 | Use of plasma brain natriuretic peptide concentration to aid in the diagnosis of heart failure显示文摘 | Shapiro MD Homg H | 2003 | Mayo clinproe2003，78，6： | 1 |
| 8 | Anti-inflammatory prop- erties of omega-3 fatty acids in critical illness: novel mecha- nisms and an integrative perspective 显示文摘 | Singer P Shapiro H Theilla M | 2008 | Intensive Care Med2008，34，9： | 1 |
| 9 | The taking of land: When should compensation be paid ? 显示文摘 | Blume L Rubinfeld D L Shapiro P | 1984 | Quarterly Journal of Economics1984，99，1： | 1 |
| 10 | Molecular biologymechanisms in the radiation Induction of pulmonary injury syndromes: interrelationship between the alveolar macrophage and the septal fibroblast显示文摘 | Rubin P Finkelstein J Shapiro D | 1992 | Int J Radiat Oncol Biol Phys1992，24，1： | 1 |
| 11 | Systems for knowledge discovery in databases显示文摘 | MATHEUS C J CHAN P K PIATETSKY- SHAPIRO G | 1993 | IEEE Transactions on Knowledge and Data Engineering1993，5，6： | 1 |
| 12 | A stochastic theory for deep bed filtration accouating for dispersion and size distributions显示文摘 | Shapiro A A Bedrikovetsky P G | 2010 | Physica A: Statistical Mechanics and Its Applications2010，389，13： | 1 |
| 13 | Depression and the course of coronary artery disease 显示文摘 | GLASSMAN A H SHAPIRO P A | 1998 | Am J Psychiatry1998，155，1： | 1 |
| 14 | Genetic and experimental evidence for cross -species infection by swine hepatitis E virus显示文摘 | Meng X J Halbur P G Shapiro M S | 1998 | J Virol1998，72，： | 1 |
| 15 | The physcomitrella genome reveals evolutionary insights into the conquest of land by plants 显示文摘 | Rensing S A Lang D Zimmer A D Terry A Salamov A Shapiro H Nishiyama T Perroud P F Lindquist E A Kamisugi Y | 2008 | Science2008，319，5859： | 1 |
| 16 | Lupus anticoagulants and antiphospholipid antibodies 显示文摘 | Thiagara P Shapiro SS | 1998 | Hematol/Oncology Clinics North Amer1998，12，6： | 1 |
| 17 | Antimic robial suscepti- bility of fusarium, aspergillus, and other filamentous fungi isolated from keratitis 显示文摘 | Lalitha P Shapiro BL Srinivasan M | 2007 | Arch Ophthalmol2007，125，6： | 1 |
| 18 | Effects of an immunostimulating agent on acute exacerbations and hospitalizations in patients with chronic obstructive pulmonary disease显示文摘 | Collet JP Shapiro S Ernst P | 1997 | Am J Respir Crit Care Med1997，156，： | 1 |
| 19 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 20 | The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis 显示文摘 | Shapiro NI Schuetz P Yano K | 2010 | Crit Care2010，14，5： | 1 |
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