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| 1 | Current status of clinical islet transplantation显示文摘Islet transplantation(IT) is today a well-established treatment modality for selected patients with type 1 diabetes mellitus(T1DM). After the success of the University of Alberta group with a modified approach to the immune protection of islets, the international experience grew along with the numbers of transplants in highly specialized centers. Yet, long-term analysis of those initial results from the Edmonton group indicated that insulin-independence was not durable and most patients return to modest amounts of insulin around the fifth year, without recurrent hypoglycemia events. Many phenomena have been identified as limiting factor for the islet engraftment and survival, and today all efforts are aimed to improve the quality of islets and their engrafting process, as well as more optimized immunosuppression to facilitate tolerance and ultimately, better long term survival. This brief overview presents recent progress in IT. A concise historical perspective is provided, along with the latest efforts to improve islet engraftment, immune protection and ultimately, prolonged graft survival. It is apparent that as the community continues to work together further optimizing IT, it is hopeful a cure for T1 DM will soon be achievable. | Andrew R Pepper Boris Gala-Lopez Oliver Ziff AM James Shapiro | 2013 | World Journal of Transplantation2013，3，4： | 3 |
| 2 | Islet transplantation inseven patients with type 1 diabetes mellitus using a glucocorti-coid-free immunosuppressive regimen显示文摘 | Shapiro AM Lakey JR Ryan EA | 2000 | N Engl J Med2000，343，4： | 1 |
| 3 | Structural basis of cellcell adhesion by cadherins 显示文摘 | Shapiro L Fannon AM Kwong PD | 1995 | Nature1995，374，6520： | 1 |
| 4 | Population genetic evidence of restricted gene flow between host races in the butterfly genus Mitoura (Lepidoptera:Lycaenidae)显示文摘 | Nice CC Shapiro AM | | 0，，02： | 1 |
| 5 | Reduce expression of cell-cell adhesion by cadherins显示文摘 | Shapiro L Fannon AM Kwong PD | 1995 | Nature1995，374，： | 1 |
| 6 | Interventional strategies to prevent β-cell apoptosis in islet transplantation 显示文摘 | Emamaullee JA Shapiro AM | 2006 | Diabetes2006，55，7： | 1 |
| 7 | Quality of life and breast cancer:relationship to psychosocial variables显示文摘 | Shapiro SL Lopez AM Schwartz GE | 2001 | J Clin Psychol2001，57，4： | 1 |
| 8 | Islet transplantation in patients with diabetes using glucocorticoid 2 free immunosuppression显示文摘 | Shapiro AM Lakey JR Ryan E | 2000 | N Eng J Med2000，343，7： | 1 |
| 9 | International trial of theEdmonton protocol for islet transplantation显示文摘 | Shapiro AM Ricordi C Hering BJ | 2006 | N Engl J Med2006，355，13： | 1 |
| 10 | Strategic opportunities in clinical islet transplantation显示文摘 | Shapiro AM Lakey JR PatyBW | 2005 | Transplantation2005，79，4： | 1 |
| 11 | Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen显示文摘 | Shapiro AM Lakey JR Ryan EA | 2000 | N Engl J Med2000，343，4： | 1 |
| 12 | Non-myeloablative mixed chimerism approaches and tolerance, a split decision 显示文摘 | Luo B Chan WE Shapiro AM | 2007 | Eur J Immunol2007，37，5： | 1 |
| 13 | Beta-score,an assessment of beta-cell function after islet transplantation显示文摘 | Ryan EA Paty BW Senior PA Lakey JR Bigam D Shapiro AM | | 0，，： | 1 |
| 14 | Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen显示文摘 | Shapiro AM Lakey JR Ryan EA | 2000 | NEngl JMed2000，343，： | 1 |
| 15 | State of the art of clinical islet transplantation and novel protocols of immunosuppression显示文摘 | Shapiro AM | 2011 | Curr Diab Rep2011，11，5： | 1 |
| 16 | Factors influencing the collagenase digestion phase of human islet isolation 显示文摘 | Kin T Johnson PR Shapiro AM | 2007 | Transplantation2007，83，1： | 1 |
| 17 | Technical aspects of islet preparation and transplantation显示文摘 | Jonathan RT Philip W Shapiro AM | 2003 | Transpl Int2003，16，9： | 1 |
| 18 | Islet Transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen显示文摘 | Shapiro AM Lakey JR Ryan EA | 2000 | The New England Journal of Medicine2000，343，4： | 1 |
| 19 | Islet transplanta- tion in seven patients with type 1 diabetes meUitus using a glu- cocorticoid-free immunosuppressive regimen 显示文摘 | SHAPIRO AM LAKEY JR RYAN EA | 2000 | N Engl J Med2000，，4： | 1 |
| 20 | Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion 显示文摘 | Lakey JR Warnock GL Shapiro AM | 1999 | Cell Transplant1999，8，3： | 1 |
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