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| 1 | Biocompatibility of bio-Mg-Zn alloy within bone with heart, liver, kidney and spleen显示文摘A magnesium-zinc alloy rod was implanted into the marrow cavity of the distal femur in New Zealand rabbits. The femur with the implanted alloy was compared with the contralateral femur in which a bone tunnel without implant was formed as a control. Degradation of the magnesium-zinc alloy was analyzed via X-ray, scanning electron microscopy, and element energy spectrum analysis. Serum magnesium, liver and kidney function tests, and myocardial enzymes were measured. Heart, liver, kidney and spleen were sectioned for pathological analysis, and the effects of the implanted material on the histology and function of important organs were analyzed. Magnesium-zinc alloy was resorbed from the bone marrow cavity of the femur; 87% of the alloy was degraded within 14 weeks after the surgery. There were no significant differences in serum magnesium, liver or kidney function tests, or myocardial enzymes be- fore the surgery and after degradation of the magnesium-zinc alloy. Histology of the heart, liver, kidney, and spleen did not change. This study demonstrated that magnesium-zinc alloy can be resorbed in bone, and that the degradation products have good biocompatibility with heart, liver, kidney, and spleen. | HE YaoHua TAO HaiRong ZHANG Yan JIANG Yao ZHANG ShaoXiang ZHAO ChangLi LI JiaNan ZHANG BeiLei SONG Yang ZHANG XiaoNong | 2009 | Chinese Science Bulletin2009，54，3： | 18 |
| 2 | Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3inflammasome activation in LPS-induced vascular injury显示文摘The loss of endothelial connective integrity and endothelial barrier dysfunction can lead to increased vascular injury, which is related to the activation of endothelial inflammasomes. There are evidences that low concentrations of aspirin can effectively prevent cardiovascular diseases. We hypothesized that low-dose aspirin could ameliorate endothelial injury by inhibiting the activation of NLRP3 inflammasomes and ultimately prevent cardiovascular diseases. Microvascular endothelial cells were stimulated by lipopolysaccharide(2 μg/mL) and administrated by 0.1–2 mmol/L aspirin. The wild type mice were stimulated with LPS(100 μg/kg/day), and 1 h later treated with aspirin(12.5, 62.5, or125 mg/kg/day) and dexamethasone(0.0182 mg/kg/day) for 7 days. Plasma and heart were harvested for measurement of ELISA and immunofluorescence analyses. We found that aspirin could inhibit NLRP3 inflammasome formation and activation in vitro in dose-dependent manner and has correlation between the NLRP3 inflammasome and the ROS/TXNIP pathway. We also found that low-concentration aspirin could inhibit the formation and activation of NLRP3 inflammasome and restore the expression of theendothelial tight junction protein zonula occludens-1/2(ZO1/2). We assume that aspirin can ameliorate the endothelial layer dysfunction by suppressing the activation of NLRP3 inflammasome. | Xing Zhou Yanjiao Wu Lifeng Ye Yunting Wang Kaimin Zhang Lingjun Wang Yi Huang Lei Wang Shaoxiang Xian Yang Zhang Yang Chen | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 13 |
| 3 | Rolling texture and its effect on tensile property of a near-α titanium alloy Ti60 plate显示文摘Rolling texture and its effect on tensile properties of Ti60 alloy plates were investigated in the present study. The plates were β-rolled at 1070℃ and(α+β)-rolled at 980℃, using uni-directionally rolling(UDR) and cross-directionally rolling(CDR) processes, respectively.β-rolled plates exhibited weak textures, which were attributed to the dispersive orientations of secondary α during the β→α phase transformation. Strong deformation textures formed in(α+β)-rolled plates as a result of slipping mechanisms: the strong T-type texture in UDR plate was related to {10 1 0}[11 2 0] slipping, while the B-type texture in CDR plate was relevant with {0001}[11 2 0] slip. Strong T-type textures led to anisotropic tensile properties. B-type textures would decrease such an anisotropy. The(α+β)-CDR process was found to be a candidate process for reducing anisotropy of Ti60 alloy plates. | Wenyuan Li Zhiyong Chen Jianrong Liu Shaoxiang Zhu Guoxin Sui Qingjiang Wang | 2019 | Journal of Materials Science & Technology2019，35，5： | 11 |
| 4 | Experimental realization of honeycomb borophene显示文摘We report the successful preparation of a purely honeycomb,graphene-like borophene,by using an Al(11 1) surface as the substrate and molecular beam epitaxy(MBE) growth in ultrahigh vacuum.Scanning tunneling microscopy(STM) images reveal perfect monolayer borophene with planar,non-buckled honeycomb lattice similar as graphene.Theoretical calculations show that the honeycomb borophene on Al(1 1 1) is energetically stable.Remarkably,nearly one electron charge is transferred to each boron atom from the Al(1 1 1) substrate and stabilizes the honeycomb borophene structure,in contrast to the negligible charge transfer in case of borophene/Ag(1 1 1).The existence of honeycomb 2 D allotrope is important to the basic understanding of boron chemistry,and it also provides an ideal platform for fabricating boron-based materials with intriguing electronic properties such as Dirac states. | Wenbin Li Longjuan Kong Caiyun Chen Jian Gou Shaoxiang Sheng Weifeng Zhang Hui Li Lan Chen Peng Cheng Kehui Wu | 2018 | Science Bulletin2018，63，5： | 7 |
| 5 | The Mars rover subsurface penetrating radar onboard China's Mars 2020 mission显示文摘China's Mars probe,named Tianwen-1,including an orbiter and a landing rover,will be launched during the July-August 2020 Mars launch windows.Selected to be among the rover payloads is a Subsurface Penetrating Radar module(RoSPR).The main scientific objective of the RoSPR is to characterize the thickness and sub-layer distribution of the Martian soil.The RoSPR consists of two channels.The low frequency channel of the RoSPR will penetrate the Martian soil to depths of 10 to 100 m with a resolution of a few meters.The higher frequency channel will penetrate to a depth of 3 to 10 m with a resolution of a few centimeters.This paper describes the design of the instrument and some results of field experiments. | Bin Zhou ShaoXiang Shen Wei Lu Qing Liu ChuanJun Tang ShiDong Li GuangYou Fang | 2020 | Earth and Planetary Physics2020，4，4： | 6 |
| 6 | Antigenic analysis of grass carp reovirus using single-chain variable fragment antibody against IgM from Ctenopharyngodon idella显示文摘Grass carp (Ctenopharyngodon idella) is an important species of freshwater aquaculture fish in China. However, grass carp reovirus (GCRV) can cause fatal hemorrhagic disease in yearling populations. Until now, a strategy to define the antigenic capacity of the virus's structural proteins for preparing an effective vaccine has not been available. In this study, some single-chain variable fragment antibodies (scFv), which could specifically recognize grass carp IgM, were selected from a constructed mouse na ve antibody phage display cDNA library. The identified scFv C1B3 clone was shown to possess relatively higher specific binding activity to grass carp IgM. Furthermore, ELISA analysis indicated that the IgM level in serum from virus-infected grass carp was more than two times higher than that of the control group at 5-7 days post infection. Moreover, Western blot analysis demonstrated that the outer capsid protein VP7 has a specific immuno-binding-reaction with the serum IgM from virus-infected grass carp. Our results suggest that VP7 can induce a stronger immune response in grass carp than the other GCRV structural proteins, which implies that VP7 protein could be used as a preferred immunogen for vaccine design. | CHEN CongLin SUN XiaoYun LIAO LanJie LUO ShaoXiang LI ZhouQuan ZHANG XiaoHua WANG YaPing GUO QionLin FANG Qin DAI HePing | 2013 | Science China(Life Sciences)2013，56，1： | 6 |
| 7 | Research on an Mg–Zn alloy as a degradable biomaterial显示文摘 | Shaoxiang Zhang Xiaonong Zhang Changli Zhao Jianan Li Yang Song Chaoying Xie Hairong Tao Yan Zhang Yaohua He Yao Jiang Yujun Bian | 2009 | Acta Biomaterialia2009，，2： | 5 |
| 8 | Grassland Degradation and Its Control in Region AroundQinghai Lake显示文摘A quite severe degradation was found in all seven types of grasslands in the study area involving 12counties of the northwestern Qinghai Province. The slightly, moderately and severely degraded grasslandsoccupied 49.7%, 32.0% and 18.3% of the area respectively. The major factors resulting in the degradationwere overgrazing, the damages from mice and grasshopper and blown sands, and improper use of grasslands.The measures to deal with these problems should be: 1) to make livestock development in accordancewith grassland carrying capacity for animals; 2) to build more artificial grasslands with a stable and highergraas yield; 3) to put more widely the rotation grazing system into practice; 4) to clear up the poisonousgrass species; and 5) to adopt more effective measures to deal with the damages to grasslands by mice andgrasshoppers. | JIANG JIANJUN NI SHAOXIANG GONG AIQI WANG WEIJUN ZHA YONG WANG JIECHENG F. VOSS(l College of Geographic Science, Nanjing Normal University, Nanjing 210097 (China))(2 General Grassland Station of Qinghai Province, Xining 810001 (China))(3 Institute of Ceog | 1999 | Pedosphere1999，9，4： | 4 |
| 9 | Site-Dependent Osseointegration of Biodegradable High-Purity Magnesium for Orthopedic Implants in Femoral Shaft and Femoral Condyle of New Zealand Rabbits显示文摘Magnesium(Mg) has been widely accepted as osteoconductive biomaterial, but osseointegration of Mg device at different implantation sites is still unclear. In the present study, high-purity magnesium(HP Mg)pins were implanted into femoral shaft and condyle of New Zealand rabbits concurrently. 2, 8, 12 and 16 weeks after surgery, rabbit femurs were harvested for micro-computed tomography(micro-CT) scanning and subsequent histological examinations. HP Mg pins were retrieved for scanning electron microscope and energy dispersive spectrum(SEM/EDS) analyses. HP Mg pins at both implantation sites performed stable corrosion with mineral deposition and bone incorporation on surface. However, difference in distribution of contact osteogenesis centers and biological properties of peri-implant bone tissues was detected between femoral shaft and femoral condyle. In femoral condyle, contact osteogenesis centers originated from both periosteum and cancellous bones and the whole HP Mg pin was encapsuled in trabecular bone at 16 weeks.Meanwhile, bone volume to total bone volume(BV/TV) and bone mineral density(BMD) of peri-implant bone tissues were above those of normal bone tissues. In femoral shaft, contact osteogenesis centers were only from periosteum and direct bone contact was confined in cortical bone, while BV/TV and BMD kept lower than normal. Furthermore, new formation of peri-implant bone tissues was more active in femoral condyle than in femoral shaft at 16 weeks. Therefore, although HP Mg performed good biocompatibility and corrosion behavior in vivo, its bioadaption of osseointegration at different implantations sites should be taken into consideration. Bone metaphysic was suitable for Mg devices where peri-implant bone tissues regenerated rapidly and the biological properties were close to normal bone tissues. | Pengfei Cheng Changli Zhao Pei Han Jiahua Ni Shaoxiang Zhang Xiaonong Zhang Yimin Chai | 2016 | Journal of Materials Science & Technology2016，32，9： | 4 |
| 10 | Research of a novel biodegradable surgical staple made of high purity magnesium显示文摘Surgical staples made of pure titanium and titanium alloys are widely used in gastrointestinal anastomosis.However the Ti staple cannot be absorbed in human body and produce artifacts on computed tomography(CT)and other imaging examination,and cause the risk of incorrect diagnosis.The bioabsorbable staple made from polymers that can degrade in human body environment,is an alternative.In the present study,biodegradable high purity magnesium staples were developed for gastric anastomosis.U-shape staples with two different interior angles,namely original 90and modified 100,were designed.Finite element analysis(FEA)showed that the residual stress concentrated on the arc part when the original staple was closed to B-shape,while it concentrated on the feet for the modified staple after closure.The in vitro tests indicated that the arc part of the original staple ruptured firstly after 7 days immersion,whereas the modified one kept intact,demonstrating residual stress greatly affected the corrosion behavior of the HP-Mg staples.The in vivo implantation showed good biocompatibility of the modified Mg staples,without inflammatory reaction 9 weeks post-operation.The Mg staples kept good closure to the Anastomosis,no leaking and bleeding were found,and the staples exhibited no fracture or severe corrosion cracks during the degradation. | Hongliu Wu Changli Zhao Jiahua Ni Shaoxiang Zhang Jingyi Liu Jun Yan Yigang Chen Xiaonong Zhang | 2016 | Bioactive Materials2016，1，2： | 3 |
| 11 | High-purity magnesium pin enhances bone consolidation in distraction osteogenesis via regulating Ptch protein activating Hedgehog-alternative Wnt signaling显示文摘Magnesium alloys are promising biomaterials for orthopedic implants because of their degradability,osteogenic effects,and biocompatibility.Magnesium has been proven to promote distraction osteogenesis.However,its mechanism of promoting distraction osteogenesis is not thoroughly studied.In this work,a high-purity magnesium pin developed and applied in rat femur distraction osteogenesis.Mechanical test,radiological and histological analysis suggested that high-purity magnesium pin can promote distraction osteogenesis and shorten the consolidation time.Further RNA sequencing investigation found that alternative Wnt signaling was activated.In further bioinformatics analysis,it was found that the Hedgehog pathway is the upstream signaling pathway of the alternative Wnt pathway.We found that Ptch protein is a potential target of magnesium and verified by molecular dynamics that magnesium ions can bind to Ptch protein.In conclusion,HP Mg implants have the potential to enhance bone consolidation in the DO application,and this process might be via regulating Ptch protein activating Hedgehog-alternative Wnt signaling. | Musha Hamushan Weijie Cai Yubo Zhang Zun Ren Jiafei Du Shaoxiang Zhang Changli Zhao Pengfei Cheng Xiaonong Zhang Hao Shen Pei Han | 2021 | Bioactive Materials2021，6，6： | 3 |
| 12 | Comparative Study about Degradation of High-purity Magnesium Screw in Intact Femoral Intracondyle and in Fixation of Femoral Intracondylar Fracture显示文摘Bone screws encounter complex mechanical environment in fracture fixation of weight-bearing bone.In the present study, high-purity magnesium(HP Mg) screws were applied in fixation of rabbit femoral intracondylar fracture with 3 mm gap. In the control group, HP Mg screws of the same design were implanted at corresponding position of contralateral leg. At 4, 8 and 16 weeks after surgery, retrieved femurs went through micro-computed tomography(micro-CT) scanning and hard tissue processing. Under mechanical stress involved in fracture fixation, bending of screw bolt was observed at the portion exposed to facture gap at 4 weeks. Then local corrosion at the same portion was detected 16 weeks after surgery,which indicated the accumulation effect of mechanical stress on Mg corrosion. HP Mg screws in the fracture group had no significant difference with the control group in screw volume, surface area, surfaceto-volume ratio(S/V). And peri-implant bone volume/tissues volume(BV/TV) and bone volume density(BMD) in the fracture group was comparable to that in the control group. Furthermore, histological analysis showed new formed bone tissues in fracture gap and fracture healing 16 weeks after surgery. Under mechanical stress, HP Mg screw suffered bolt bending and local corrosion at the portion exposed to fracture gap. But it had no influence on the integral corrosion behaviors, osseointegration of HP Mg screw and the fracture healing. Therefore, HP Mg screws possessed good potential in fracture fixation of weightbearing bones. | Pei Han Pengfei Cheng Changli Zhao Shaoxiang Zhang Runhua Zhou Xiaonong Zhang Yimin Chai | 2017 | Journal of Materials Science & Technology2017，33，3： | 2 |
| 13 | Study of Cell Behaviors on Anodized TiO_2 Nanotube Arrays with Coexisting Multi-Size Diameters显示文摘It has been revealed that the different morphologies of anodized TiO_2 nanotubes, especially nanotube diameters, triggered different cell behaviors. However, the influence of TiO_2 nanotubes with coexisting multi-size diameters on cell behaviors is seldom reported. In this work, coexisting four-diameter TiO_2 nanotube samples, namely,one single substrate with the integration of four different nanotube diameters(60, 150, 250, and 350 nm), were prepared by repeated anodization. The boundaries between two different diameter regions show well-organized structure without obvious difference in height. The adhesion behaviors of MC3T3-E1 cells on the coexisting fourdiameter TiO_2 nanotube arrays were investigated. The results exhibit a significant difference of cell density between smaller diameters(60 and 150 nm) and larger diameters(250 and 350 nm) within 24 h incubation with the coexistence of different diameters, which is totally different from that on the single-diameter TiO_2 nanotube arrays. The coexistence of four different diameters does not change greatly the cell morphologies compared with the singlediameter nanotubes. The findings in this work are expected to offer further understanding of the interaction between cells and materials. | Yifan Chen Jiahua Ni Hongliu Wu Ruopeng Zhang Changli Zhao Wenzhi Chen Feiqing Zhang Shaoxiang Zhang Xiaonong Zhang | 2016 | Nano-Micro Letters2016，8，1： | 2 |
| 14 | The trajectory parameters analysis of saltating sand grains driven by wind显示文摘The study of trajectory parameters of saltating sand grains is of great importance to forming the kinematic theory of wind-sand current. By establishing the simplified theoretical pattern and probing into the relationship between lift-off angle (α) and landing angle (β), relationship between the ratio of saltation length ( L) to maximum height (H) and lift-off angle as | Xueyong Zou Qingzhen Hao Chunlai Zhang Bao Yang Yuzhang Liu Guangrong Dong Shaoxiang Zhou | 1999 | Chinese Science Bulletin1999，44，18： | 2 |
| 15 | Translational status of biomedical Mg devices in China显示文摘Magnesium(Mg)and its alloys as temporary medical implants with biodegradable and properly mechanical properties have been investigated for a long time.There are already three kinds of biodegradable Mg implants which are approved by Conformite Europeene(CE)or Korea Food and Drug Administration(KFDA),but not China Food and Drug Administration(CFDA,now it is National Medical Products Administration,NMPA).As we know,Chinese researchers,surgeons,and entrepreneurs have tried a lot to research and develop biodegradable Mg implants which might become other new approved implants for clinical applications.So in this review,we present the representative Mg implants of three categories,orthopedic implants,surgical implants,and intervention implants and provide an overview of current achievement in China from academic publications and Chinese patents.We would like to provide a systematic way to translate Mg and its alloy implants from experiment designs to clinical products. | Yu Sun Hongliu Wu Wenhui Wang Rui Zan Hongzhou Peng Shaoxiang Zhang Xiaonong Zhang | 2019 | Bioactive Materials2019，4，1： | 2 |
| 16 | In vitro degradation, hemolysis and MC3T3-E1 cell adhesion of biodegradable Mg–Zn alloy显示文摘 | Shaoxiang Zhang Jianan Li Yang Song Changli Zhao Xiaonong Zhang Chaoying Xie Yan Zhang Hairong Tao Yaohua He Yao Jiang Yujun Bian | 2009 | Materials Science & Engineering C2009，，6： | 2 |
| 17 | Production Practice on Decreasing of Direct Current Power Consumption in Zinc Electrowinning 显示文摘 | Lv Shaoxiang Dai Xi | 2001 | Trans Nonferrous Met Soc China2001，，6： | 1 |
| 18 | Damage localization in plate structures from uniform load surface curvature显示文摘 | Wu Di Luo Shaoxiang | 2004 | Journal of Sound and Vibration2004，276，2： | 1 |
| 19 | Flame retardant epoxy resins from bisphenol-A epoxy cured with hyperbranched polyphosphate ester显示文摘 | Chen Xilei Jiao Chuanmei Li Shaoxiang | 2011 | Journal of Polymer Research2011，18，： | 1 |
| 20 | Segmentation and three-dimension reconstruction ofChinese digitized human cerebrum 显示文摘 | Li Qiyu Zhang Shaoxiang Heng Phengann | 2006 | Computerized Medical Imaging and Graphics2006，30，： | 1 |
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